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UniProtKB - P18206 (VINC_HUMAN)

Entry version 229 (10 Feb 2021)
Sequence version 4 (23 Jan 2007)
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Protein

Vinculin

Gene

VCL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding
Biological processCell adhesion

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P18206

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-114608, Platelet degranulation
R-HSA-445355, Smooth Muscle Contraction
R-HSA-5674135, MAP2K and MAPK activation
R-HSA-6798695, Neutrophil degranulation
R-HSA-6802946, Signaling by moderate kinase activity BRAF mutants
R-HSA-6802948, Signaling by high-kinase activity BRAF mutants
R-HSA-6802952, Signaling by BRAF and RAF fusions
R-HSA-6802955, Paradoxical activation of RAF signaling by kinase inactive BRAF
R-HSA-9649948, Signaling downstream of RAS mutants
R-HSA-9656223, Signaling by RAF1 mutants

SIGNOR Signaling Network Open Resource

More...SIGNORi		P18206

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Vinculin
Alternative name(s):
Metavinculin
Short name:
MV
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:VCL
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:12665, VCL

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		193065, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P18206

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000035403.16

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Cardiomyopathy, dilated 1W (CMD1W)2 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_035104954Missing in CMD1W. 1 Publication1
Natural variantiVAR_035105975R → W in CMD1W; significantly alters metavinculin-mediated cross-linking of actin filaments. 2 PublicationsCorresponds to variant dbSNP:rs121917776EnsemblClinVar.1
Cardiomyopathy, familial hypertrophic 15 (CMH15)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035101277L → M in CMH15. 1 PublicationCorresponds to variant dbSNP:rs71579353EnsemblClinVar.1

Keywords - Diseasei

Cardiomyopathy, Disease variant

Organism-specific databases

DisGeNET

More...DisGeNETi		7414

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...GeneReviewsi		VCL

MalaCards human disease database

More...MalaCardsi		VCL
MIMi611407, phenotype
613255, phenotype

Open Targets

More...OpenTargetsi		ENSG00000035403

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		154, Familial isolated dilated cardiomyopathy
155, NON RARE IN EUROPE: Familial isolated hypertrophic cardiomyopathy

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA37288

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P18206, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL4295723

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		VCL

Domain mapping of disease mutations (DMDM)

More...DMDMi		21903479

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000642521 – 1134VinculinAdd BLAST1134

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei97PhosphoserineBy similarity1
Modified residuei173N6-acetyllysineCombined sources1
Modified residuei260PhosphoserineCombined sources1
Modified residuei272PhosphoserineBy similarity1
Modified residuei275PhosphoserineCombined sources1
Modified residuei288PhosphoserineCombined sources1
Modified residuei290PhosphoserineCombined sources1
Modified residuei346PhosphoserineCombined sources1
Modified residuei434PhosphoserineCombined sources1
Modified residuei496N6-acetyllysineCombined sources1
Modified residuei537PhosphotyrosineCurated1
Modified residuei574PhosphoserineBy similarity1
Modified residuei579PhosphoserineCombined sources1
Modified residuei600PhosphoserineCombined sources1
Modified residuei604PhosphothreonineCombined sources1
Modified residuei672PhosphothreonineCombined sources1
Modified residuei721PhosphoserineCombined sources1
Modified residuei795PhosphoserineCombined sources1
Modified residuei809PhosphoserineCombined sources1
Modified residuei822PhosphotyrosineCombined sources1
Modified residuei1133Phosphotyrosine; by SRC-type Tyr-kinases1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated; on serines, threonines and tyrosines. Phosphorylation on Tyr-1133 in activated platelets affects head-tail interactions and cell spreading but has no effect on actin binding nor on localization to focal adhesion plaques (By similarity).By similarity
Acetylated; mainly by myristic acid but also by a small amount of palmitic acid.By similarity

Keywords - PTMi

Acetylation, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P18206

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P18206

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P18206

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P18206

PeptideAtlas

More...PeptideAtlasi		P18206

PRoteomics IDEntifications database

More...PRIDEi		P18206

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		53553 [P18206-1]
53554 [P18206-2]
53555 [P18206-3]

2D gel databases

DOSAC-COBS 2D-PAGE database

More...DOSAC-COBS-2DPAGEi		P18206

USC-OGP 2-DE database

More...OGPi		P18206

REPRODUCTION-2DPAGE

More...REPRODUCTION-2DPAGEi		IPI00291175

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

More...SWISS-2DPAGEi		P18206

University College Dublin 2-DE Proteome Database

More...UCD-2DPAGEi		P18206

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P18206

MetOSite database of methionine sulfoxide sites

More...MetOSitei		P18206

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P18206

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P18206

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Metavinculin is muscle-specific.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000035403, Expressed in myometrium and 252 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P18206, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P18206, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000035403, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Exhibits self-association properties.

