UniProtKB - P18206 (VINC_HUMAN)
Vinculin
VCL
Functioni
GO - Molecular functioni
- actin binding Source: BHF-UCL
- alpha-catenin binding Source: UniProtKB
- beta-catenin binding Source: BHF-UCL
- cadherin binding Source: BHF-UCL
- dystroglycan binding Source: UniProtKB
- structural molecule activity Source: InterPro
- ubiquitin protein ligase binding Source: ParkinsonsUK-UCL
GO - Biological processi
- adherens junction assembly Source: BHF-UCL
- apical junction assembly Source: UniProtKB
- axon extension Source: Ensembl
- cell adhesion Source: UniProtKB
- cell-matrix adhesion Source: BHF-UCL
- epithelial cell-cell adhesion Source: BHF-UCL
- lamellipodium assembly Source: UniProtKB
- maintenance of blood-brain barrier Source: ARUK-UCL
- morphogenesis of an epithelium Source: BHF-UCL
- muscle contraction Source: Reactome
- negative regulation of cell migration Source: UniProtKB
- neutrophil degranulation Source: Reactome
- platelet aggregation Source: UniProtKB
- platelet degranulation Source: Reactome
- protein localization to cell surface Source: BHF-UCL
- regulation of establishment of endothelial barrier Source: ARUK-UCL
- regulation of focal adhesion assembly Source: ARUK-UCL
- regulation of protein localization to adherens junction Source: ARUK-UCL
Keywordsi
Molecular function | Actin-binding |
Biological process | Cell adhesion |
Enzyme and pathway databases
PathwayCommonsi | P18206 |
Reactomei | R-HSA-114608, Platelet degranulation R-HSA-445355, Smooth Muscle Contraction R-HSA-5674135, MAP2K and MAPK activation R-HSA-6798695, Neutrophil degranulation R-HSA-6802946, Signaling by moderate kinase activity BRAF mutants R-HSA-6802948, Signaling by high-kinase activity BRAF mutants R-HSA-6802952, Signaling by BRAF and RAF fusions R-HSA-6802955, Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-9649948, Signaling downstream of RAS mutants R-HSA-9656223, Signaling by RAF1 mutants |
SIGNORi | P18206 |
Names & Taxonomyi
Protein namesi | Recommended name: VinculinAlternative name(s): Metavinculin Short name: MV |
Gene namesi | Name:VCL |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:12665, VCL |
MIMi | 193065, gene |
neXtProti | NX_P18206 |
VEuPathDBi | HostDB:ENSG00000035403.16 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity
- sarcolemma By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity
Cytoskeleton
- cytoskeleton By similarity
Other locations
- adherens junction By similarity
- focal adhesion By similarity
Note: Recruitment to cell-cell junctions occurs in a myosin II-dependent manner. Interaction with CTNNB1 is necessary for its localization to the cell-cell junctions.By similarity
Cytoskeleton
- cytoskeleton Source: UniProtKB
- podosome Source: Ensembl
- terminal web Source: AgBase
Cytosol
- cytosol Source: Reactome
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
- extracellular region Source: Reactome
- extracellular vesicle Source: UniProtKB
Plasma Membrane
- plasma membrane Source: AgBase
- sarcolemma Source: UniProtKB
Other locations
- adherens junction Source: BHF-UCL
- brush border Source: AgBase
- cell-cell contact zone Source: ARUK-UCL
- cell-cell junction Source: ARUK-UCL
- cell-substrate junction Source: UniProtKB
- costamere Source: MGI
- fascia adherens Source: Ensembl
- ficolin-1-rich granule lumen Source: Reactome
- focal adhesion Source: BHF-UCL
- inner dense plaque of desmosome Source: AgBase
- membrane raft Source: UniProtKB
- outer dense plaque of desmosome Source: AgBase
- protein-containing complex Source: UniProtKB
- secretory granule lumen Source: Reactome
- specific granule lumen Source: Reactome
- zonula adherens Source: AgBase
Keywords - Cellular componenti
Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, MembranePathology & Biotechi
Involvement in diseasei
Cardiomyopathy, dilated 1W (CMD1W)2 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_035104 | 954 | Missing in CMD1W. 1 Publication | 1 | |
