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Entry version 123 (16 Oct 2019)
Sequence version 3 (23 Jan 2007)
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Protein

Toxin B

Gene

toxB

Organism
Clostridioides difficile (Peptoclostridium difficile)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cytotoxin.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei653PROSITE-ProRule annotation1
Active sitei698NucleophilePROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • pathogenesis Source: CACAO

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, Thiol protease, Toxin
Biological processVirulence

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.4.1.B62 13625

Protein family/group databases

Carbohydrate-Active enZymes

More...
CAZyi
GT44 Glycosyltransferase Family 44

MEROPS protease database

More...
MEROPSi
C80.003

Transport Classification Database

More...
TCDBi
1.C.57.1.1 the clostridial cytotoxin (cct) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Toxin B (EC:3.4.22.-)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:toxB
Synonyms:tcdB
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiClostridioides difficile (Peptoclostridium difficile)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1496 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptostreptococcaceaeClostridioides

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3580505

Drug and drug target database

More...
DrugBanki
DB13140 Bezlotoxumab

DrugCentral

More...
DrugCentrali
P18177

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000726362 – 2366Toxin BAdd BLAST2365

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
P18177

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
P18177, 3 interactors

Molecular INTeraction database

More...
MINTi
P18177

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

12366
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P18177

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P18177

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini567 – 774Peptidase C80PROSITE-ProRule annotationAdd BLAST208
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati1832 – 1851Cell wall-binding 1Add BLAST20
Repeati1853 – 1872Cell wall-binding 2Add BLAST20
Repeati1875 – 1894Cell wall-binding 3Add BLAST20
Repeati1925 – 1944Cell wall-binding 4Add BLAST20
Repeati1966 – 1985Cell wall-binding 5Add BLAST20
Repeati1986 – 2005Cell wall-binding 6Add BLAST20
Repeati2006 – 2025Cell wall-binding 7Add BLAST20
Repeati2056 – 2075Cell wall-binding 8Add BLAST20
Repeati2076 – 2096Cell wall-binding 9Add BLAST21
Repeati2098 – 2117Cell wall-binding 10Add BLAST20
Repeati2118 – 2137Cell wall-binding 11Add BLAST20
Repeati2138 – 2157Cell wall-binding 12Add BLAST20
Repeati2208 – 2230Cell wall-binding 13Add BLAST23
Repeati2232 – 2251Cell wall-binding 14Add BLAST20
Repeati2252 – 2271Cell wall-binding 15Add BLAST20
Repeati2272 – 2291Cell wall-binding 16Add BLAST20
Repeati2322 – 2341Cell wall-binding 17Add BLAST20
Repeati2342 – 2361Cell wall-binding 18Add BLAST20

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4108N67 Bacteria
COG5263 LUCA

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.11050, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR018337 Cell_wall/Cho-bd_repeat
IPR020974 CPD_dom
IPR038383 CPD_dom_sf
IPR029044 Nucleotide-diphossugar_trans
IPR024770 TcdA/TcdB_cat
IPR024772 TcdA/TcdB_N
IPR024769 TcdA/TcdB_pore_forming

