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UniProtKB - P18200 (PGPA_ECOLI)
Protein
Phosphatidylglycerophosphatase A
Gene
pgpA
Organism
Escherichia coli (strain K12)
Status
Functioni
Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG).
4 PublicationsCatalytic activityi
- 1,2-diacyl-sn-glycero-3-phospho-(1ʼ-sn-glycero-3ʼ-phosphate) + H2O = 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + phosphate4 PublicationsEC:3.1.3.274 Publications
Cofactori
Mg2+1 Publication
: phosphatidylglycerol biosynthesis Pathwayi
This protein is involved in step 2 of the subpathway that synthesizes phosphatidylglycerol from CDP-diacylglycerol. This subpathway is part of the pathway phosphatidylglycerol biosynthesis, which is itself part of Phospholipid metabolism.View all proteins of this organism that are known to be involved in the subpathway that synthesizes phosphatidylglycerol from CDP-diacylglycerol, the pathway phosphatidylglycerol biosynthesis and in Phospholipid metabolism.
GO - Molecular functioni
- lipid phosphatase activity Source: UniProtKB
- metal ion binding Source: UniProtKB-KW
- phosphatidylglycerophosphatase activity Source: UniProtKB
GO - Biological processi
- glycerophospholipid biosynthetic process Source: EcoCyc
- phosphatidylglycerol biosynthetic process Source: UniProtKB
- phospholipid catabolic process Source: UniProtKB-KW
- phospholipid dephosphorylation Source: UniProtKB
- response to magnesium ion Source: UniProtKB
Keywordsi
Molecular function | Hydrolase |
Biological process | Lipid degradation, Lipid metabolism, Phospholipid degradation, Phospholipid metabolism |
Ligand | Magnesium, Metal-binding |
Enzyme and pathway databases
BioCyci | EcoCyc:PGPPHOSPHAA-MONOMER |
UniPathwayi | UPA00084;UER00504 |
Chemistry databases
SwissLipidsi | SLP:000000222 |
Names & Taxonomyi
Protein namesi | Recommended name: Phosphatidylglycerophosphatase A (EC:3.1.3.27)Alternative name(s): Phosphatidylglycerolphosphate phosphatase A Short name: PGP phosphatase A |
Gene namesi | Name:pgpA Synonyms:yajN Ordered Locus Names:b0418, JW0408 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
Plasma membrane
- Cell inner membrane 1 Publication; Multi-pass membrane protein 1 Publication
Plasma Membrane
- integral component of plasma membrane Source: EcoCyc
- plasma membrane Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 31 | CytoplasmicSequence analysisAdd BLAST | 31 | |
Transmembranei | 32 – 52 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 53 | PeriplasmicSequence analysis | 1 | |
Transmembranei | 54 – 74 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 75 – 141 | CytoplasmicSequence analysisAdd BLAST | 67 | |
Transmembranei | 142 – 162 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 163 – 172 | PeriplasmicSequence analysis | 10 |
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePathology & Biotechi
Disruption phenotypei
Displays 7-10 fold higher levels of phosphatidylglycerophosphate (PGP) than wild-type. Simultaneous deletion of pgpA and pgpB leads to 40 times higher PGP levels compared to wild-type, while simultaneous deletion of pgpA and pgpC leads to almost 100 times higher PGP levels. Lethal when combined with the deletion of both pgpB and pgpC.3 Publications
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000058359 | 1 – 172 | Phosphatidylglycerophosphatase AAdd BLAST | 172 |
Proteomic databases
PaxDbi | P18200 |
PRIDEi | P18200 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 4259341, 300 interactors |
STRINGi | 511145.b0418 |
Structurei
Family & Domainsi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | COG1267, Bacteria |
HOGENOMi | CLU_103734_0_1_6 |
InParanoidi | P18200 |
PhylomeDBi | P18200 |
Family and domain databases
CDDi | cd06971, PgpA, 1 hit |
InterProi | View protein in InterPro IPR026037, PgpA IPR036681, PgpA-like_sf IPR007686, YutG/PgpA |
PANTHERi | PTHR36305, PTHR36305, 1 hit |
Pfami | View protein in Pfam PF04608, PgpA, 1 hit |
PIRSFi | PIRSF006162, PgpA, 1 hit |
SUPFAMi | SSF101307, SSF101307, 1 hit |
i Sequence
Sequence statusi: Complete.