Natural variantiVAR_035105 | 975 | R → W in CMD1W; significantly alters metavinculin-mediated cross-linking of actin filaments. 2 PublicationsCorresponds to variant dbSNP:rs121917776EnsemblClinVar. | 1 |
Cardiomyopathy, familial hypertrophic 15 (CMH15)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_035101 | 277 | L → M in CMH15. 1 PublicationCorresponds to variant dbSNP:rs71579353EnsemblClinVar. | 1 |
Keywords - Diseasei
Cardiomyopathy, Disease variantOrganism-specific databases
DisGeNETi | 7414 |
GeneReviewsi | VCL |
MalaCardsi | VCL |
MIMi | 611407, phenotype 613255, phenotype |
OpenTargetsi | ENSG00000035403 |
Orphaneti | 154, Familial isolated dilated cardiomyopathy 155, NON RARE IN EUROPE: Familial isolated hypertrophic cardiomyopathy |
PharmGKBi | PA37288 |
Miscellaneous databases
Pharosi | P18206, Tbio |
Chemistry databases
ChEMBLi | CHEMBL4295723 |
Genetic variation databases
BioMutai | VCL |
DMDMi | 21903479 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000064252 | 1 – 1134 | VinculinAdd BLAST | 1134 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 97 | PhosphoserineBy similarity | 1 | |
Modified residuei | 173 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 260 | PhosphoserineCombined sources | 1 | |
Modified residuei | 272 | PhosphoserineBy similarity | 1 | |
Modified residuei | 275 | PhosphoserineCombined sources | 1 | |
Modified residuei | 288 | PhosphoserineCombined sources | 1 | |
Modified residuei | 290 | PhosphoserineCombined sources | 1 | |
Modified residuei | 346 | PhosphoserineCombined sources | 1 | |
Modified residuei | 434 | PhosphoserineCombined sources | 1 | |
Modified residuei | 496 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 537 | PhosphotyrosineCurated | 1 | |
Modified residuei | 574 | PhosphoserineBy similarity | 1 | |
Modified residuei | 579 | PhosphoserineCombined sources | 1 | |
Modified residuei | 600 | PhosphoserineCombined sources | 1 | |
Modified residuei | 604 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 672 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 721 | PhosphoserineCombined sources | 1 | |
Modified residuei | 795 | PhosphoserineCombined sources | 1 | |
Modified residuei | 809 | PhosphoserineCombined sources | 1 | |
Modified residuei | 822 | PhosphotyrosineCombined sources | 1 | |
Modified residuei | 1133 | Phosphotyrosine; by SRC-type Tyr-kinases1 Publication | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, Lipoprotein, Palmitate, PhosphoproteinProteomic databases
EPDi | P18206 |
jPOSTi | P18206 |
MassIVEi | P18206 |
PaxDbi | P18206 |
PeptideAtlasi | P18206 |
PRIDEi | P18206 |
ProteomicsDBi | 53553 [P18206-1] 53554 [P18206-2] 53555 [P18206-3] |
2D gel databases
DOSAC-COBS-2DPAGEi | P18206 |
OGPi | P18206 |
REPRODUCTION-2DPAGEi | IPI00291175 |
SWISS-2DPAGEi | P18206 |
UCD-2DPAGEi | P18206 |
PTM databases
iPTMneti | P18206 |
MetOSitei | P18206 |
PhosphoSitePlusi | P18206 |
SwissPalmi | P18206 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000035403, Expressed in myometrium and 252 other tissues |
ExpressionAtlasi | P18206, baseline and differential |
Genevisiblei | P18206, HS |
Organism-specific databases
HPAi | ENSG00000035403, Low tissue specificity |
Interactioni
Subunit structurei
Exhibits self-association properties.
Part of a complex composed of THSD1, PTK2/FAK1, TLN1 and VCL (PubMed:29069646).
Interacts with APBB1IP and NRAP (By similarity).
Interacts with TLN1.
Interacts with CTNNB1 and this interaction is necessary for its localization to the cell-cell junctions and for its function in regulating cell surface expression of E-cadherin (By similarity).
Interacts with SYNM.
Interacts with SORBS1 (By similarity).
Interacts with CTNNA1 (PubMed:26691986). Binds to ACTN4; this interaction triggers conformational changes (PubMed:15988023).
By similarity6 PublicationsBinary interactionsi
Hide detailsP18206
Isoform 1 [P18206-2]
GO - Molecular functioni
- actin binding Source: BHF-UCL
- alpha-catenin binding Source: UniProtKB
- beta-catenin binding Source: BHF-UCL
- cadherin binding Source: BHF-UCL
- dystroglycan binding Source: UniProtKB
- ubiquitin protein ligase binding Source: ParkinsonsUK-UCL
Protein-protein interaction databases
BioGRIDi | 113257, 143 interactors |
ComplexPortali | CPX-791, Talin-1-Vinculin focal adhesion activation complex |
CORUMi | P18206 |
DIPi | DIP-35570N |
ELMi | P18206 |
IntActi | P18206, 60 interactors |
MINTi | P18206 |
STRINGi | 9606.ENSP00000211998 |
Miscellaneous databases
RNActi | P18206, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P18206 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P18206 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 259 – 369 | 1Sequence analysisAdd BLAST | 111 | |
Repeati | 370 – 479 | 2Sequence analysisAdd BLAST | 110 | |
Repeati | 480 – 589 | 3Sequence analysisAdd BLAST | 110 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 835 | N-terminal globular head1 PublicationAdd BLAST | 835 | |
Regioni | 168 – 208 | Talin-interactionBy similarityAdd BLAST | 41 | |
Regioni | 259 – 589 | 3 X 112 AA tandem repeatsSequence analysisAdd BLAST | 331 | |
Regioni | 741 – 764 | Interaction with ACTN4Combined sources1 PublicationAdd BLAST | 24 | |
Regioni | 836 – 878 | Linker (Pro-rich)1 PublicationAdd BLAST | 43 | |
Regioni | 879 – 1134 | C-terminal tail1 PublicationAdd BLAST | 256 | |
Regioni | 1003 – 1046 | Facilitates phospholipid membrane insertionBy similarityAdd BLAST | 44 | |
Regioni | 1120 – 1134 | Facilitates phospholipid membrane insertionBy similarityAdd BLAST | 15 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 837 – 878 | Pro-richPROSITE-ProRule annotationAdd BLAST | 42 |
Domaini
Sequence similaritiesi
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG3681, Eukaryota |
GeneTreei | ENSGT00990000203614 |
HOGENOMi | CLU_012338_0_0_1 |
InParanoidi | P18206 |
OMAi | TPGREQN |
PhylomeDBi | P18206 |
TreeFami | TF313686 |
Family and domain databases
InterProi | View protein in InterPro IPR036723, Alpha-catenin/vinculin-like_sf IPR017997, Vinculin IPR006077, Vinculin/catenin IPR000633, Vinculin_CS |
PANTHERi | PTHR46180, PTHR46180, 2 hits |
Pfami | View protein in Pfam PF01044, Vinculin, 3 hits |
SUPFAMi | SSF47220, SSF47220, 6 hits |
PROSITEi | View protein in PROSITE PS00663, VINCULIN_1, 1 hit PS00664, VINCULIN_2, 3 hits |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MPVFHTRTIE SILEPVAQQI SHLVIMHEEG EVDGKAIPDL TAPVAAVQAA
60 70 80 90 100
VSNLVRVGKE TVQTTEDQIL KRDMPPAFIK VENACTKLVQ AAQMLQSDPY
110 120 130 140 150
SVPARDYLID GSRGILSGTS DLLLTFDEAE VRKIIRVCKG ILEYLTVAEV
160 170 180 190 200
VETMEDLVTY TKNLGPGMTK MAKMIDERQQ ELTHQEHRVM LVNSMNTVKE
210 220 230 240 250
LLPVLISAMK IFVTTKNSKN QGIEEALKNR NFTVEKMSAE INEIIRVLQL
260 270 280 290 300
TSWDEDAWAS KDTEAMKRAL ASIDSKLNQA KGWLRDPSAS PGDAGEQAIR
310 320 330 340 350
QILDEAGKVG ELCAGKERRE ILGTCKMLGQ MTDQVADLRA RGQGSSPVAM
360 370 380 390 400
