Rano class II histocompatibility antigen, D-1 beta chain

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• CD4 receptor binding Source: RGDInferred from sequence orthologyⁱ
  • "CD4 ligation on human blood monocytes triggers macrophage differentiation and enhances HIV infection."
    Zhen A., Krutzik S.R., Levin B.R., Kasparian S., Zack J.A., Kitchen S.G.
    J. Virol. 88:9934-9946(2014) [PubMed] [Europe PMC] [Abstract]
• peptide antigen binding Source: RGDInferred from sequence orthologyⁱ
  • "HLA-DR molecules from an antigen-processing mutant cell line are associated with invariant chain peptides."
    Riberdy J.M., Newcomb J.R., Surman M.J., Barbosa J.A., Cresswell P.
    Nature 360:474-477(1992) [PubMed] [Europe PMC] [Abstract]
  • "Tracking antigen-specific T-cells during clinical tolerance induction in humans."
    Aslam A., Chan H., Warrell D.A., Misbah S., Ogg G.S.
    PLoS ONE 5:e11028-e11028(2010) [PubMed] [Europe PMC] [Abstract]
  • "MHCII glycosylation modulates Bacteroides fragilis carbohydrate antigen presentation."
    Ryan S.O., Bonomo J.A., Zhao F., Cobb B.A.
    J. Exp. Med. 208:1041-1053(2011) [PubMed] [Europe PMC] [Abstract]
  • "Mapping the HLA-DO/HLA-DM complex by FRET and mutagenesis."
    Yoon T., Macmillan H., Mortimer S.E., Jiang W., Rinderknecht C.H., Stern L.J., Mellins E.D.
    Proc. Natl. Acad. Sci. U.S.A. 109:11276-11281(2012) [PubMed] [Europe PMC] [Abstract]
  • "The structure of an intermediate in class II MHC maturation: CLIP bound to HLA-DR3."
    Ghosh P., Amaya M., Mellins E., Wiley D.C.
    Nature 378:457-462(1995) [PubMed] [Europe PMC] [Abstract]
  • "HLA-DM induces CLIP dissociation from MHC class II alpha beta dimers and facilitates peptide loading."
    Denzin L.K., Cresswell P.
    Cell 82:155-165(1995) [PubMed] [Europe PMC] [Abstract]
• polysaccharide binding Source: RGDInferred from sequence orthologyⁱ
  • "MHCII glycosylation modulates Bacteroides fragilis carbohydrate antigen presentation."
    Ryan S.O., Bonomo J.A., Zhao F., Cobb B.A.
    J. Exp. Med. 208:1041-1053(2011) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• antigen processing and presentation of exogenous peptide antigen via MHC class II Source: RGDInferred from sequence orthologyⁱ
  • "MHC class II antigen presentation pathway in murine tumours: tumour evasion from immunosurveillance?"
    Walter W., Lingnau K., Schmitt E., Loos M., Maeurer M.J.
    Br. J. Cancer 83:1192-1201(2000) [PubMed] [Europe PMC] [Abstract]
  • "The impact of H2-DM on humoral immune responses."
    Alfonso C., Han J.O., Williams G.S., Karlsson L.
    J. Immunol. 167:6348-6355(2001) [PubMed] [Europe PMC] [Abstract]
• detection of bacterium Source: RGDInferred from sequence orthologyⁱ
  • "HLA molecules and nasal carriage of Staphylococcus aureus isolated from dialysis and kidney transplant patients at a hospital in Southern Brazil."
    Giarola L.B., Dos Santos R.R., Bedendo J., da Silva Junior W.V., Borelli S.D.
    BMC Res Notes 5:90-90(2012) [PubMed] [Europe PMC] [Abstract]
• humoral immune response mediated by circulating immunoglobulin Source: RGDInferred from sequence orthologyⁱ
  • "HLA class II influences humoral autoimmunity in patients with type 2 autoimmune hepatitis."
    Djilali-Saiah I., Fakhfakh A., Louafi H., Caillat-Zucman S., Debray D., Alvarez F.
    J. Hepatol. 45:844-850(2006) [PubMed] [Europe PMC] [Abstract]
• immune response Source: RGDInferred from sequence orthologyⁱ
  • "Tracking antigen-specific T-cells during clinical tolerance induction in humans."