P18200-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTILPRHKDV AKSRLKMSNP WHLLAVGFGS GLSPIVPGTM GSLAAIPFWY
60 70 80 90 100
LMTFLPWQLY SLVVMLGICI GVYLCHQTAK DMGVHDHGSI VWDEFIGMWI
110 120 130 140 150
TLMALPTNDW QWVAAGFVIF RILDMWKPWP IRWFDRNVHG GMGIMIDDIV
160 170
AGVISAGILY FIGHHWPLGI LS
Sequence cautioni
The sequence AAA24325 differs from that shown. Reason: Frameshift. In addition, due to translation of the incorrect DNA strand, an unrelated ORF was predicted.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M23546 Genomic DNA Translation: AAA24325.1 Sequence problems. D17333 Genomic DNA Translation: BAA21779.1 U82664 Genomic DNA Translation: AAB40174.1 U00096 Genomic DNA Translation: AAC73521.1 AP009048 Genomic DNA Translation: BAE76198.1 |
PIRi | A30192, PAECGA B64771 |
RefSeqi | NP_414952.1, NC_000913.3 WP_000154044.1, NZ_STEB01000007.1 |
Genome annotation databases
EnsemblBacteriai | AAC73521; AAC73521; b0418 BAE76198; BAE76198; BAE76198 |
GeneIDi | 66671283 947542 |
KEGGi | ecj:JW0408 eco:b0418 |
PATRICi | fig|1411691.4.peg.1859 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M23546 Genomic DNA Translation: AAA24325.1 Sequence problems. D17333 Genomic DNA Translation: BAA21779.1 U82664 Genomic DNA Translation: AAB40174.1 U00096 Genomic DNA Translation: AAC73521.1 AP009048 Genomic DNA Translation: BAE76198.1 |
PIRi | A30192, PAECGA B64771 |
RefSeqi | NP_414952.1, NC_000913.3 WP_000154044.1, NZ_STEB01000007.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 4259341, 300 interactors |
STRINGi | 511145.b0418 |
Chemistry databases
SwissLipidsi | SLP:000000222 |
Proteomic databases
PaxDbi | P18200 |
PRIDEi | P18200 |
Genome annotation databases
EnsemblBacteriai | AAC73521; AAC73521; b0418 BAE76198; BAE76198; BAE76198 |
GeneIDi | 66671283 947542 |
KEGGi | ecj:JW0408 eco:b0418 |
PATRICi | fig|1411691.4.peg.1859 |
Organism-specific databases
EchoBASEi | EB0698 |
Phylogenomic databases
eggNOGi | COG1267, Bacteria |
HOGENOMi | CLU_103734_0_1_6 |
InParanoidi | P18200 |
PhylomeDBi | P18200 |
Enzyme and pathway databases
UniPathwayi | UPA00084;UER00504 |
BioCyci | EcoCyc:PGPPHOSPHAA-MONOMER |
Miscellaneous databases
PROi | PR:P18200 |
Family and domain databases
CDDi | cd06971, PgpA, 1 hit |
InterProi | View protein in InterPro IPR026037, PgpA IPR036681, PgpA-like_sf IPR007686, YutG/PgpA |
PANTHERi | PTHR36305, PTHR36305, 1 hit |
Pfami | View protein in Pfam PF04608, PgpA, 1 hit |
PIRSFi | PIRSF006162, PgpA, 1 hit |
SUPFAMi | SSF101307, SSF101307, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PGPA_ECOLI | |
Accessioni | P18200Primary (citable) accession number: P18200 Secondary accession number(s): P77321, Q2MC08 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1990 |
Last sequence update: | November 1, 1997 | |
Last modified: | February 23, 2022 | |
This is version 156 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways