UniProtKB - P18238 (ADT3_YEAST)
Protein
ADP,ATP carrier protein 3
Gene
AAC3
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Catalyzes the exchange of ADP and ATP across the mitochondrial inner membrane.
Miscellaneous
Present with 1080 molecules/cell in log phase SD medium.1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 85 | ADP1 Publication | 1 | |
Binding sitei | 97 | ADP1 Publication | 1 | |
Binding sitei | 241 | ADP1 Publication | 1 |
GO - Molecular functioni
- ATP:ADP antiporter activity Source: SGD
- identical protein binding Source: IntAct
GO - Biological processi
- anaerobic respiration Source: SGD
- heme transport Source: SGD
- mitochondrial ADP transmembrane transport Source: InterPro
- mitochondrial ATP transmembrane transport Source: InterPro
- transmembrane transport Source: SGD
Keywordsi
Biological process | Transport |
Protein family/group databases
TCDBi | 2.A.29.1.9, the mitochondrial carrier (mc) family |
Names & Taxonomyi
Protein namesi | Recommended name: ADP,ATP carrier protein 3Alternative name(s): ADP/ATP translocase 3 Adenine nucleotide translocator 3 Short name: ANT 3 |
Gene namesi | Name:AAC3 Ordered Locus Names:YBR085W ORF Names:YBR0753 |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
EuPathDBi | FungiDB:YBR085W |
SGDi | S000000289, AAC3 |
Subcellular locationi
Mitochondrion
Mitochondrion
- mitochondrial inner membrane Source: SGD
- mitochondrion Source: SGD
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 12 – 39 | Helical; Name=11 PublicationAdd BLAST | 28 | |
Transmembranei | 80 – 104 | Helical; Name=21 PublicationAdd BLAST | 25 | |
Transmembranei | 112 – 132 | Helical; Name=31 PublicationAdd BLAST | 21 | |
Transmembranei | 182 – 203 | Helical; Name=41 PublicationAdd BLAST | 22 | |
Transmembranei | 217 – 237 | Helical; Name=51 PublicationAdd BLAST | 21 | |
Transmembranei | 277 – 297 | Helical; Name=6By similarityAdd BLAST | 21 |
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion inner membranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000090595 | 1 – 307 | ADP,ATP carrier protein 3Add BLAST | 307 |
Proteomic databases
MaxQBi | P18238 |
PaxDbi | P18238 |
PRIDEi | P18238 |
Interactioni
Subunit structurei
Homodimer.
Binary interactionsi
P18238
With | #Exp. | IntAct |
---|---|---|
itself | 2 | EBI-2300,EBI-2300 |
GO - Molecular functioni
- identical protein binding Source: IntAct
Protein-protein interaction databases
BioGRIDi | 32790, 201 interactors |
DIPi | DIP-6289N |
IntActi | P18238, 20 interactors |
MINTi | P18238 |
STRINGi | 4932.YBR085W |
Miscellaneous databases
RNActi | P18238, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
BMRBi | P18238 |
SMRi | P18238 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 10 – 103 | Solcar 1Add BLAST | 94 | |
Repeati | 114 – 206 | Solcar 2Add BLAST | 93 | |
Repeati | 214 – 300 | Solcar 3Add BLAST | 87 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 241 – 246 | Important for transport activityBy similarity | 6 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 241 – 246 | Nucleotide carrier signature motifBy similarity | 6 |
Domaini
The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. At least 2 of the odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue.By similarity
Sequence similaritiesi
Keywords - Domaini
Repeat, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0749, Eukaryota |
GeneTreei | ENSGT00940000176325 |
HOGENOMi | CLU_015166_12_0_1 |
InParanoidi | P18238 |
OMAi | LGWIVTT |
Family and domain databases
Gene3Di | 1.50.40.10, 1 hit |
InterProi | View protein in InterPro IPR002113, ADT_euk_type IPR002067, Mit_carrier IPR018108, Mitochondrial_sb/sol_carrier IPR023395, Mt_carrier_dom_sf |
PANTHERi | PTHR45635, PTHR45635, 1 hit |
Pfami | View protein in Pfam PF00153, Mito_carr, 3 hits |
PRINTSi | PR00927, ADPTRNSLCASE PR00926, MITOCARRIER |
SUPFAMi | SSF103506, SSF103506, 1 hit |
PROSITEi | View protein in PROSITE PS50920, SOLCAR, 3 hits |
i Sequence
Sequence statusi: Complete.