    Aslam A., Chan H., Warrell D.A., Misbah S., Ogg G.S.
    PLoS ONE 5:e11028-e11028(2010) [PubMed] [Europe PMC] [Abstract]
  • "The association of HLA-DQB1, -DQA1 and -DPB1 alleles with anti- glomerular basement membrane (GBM) disease in Chinese patients."
    Luo H., Chen M., Cui Z., Yang R., Xu P.C., Zhou X.J., Zhao M.H.
    BMC Nephrol 12:21-21(2011) [PubMed] [Europe PMC] [Abstract]
  • "HLA molecules and nasal carriage of Staphylococcus aureus isolated from dialysis and kidney transplant patients at a hospital in Southern Brazil."
    Giarola L.B., Dos Santos R.R., Bedendo J., da Silva Junior W.V., Borelli S.D.
    BMC Res Notes 5:90-90(2012) [PubMed] [Europe PMC] [Abstract]
• immunoglobulin production involved in immunoglobulin mediated immune response Source: RGDInferred from sequence orthologyⁱ
  • "HLA class II influences humoral autoimmunity in patients with type 2 autoimmune hepatitis."
    Djilali-Saiah I., Fakhfakh A., Louafi H., Caillat-Zucman S., Debray D., Alvarez F.
    J. Hepatol. 45:844-850(2006) [PubMed] [Europe PMC] [Abstract]
• inflammatory response to antigenic stimulus Source: RGDInferred from sequence orthologyⁱ
  • "HLA DR B1*04, *07-restricted epitopes on Keratin 17 for autoreactive T cells in psoriasis."
    Shen Z., Wang G., Fan J.-Y., Li W., Liu Y.-F.
    J. Dermatol. Sci. 38:25-39(2005) [PubMed] [Europe PMC] [Abstract]
• macrophage differentiation Source: RGDInferred from sequence orthologyⁱ
  • "CD4 ligation on human blood monocytes triggers macrophage differentiation and enhances HIV infection."
    Zhen A., Krutzik S.R., Levin B.R., Kasparian S., Zack J.A., Kitchen S.G.
    J. Virol. 88:9934-9946(2014) [PubMed] [Europe PMC] [Abstract]
• negative regulation of inflammatory response to antigenic stimulus Source: RGDInferred from sequence orthologyⁱ
  • "Nephropathy in type 1 diabetes is diminished in carriers of HLA-DRB1*04: the genetics of kidneys in diabetes (GoKinD) study."
    Cordovado S.K., Zhao Y., Warram J.H., Gong H., Anderson K.L., Hendrix M.M., Hancock L.N., Cleary P.A., Mueller P.W.
    Diabetes 57:518-522(2008) [PubMed] [Europe PMC] [Abstract]
• negative regulation of interferon-gamma production Source: RGDInferred from sequence orthologyⁱ
  • "HLA DR B1*04, *07-restricted epitopes on Keratin 17 for autoreactive T cells in psoriasis."
    Shen Z., Wang G., Fan J.-Y., Li W., Liu Y.-F.
    J. Dermatol. Sci. 38:25-39(2005) [PubMed] [Europe PMC] [Abstract]
• negative regulation of T cell proliferation Source: RGDInferred from sequence orthologyⁱ
  • "HLA DR B1*04, *07-restricted epitopes on Keratin 17 for autoreactive T cells in psoriasis."
    Shen Z., Wang G., Fan J.-Y., Li W., Liu Y.-F.
    J. Dermatol. Sci. 38:25-39(2005) [PubMed] [Europe PMC] [Abstract]
• peptide antigen assembly with MHC class II protein complex Source: RGDInferred from sequence orthologyⁱ
  • "HLA-DR molecules from an antigen-processing mutant cell line are associated with invariant chain peptides."
    Riberdy J.M., Newcomb J.R., Surman M.J., Barbosa J.A., Cresswell P.
    Nature 360:474-477(1992) [PubMed] [Europe PMC] [Abstract]
  • "Mapping the HLA-DO/HLA-DM complex by FRET and mutagenesis."
    Yoon T., Macmillan H., Mortimer S.E., Jiang W., Rinderknecht C.H., Stern L.J., Mellins E.D.