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01473 CW_binding_1, 4 hits
PF11713 Peptidase_C80, 1 hit
PF12919 TcdA_TcdB, 1 hit
PF12920 TcdA_TcdB_pore, 1 hit
PF12918 TcdB_N, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53448 SSF53448, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51771 CGT_MARTX_CPD, 1 hit
PS51170 CW, 18 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P18177-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLVNRKQLE KMANVRFRTQ EDEYVAILDA LEEYHNMSEN TVVEKYLKLK
60 70 80 90 100
DINSLTDIYI DTYKKSGRNK ALKKFKEYLV TEVLELKNNN LTPVEKNLHF
110 120 130 140 150
VWIGGQINDT AINYINQWKD VNSDYNVNVF YDSNAFLINT LKKTVVESAI
160 170 180 190 200
NDTLESFREN LNDPRFDYNK FFRKRMEIIY DKQKNFINYY KAQREENPEL
210 220 230 240 250
IIDDIVKTYL SNEYSKEIDE LNTYIEESLN KITQNSGNDV RNFEEFKNGE
260 270 280 290 300
SFNLYEQELV ERWNLAAASD ILRISALKEI GGMYLDVDML PGIQPDLFES
310 320 330 340 350
IEKPSSVTVD FWEMTKLEAI MKYKEYIPEY TSEHFDMLDE EVQSSFESVL
360 370 380 390 400
ASKSDKSEIF SSLGDMEASP LEVKIAFNSK GIINQGLISV KDSYCSNLIV
410 420 430 440 450
KQIENRYKIL NNSLNPAISE DNDFNTTTNT FIDSIMAEAN ADNGRFMMEL
460 470 480 490 500
GKYLRVGFFP DVKTTINLSG PEAYAAAYQD LLMFKEGSMN IHLIEADLRN
510 520 530 540 550
FEISKTNISQ STEQEMASLW SFDDARAKAQ FEEYKRNYFE GSLGEDDNLD
560 570 580 590 600
FSQNIVVDKE YLLEKISSLA RSSERGYIHY IVQLQGDKIS YEAACNLFAK
610 620 630 640 650
TPYDSVLFQK NIEDSEIAYY YNPGDGEIQE IDKYKIPSII SDRPKIKLTF
660 670 680 690 700
IGHGKDEFNT DIFAGFDVDS LSTEIEAAID LAKEDISPKS IEINLLGCNM
710 720 730 740 750
FSYSINVEET YPGKLLLKVK DKISELMPSI SQDSIIVSAN QYEVRINSEG
760 770 780 790 800
RRELLDHSGE WINKEESIIK DISSKEYISF NPKENKITVK SKNLPELSTL
810 820 830 840 850
LQEIRNNSNS SDIELEEKVM LTECEINVIS NIDTQIVEER IEEAKNLTSD
860 870 880 890 900
SINYIKDEFK LIESISDALC DLKQQNELED SHFISFEDIS ETDEGFSIRF
910 920 930 940 950
INKETGESIF VETEKTIFSE YANHITEEIS KIKGTIFDTV NGKLVKKVNL
960 970 980 990 1000
DTTHEVNTLN AAFFIQSLIE YNSSKESLSN LSVAMKVQVY AQLFSTGLNT
1010 1020 1030 1040 1050
ITDAAKVVEL VSTALDETID LLPTLSEGLP IIATIIDGVS LGAAIKELSE
1060 1070 1080 1090 1100
TSDPLLRQEI EAKIGIMAVN LTTATTAIIT SSLGIASGFS ILLVPLAGIS
1110 1120 1130 1140 1150
AGIPSLVNNE LVLRDKATKV VDYFKHVSLV ETEGVFTLLD DKIMMPQDDL
1160 1170 1180 1190 1200
VISEIDFNNN SIVLGKCEIW RMEGGSGHTV TDDIDHFFSA PSITYREPHL
1210 1220 1230 1240 1250
SIYDVLEVQK EELDLSKDLM VLPNAPNRVF AWETGWTPGL RSLENDGTKL
1260 1270 1280 1290 1300
LDRIRDNYEG EFYWRYFAFI ADALITTLKP RYEDTNIRIN LDSNTRSFIV
1310 1320 1330 1340 1350
PIITTEYIRE KLSYSFYGSG GTYALSLSQY NMGINIELSE SDVWIIDVDN
1360 1370 1380 1390 1400
VVRDVTIESD KIKKGDLIEG ILSTLSIEEN KIILNSHEIN FSGEVNGSNG
1410 1420 1430 1440 1450
FVSLTFSILE GINAIIEVDL LSKSYKLLIS GELKILMLNS NHIQQKIDYI
1460 1470 1480 1490 1500
GFNSELQKNI PYSFVDSEGK ENGFINGSTK EGLFVSELPD VVLISKVYMD
1510 1520 1530 1540 1550
DSKPSFGYYS NNLKDVKVIT KDNVNILTGY YLKDDIKISL SLTLQDEKTI
1560 1570 1580 1590 1600
KLNSVHLDES GVAEILKFMN RKGNTNTSDS LMSFLESMNI KSIFVNFLQS
1610 1620 1630 1640 1650
NIKFILDANF IISGTTSIGQ FEFICDENDN IQPYFIKFNT LETNYTLYVG
1660 1670 1680 1690 1700
NRQNMIVEPN YDLDDSGDIS STVINFSQKY LYGIDSCVNK VVISPNIYTD
1710 1720 1730 1740 1750
EINITPVYET NNTYPEVIVL DANYINEKIN VNINDLSIRY VWSNDGNDFI
1760 1770 1780 1790 1800
LMSTSEENKV SQVKIRFVNV FKDKTLANKL SFNFSDKQDV PVSEIILSFT
1810 1820 1830 1840 1850
PSYYEDGLIG YDLGLVSLYN EKFYINNFGM MVSGLIYIND SLYYFKPPVN
1860 1870 1880 1890 1900
NLITGFVTVG DDKYYFNPIN GGAASIGETI IDDKNYYFNQ SGVLQTGVFS
1910 1920 1930 1940 1950
TEDGFKYFAP ANTLDENLEG EAIDFTGKLI IDENIYYFDD NYRGAVEWKE
1960 1970 1980 1990 2000
LDGEMHYFSP ETGKAFKGLN QIGDYKYYFN SDGVMQKGFV SINDNKHYFD
2010 2020 2030 2040 2050
DSGVMKVGYT EIDGKHFYFA ENGEMQIGVF NTEDGFKYFA HHNEDLGNEE
2060 2070 2080 2090 2100
GEEISYSGIL NFNNKIYYFD DSFTAVVGWK DLEDGSKYYF DEDTAEAYIG
2110 2120 2130 2140 2150
LSLINDGQYY FNDDGIMQVG FVTINDKVFY FSDSGIIESG VQNIDDNYFY
2160 2170 2180 2190 2200
IDDNGIVQIG VFDTSDGYKY FAPANTVNDN IYGQAVEYSG LVRVGEDVYY
2210 2220 2230 2240 2250
FGETYTIETG WIYDMENESD KYYFNPETKK ACKGINLIDD IKYYFDEKGI
2260 2270 2280 2290 2300
MRTGLISFEN NNYYFNENGE MQFGYINIED KMFYFGEDGV MQIGVFNTPD
2310 2320 2330 2340 2350
GFKYFAHQNT LDENFEGESI NYTGWLDLDE KRYYFTDEYI AATGSVIIDG
2360
EEYYFDPDTA QLVISE
Length:2,366
Mass (Da):269,712
Last modified:January 23, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE1024BD8B8A56ADF
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X53138 Genomic DNA Translation: CAA37298.1
X92982 Genomic DNA Translation: CAA63562.1
X60984 Genomic DNA Translation: CAA43299.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A27636
S10317

