UniProtKB - P18266 (GSK3B_RAT)
Glycogen synthase kinase-3 beta
Gsk3b
Functioni
Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC, AXIN1, DPYSL2/CRMP2, JUN, NFATC1/NFATC, MAPT/TAU and MACF1. Requires primed phosphorylation of the majority of its substrates (PubMed:9482734).
In skeletal muscle, contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis (By similarity).
May also mediate the development of insulin resistance by regulating activation of transcription factors (By similarity).
Regulates protein synthesis by controlling the activity of initiation factor 2B (EIF2BE/EIF2B5) in the same manner as glycogen synthase (By similarity).
In Wnt signaling, GSK3B forms a multimeric complex with APC, AXIN1 and CTNNB1/beta-catenin and phosphorylates the N-terminus of CTNNB1 leading to its degradation mediated by ubiquitin/proteasomes (PubMed:9482734).
Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. Phosphorylates NFATC1/NFATC on conserved serine residues promoting NFATC1/NFATC nuclear export, shutting off NFATC1/NFATC gene regulation, and thereby opposing the action of calcineurin. Phosphorylates MAPT/TAU on 'Thr-548', decreasing significantly MAPT/TAU ability to bind and stabilize microtubules. MAPT/TAU is the principal component of neurofibrillary tangles in Alzheimer disease. Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex (By similarity).
Phosphorylates MACF1, inhibiting its binding to microtubules which is critical for its role in bulge stem cell migration and skin wound repair. Probably regulates NF-kappa-B (NFKB1) at the transcriptional level and is required for the NF-kappa-B-mediated anti-apoptotic response to TNF-alpha (TNF/TNFA) (By similarity).
Negatively regulates replication in pancreatic beta-cells, resulting in apoptosis, loss of beta-cells and diabetes (PubMed:17242403).
Through phosphorylation of the anti-apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation (By similarity).
Phosphorylates MUC1 in breast cancer cells, decreasing the interaction of MUC1 with CTNNB1/beta-catenin. Is necessary for the establishment of neuronal polarity and axon outgrowth (By similarity).
Phosphorylates MARK2, leading to inhibition of its activity (PubMed:18424437).
Phosphorylates SIK1 at 'Thr-182', leading to sustainment of its activity. Phosphorylates ZC3HAV1 which enhances its antiviral activity. Phosphorylates SNAI1, leading to its BTRC-triggered ubiquitination and proteasomal degradation. Phosphorylates SFPQ at 'Thr-687' upon T-cell activation. Phosphorylates NR1D1 st 'Ser-55' and 'Ser-59' and stabilizes it by protecting it from proteasomal degradation. Regulates the circadian clock via phosphorylation of the major clock components including ARNTL/BMAL1, CLOCK and PER2. Phosphorylates CLOCK AT 'Ser-427' and targets it for proteasomal degradation. Phosphorylates ARNTL/BMAL1 at 'Ser-17' and 'Ser-21' and primes it for ubiquitination and proteasomal degradation. Phosphorylates OGT at 'Ser-3' or 'Ser-4' which positively regulates its activity. Phosphorylates MYCN in neuroblastoma cells which may promote its degradation (By similarity).
Regulates the circadian rhythmicity of hippocampal long-term potentiation and ARNTL/BMLA1 and PER2 expression (By similarity).
Acts as a regulator of autophagy by mediating phosphorylation of KAT5/TIP60 under starvation conditions, activating KAT5/TIP60 acetyltransferase activity and promoting acetylation of key autophagy regulators, such as ULK1 and RUBCNL/Pacer. Negatively regulates extrinsic apoptotic signaling pathway via death domain receptors. Promotes the formation of an anti-apoptotic complex, made of DDX3X, BRIC2 and GSK3B, at death receptors, including TNFRSF10B. The anti-apoptotic function is most effective with weak apoptotic signals and can be overcome by stronger stimulation (By similarity).
Phosphorylates E2F1, promoting the interaction between E2F1 and USP11, stabilizing E2F1 and promoting its activity (By similarity).