    Proc. Natl. Acad. Sci. U.S.A. 109:11276-11281(2012) [PubMed] [Europe PMC] [Abstract]
  • "HLA-DM induces CLIP dissociation from MHC class II alpha beta dimers and facilitates peptide loading."
    Denzin L.K., Cresswell P.
    Cell 82:155-165(1995) [PubMed] [Europe PMC] [Abstract]
• positive regulation of ERK1 and ERK2 cascade Source: RGDInferred from sequence orthologyⁱ
  • "CD4 ligation on human blood monocytes triggers macrophage differentiation and enhances HIV infection."
    Zhen A., Krutzik S.R., Levin B.R., Kasparian S., Zack J.A., Kitchen S.G.
    J. Virol. 88:9934-9946(2014) [PubMed] [Europe PMC] [Abstract]
• positive regulation of I-kappaB kinase/NF-kappaB signaling Source: RGDInferred from sequence orthologyⁱ
  • "CD4 ligation on human blood monocytes triggers macrophage differentiation and enhances HIV infection."
    Zhen A., Krutzik S.R., Levin B.R., Kasparian S., Zack J.A., Kitchen S.G.
    J. Virol. 88:9934-9946(2014) [PubMed] [Europe PMC] [Abstract]
• positive regulation of insulin secretion involved in cellular response to glucose stimulus Source: RGDInferred from sequence orthologyⁱ
  • "HLA-DRB1 reduces the risk of type 2 diabetes mellitus by increased insulin secretion."
    Williams R.C., Muller Y.L., Hanson R.L., Knowler W.C., Mason C.C., Bian L., Ossowski V., Wiedrich K., Chen Y.F., Marcovina S., Hahnke J., Nelson R.G., Baier L.J., Bogardus C.
    Diabetologia 54:1684-1692(2011) [PubMed] [Europe PMC] [Abstract]
• positive regulation of kinase activity Source: RGDInferred from sequence orthologyⁱ
  • "CD4 ligation on human blood monocytes triggers macrophage differentiation and enhances HIV infection."
    Zhen A., Krutzik S.R., Levin B.R., Kasparian S., Zack J.A., Kitchen S.G.
    J. Virol. 88:9934-9946(2014) [PubMed] [Europe PMC] [Abstract]
• positive regulation of MAPK cascade Source: RGDInferred from sequence orthologyⁱ
  • "CD4 ligation on human blood monocytes triggers macrophage differentiation and enhances HIV infection."
    Zhen A., Krutzik S.R., Levin B.R., Kasparian S., Zack J.A., Kitchen S.G.
    J. Virol. 88:9934-9946(2014) [PubMed] [Europe PMC] [Abstract]
• positive regulation of monocyte differentiation Source: RGDInferred from sequence orthologyⁱ
  • "CD4 ligation on human blood monocytes triggers macrophage differentiation and enhances HIV infection."
    Zhen A., Krutzik S.R., Levin B.R., Kasparian S., Zack J.A., Kitchen S.G.
    J. Virol. 88:9934-9946(2014) [PubMed] [Europe PMC] [Abstract]
• positive regulation of protein phosphorylation Source: RGDInferred from sequence orthologyⁱ
  • "CD4 ligation on human blood monocytes triggers macrophage differentiation and enhances HIV infection."
    Zhen A., Krutzik S.R., Levin B.R., Kasparian S., Zack J.A., Kitchen S.G.
    J. Virol. 88:9934-9946(2014) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription, DNA-templated Source: RGDInferred from sequence orthologyⁱ
  • "CD4 ligation on human blood monocytes triggers macrophage differentiation and enhances HIV infection."
    Zhen A., Krutzik S.R., Levin B.R., Kasparian S., Zack J.A., Kitchen S.G.
    J. Virol. 88:9934-9946(2014) [PubMed] [Europe PMC] [Abstract]
• positive regulation of viral entry into host cell Source: RGDInferred from sequence orthologyⁱ
  • "CD4 ligation on human blood monocytes triggers macrophage differentiation and enhances HIV infection."
    Zhen A., Krutzik S.R., Levin B.R., Kasparian S., Zack J.A., Kitchen S.G.
    J. Virol. 88:9934-9946(2014) [PubMed] [Europe PMC] [Abstract]
• protein heterotetramerization Source: RGDInferred from sequence orthologyⁱ
  • "CD4 ligation on human blood monocytes triggers macrophage differentiation and enhances HIV infection."