P18238-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSSDAKQQET NFAINFLMGG VSAAIAKTAA SPIERVKILI QNQDEMIKQG
60 70 80 90 100
TLDKKYSGIV DCFKRTAKQE GLISFWRGNT ANVIRYFPTQ ALNFAFKDKI
110 120 130 140 150
KLMFGFKKEE GYGKWFAGNL ASGGAAGALS LLFVYSLDFA RTRLAADAKS
160 170 180 190 200
SKKGGARQFN GLTDVYKKTL KSDGIAGLYR GFMPSVVGIV VYRGLYFGMF
210 220 230 240 250
DSLKPLVLTG SLDGSFLASF LLGWVVTTGA STCSYPLDTV RRRMMMTSGQ
260 270 280 290 300
AVKYNGAIDC LKKIVASEGV GSLFKGCGAN ILRSVAGAGV ISMYDQLQMI
LFGKKFK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M34076 Genomic DNA Translation: AAA97485.1 Z35954 Genomic DNA Translation: CAA85031.1 BK006936 Genomic DNA Translation: DAA07205.1 |
PIRi | A36582 |
RefSeqi | NP_009642.3, NM_001178433.3 |
Genome annotation databases
EnsemblFungii | YBR085W_mRNA; YBR085W; YBR085W |
GeneIDi | 852380 |
KEGGi | sce:YBR085W |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M34076 Genomic DNA Translation: AAA97485.1 Z35954 Genomic DNA Translation: CAA85031.1 BK006936 Genomic DNA Translation: DAA07205.1 |
PIRi | A36582 |
RefSeqi | NP_009642.3, NM_001178433.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4C9J | X-ray | 3.40 | A/B | 3-307 | [»] | |
4C9Q | X-ray | 3.20 | A/B | 3-307 | [»] | |
BMRBi | P18238 | |||||
SMRi | P18238 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 32790, 201 interactors |
DIPi | DIP-6289N |
IntActi | P18238, 20 interactors |
MINTi | P18238 |
STRINGi | 4932.YBR085W |
Protein family/group databases
TCDBi | 2.A.29.1.9, the mitochondrial carrier (mc) family |
Proteomic databases
MaxQBi | P18238 |
PaxDbi | P18238 |
PRIDEi | P18238 |
Protocols and materials databases
DNASUi | 852380 |
Genome annotation databases
EnsemblFungii | YBR085W_mRNA; YBR085W; YBR085W |
GeneIDi | 852380 |
KEGGi | sce:YBR085W |
Organism-specific databases
EuPathDBi | FungiDB:YBR085W |
SGDi | S000000289, AAC3 |
Phylogenomic databases
eggNOGi | KOG0749, Eukaryota |
GeneTreei | ENSGT00940000176325 |
HOGENOMi | CLU_015166_12_0_1 |
InParanoidi | P18238 |
OMAi | LGWIVTT |
Miscellaneous databases
PROi | PR:P18238 |
RNActi | P18238, protein |
Family and domain databases
Gene3Di | 1.50.40.10, 1 hit |
InterProi | View protein in InterPro IPR002113, ADT_euk_type IPR002067, Mit_carrier IPR018108, Mitochondrial_sb/sol_carrier IPR023395, Mt_carrier_dom_sf |
PANTHERi | PTHR45635, PTHR45635, 1 hit |
Pfami | View protein in Pfam PF00153, Mito_carr, 3 hits |
PRINTSi | PR00927, ADPTRNSLCASE PR00926, MITOCARRIER |
SUPFAMi | SSF103506, SSF103506, 1 hit |
PROSITEi | View protein in PROSITE PS50920, SOLCAR, 3 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ADT3_YEAST | |
Accessioni | P18238Primary (citable) accession number: P18238 Secondary accession number(s): D6VQ85 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1990 |
Last sequence update: | November 1, 1990 | |
Last modified: | December 2, 2020 | |
This is version 178 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome II
Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names