UniProtKB - P18238 (ADT3_YEAST)

BLAST

>sp|P18238|ADT3_YEAST ADP,ATP carrier protein 3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=AAC3 PE=1 SV=1
MSSDAKQQETNFAINFLMGGVSAAIAKTAASPIERVKILIQNQDEMIKQGTLDKKYSGIV
DCFKRTAKQEGLISFWRGNTANVIRYFPTQALNFAFKDKIKLMFGFKKEEGYGKWFAGNL
ASGGAAGALSLLFVYSLDFARTRLAADAKSSKKGGARQFNGLTDVYKKTLKSDGIAGLYR
GFMPSVVGIVVYRGLYFGMFDSLKPLVLTGSLDGSFLASFLLGWVVTTGASTCSYPLDTV
RRRMMMTSGQAVKYNGAIDCLKKIVASEGVGSLFKGCGANILRSVAGAGVISMYDQLQMI
LFGKKFK

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History
Entry version 163 (12 Sep 2018)
Sequence version 1 (01 Nov 1990)
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Protein

ADP,ATP carrier protein 3

Gene

AAC3

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Catalyzes the exchange of ADP and ATP across the mitochondrial inner membrane.

Miscellaneous

Present with 1080 molecules/cell in log phase SD medium.1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	85	ADP1 Publication	1
Binding siteⁱ	97	ADP1 Publication	1
Binding siteⁱ	241	ADP1 Publication	1

GO - Molecular functionⁱ

ATP:ADP antiporter activity
Source: SGD
Inferred from sequence alignmentⁱ
- 2165073
identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- 20152151

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

anaerobic respiration
Source: SGD
Inferred from genetic interactionⁱ
- 1915842
- 2165073
heme transport
Source: SGD
Inferred from mutant phenotypeⁱ
- 18728780
regulation of mitochondrial membrane permeability Source: GO_Central
transmembrane transport
Source: SGD
Inferred from sequence alignmentⁱ
- 2165073

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Transport

Biological process

Transport

Enzyme and pathway databases

BioCycⁱ	YEAST:G3O-29052-MONOMER
Reactomeⁱ	R-SCE-422356 Regulation of insulin secretion

Protein family/group databases

TCDBⁱ	2.A.29.1.9 the mitochondrial carrier (mc) family

TCDBⁱ

2.A.29.1.9 the mitochondrial carrier (mc) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: ADP,ATP carrier protein 3 Alternative name(s): ADP/ATP translocase 3 Adenine nucleotide translocator 3 Short name: ANT 3
Gene namesⁱ	Name:AAC3 Ordered Locus Names:YBR085W ORF Names:YBR0753
Organismⁱ	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifierⁱ	559292 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae
Proteomesⁱ	UP000002311 Componentⁱ: Chromosome II

Organism-specific databases

EuPathDBⁱ	FungiDB:YBR085W
Saccharomyces Genome Database More...SGDⁱ	S000000289 AAC3

Topology

Feature key	Position(s)	DescriptionActions	Length
Transmembraneⁱ	12 – 39	Helical; Name=11 PublicationAdd BLAST	28
Transmembraneⁱ	80 – 104	Helical; Name=21 PublicationAdd BLAST	25
Transmembraneⁱ	112 – 132	Helical; Name=31 PublicationAdd BLAST	21
Transmembraneⁱ	182 – 203	Helical; Name=41 PublicationAdd BLAST	22
Transmembraneⁱ	217 – 237	Helical; Name=51 PublicationAdd BLAST	21
Transmembraneⁱ	277 – 297	Helical; Name=6By similarityAdd BLAST	21

Keywords - Cellular componentⁱ

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000090595	1 – 307	ADP,ATP carrier protein 3Add BLAST		307

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P18238
PaxDbⁱ	P18238
PRIDEⁱ	P18238

Interactionⁱ

Subunit structureⁱ

Homodimer.

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
itself		2	EBI-2300,EBI-2300

With

Entry

#Exp.