    Zhen A., Krutzik S.R., Levin B.R., Kasparian S., Zack J.A., Kitchen S.G.
    J. Virol. 88:9934-9946(2014) [PubMed] [Europe PMC] [Abstract]
• protein tetramerization Source: RGDInferred from sequence orthologyⁱ
  • "Tracking antigen-specific T-cells during clinical tolerance induction in humans."
    Aslam A., Chan H., Warrell D.A., Misbah S., Ogg G.S.
    PLoS ONE 5:e11028-e11028(2010) [PubMed] [Europe PMC] [Abstract]
• regulation of interleukin-10 secretion Source: RGDInferred from sequence orthologyⁱ
  • "Tracking antigen-specific T-cells during clinical tolerance induction in humans."
    Aslam A., Chan H., Warrell D.A., Misbah S., Ogg G.S.
    PLoS ONE 5:e11028-e11028(2010) [PubMed] [Europe PMC] [Abstract]
• regulation of interleukin-4 production Source: RGDInferred from sequence orthologyⁱ
  • "Tracking antigen-specific T-cells during clinical tolerance induction in humans."
    Aslam A., Chan H., Warrell D.A., Misbah S., Ogg G.S.
    PLoS ONE 5:e11028-e11028(2010) [PubMed] [Europe PMC] [Abstract]
• response to dexamethasone Source: RGD <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "Microarray studies on effects of Pneumocystis carinii infection on global gene expression in alveolar macrophages."
    Cheng B.H., Liu Y., Xuei X., Liao C.P., Lu D., Lasbury M.E., Durant P.J., Lee C.H.
    BMC Microbiol. 10:103-103(2010) [PubMed] [Europe PMC] [Abstract]
• response to interferon-gamma Source: RGDInferred from sequence orthologyⁱ
  • "Toxoplasma gondii down-regulates MHC class II gene expression and antigen presentation by murine macrophages via interference with nuclear translocation of STAT1alpha."
    Luder C.G., Walter W., Beuerle B., Maeurer M.J., Gross U.
    Eur. J. Immunol. 31:1475-1484(2001) [PubMed] [Europe PMC] [Abstract]
• response to organic substance Source: RGDInferred from expression patternⁱ
  • "Korean Red Ginseng Up-regulates C21-Steroid Hormone Metabolism via Cyp11a1 Gene in Senescent Rat Testes."
    Kim I.H., Kim S.K., Kim E.H., Kim S.W., Sohn S.H., Lee S.C., Choi S., Pyo S., Rhee D.K.
    J Ginseng Res 35:272-282(2011) [PubMed] [Europe PMC] [Abstract]
• T-helper 1 type immune response Source: RGDInferred from sequence orthologyⁱ
  • "HLA DR B1*04, *07-restricted epitopes on Keratin 17 for autoreactive T cells in psoriasis."
    Shen Z., Wang G., Fan J.-Y., Li W., Liu Y.-F.
    J. Dermatol. Sci. 38:25-39(2005) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Topology

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• CD4 receptor binding Source: RGDInferred from sequence orthologyⁱ
  • "CD4 ligation on human blood monocytes triggers macrophage differentiation and enhances HIV infection."
    Zhen A., Krutzik S.R., Levin B.R., Kasparian S., Zack J.A., Kitchen S.G.
    J. Virol. 88:9934-9946(2014) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MVWLARDSCV AAVILLLTVL SPPVALVRDP TPRFLEQVKG ECHFYNGTQR 
        60         70         80         90        100
VRFLARYIYN REEYTRFDSD VGEFRAVTEL GRPSAEYYNK QKEYMEQLRA 
       110        120        130        140        150
TVDTACKHDY EISESFLVPR TVEPKVTVYP SKTQPLEHHN LLVCSVSDFY 
       160        170        180        190        200
PGSVEVRWFR NGEEEKDGLV STGLIRNGDW TFQLLVMLET VPQGGEVYTC 
       210        220        230        240        250
QVEHPSLPSP VRVEWKAQST SAQNKKMSGV GGIVLGLLFL GAGLFVYFRN 
       260 
QKGQSGLQPT GLLN                                        

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. SIMILARITY comments
   Index of protein domains and families