QKAQQVSQGL DVLTAKVENA ARKLEAMTNS KQSIAKKIDA AQNWLADPNG
410 420 430 440 450
GPEGEEQIRG ALAEARKIAE LCDDPKERDD ILRSLGEISA LTSKLADLRR
460 470 480 490 500
QGKGDSPEAR ALAKQVATAL QNLQTKTNRA VANSRPAKAA VHLEGKIEQA
510 520 530 540 550
QRWIDNPTVD DRGVGQAAIR GLVAEGHRLA NVMMGPYRQD LLAKCDRVDQ
560 570 580 590 600
LTAQLADLAA RGEGESPQAR ALASQLQDSL KDLKARMQEA MTQEVSDVFS
610 620 630 640 650
DTTTPIKLLA VAATAPPDAP NREEVFDERA ANFENHSGKL GATAEKAAAV
660 670 680 690 700
GTANKSTVEG IQASVKTARE LTPQVVSAAR ILLRNPGNQA AYEHFETMKN
710 720 730 740 750
QWIDNVEKMT GLVDEAIDTK SLLDASEEAI KKDLDKCKVA MANIQPQMLV
760 770 780 790 800
AGATSIARRA NRILLVAKRE VENSEDPKFR EAVKAASDEL SKTISPMVMD
810 820 830 840 850
AKAVAGNISD PGLQKSFLDS GYRILGAVAK VREAFQPQEP DFPPPPPDLE
860 870 880 890 900
QLRLTDELAP PKPPLPEGEV PPPRPPPPEE KDEEFPEQKA GEVINQPMMM
910 920 930 940 950
AARQLHDEAR KWSSKPGIPA AEVGIGVVAE ADAADAAGFP VPPDMEDDYE
960 970 980 990 1000
PELLLMPSNQ PVNQPILAAA QSLHREATKW SSKGNDIIAA AKRMALLMAE
1010 1020 1030 1040 1050
MSRLVRGGSG TKRALIQCAK DIAKASDEVT RLAKEVAKQC TDKRIRTNLL
1060 1070 1080 1090 1100
QVCERIPTIS TQLKILSTVK ATMLGRTNIS DEESEQATEM LVHNAQNLMQ
1110 1120 1130
SVKETVREAE AASIKIRTDA GFTLRWVRKT PWYQ
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A096LPE1 | A0A096LPE1_HUMAN | Metavinculin | VCL | 57 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_037667 | 234 | V → L1 PublicationCorresponds to variant dbSNP:rs17853882Ensembl. | 1 | |
Natural variantiVAR_035101 | 277 | L → M in CMH15. 1 PublicationCorresponds to variant dbSNP:rs71579353EnsemblClinVar. | 1 | |
Natural variantiVAR_035102 | 934 | A → V1 PublicationCorresponds to variant dbSNP:rs16931179EnsemblClinVar. | 1 | |
Natural variantiVAR_035103 | 943 | P → A1 PublicationCorresponds to variant dbSNP:rs71579375EnsemblClinVar. | 1 | |
Natural variantiVAR_035104 | 954 | Missing in CMD1W. 1 Publication | 1 | |
Natural variantiVAR_035105 | 975 | R → W in CMD1W; significantly alters metavinculin-mediated cross-linking of actin filaments. 2 PublicationsCorresponds to variant dbSNP:rs121917776EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_011857 | 1 – 73 | Missing in isoform 3. 1 PublicationAdd BLAST | 73 | |
Alternative sequenceiVSP_011858 | 262 – 295 | DTEAM…PGDAG → VRVLSGEISKIPNSPWLGVL IGTCLILYLVIFVA in isoform 3. 1 PublicationAdd BLAST | 34 | |
Alternative sequenceiVSP_011859 | 296 – 1134 | Missing in isoform 3. 1 PublicationAdd BLAST | 839 | |
Alternative sequenceiVSP_006731 | 916 – 983 | Missing in isoform 1. 2 PublicationsAdd BLAST | 68 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M33308 mRNA Translation: AAA61283.1 BX537994 mRNA Translation: CAD97952.1 AL596247, AL731576 Genomic DNA Translation: CAI13972.1 AL731576, AL596247 Genomic DNA Translation: CAI39673.1 BC039174 mRNA Translation: AAH39174.1 L04933 Genomic DNA Translation: AAA61271.1 S87180, S87175, S87178 Genomic DNA Translation: AAB21656.1 S87223, S87218 Genomic DNA Translation: AAB21657.1 |
CCDSi | CCDS7340.1 [P18206-2] CCDS7341.1 [P18206-1] |
PIRi | A35955 |
RefSeqi | NP_003364.1, NM_003373.3 [P18206-2] NP_054706.1, NM_014000.2 [P18206-1] |
