UniProtKB - P18211 (HB2D_RAT)
Protein
Rano class II histocompatibility antigen, D-1 beta chain
Gene
RT1-Db1
Organism
Rattus norvegicus (Rat)
Status
Functioni
Involved in the presentation of foreign antigens to the immune system.
GO - Molecular functioni
- CD4 receptor binding Source: RGD
- MHC class II receptor activity Source: RGD
- peptide antigen binding Source: RGD
- polysaccharide binding Source: RGD
GO - Biological processi
- antigen processing and presentation of exogenous peptide antigen via MHC class II Source: RGD
- detection of bacterium Source: RGD
- humoral immune response mediated by circulating immunoglobulin Source: RGD
- immune response Source: RGD
- immunoglobulin production involved in immunoglobulin mediated immune response Source: RGD
- inflammatory response to antigenic stimulus Source: RGD
- macrophage differentiation Source: RGD
- negative regulation of inflammatory response to antigenic stimulus Source: RGD
- negative regulation of interferon-gamma production Source: RGD
- negative regulation of T cell proliferation Source: RGD
- peptide antigen assembly with MHC class II protein complex Source: RGD
- positive regulation of ERK1 and ERK2 cascade Source: RGD
- positive regulation of I-kappaB kinase/NF-kappaB signaling Source: RGD
- positive regulation of insulin secretion involved in cellular response to glucose stimulus Source: RGD
- positive regulation of kinase activity Source: RGD
- positive regulation of MAPK cascade Source: RGD
- positive regulation of monocyte differentiation Source: RGD
- positive regulation of protein phosphorylation Source: RGD
- positive regulation of transcription, DNA-templated Source: RGD
- positive regulation of viral entry into host cell Source: RGD
- protein tetramerization Source: RGD
- regulation of interleukin-10 production Source: RGD
- regulation of interleukin-4 production Source: RGD
- response to dexamethasone Source: RGD
- response to interferon-gamma Source: RGD
- response to organic substance Source: RGD
- signal transduction Source: RGD
- T-helper 1 type immune response Source: RGD
Keywordsi
Biological process | Adaptive immunity, Immunity |
Enzyme and pathway databases
Reactomei | R-RNO-202424, Downstream TCR signaling R-RNO-202427, Phosphorylation of CD3 and TCR zeta chains R-RNO-202430, Translocation of ZAP-70 to Immunological synapse R-RNO-202433, Generation of second messenger molecules R-RNO-2132295, MHC class II antigen presentation R-RNO-389948, PD-1 signaling |
Names & Taxonomyi
Protein namesi | Recommended name: Rano class II histocompatibility antigen, D-1 beta chainAlternative name(s): RT1 class II histocompatibility antigen, D-1 beta chain |
Gene namesi | Name:RT1-Db1 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1593282, RT1-Db1 |
Subcellular locationi
Other locations
- Membrane Curated; Single-pass type I membrane protein Curated
Endosome
- late endosome membrane Source: RGD
Lysosome
- lysosomal membrane Source: RGD
Plasma Membrane
- external side of plasma membrane Source: RGD
- MHC class II protein complex Source: RGD
Other locations
- cell surface Source: RGD
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 27 – 226 | ExtracellularSequence analysisAdd BLAST | 200 | |
Transmembranei | 227 – 248 | HelicalSequence analysisAdd BLAST | 22 | |
Topological domaini | 249 – 264 | CytoplasmicSequence analysisAdd BLAST | 16 |
Keywords - Cellular componenti
Membrane, MHC IIPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 26 | Add BLAST | 26 | |
ChainiPRO_0000019006 | 27 – 264 | Rano class II histocompatibility antigen, D-1 beta chainAdd BLAST | 238 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 42 ↔ 106 | PROSITE-ProRule annotation | ||
Glycosylationi | 46 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 144 ↔ 200 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PRIDEi | P18211 |
PTM databases
GlyGeni | P18211, 1 site |
iPTMneti | P18211 |
PhosphoSitePlusi | P18211 |
Interactioni