By similarity3 PublicationsMiscellaneous
Catalytic activityi
- EC:2.7.11.26By similarity
- EC:2.7.11.26By similarity
- EC:2.7.11.1By similarity
- EC:2.7.11.1By similarity
Activity regulationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 85 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 181 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 62 – 70 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: RGD
- beta-catenin binding Source: RGD
- dynactin binding Source: RGD
- dynein complex binding Source: RGD
- integrin binding Source: RGD
- ionotropic glutamate receptor binding Source: RGD
- kinase activity Source: RGD
- NF-kappaB binding Source: RGD
- p53 binding Source: RGD
- protease binding Source: RGD
- protein kinase A catalytic subunit binding Source: RGD
- protein kinase activity Source: UniProtKB
- protein kinase binding Source: RGD
- protein serine/threonine/tyrosine kinase activity Source: RHEA
- protein serine/threonine kinase activity Source: BHF-UCL
- protein serine kinase activity Source: RGD
- RNA polymerase II-specific DNA-binding transcription factor binding Source: RGD
- tau protein binding Source: RGD
- tau-protein kinase activity Source: RGD
- ubiquitin protein ligase binding Source: RGD
GO - Biological processi
- aging Source: RGD
- animal organ morphogenesis Source: RGD
- axonogenesis Source: RGD
- beta-catenin destruction complex disassembly Source: RGD
- bone remodeling Source: RGD
- canonical Wnt signaling pathway Source: RGD
- cell growth involved in cardiac muscle cell development Source: RGD
- cell migration Source: RGD
- cellular response to amyloid-beta Source: ARUK-UCL
- cellular response to dopamine Source: RGD
- cellular response to erythropoietin Source: RGD
- cellular response to hepatocyte growth factor stimulus Source: RGD
- cellular response to hydrogen peroxide Source: RGD
- cellular response to interleukin-3 Source: UniProtKB
- cellular response to iron(II) ion Source: RGD
- cellular response to lithium ion Source: RGD
- cellular response to mechanical stimulus Source: RGD
- cellular response to retinoic acid Source: RGD
- circadian rhythm Source: UniProtKB
- epithelial to mesenchymal transition Source: UniProtKB
- ER overload response Source: RGD
- establishment of cell polarity Source: RGD
- establishment or maintenance of cell polarity Source: RGD
- extrinsic apoptotic signaling pathway Source: RGD
- extrinsic apoptotic signaling pathway in absence of ligand Source: UniProtKB
- fat cell differentiation Source: RGD
- glycogen metabolic process Source: RGD
- hepatic stellate cell activation Source: RGD
- hepatocyte apoptotic process Source: RGD
- hippocampus development Source: RGD
- hypermethylation of CpG island Source: RGD
- insulin receptor signaling pathway Source: RGD
- intracellular signal transduction Source: RGD
- intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress Source: RGD
- maintenance of cell polarity Source: ARUK-UCL
- myoblast fusion Source: RGD
- myotube differentiation Source: RGD
- negative regulation of apoptotic process Source: RGD
- negative regulation of calcineurin-NFAT signaling cascade Source: UniProtKB
- negative regulation of canonical Wnt signaling pathway Source: RGD
- negative regulation of canonical Wnt signaling pathway involved in osteoblast differentiation Source: RGD
- negative regulation of cardiac muscle hypertrophy Source: RGD
- negative regulation of dendrite development Source: RGD
- negative regulation of dendrite morphogenesis Source: RGD
- negative regulation of dopaminergic neuron differentiation Source: RGD
- negative regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: UniProtKB
- negative regulation of gene expression Source: RGD
- negative regulation of MAP kinase activity Source: RGD
- negative regulation of mesenchymal stem cell differentiation Source: RGD
- negative regulation of neuron death Source: UniProtKB
- negative regulation of neuron maturation Source: RGD
- negative regulation of neuron migration Source: RGD
- negative regulation of neuron projection development Source: RGD
- negative regulation of nitric-oxide synthase activity Source: RGD
- negative regulation of protein acetylation Source: ARUK-UCL
- negative regulation of protein binding Source: RGD
- negative regulation of protein-containing complex assembly Source: RGD
- negative regulation of protein localization to centrosome Source: RGD
- negative regulation of protein localization to nucleus Source: BHF-UCL
- negative regulation of smooth muscle cell apoptotic process Source: RGD
- negative regulation of synaptic assembly at neuromuscular junction Source: CACAO
- negative regulation of TOR signaling Source: RGD
- neuron projection development Source: UniProtKB
- neuron projection organization Source: ARUK-UCL
- peptidyl-serine phosphorylation Source: UniProtKB
- peptidyl-threonine phosphorylation Source: RGD
- phosphorylation Source: RGD
- positive regulation of apoptotic process Source: RGD
- positive regulation of autophagy Source: UniProtKB
- positive regulation of axon extension Source: RGD
- positive regulation of cardiac muscle cell differentiation Source: RGD
- positive regulation of cell differentiation Source: RGD
- positive regulation of cell-matrix adhesion Source: RGD
- positive regulation of cilium assembly Source: UniProtKB
- positive regulation of DNA biosynthetic process Source: RGD
- positive regulation of excitatory postsynaptic potential Source: RGD
- positive regulation of gene expression Source: RGD
- positive regulation of GTPase activity Source: RGD
- positive regulation of mitochondrial membrane potential Source: RGD
- positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway Source: UniProtKB
- positive regulation of mitochondrion organization Source: RGD
- positive regulation of neuron apoptotic process Source: RGD
- positive regulation of neuron death Source: RGD
- positive regulation of osteoblast proliferation Source: RGD
- positive regulation of osteoclast differentiation Source: RGD
- positive regulation of osteoclast proliferation Source: RGD
- positive regulation of peptidyl-threonine phosphorylation Source: RGD
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: RGD
- positive regulation of protein binding Source: UniProtKB
- positive regulation of protein catabolic process Source: RGD
- positive regulation of protein-containing complex assembly Source: RGD
- positive regulation of protein export from nucleus Source: RGD
- positive regulation of protein localization to centrosome Source: RGD
- positive regulation of protein localization to cilium Source: UniProtKB
- positive regulation of smooth muscle cell proliferation Source: RGD
- positive regulation of stem cell differentiation Source: RGD
- positive regulation of synaptic assembly at neuromuscular junction Source: CACAO
- positive regulation of transcription by RNA polymerase II Source: RGD
- protein autophosphorylation Source: RGD
- protein export from nucleus Source: RGD
- protein localization to microtubule Source: RGD
- protein phosphorylation Source: BHF-UCL
- re-entry into mitotic cell cycle Source: RGD
- regulation of apoptotic process Source: RGD
- regulation of axon extension Source: RGD
- regulation of axonogenesis Source: RGD
- regulation of cell growth Source: RGD
- regulation of circadian rhythm Source: UniProtKB
- regulation of dendrite morphogenesis Source: RGD
- regulation of gene expression by genomic imprinting Source: RGD
- regulation of long-term synaptic potentiation Source: UniProtKB
- regulation of microtubule anchoring at centrosome Source: RGD
- regulation of microtubule-based process Source: UniProtKB
- regulation of microtubule cytoskeleton organization Source: ARUK-UCL
- regulation of modification of postsynaptic structure Source: SynGO
- regulation of neuronal synaptic plasticity Source: RGD
- regulation of neuron projection development Source: RGD
- regulation of neurotransmitter receptor localization to postsynaptic specialization membrane Source: SynGO
- regulation of osteoblast differentiation Source: RGD
- regulation of protein export from nucleus Source: RGD
- regulation of synaptic vesicle exocytosis Source: RGD
- response to activity Source: RGD
- response to angiotensin Source: RGD
- response to epinephrine Source: RGD
- response to estradiol Source: RGD
- response to insulin Source: RGD
- response to insulin-like growth factor stimulus Source: RGD
- response to L-glutamate Source: RGD
- response to lithium ion Source: RGD
- response to ultrasound Source: RGD
- response to xenobiotic stimulus Source: RGD
- response to zinc ion Source: RGD
- signal transduction Source: GO_Central
- superior temporal gyrus development Source: RGD
- Wnt signaling pathway Source: RGD
Keywordsi
Molecular function | Developmental protein, Kinase, Serine/threonine-protein kinase, Signal transduction inhibitor, Transferase |
Biological process | Biological rhythms, Carbohydrate metabolism, Differentiation, Glycogen metabolism, Neurogenesis, Wnt signaling pathway |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 2.7.11.1, 5301 2.7.11.26, 5301 |
Reactomei | R-RNO-195253, Degradation of beta-catenin by the destruction complex R-RNO-196299, Beta-catenin phosphorylation cascade R-RNO-3371453, Regulation of HSF1-mediated heat shock response R-RNO-399956, CRMPs in Sema3A signaling R-RNO-4641262, Disassembly of the destruction complex and recruitment of AXIN to the membrane R-RNO-5250924, B-WICH complex positively regulates rRNA expression R-RNO-5610785, GLI3 is processed to GLI3R by the proteasome |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:Gsk3b |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 70982, Gsk3b |
Subcellular locationi
Nucleus
- Nucleus By similarity
Cytoplasm and Cytosol
- Cytoplasm By similarity
Plasma membrane
- Cell membrane By similarity
Other locations
- Membrane 1 Publication
Note: The phosphorylated form shows localization to cytoplasm and cell membrane. The MEMO1-RHOA-DIAPH1 signaling pathway controls localization of the phosphorylated form to the cell membrane (By similarity).By similarity
Cytoskeleton
- centrosome Source: RGD
- microtubule Source: RGD
Cytosol
- cytosol Source: RGD
Mitochondrion
- mitochondrion Source: RGD
Nucleus
- nucleus Source: RGD
Plasma Membrane
- plasma membrane Source: RGD
Other locations
- axon Source: RGD
- beta-catenin destruction complex Source: BHF-UCL
- cell body Source: RGD
- cytoplasm Source: RGD
- dendrite Source: RGD
- dendritic shaft Source: RGD
- dendritic spine Source: RGD
- glutamatergic synapse Source: SynGO
- growth cone Source: RGD
- membrane Source: UniProtKB
- membrane raft Source: RGD
- membrane-bounded organelle Source: RGD
- neuronal cell body Source: RGD
- perinuclear region of cytoplasm Source: RGD
- postsynaptic density Source: RGD
- protein-containing complex Source: RGD
- ribonucleoprotein complex Source: RGD
- Schaffer collateral - CA1 synapse Source: SynGO
- Wnt signalosome Source: RGD
Keywords - Cellular componenti
Cell membrane, Cytoplasm, Membrane, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 9 | S → A: Loss of phosphorylation; No inhibition of activity. 1 Publication | 1 | |
Mutagenesisi | 216 | Y → F: Loss of phosphorylation and strong reduction of activity. 1 Publication | 1 |
Chemistry databases
ChEMBLi | CHEMBL3669 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000085982 | 1 – 420 | Glycogen synthase kinase-3 betaAdd BLAST | 420 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 9 | Phosphoserine; by PKB/AKT1, RPS6KA3 and SGK3By similarity | 1 | |
Modified residuei | 216 | Phosphotyrosine1 Publication | 1 | |
Modified residuei | 389 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
ADP-ribosylation, PhosphoproteinProteomic databases
jPOSTi | P18266 |
PaxDbi | P18266 |
PRIDEi | P18266 |
PTM databases
iPTMneti | P18266 |
PhosphoSitePlusi | P18266 |
Interactioni
Subunit structurei
Monomer (By similarity).
Interacts with DAB2IP (via C2 domain); the interaction stimulates GSK3B kinase activation (By similarity).
Interacts (via C2 domain) with PPP2CA (By similarity).
Interacts with ARRB2, AXIN1, CABYR, DISC1, MMP2, MUC1, NIN, PRUNE1 and ZBED3 (By similarity).
Interacts with AXIN1; the interaction mediates hyperphosphorylation of CTNNB1 leading to its ubiquitination and destruction (PubMed:9482734).
Interacts with and phosphorylates SNAI1 (By similarity).
Interacts with DNM1L (via a C-terminal domain) (By similarity).
Found in a complex composed of MACF1, APC, AXIN1, CTNNB1 and GSK3B (PubMed:16815997).
Interacts with SGK3 (By similarity).
Interacts with the CLOCK-ARNTL/BMAL1 heterodimer (By similarity).
Interacts with the ARNTL/BMAL1 (By similarity).
Interacts with CTNND2 (By similarity). The complex composed, at least, of APC, CTNNB1 and GSK3B interacts with JPT1; the interaction requires the inactive form of GSK3B (phosphorylated at 'Ser-9') (By similarity).
Forms a complex composed of PRKAR2A or PRKAR2B, GSK3B and GSKIP through GSKIP interaction; facilitates PKA-induced phosphorylation and regulates GSK3B activity (By similarity).
Interacts with GSKIP (By similarity).
Interacts with GID8 (By similarity).
Interacts with PIWIL2 (By similarity).
Interacts with LMBR1L (By similarity).
Interacts with DDX3X (By similarity).
Interacts with BIRC2 (By similarity).
Interacts with TNFRSF10B; TNFRSF10B stimulation inhibits GSK3B kinase activity (By similarity).
By similarity2 PublicationsGO - Molecular functioni
- beta-catenin binding Source: RGD
- dynactin binding Source: RGD
- integrin binding Source: RGD
- ionotropic glutamate receptor binding Source: RGD
- NF-kappaB binding Source: RGD
- p53 binding Source: RGD
- protease binding Source: RGD
- protein kinase A catalytic subunit binding Source: RGD
- protein kinase binding Source: RGD
- RNA polymerase II-specific DNA-binding transcription factor binding Source: RGD
- tau protein binding Source: RGD
- ubiquitin protein ligase binding Source: RGD
Protein-protein interaction databases
BioGRIDi | 249893, 12 interactors |
CORUMi | P18266 |
DIPi | DIP-40957N |
IntActi | P18266, 1 interactor |
MINTi | P18266 |
STRINGi | 10116.ENSRNOP00000003867 |
Chemistry databases
BindingDBi | P18266 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 56 – 340 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 285 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 53 | DisorderedSequence analysisAdd BLAST | 53 | |
Regioni | 385 – 420 | DisorderedSequence analysisAdd BLAST | 36 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 25 | Polar residuesSequence analysisAdd BLAST | 25 | |
Compositional biasi | 391 – 420 | Polar residuesSequence analysisAdd BLAST | 30 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0658, Eukaryota |
InParanoidi | P18266 |
OrthoDBi | 990896at2759 |
PhylomeDBi | P18266 |
TreeFami | TF101104 |
Family and domain databases
CDDi | cd14137, STKc_GSK3, 1 hit |
InterProi | View protein in InterPro IPR033573, GSK3B IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS IPR039192, STKc_GSK3 |
PANTHERi | PTHR24057:SF8, PTHR24057:SF8, 1 hit |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MSGRPRTTSF AESCKPVQQP SAFGSMKVSR DKDGSKVTTV VATPGQGPDR
60 70 80 90 100
PQEVSYTDTK VIGNGSFGVV YQAKLCDSGE LVAIKKVLQD KRFKNRELQI
110 120 130 140 150