Genome annotation databases
Ensembli | ENST00000211998; ENSP00000211998; ENSG00000035403 [P18206-1] ENST00000372755; ENSP00000361841; ENSG00000035403 [P18206-2] |
GeneIDi | 7414 |
KEGGi | hsa:7414 |
UCSCi | uc001jwe.4, human [P18206-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Wikipedia Vinculin entry |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M33308 mRNA Translation: AAA61283.1 BX537994 mRNA Translation: CAD97952.1 AL596247, AL731576 Genomic DNA Translation: CAI13972.1 AL731576, AL596247 Genomic DNA Translation: CAI39673.1 BC039174 mRNA Translation: AAH39174.1 L04933 Genomic DNA Translation: AAA61271.1 S87180, S87175, S87178 Genomic DNA Translation: AAB21656.1 S87223, S87218 Genomic DNA Translation: AAB21657.1 |
CCDSi | CCDS7340.1 [P18206-2] CCDS7341.1 [P18206-1] |
PIRi | A35955 |
RefSeqi | NP_003364.1, NM_003373.3 [P18206-2] NP_054706.1, NM_014000.2 [P18206-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1RKC | X-ray | 2.70 | A | 1-258 | [»] | |
1RKE | X-ray | 2.35 | A | 1-258 | [»] | |
B | 882-1134 | [»] | ||||
1SYQ | X-ray | 2.42 | A | 1-258 | [»] | |
1TR2 | X-ray | 2.90 | A/B | 1-1134 | [»] | |
1YDI | X-ray | 1.80 | A | 1-258 | [»] | |
2GWW | X-ray | 2.72 | A | 1-258 | [»] | |
2HSQ | X-ray | 3.97 | A | 1-258 | [»] | |
2IBF | X-ray | 3.20 | A | 1-258 | [»] | |
3H2U | X-ray | 2.75 | A/C | 879-1134 | [»] | |
3H2V | X-ray | 2.90 | A/B/C/D | 879-1134 | [»] | |
3JBK | electron microscopy | 8.20 | M | 858-1129 | [»] | |
3MYI | X-ray | 2.20 | A | 959-1130 | [»] | |
3RF3 | X-ray | 1.61 | A/B | 1-258 | [»] | |
3S90 | X-ray | 1.97 | A/B | 1-252 | [»] | |
3TJ5 | X-ray | 1.99 | A | 1-255 | [»] | |
3TJ6 | X-ray | 2.76 | A | 1-257 | [»] | |
3VF0 | X-ray | 2.54 | A | 856-1134 | [»] | |
4DJ9 | X-ray | 2.25 | A | 1-258 | [»] | |
4EHP | X-ray | 2.66 | A | 1-252 | [»] | |
4LN2 | X-ray | 1.00 | B | 857-867 | [»] | |
4LNP | X-ray | 1.41 | B | 870-879 | [»] | |
4PR9 | X-ray | 3.20 | A/B/C/D/E/F | 891-1134 | [»] | |
5L0C | X-ray | 3.10 | A/B/C/D | 959-1134 | [»] | |
5L0D | X-ray | 2.75 | A/B/C/D | 959-1130 | [»] | |
5L0F | X-ray | 2.76 | A/B | 959-1134 | [»] | |
5L0G | X-ray | 3.40 | A/B/C/D | 959-1134 | [»] | |
5L0H | X-ray | 2.90 | A | 959-1134 | [»] | |
5L0I | X-ray | 2.45 | A | 959-1134 | [»] | |
5L0J | X-ray | 4.00 | A/B | 969-1134 | [»] | |
5O2Q | NMR | - | A | 854-870 | [»] | |
6FUY | X-ray | 3.00 | A | 1-1134 | [»] | |
6UPW | electron microscopy | 2.90 | L/M | 1-1134 | [»] | |
SMRi | P18206 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 113257, 143 interactors |
ComplexPortali | CPX-791, Talin-1-Vinculin focal adhesion activation complex |
CORUMi | P18206 |
DIPi | DIP-35570N |
ELMi | P18206 |
IntActi | P18206, 60 interactors |
MINTi | P18206 |
STRINGi | 9606.ENSP00000211998 |
Chemistry databases
ChEMBLi | CHEMBL4295723 |
PTM databases
iPTMneti | P18206 |
MetOSitei | P18206 |
PhosphoSitePlusi | P18206 |
SwissPalmi | P18206 |
Genetic variation databases
BioMutai | VCL |
DMDMi | 21903479 |
2D gel databases
DOSAC-COBS-2DPAGEi | P18206 |
OGPi | P18206 |
REPRODUCTION-2DPAGEi | IPI00291175 |
SWISS-2DPAGEi | P18206 |