Part of a complex composed of THSD1, PTK2/FAK1, TLN1 and VCL (PubMed:29069646).

Interacts with APBB1IP and NRAP (By similarity).

Interacts with TLN1.

Interacts with CTNNB1 and this interaction is necessary for its localization to the cell-cell junctions and for its function in regulating cell surface expression of E-cadherin (By similarity).

Interacts with SYNM.

Interacts with SORBS1 (By similarity).

Interacts with CTNNA1 (PubMed:26691986). Binds to ACTN4; this interaction triggers conformational changes (PubMed:15988023).

By similarity6 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		113257, 143 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-791, Talin-1-Vinculin focal adhesion activation complex

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P18206

Database of interacting proteins

More...DIPi		DIP-35570N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...ELMi		P18206

Protein interaction database and analysis system

More...IntActi		P18206, 60 interactors

Molecular INTeraction database

More...MINTi		P18206

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000211998

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P18206, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11134
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P18206

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P18206

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati259 – 3691Sequence analysisAdd BLAST111
Repeati370 – 4792Sequence analysisAdd BLAST110
Repeati480 – 5893Sequence analysisAdd BLAST110

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 835N-terminal globular head1 PublicationAdd BLAST835
Regioni168 – 208Talin-interactionBy similarityAdd BLAST41
Regioni259 – 5893 X 112 AA tandem repeatsSequence analysisAdd BLAST331
Regioni741 – 764Interaction with ACTN4Combined sources1 PublicationAdd BLAST24
Regioni836 – 878Linker (Pro-rich)1 PublicationAdd BLAST43
Regioni879 – 1134C-terminal tail1 PublicationAdd BLAST256
Regioni1003 – 1046Facilitates phospholipid membrane insertionBy similarityAdd BLAST44
Regioni1120 – 1134Facilitates phospholipid membrane insertionBy similarityAdd BLAST15

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi837 – 878Pro-richPROSITE-ProRule annotationAdd BLAST42

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Exists in at least two conformations. When in the closed, 'inactive' conformation, extensive interactions between the head and tail domains prevent detectable binding to most of its ligands. It takes on an 'active' conformation after cooperative and simultaneous binding of two different ligands. This activation involves displacement of the head-tail interactions and leads to a significant accumulation of ternary complexes. The active form then binds a number of proteins that have both signaling and structural roles that are essential for cell adhesion.1 Publication
The N-terminal globular head (Vh) comprises of subdomains D1-D4. The C-terminal tail (Vt) binds F-actin and cross-links actin filaments into bundles. In isoform 2 (metavinculin) a 68 residue insertion in the tail domain promotes actin severing instead of bundling. An intramolecular interaction between Vh and Vt masks the F-actin-binding domain located in Vt. The binding of talin and alpha-actinin to the D1 subdomain of vinculin induces a helical bundle conversion of this subdomain, leading to the disruption of the intramolecular interaction and the exposure of the cryptic F-actin-binding domain of Vt. Vt inhibits actin filament barbed end elongation without affecting the critical concentration of actin assembly.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the vinculin/alpha-catenin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3681, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00990000203614

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_012338_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P18206

Identification of Orthologs from Complete Genome Data

More...OMAi		TPGREQN

Database for complete collections of gene phylogenies

More...PhylomeDBi		P18206

TreeFam database of animal gene trees

More...TreeFami		TF313686

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR036723, Alpha-catenin/vinculin-like_sf
IPR017997, Vinculin
IPR006077, Vinculin/catenin
IPR000633, Vinculin_CS

The PANTHER Classification System

More...PANTHERi		PTHR46180, PTHR46180, 2 hits

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01044, Vinculin, 3 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47220, SSF47220, 6 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00663, VINCULIN_1, 1 hit
PS00664, VINCULIN_2, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 2 (identifier: P18206-1) [UniParc]FASTAAdd to basket
Also known as: Metavinculin