MRKLDHCNIV RLRYFFYSSG EKKDEVYLNL VLDYVPETVY RVARHYSRAK
160 170 180 190 200
QTLPVIYVKL YMYQLFRSLA YIHSFGICHR DIKPQNLLLD PDTAVLKLCD
210 220 230 240 250
FGSAKQLVRG EPNVSYICSR YYRAPELIFG ATDYTSSIDM WSAGCVLAEL
260 270 280 290 300
LLGQPIFPGD SGVDQLVEII KVLGTPTREQ IREMNPNYTE FKFPQIKAHP
310 320 330 340 350
WTKVFRPRTP PEAIALCSRL LEYTPTARLT PLEACAHSFF DELRDPNVKL
360 370 380 390 400
PNGRDTPALF NFTTQELSSN PPLATILIPP HARIQAAASP PANATAASDT
410 420
NAGDRGQTNN AASASASNST
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0G2JSH4 | A0A0G2JSH4_RAT | Glycogen synthase kinase-3 beta | Gsk3b | 433 | Annotation score: | ||
A0A0G2KB98 | A0A0G2KB98_RAT | Glycogen synthase kinase-3 beta | Gsk3b | 430 | Annotation score: | ||
A0A8I6GL38 | A0A8I6GL38_RAT | Glycogen synthase kinase-3 beta | Gsk3b | 417 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 240 | M → V in CAA52020 (PubMed:7686508).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X53428 mRNA Translation: CAA37519.1 X73653 mRNA Translation: CAA52020.1 |
PIRi | S14708, TVRTKB |
RefSeqi | NP_114469.1, NM_032080.1 |
Genome annotation databases
GeneIDi | 84027 |
KEGGi | rno:84027 |
UCSCi | RGD:70982, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X53428 mRNA Translation: CAA37519.1 X73653 mRNA Translation: CAA52020.1 |
PIRi | S14708, TVRTKB |
RefSeqi | NP_114469.1, NM_032080.1 |
3D structure databases
AlphaFoldDBi | P18266 |
SMRi | P18266 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 249893, 12 interactors |
CORUMi | P18266 |
DIPi | DIP-40957N |
IntActi | P18266, 1 interactor |
MINTi | P18266 |
STRINGi | 10116.ENSRNOP00000003867 |
Chemistry databases
BindingDBi | P18266 |
ChEMBLi | CHEMBL3669 |
PTM databases
iPTMneti | P18266 |
PhosphoSitePlusi | P18266 |
Proteomic databases
jPOSTi | P18266 |
PaxDbi | P18266 |
PRIDEi | P18266 |
Genome annotation databases
GeneIDi | 84027 |
KEGGi | rno:84027 |
UCSCi | RGD:70982, rat |
Organism-specific databases
CTDi | 2932 |
RGDi | 70982, Gsk3b |
Phylogenomic databases
eggNOGi | KOG0658, Eukaryota |
InParanoidi | P18266 |
OrthoDBi | 990896at2759 |
PhylomeDBi | P18266 |
TreeFami | TF101104 |
Enzyme and pathway databases
BRENDAi | 2.7.11.1, 5301 2.7.11.26, 5301 |
Reactomei | R-RNO-195253, Degradation of beta-catenin by the destruction complex R-RNO-196299, Beta-catenin phosphorylation cascade R-RNO-3371453, Regulation of HSF1-mediated heat shock response R-RNO-399956, CRMPs in Sema3A signaling R-RNO-4641262, Disassembly of the destruction complex and recruitment of AXIN to the membrane R-RNO-5250924, B-WICH complex positively regulates rRNA expression R-RNO-5610785, GLI3 is processed to GLI3R by the proteasome |
Miscellaneous databases
PROi | PR:P18266 |
Family and domain databases
CDDi | cd14137, STKc_GSK3, 1 hit |
InterProi | View protein in InterPro IPR033573, GSK3B IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS IPR039192, STKc_GSK3 |
PANTHERi | PTHR24057:SF8, PTHR24057:SF8, 1 hit |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | GSK3B_RAT | |
Accessioni | P18266Primary (citable) accession number: P18266 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1990 |
Last sequence update: | November 1, 1990 | |
Last modified: | May 25, 2022 | |
This is version 212 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families