IntAct

Notes

itself

EBI-2300,EBI-2300

GO - Molecular functionⁱ

identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- 20152151

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	32790, 199 interactors
Database of interacting proteins More...DIPⁱ	DIP-6289N
IntActⁱ	P18238, 20 interactors
Molecular INTeraction database More...MINTⁱ	P18238
STRINGⁱ	4932.YBR085W

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	5 – 29	Combined sources	25
Helixⁱ	31 – 41	Combined sources	11
Helixⁱ	43 – 48	Combined sources	6
Helixⁱ	59 – 69	Combined sources	11
Helixⁱ	73 – 76	Combined sources	4
Helixⁱ	79 – 104	Combined sources	26
Turnⁱ	108 – 110	Combined sources	3
Helixⁱ	112 – 146	Combined sources	35
Helixⁱ	162 – 172	Combined sources	11
Helixⁱ	175 – 178	Combined sources	4
Turnⁱ	179 – 181	Combined sources	3
Helixⁱ	182 – 202	Combined sources	21
Helixⁱ	217 – 233	Combined sources	17
Helixⁱ	235 – 246	Combined sources	12
Turnⁱ	247 – 249	Combined sources	3
Helixⁱ	257 – 268	Combined sources	12
Helixⁱ	270 – 274	Combined sources	5
Helixⁱ	277 – 301	Combined sources	25
Beta strandⁱ	302 – 304	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	P18238
SMRⁱ	P18238
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	10 – 103	Solcar 1Add BLAST	94
Repeatⁱ	114 – 206	Solcar 2Add BLAST	93
Repeatⁱ	214 – 300	Solcar 3Add BLAST	87

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	241 – 246	Important for transport activityBy similarity		6

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	241 – 246	Nucleotide carrier signature motifBy similarity		6

Domainⁱ

The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. At least 2 of the odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue.By similarity

Sequence similaritiesⁱ

Belongs to the mitochondrial carrier (TC 2.A.29) family. [View classification]Curated

Keywords - Domainⁱ

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000011543
HOGENOMⁱ	HOG000165727
InParanoidⁱ	P18238
KEGG Orthology (KO) More...KOⁱ	K05863
OMAⁱ	MSKEKSF
Database of Orthologous Groups More...OrthoDBⁱ	EOG092C3PSA

Family and domain databases

Gene3Dⁱ	1.50.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR002113 Aden_trnslctor IPR002067 Mit_carrier IPR018108 Mitochondrial_sb/sol_carrier IPR023395 Mt_carrier_dom_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00153 Mito_carr, 3 hits
PRINTSⁱ	PR00927 ADPTRNSLCASE PR00926 MITOCARRIER
SUPFAMⁱ	SSF103506 SSF103506, 1 hit
PROSITEⁱ	View protein in PROSITE PS50920 SOLCAR, 3 hits

Sequenceⁱ

Sequence statusⁱ: Complete.

P18238-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSSDAKQQET NFAINFLMGG VSAAIAKTAA SPIERVKILI QNQDEMIKQG 
        60         70         80         90        100
TLDKKYSGIV DCFKRTAKQE GLISFWRGNT ANVIRYFPTQ ALNFAFKDKI 
       110        120        130        140        150
KLMFGFKKEE GYGKWFAGNL ASGGAAGALS LLFVYSLDFA RTRLAADAKS 
       160        170        180        190        200
SKKGGARQFN GLTDVYKKTL KSDGIAGLYR GFMPSVVGIV VYRGLYFGMF 
       210        220        230        240        250
DSLKPLVLTG SLDGSFLASF LLGWVVTTGA STCSYPLDTV RRRMMMTSGQ 
       260        270        280        290        300
AVKYNGAIDC LKKIVASEGV GSLFKGCGAN ILRSVAGAGV ISMYDQLQMI 

LFGKKFK

Length:307

Mass (Da):33,313

Last modified:November 1, 1990 - v1

Checksum:ⁱD0C1329FEC1B4DC8

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M34076 Genomic DNA Translation: AAA97485.1 Z35954 Genomic DNA Translation: CAA85031.1 BK006936 Genomic DNA Translation: DAA07205.1
PIRⁱ	A36582
NCBI Reference Sequences More...RefSeqⁱ	NP_009642.3, NM_001178433.3