GO - Molecular functioni
- CD4 receptor binding Source: RGD
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000000522 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 124 – 228 | Ig-like C1-typeAdd BLAST | 105 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 27 – 120 | Beta-1Add BLAST | 94 | |
Regioni | 121 – 215 | Beta-2Add BLAST | 95 | |
Regioni | 216 – 226 | Connecting peptideAdd BLAST | 11 |
Sequence similaritiesi
Belongs to the MHC class II family.Curated
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502RYBQ, Eukaryota |
InParanoidi | P18211 |
PhylomeDBi | P18211 |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit 3.10.320.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003006, Ig/MHC_CS IPR003597, Ig_C1-set IPR011162, MHC_I/II-like_Ag-recog IPR014745, MHC_II_a/b_N IPR000353, MHC_II_b_N |
Pfami | View protein in Pfam PF07654, C1-set, 1 hit PF00969, MHC_II_beta, 1 hit |
SMARTi | View protein in SMART SM00407, IGc1, 1 hit SM00921, MHC_II_beta, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit SSF54452, SSF54452, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit PS00290, IG_MHC, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
P18211-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVWLARDSCV AAVILLLTVL SPPVALVRDP TPRFLEQVKG ECHFYNGTQR
60 70 80 90 100
VRFLARYIYN REEYTRFDSD VGEFRAVTEL GRPSAEYYNK QKEYMEQLRA
110 120 130 140 150
TVDTACKHDY EISESFLVPR TVEPKVTVYP SKTQPLEHHN LLVCSVSDFY
160 170 180 190 200
PGSVEVRWFR NGEEEKDGLV STGLIRNGDW TFQLLVMLET VPQGGEVYTC
210 220 230 240 250
QVEHPSLPSP VRVEWKAQST SAQNKKMSGV GGIVLGLLFL GAGLFVYFRN
260
QKGQSGLQPT GLLN
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ9TQA6 | Q9TQA6_RAT | Class II MHC RT1.D(N) beta chain | RT1-Db1 Arrb2-ps, Db1, Hla-dma, Hla-dmb, Psmb9 | 264 | Annotation score: | ||
F1M7F9 | F1M7F9_RAT | Rano class II histocompatibility an... | RT1-Db1 | 248 | Annotation score: | ||
A0A0G2JW17 | A0A0G2JW17_RAT | Rano class II histocompatibility an... | RT1-Db1 | 261 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X53054 mRNA Translation: CAA37221.1 |
PIRi | B60497 S10989 |
Genome annotation databases
UCSCi | RGD:1593282, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X53054 mRNA Translation: CAA37221.1 |
PIRi | B60497 S10989 |
3D structure databases
SMRi | P18211 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000000522 |
PTM databases
GlyGeni | P18211, 1 site |
iPTMneti | P18211 |
PhosphoSitePlusi | P18211 |
Proteomic databases
PRIDEi | P18211 |
Genome annotation databases
UCSCi | RGD:1593282, rat |
Organism-specific databases
RGDi | 1593282, RT1-Db1 |
Phylogenomic databases
eggNOGi | ENOG502RYBQ, Eukaryota |
InParanoidi | P18211 |
PhylomeDBi | P18211 |
Enzyme and pathway databases
Reactomei | R-RNO-202424, Downstream TCR signaling R-RNO-202427, Phosphorylation of CD3 and TCR zeta chains R-RNO-202430, Translocation of ZAP-70 to Immunological synapse R-RNO-202433, Generation of second messenger molecules R-RNO-2132295, MHC class II antigen presentation R-RNO-389948, PD-1 signaling |
Miscellaneous databases
PROi | PR:P18211 |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit 3.10.320.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003006, Ig/MHC_CS IPR003597, Ig_C1-set IPR011162, MHC_I/II-like_Ag-recog IPR014745, MHC_II_a/b_N IPR000353, MHC_II_b_N |
Pfami | View protein in Pfam PF07654, C1-set, 1 hit PF00969, MHC_II_beta, 1 hit |
SMARTi | View protein in SMART SM00407, IGc1, 1 hit SM00921, MHC_II_beta, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit SSF54452, SSF54452, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit PS00290, IG_MHC, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | HB2D_RAT | |
Accessioni | P18211Primary (citable) accession number: P18211 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1990 |
Last sequence update: | November 1, 1990 | |
Last modified: | December 2, 2020 | |
This is version 123 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families