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Protein

ADP,ATP carrier protein 3

Gene

AAC3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the exchange of ADP and ATP across the mitochondrial inner membrane.

Miscellaneous

Present with 1080 molecules/cell in log phase SD medium.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei85ADP1 Publication1
Binding sitei97ADP1 Publication1
Binding sitei241ADP1 Publication1

GO - Molecular functioni

  • ATP:ADP antiporter activity Source: SGD
  • identical protein binding Source: IntAct

GO - Biological processi

  • anaerobic respiration Source: SGD
  • heme transport Source: SGD
  • regulation of mitochondrial membrane permeability Source: GO_Central
  • transmembrane transport Source: SGD

Keywordsi

Biological processTransport

Enzyme and pathway databases

BioCyciYEAST:G3O-29052-MONOMER
ReactomeiR-SCE-422356 Regulation of insulin secretion

Protein family/group databases

TCDBi2.A.29.1.9 the mitochondrial carrier (mc) family

Names & Taxonomyi

Protein namesi
Recommended name:
ADP,ATP carrier protein 3
Alternative name(s):
ADP/ATP translocase 3
Adenine nucleotide translocator 3
Short name:
ANT 3
Gene namesi
Name:AAC3
Ordered Locus Names:YBR085W
ORF Names:YBR0753
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:YBR085W
SGDiS000000289 AAC3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei12 – 39Helical; Name=11 PublicationAdd BLAST28
Transmembranei80 – 104Helical; Name=21 PublicationAdd BLAST25
Transmembranei112 – 132Helical; Name=31 PublicationAdd BLAST21
Transmembranei182 – 203Helical; Name=41 PublicationAdd BLAST22
Transmembranei217 – 237Helical; Name=51 PublicationAdd BLAST21
Transmembranei277 – 297Helical; Name=6By similarityAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000905951 – 307ADP,ATP carrier protein 3Add BLAST307

Proteomic databases

MaxQBiP18238
PaxDbiP18238
PRIDEiP18238

Interactioni

Subunit structurei

Homodimer.

Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-2300,EBI-2300

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi32790, 199 interactors
DIPiDIP-6289N
IntActiP18238, 20 interactors
MINTiP18238
STRINGi4932.YBR085W

Structurei

Secondary structure

1307
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi5 – 29Combined sources25
Helixi31 – 41Combined sources11
Helixi43 – 48Combined sources6
Helixi59 – 69Combined sources11
Helixi73 – 76Combined sources4
Helixi79 – 104Combined sources26
Turni108 – 110Combined sources3
Helixi112 – 146Combined sources35
Helixi162 – 172Combined sources11
Helixi175 – 178Combined sources4
Turni179 – 181Combined sources3
Helixi182 – 202Combined sources21
Helixi217 – 233Combined sources17
Helixi235 – 246Combined sources12
Turni247 – 249Combined sources3
Helixi257 – 268Combined sources12
Helixi270 – 274Combined sources5
Helixi277 – 301Combined sources25
Beta strandi302 – 304Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4C9JX-ray3.40A/B3-307[»]
4C9QX-ray3.20A/B3-307[»]
ProteinModelPortaliP18238
SMRiP18238
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati10 – 103Solcar 1Add BLAST94
Repeati114 – 206Solcar 2Add BLAST93
Repeati214 – 300Solcar 3Add BLAST87

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni241 – 246Important for transport activityBy similarity6

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi241 – 246Nucleotide carrier signature motifBy similarity6

Domaini

The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. At least 2 of the odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue.By similarity

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000011543
HOGENOMiHOG000165727
InParanoidiP18238
KOiK05863
OMAiMSKEKSF
OrthoDBiEOG092C3PSA

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR002113 Aden_trnslctor
IPR002067 Mit_carrier
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
PRINTSiPR00927 ADPTRNSLCASE
PR00926 MITOCARRIER
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequencei

Sequence statusi: Complete.

P18238-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSDAKQQET NFAINFLMGG VSAAIAKTAA SPIERVKILI QNQDEMIKQG
60 70 80 90 100
TLDKKYSGIV DCFKRTAKQE GLISFWRGNT ANVIRYFPTQ ALNFAFKDKI
110 120 130 140 150
KLMFGFKKEE GYGKWFAGNL ASGGAAGALS LLFVYSLDFA RTRLAADAKS
160 170 180 190 200
SKKGGARQFN GLTDVYKKTL KSDGIAGLYR GFMPSVVGIV VYRGLYFGMF
210 220 230 240 250
DSLKPLVLTG SLDGSFLASF LLGWVVTTGA STCSYPLDTV RRRMMMTSGQ
260 270 280 290 300
AVKYNGAIDC LKKIVASEGV GSLFKGCGAN ILRSVAGAGV ISMYDQLQMI

LFGKKFK
Length:307
Mass (Da):33,313
Last modified:November 1, 1990 - v1
Checksum:iD0C1329FEC1B4DC8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M34076 Genomic DNA Translation: AAA97485.1
Z35954 Genomic DNA Translation: CAA85031.1
BK006936 Genomic DNA Translation: DAA07205.1
PIRiA36582
RefSeqiNP_009642.3, NM_001178433.3

Genome annotation databases

EnsemblFungiiYBR085W; YBR085W; YBR085W
GeneIDi852380
KEGGisce:YBR085W

Similar proteinsi

Entry informationi

Entry nameiADT3_YEAST
AccessioniPrimary (citable) accession number: P18238
Secondary accession number(s): D6VQ85
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: May 23, 2018
This is version 161 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

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