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPVFHTRTIE SILEPVAQQI SHLVIMHEEG EVDGKAIPDL TAPVAAVQAA 
        60         70         80         90        100
VSNLVRVGKE TVQTTEDQIL KRDMPPAFIK VENACTKLVQ AAQMLQSDPY 
       110        120        130        140        150
SVPARDYLID GSRGILSGTS DLLLTFDEAE VRKIIRVCKG ILEYLTVAEV 
       160        170        180        190        200
VETMEDLVTY TKNLGPGMTK MAKMIDERQQ ELTHQEHRVM LVNSMNTVKE 
       210        220        230        240        250
LLPVLISAMK IFVTTKNSKN QGIEEALKNR NFTVEKMSAE INEIIRVLQL 
       260        270        280        290        300
TSWDEDAWAS KDTEAMKRAL ASIDSKLNQA KGWLRDPSAS PGDAGEQAIR 
       310        320        330        340        350
QILDEAGKVG ELCAGKERRE ILGTCKMLGQ MTDQVADLRA RGQGSSPVAM 
       360        370        380        390        400
QKAQQVSQGL DVLTAKVENA ARKLEAMTNS KQSIAKKIDA AQNWLADPNG 
       410        420        430        440        450
GPEGEEQIRG ALAEARKIAE LCDDPKERDD ILRSLGEISA LTSKLADLRR 
       460        470        480        490        500
QGKGDSPEAR ALAKQVATAL QNLQTKTNRA VANSRPAKAA VHLEGKIEQA 
       510        520        530        540        550
QRWIDNPTVD DRGVGQAAIR GLVAEGHRLA NVMMGPYRQD LLAKCDRVDQ 
       560        570        580        590        600
LTAQLADLAA RGEGESPQAR ALASQLQDSL KDLKARMQEA MTQEVSDVFS 
       610        620        630        640        650
DTTTPIKLLA VAATAPPDAP NREEVFDERA ANFENHSGKL GATAEKAAAV 
       660        670        680        690        700
GTANKSTVEG IQASVKTARE LTPQVVSAAR ILLRNPGNQA AYEHFETMKN 
       710        720        730        740        750
QWIDNVEKMT GLVDEAIDTK SLLDASEEAI KKDLDKCKVA MANIQPQMLV 
       760        770        780        790        800
AGATSIARRA NRILLVAKRE VENSEDPKFR EAVKAASDEL SKTISPMVMD 
       810        820        830        840        850
AKAVAGNISD PGLQKSFLDS GYRILGAVAK VREAFQPQEP DFPPPPPDLE 
       860        870        880        890        900
QLRLTDELAP PKPPLPEGEV PPPRPPPPEE KDEEFPEQKA GEVINQPMMM 
       910        920        930        940        950
AARQLHDEAR KWSSKPGIPA AEVGIGVVAE ADAADAAGFP VPPDMEDDYE 
       960        970        980        990       1000
PELLLMPSNQ PVNQPILAAA QSLHREATKW SSKGNDIIAA AKRMALLMAE 
      1010       1020       1030       1040       1050
MSRLVRGGSG TKRALIQCAK DIAKASDEVT RLAKEVAKQC TDKRIRTNLL 
      1060       1070       1080       1090       1100
QVCERIPTIS TQLKILSTVK ATMLGRTNIS DEESEQATEM LVHNAQNLMQ 
      1110       1120       1130 
SVKETVREAE AASIKIRTDA GFTLRWVRKT PWYQ
Length:1,134
Mass (Da):123,799
Last modified:January 23, 2007 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBFBD687DA836B0FA
GO
Isoform 1 (identifier: P18206-2) [UniParc]FASTAAdd to basket
Also known as: Vinculin

The sequence of this isoform differs from the canonical sequence as follows:
     916-983: Missing.

Show »
Length:1,066
Mass (Da):116,722
Checksum:iC9B67AA072009EBD
GO
Isoform 3 (identifier: P18206-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-73: Missing.
     262-295: DTEAMKRALASIDSKLNQAKGWLRDPSASPGDAG → VRVLSGEISKIPNSPWLGVLIGTCLILYLVIFVA
     296-1134: Missing.

Show »
Length:222
Mass (Da):24,904
Checksum:iCBC9C4E86C7B5002
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A096LPE1A0A096LPE1_HUMAN
Metavinculin
VCL
57Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_037667234V → L1 PublicationCorresponds to variant dbSNP:rs17853882Ensembl.1
Natural variantiVAR_035101277L → M in CMH15. 1 PublicationCorresponds to variant dbSNP:rs71579353EnsemblClinVar.1
Natural variantiVAR_035102934A → V1 PublicationCorresponds to variant dbSNP:rs16931179EnsemblClinVar.1
Natural variantiVAR_035103943P → A1 PublicationCorresponds to variant dbSNP:rs71579375EnsemblClinVar.1
Natural variantiVAR_035104954Missing in CMD1W. 1 Publication1
Natural variantiVAR_035105975R → W in CMD1W; significantly alters metavinculin-mediated cross-linking of actin filaments. 2 PublicationsCorresponds to variant dbSNP:rs121917776EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0118571 – 73Missing in isoform 3. 1 PublicationAdd BLAST73
Alternative sequenceiVSP_011858262 – 295DTEAM…PGDAG → VRVLSGEISKIPNSPWLGVL IGTCLILYLVIFVA in isoform 3. 1 PublicationAdd BLAST34
Alternative sequenceiVSP_011859296 – 1134Missing in isoform 3. 1 PublicationAdd BLAST839
Alternative sequenceiVSP_006731916 – 983Missing in isoform 1. 2 PublicationsAdd BLAST68

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M33308 mRNA Translation: AAA61283.1
BX537994 mRNA Translation: CAD97952.1
AL596247, AL731576 Genomic DNA Translation: CAI13972.1
AL731576, AL596247 Genomic DNA Translation: CAI39673.1
BC039174 mRNA Translation: AAH39174.1
L04933 Genomic DNA Translation: AAA61271.1
S87180, S87175, S87178 Genomic DNA Translation: AAB21656.1
S87223, S87218 Genomic DNA Translation: AAB21657.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS7340.1 [P18206-2]
CCDS7341.1 [P18206-1]

Protein sequence database of the Protein Information Resource

More...PIRi		A35955

NCBI Reference Sequences

More...RefSeqi		NP_003364.1, NM_003373.3 [P18206-2]
NP_054706.1, NM_014000.2 [P18206-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000211998; ENSP00000211998; ENSG00000035403 [P18206-1]
ENST00000372755; ENSP00000361841; ENSG00000035403 [P18206-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		7414

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:7414

UCSC genome browser

More...UCSCi		uc001jwe.4, human [P18206-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

Vinculin entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M33308 mRNA Translation: AAA61283.1
BX537994 mRNA Translation: CAD97952.1
AL596247, AL731576 Genomic DNA Translation: CAI13972.1
AL731576, AL596247 Genomic DNA Translation: CAI39673.1
BC039174 mRNA Translation: AAH39174.1
L04933 Genomic DNA Translation: AAA61271.1
S87180, S87175, S87178 Genomic DNA Translation: AAB21656.1
S87223, S87218 Genomic DNA Translation: AAB21657.1
CCDSiCCDS7340.1 [P18206-2]
CCDS7341.1 [P18206-1]
PIRiA35955
RefSeqiNP_003364.1, NM_003373.3 [P18206-2]
NP_054706.1, NM_014000.2 [P18206-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1RKCX-ray2.70A1-258[»]
1RKEX-ray2.35A1-258[»]
B882-1134[»]
1SYQX-ray2.42A1-258[»]
1TR2X-ray2.90A/B1-1134[»]
1YDIX-ray1.80A1-258[»]
2GWWX-ray2.72A1-258[»]
2HSQX-ray3.97A1-258[»]
2IBFX-ray3.20A1-258[»]
3H2UX-ray2.75A/C879-1134[»]
3H2VX-ray2.90A/B/C/D879-1134[»]
3JBKelectron microscopy8.20M858-1129[»]
3MYIX-ray2.20A959-1130[»]
3RF3X-ray1.61A/B1-258[»]
3S90X-ray1.97A/B1-252[»]
3TJ5X-ray1.99A1-255[»]
3TJ6X-ray2.76A1-257[»]
3VF0X-ray2.54A856-1134[»]
4DJ9X-ray2.25A1-258[»]
4EHPX-ray2.66A1-252[»]
4LN2X-ray1.00B857-867[»]
4LNPX-ray1.41B870-879[»]
4PR9X-ray3.20A/B/C/D/E/F891-1134[»]
5L0CX-ray3.10A/B/C/D959-1134[»]
5L0DX-ray2.75A/B/C/D959-1130[»]
5L0FX-ray2.76A/B959-1134[»]
5L0GX-ray3.40A/B/C/D959-1134[»]
5L0HX-ray2.90A959-1134[»]
5L0IX-ray2.45A959-1134[»]
5L0JX-ray4.00A/B969-1134[»]
5O2QNMR-A854-870[»]
6FUYX-ray3.00A1-1134[»]
6UPWelectron microscopy2.90L/M1-1134[»]
SMRiP18206
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi113257, 143 interactors
ComplexPortaliCPX-791, Talin-1-Vinculin focal adhesion activation complex
CORUMiP18206
DIPiDIP-35570N
ELMiP18206
IntActiP18206, 60 interactors
MINTiP18206
STRINGi9606.ENSP00000211998