Genome annotation databases

EnsemblFungiⁱ	YBR085W; YBR085W; YBR085W
GeneIDⁱ	852380
KEGGⁱ	sce:YBR085W

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P18238	K7_Aac3p		YEASK		307	UniRef100_P18238
Aac3p		YEASO		307
Aac3p		YEASC		307
ADP/ATP carrier		YEAS7		307

Protein	Similar proteins		Species	Score	Length	Source
P18238	K7_Aac3p		YEASK		307	UniRef90_P18238
Aac3p		YEASO		307
Aac3p		YEASC		307
ADP/ATP carrier		YEAS7		307
Uncharacterized protein		SACEU		307
+13

Protein	Similar proteins		Species	Score	Length	Source
P18238	ADP,ATP carrier protein 1		YEAST		309	UniRef50_P04710
ADP/ATP carrier		YEAS7		309
Aac1p		YEASV		321
Aac1p		YEASA		321
ADP/ATP translocator		YEAS1		309
+222

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M34076 Genomic DNA Translation: AAA97485.1 Z35954 Genomic DNA Translation: CAA85031.1 BK006936 Genomic DNA Translation: DAA07205.1
PIRⁱ	A36582
RefSeqⁱ	NP_009642.3, NM_001178433.3

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	4C9J	X-ray	3.40	A/B	3-307	[»]
	4C9Q	X-ray	3.20	A/B	3-307	[»]
ProteinModelPortalⁱ	P18238
SMRⁱ	P18238
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	32790, 199 interactors
DIPⁱ	DIP-6289N
IntActⁱ	P18238, 20 interactors
MINTⁱ	P18238
STRINGⁱ	4932.YBR085W

Protein family/group databases

TCDBⁱ	2.A.29.1.9 the mitochondrial carrier (mc) family

TCDBⁱ

2.A.29.1.9 the mitochondrial carrier (mc) family

Proteomic databases

MaxQBⁱ	P18238
PaxDbⁱ	P18238
PRIDEⁱ	P18238

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	852380
Structural Biology Knowledgebase	Search...

Genome annotation databases

EnsemblFungiⁱ	YBR085W; YBR085W; YBR085W
GeneIDⁱ	852380
KEGGⁱ	sce:YBR085W

Organism-specific databases

EuPathDBⁱ	FungiDB:YBR085W
SGDⁱ	S000000289 AAC3

Phylogenomic databases

GeneTreeⁱ	ENSGT00390000011543
HOGENOMⁱ	HOG000165727
InParanoidⁱ	P18238
KOⁱ	K05863
OMAⁱ	MSKEKSF
OrthoDBⁱ	EOG092C3PSA

Enzyme and pathway databases

BioCycⁱ	YEAST:G3O-29052-MONOMER
Reactomeⁱ	R-SCE-422356 Regulation of insulin secretion

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P18238

PROⁱ

PR:P18238

Family and domain databases

Gene3Dⁱ	1.50.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR002113 Aden_trnslctor IPR002067 Mit_carrier IPR018108 Mitochondrial_sb/sol_carrier IPR023395 Mt_carrier_dom_sf
Pfamⁱ	View protein in Pfam PF00153 Mito_carr, 3 hits
PRINTSⁱ	PR00927 ADPTRNSLCASE PR00926 MITOCARRIER
SUPFAMⁱ	SSF103506 SSF103506, 1 hit
PROSITEⁱ	View protein in PROSITE PS50920 SOLCAR, 3 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ADT3_YEAST
Accessionⁱ	P18238Primary (citable) accession number: P18238 Secondary accession number(s): D6VQ85
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1990
	Last sequence update:	November 1, 1990
	Last modified:	September 12, 2018
	This is version 163 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Fungal Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
Yeast chromosome II
Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P18238 (ADT3_YEAST)

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ADP,ATP carrier protein 3

AAC3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Mitochondrion

Mitochondrion

Other locations

Topology

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