UCD-2DPAGEi | P18206 |
Proteomic databases
EPDi | P18206 |
jPOSTi | P18206 |
MassIVEi | P18206 |
PaxDbi | P18206 |
PeptideAtlasi | P18206 |
PRIDEi | P18206 |
ProteomicsDBi | 53553 [P18206-1] 53554 [P18206-2] 53555 [P18206-3] |
Protocols and materials databases
Antibodypediai | 884, 872 antibodies |
DNASUi | 7414 |
Genome annotation databases
Ensembli | ENST00000211998; ENSP00000211998; ENSG00000035403 [P18206-1] ENST00000372755; ENSP00000361841; ENSG00000035403 [P18206-2] |
GeneIDi | 7414 |
KEGGi | hsa:7414 |
UCSCi | uc001jwe.4, human [P18206-1] |
Organism-specific databases
CTDi | 7414 |
DisGeNETi | 7414 |
GeneCardsi | VCL |
GeneReviewsi | VCL |
HGNCi | HGNC:12665, VCL |
HPAi | ENSG00000035403, Low tissue specificity |
MalaCardsi | VCL |
MIMi | 193065, gene 611407, phenotype 613255, phenotype |
neXtProti | NX_P18206 |
OpenTargetsi | ENSG00000035403 |
Orphaneti | 154, Familial isolated dilated cardiomyopathy 155, NON RARE IN EUROPE: Familial isolated hypertrophic cardiomyopathy |
PharmGKBi | PA37288 |
VEuPathDBi | HostDB:ENSG00000035403.16 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3681, Eukaryota |
GeneTreei | ENSGT00990000203614 |
HOGENOMi | CLU_012338_0_0_1 |
InParanoidi | P18206 |
OMAi | TPGREQN |
PhylomeDBi | P18206 |
TreeFami | TF313686 |
Enzyme and pathway databases
PathwayCommonsi | P18206 |
Reactomei | R-HSA-114608, Platelet degranulation R-HSA-445355, Smooth Muscle Contraction R-HSA-5674135, MAP2K and MAPK activation R-HSA-6798695, Neutrophil degranulation R-HSA-6802946, Signaling by moderate kinase activity BRAF mutants R-HSA-6802948, Signaling by high-kinase activity BRAF mutants R-HSA-6802952, Signaling by BRAF and RAF fusions R-HSA-6802955, Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-9649948, Signaling downstream of RAS mutants R-HSA-9656223, Signaling by RAF1 mutants |
SIGNORi | P18206 |
Miscellaneous databases
BioGRID-ORCSi | 7414, 111 hits in 870 CRISPR screens |
ChiTaRSi | VCL, human |
EvolutionaryTracei | P18206 |
GeneWikii | Vinculin |
GenomeRNAii | 7414 |
Pharosi | P18206, Tbio |
PROi | PR:P18206 |
RNActi | P18206, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000035403, Expressed in myometrium and 252 other tissues |
ExpressionAtlasi | P18206, baseline and differential |
Genevisiblei | P18206, HS |
Family and domain databases
InterProi | View protein in InterPro IPR036723, Alpha-catenin/vinculin-like_sf IPR017997, Vinculin IPR006077, Vinculin/catenin IPR000633, Vinculin_CS |
PANTHERi | PTHR46180, PTHR46180, 2 hits |
Pfami | View protein in Pfam PF01044, Vinculin, 3 hits |
SUPFAMi | SSF47220, SSF47220, 6 hits |
PROSITEi | View protein in PROSITE PS00663, VINCULIN_1, 1 hit PS00664, VINCULIN_2, 3 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | VINC_HUMAN | |
Accessioni | P18206Primary (citable) accession number: P18206 Secondary accession number(s): Q16450 Q8IXU7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1990 |
Last sequence update: | January 23, 2007 | |
Last modified: | February 10, 2021 | |
This is version 229 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families