Chemistry databases

ChEMBLiCHEMBL4295723

PTM databases

iPTMnetiP18206
MetOSiteiP18206
PhosphoSitePlusiP18206
SwissPalmiP18206

Genetic variation databases

BioMutaiVCL
DMDMi21903479

2D gel databases

DOSAC-COBS-2DPAGEiP18206
OGPiP18206
REPRODUCTION-2DPAGEiIPI00291175
SWISS-2DPAGEiP18206
UCD-2DPAGEiP18206

Proteomic databases

EPDiP18206
jPOSTiP18206
MassIVEiP18206
PaxDbiP18206
PeptideAtlasiP18206
PRIDEiP18206
ProteomicsDBi53553 [P18206-1]
53554 [P18206-2]
53555 [P18206-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		884, 872 antibodies

The DNASU plasmid repository

More...DNASUi		7414

Genome annotation databases

EnsembliENST00000211998; ENSP00000211998; ENSG00000035403 [P18206-1]
ENST00000372755; ENSP00000361841; ENSG00000035403 [P18206-2]
GeneIDi7414
KEGGihsa:7414
UCSCiuc001jwe.4, human [P18206-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		7414
DisGeNETi7414

GeneCards: human genes, protein and diseases

More...GeneCardsi		VCL
GeneReviewsiVCL
HGNCiHGNC:12665, VCL
HPAiENSG00000035403, Low tissue specificity
MalaCardsiVCL
MIMi193065, gene
611407, phenotype
613255, phenotype
neXtProtiNX_P18206
OpenTargetsiENSG00000035403
Orphaneti154, Familial isolated dilated cardiomyopathy
155, NON RARE IN EUROPE: Familial isolated hypertrophic cardiomyopathy
PharmGKBiPA37288
VEuPathDBiHostDB:ENSG00000035403.16

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3681, Eukaryota
GeneTreeiENSGT00990000203614
HOGENOMiCLU_012338_0_0_1
InParanoidiP18206
OMAiTPGREQN
PhylomeDBiP18206
TreeFamiTF313686

Enzyme and pathway databases

PathwayCommonsiP18206
ReactomeiR-HSA-114608, Platelet degranulation
R-HSA-445355, Smooth Muscle Contraction
R-HSA-5674135, MAP2K and MAPK activation
R-HSA-6798695, Neutrophil degranulation
R-HSA-6802946, Signaling by moderate kinase activity BRAF mutants
R-HSA-6802948, Signaling by high-kinase activity BRAF mutants
R-HSA-6802952, Signaling by BRAF and RAF fusions
R-HSA-6802955, Paradoxical activation of RAF signaling by kinase inactive BRAF
R-HSA-9649948, Signaling downstream of RAS mutants
R-HSA-9656223, Signaling by RAF1 mutants
SIGNORiP18206

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		7414, 111 hits in 870 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		VCL, human
EvolutionaryTraceiP18206

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Vinculin

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		7414
PharosiP18206, Tbio

Protein Ontology

More...PROi		PR:P18206
RNActiP18206, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000035403, Expressed in myometrium and 252 other tissues
ExpressionAtlasiP18206, baseline and differential
GenevisibleiP18206, HS

Family and domain databases

InterProiView protein in InterPro
IPR036723, Alpha-catenin/vinculin-like_sf
IPR017997, Vinculin
IPR006077, Vinculin/catenin
IPR000633, Vinculin_CS
PANTHERiPTHR46180, PTHR46180, 2 hits
PfamiView protein in Pfam
PF01044, Vinculin, 3 hits
SUPFAMiSSF47220, SSF47220, 6 hits
PROSITEiView protein in PROSITE
PS00663, VINCULIN_1, 1 hit
PS00664, VINCULIN_2, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiVINC_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P18206
Secondary accession number(s): Q16450
, Q5SWX2, Q7Z3B8, Q8IXU7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: January 23, 2007
Last modified: February 10, 2021
This is version 229 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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