NCBI Reference Sequences

More...
RefSeqi
WP_009902069.1, NZ_SRKJ01000018.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53138 Genomic DNA Translation: CAA37298.1
X92982 Genomic DNA Translation: CAA63562.1
X60984 Genomic DNA Translation: CAA43299.1
PIRiA27636
S10317
RefSeqiWP_009902069.1, NZ_SRKJ01000018.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2BVLX-ray2.20A2-541[»]
2BVMX-ray2.55A2-542[»]
4NC2X-ray2.50A2248-2366[»]
4NP4X-ray2.89A1834-2099[»]
5UQMX-ray2.03A1-543[»]
5UQNX-ray2.06A1-543[»]
5UQTX-ray2.75A/B1-543[»]
6AR6electron microscopy9.00A4-2099[»]
6C0BX-ray2.50A1285-1804[»]
6OQ8X-ray2.20A/B1-542[»]
SMRiP18177
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

IntActiP18177, 3 interactors
MINTiP18177

Chemistry databases

ChEMBLiCHEMBL3580505
DrugBankiDB13140 Bezlotoxumab
DrugCentraliP18177

Protein family/group databases

CAZyiGT44 Glycosyltransferase Family 44
MEROPSiC80.003
TCDBi1.C.57.1.1 the clostridial cytotoxin (cct) family

Proteomic databases

PRIDEiP18177

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...
ABCDi
P18177

Phylogenomic databases

eggNOGiENOG4108N67 Bacteria
COG5263 LUCA

Enzyme and pathway databases

BRENDAi2.4.1.B62 13625

Miscellaneous databases

EvolutionaryTraceiP18177

Family and domain databases

Gene3Di3.40.50.11050, 1 hit
InterProiView protein in InterPro
IPR018337 Cell_wall/Cho-bd_repeat
IPR020974 CPD_dom
IPR038383 CPD_dom_sf
IPR029044 Nucleotide-diphossugar_trans
IPR024770 TcdA/TcdB_cat
IPR024772 TcdA/TcdB_N
IPR024769 TcdA/TcdB_pore_forming
PfamiView protein in Pfam
PF01473 CW_binding_1, 4 hits
PF11713 Peptidase_C80, 1 hit
PF12919 TcdA_TcdB, 1 hit
PF12920 TcdA_TcdB_pore, 1 hit
PF12918 TcdB_N, 1 hit
SUPFAMiSSF53448 SSF53448, 1 hit
PROSITEiView protein in PROSITE
PS51771 CGT_MARTX_CPD, 1 hit
PS51170 CW, 18 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTOXB_CLODI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P18177
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: January 23, 2007
Last modified: October 16, 2019
This is version 123 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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