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Protein

ADP,ATP carrier protein 2

Gene

PET9

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the exchange of ADP and ATP across the mitochondrial inner membrane.1 Publication

Enzyme regulationi

Inhibited by carboxyatractyloside and bongkrekic acid.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei96ADP1 Publication1
Binding sitei108ADP1 Publication1
Binding sitei252ADP1 Publication1

GO - Molecular functioni

  • ATP:ADP antiporter activity Source: UniProtKB

GO - Biological processi

  • ADP transport Source: SGD
  • aerobic respiration Source: SGD
  • anaerobic respiration Source: SGD
  • apoptotic process Source: SGD
  • ATP transport Source: SGD
  • heme transport Source: SGD
  • mitochondrial transport Source: SGD
  • regulation of mitochondrial membrane permeability Source: GO_Central
  • transmembrane transport Source: SGD

Keywordsi

Biological processTransport

Enzyme and pathway databases

BioCyciYEAST:G3O-28933-MONOMER

Protein family/group databases

TCDBi2.A.29.1.7 the mitochondrial carrier (mc) family

Names & Taxonomyi

Protein namesi
Recommended name:
ADP,ATP carrier protein 2
Alternative name(s):
ADP/ATP translocase 2
Adenine nucleotide translocator 2
Short name:
ANT 2
Petite colonies protein 9
Gene namesi
Name:PET9
Synonyms:AAC2
Ordered Locus Names:YBL030C
ORF Names:YBL0421
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:YBL030C
SGDiS000000126 PET9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei23 – 50Helical; Name=11 PublicationAdd BLAST28
Transmembranei91 – 115Helical; Name=21 PublicationAdd BLAST25
Transmembranei123 – 143Helical; Name=31 PublicationAdd BLAST21
Transmembranei193 – 214Helical; Name=41 PublicationAdd BLAST22
Transmembranei228 – 248Helical; Name=51 PublicationAdd BLAST21
Transmembranei288 – 308Helical; Name=61 PublicationAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi109D → K: Loss of transport activity; when associated with K-212 and K-306. Restored transport activity; when associated with D-112; K-212; D-215; K-306 and D-309. 1 Publication1
Mutagenesisi112K → D: Loss of transport activity; when associated with D-215 and D-309. Restored transport activity; when associated with K-109; K-212; D-215; K-306 and D-309. 1 Publication1
Mutagenesisi212D → K: Loss of transport activity; when associated with K-109 and K-306. Restored transport activity; when associated with D-109; D-112; D-215; K-306 and D-309. 1 Publication1
Mutagenesisi215K → D: Loss of transport activity; when associated with D-112 and D-309. Restored transport activity; when associated with K-109; D-112; K-212; K-306 and D-309. 1 Publication1
Mutagenesisi306D → K: Loss of transport activity; when associated with K-109 and K-212. Restored transport activity; when associated with D-109; D-112; K-212; D-215 and D-309. 1 Publication1
Mutagenesisi309Q → D: Loss of transport activity; when associated with D-112 and D-215. Restored transport activity; when associated with K-109; D-112; K-212; D-215 and K-306. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000905941 – 318ADP,ATP carrier protein 2Add BLAST318

Proteomic databases

MaxQBiP18239
PaxDbiP18239
PRIDEiP18239

PTM databases

iPTMnetiP18239

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

BioGridi32667, 190 interactors
DIPiDIP-2917N
IntActiP18239, 77 interactors
MINTiP18239
STRINGi4932.YBL030C

Structurei

Secondary structure

1318
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi25 – 52Combined sources28
Helixi54 – 59Combined sources6
Helixi70 – 81Combined sources12
Helixi84 – 87Combined sources4
Helixi90 – 95Combined sources6
Helixi97 – 115Combined sources19
Helixi119 – 121Combined sources3
Helixi123 – 156Combined sources34
Helixi173 – 183Combined sources11
Turni187 – 189Combined sources3
Helixi193 – 213Combined sources21
Helixi229 – 244Combined sources16
Helixi246 – 257Combined sources12
Turni258 – 260Combined sources3
Helixi268 – 279Combined sources12
Helixi281 – 285Combined sources5
Helixi288 – 308Combined sources21
Beta strandi313 – 315Combined sources3

3D structure databases

ProteinModelPortaliP18239
SMRiP18239
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati21 – 114Solcar 1Add BLAST94
Repeati125 – 217Solcar 2Add BLAST93
Repeati225 – 311Solcar 3Add BLAST87

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni252 – 257Important for transport activityBy similarity6

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi252 – 257Nucleotide carrier signature motifBy similarity6

Domaini

The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. At least 2 of the odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue.1 Publication

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00920000150552
HOGENOMiHOG000165727
InParanoidiP18239
KOiK05863
OMAiECFKRTA
OrthoDBiEOG092C3PSA

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR002113 Aden_trnslctor
IPR002067 Mit_carrier
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
PRINTSiPR00927 ADPTRNSLCASE
PR00926 MITOCARRIER
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequencei

Sequence statusi: Complete.

P18239-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSNAQVKTP LPPAPAPKKE SNFLIDFLMG GVSAAVAKTA ASPIERVKLL
60 70 80 90 100
IQNQDEMLKQ GTLDRKYAGI LDCFKRTATQ EGVISFWRGN TANVIRYFPT
110 120 130 140 150
QALNFAFKDK IKAMFGFKKE EGYAKWFAGN LASGGAAGAL SLLFVYSLDY
160 170 180 190 200
ARTRLAADSK SSKKGGARQF NGLIDVYKKT LKSDGVAGLY RGFLPSVVGI
210 220 230 240 250
VVYRGLYFGM YDSLKPLLLT GSLEGSFLAS FLLGWVVTTG ASTCSYPLDT
260 270 280 290 300
VRRRMMMTSG QAVKYDGAFD CLRKIVAAEG VGSLFKGCGA NILRGVAGAG
310
VISMYDQLQM ILFGKKFK
Length:318
Mass (Da):34,426
Last modified:October 1, 1994 - v2
Checksum:iA9805DC33D9E24AC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti58L → I in AAA97484 (PubMed:2165073).Curated1
Sequence conflicti65R → K in AAA97484 (PubMed:2165073).Curated1
Sequence conflicti68A → S in AAA97484 (PubMed:2165073).Curated1
Sequence conflicti71L → V in AAA97484 (PubMed:2165073).Curated1
Sequence conflicti79T → K in AAA97484 (PubMed:2165073).Curated1
Sequence conflicti83V → L in AAA97484 (PubMed:2165073).Curated1
Sequence conflicti113A → L in AAA97484 (PubMed:2165073).Curated1
Sequence conflicti124A → G in AAA97484 (PubMed:2165073).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X77291 Genomic DNA Translation: CAA54501.1
J04021 Genomic DNA Translation: AAA34381.1
M34075 Genomic DNA Translation: AAA97484.1
X74427 Genomic DNA Translation: CAA52446.1
Z35791 Genomic DNA Translation: CAA84850.1
BK006936 Genomic DNA Translation: DAA07089.1
PIRiA31978
RefSeqiNP_009523.1, NM_001178270.1

Genome annotation databases

EnsemblFungiiYBL030C; YBL030C; YBL030C
GeneIDi852250
KEGGisce:YBL030C

Similar proteinsi

Entry informationi

Entry nameiADT2_YEAST
AccessioniPrimary (citable) accession number: P18239
Secondary accession number(s): D6VPW9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: October 1, 1994
Last modified: July 18, 2018
This is version 171 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

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