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Protein

Toxin B

Gene

toxB

Organism
Clostridioides difficile (Peptoclostridium difficile)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cytotoxin.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei653PROSITE-ProRule annotation1
Active sitei698NucleophilePROSITE-ProRule annotation1

GO - Molecular functioni

  • cysteine-type peptidase activity Source: UniProtKB-KW
  • glucosyltransferase activity Source: UniProtKB
  • toxin activity Source: UniProtKB-KW

GO - Biological processi

  • pathogenesis Source: CACAO

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease, Toxin

Enzyme and pathway databases

BRENDAi2.4.1.B62 13625

Protein family/group databases

CAZyiGT44 Glycosyltransferase Family 44
MEROPSiC80.003
TCDBi1.C.57.1.1 the clostridial cytotoxin (cct) family

Names & Taxonomyi

Protein namesi
Recommended name:
Toxin B (EC:3.4.22.-)
Gene namesi
Name:toxB
Synonyms:tcdB
OrganismiClostridioides difficile (Peptoclostridium difficile)
Taxonomic identifieri1496 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptostreptococcaceaeClostridioides

Subcellular locationi

GO - Cellular componenti

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3580505

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000726362 – 2366Toxin BAdd BLAST2365

Proteomic databases

PRIDEiP18177

Interactioni

Protein-protein interaction databases

IntActiP18177, 3 interactors
MINTiP18177

Structurei

Secondary structure

12366
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP18177
SMRiP18177
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP18177

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini567 – 774Peptidase C80PROSITE-ProRule annotationAdd BLAST208
Repeati1832 – 1851Cell wall-binding 1Add BLAST20
Repeati1853 – 1872Cell wall-binding 2Add BLAST20
Repeati1875 – 1894Cell wall-binding 3Add BLAST20
Repeati1925 – 1944Cell wall-binding 4Add BLAST20
Repeati1966 – 1985Cell wall-binding 5Add BLAST20
Repeati1986 – 2005Cell wall-binding 6Add BLAST20
Repeati2006 – 2025Cell wall-binding 7Add BLAST20
Repeati2056 – 2075Cell wall-binding 8Add BLAST20
Repeati2076 – 2096Cell wall-binding 9Add BLAST21
Repeati2098 – 2117Cell wall-binding 10Add BLAST20
Repeati2118 – 2137Cell wall-binding 11Add BLAST20
Repeati2138 – 2157Cell wall-binding 12Add BLAST20
Repeati2208 – 2230Cell wall-binding 13Add BLAST23
Repeati2232 – 2251Cell wall-binding 14Add BLAST20
Repeati2252 – 2271Cell wall-binding 15Add BLAST20
Repeati2272 – 2291Cell wall-binding 16Add BLAST20
Repeati2322 – 2341Cell wall-binding 17Add BLAST20
Repeati2342 – 2361Cell wall-binding 18Add BLAST20

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG4108N67 Bacteria
COG5263 LUCA

Family and domain databases

Gene3Di3.40.50.11050, 1 hit
InterProiView protein in InterPro
IPR018337 Cell_wall/Cho-bd_repeat
IPR020974 CPD_dom
IPR038383 CPD_dom_sf
IPR029044 Nucleotide-diphossugar_trans
IPR024770 TcdA/TcdB_cat
IPR024772 TcdA/TcdB_N
IPR024769 TcdA/TcdB_pore_forming
PfamiView protein in Pfam
PF01473 CW_binding_1, 4 hits
PF11713 Peptidase_C80, 1 hit
PF12919 TcdA_TcdB, 1 hit
PF12920 TcdA_TcdB_pore, 1 hit
PF12918 TcdB_N, 1 hit
SUPFAMiSSF53448 SSF53448, 1 hit
PROSITEiView protein in PROSITE
PS51771 CGT_MARTX_CPD, 1 hit
PS51170 CW, 18 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P18177-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLVNRKQLE KMANVRFRTQ EDEYVAILDA LEEYHNMSEN TVVEKYLKLK
60 70 80 90 100
DINSLTDIYI DTYKKSGRNK ALKKFKEYLV TEVLELKNNN LTPVEKNLHF
110 120 130 140 150
VWIGGQINDT AINYINQWKD VNSDYNVNVF YDSNAFLINT LKKTVVESAI
160 170 180 190 200
NDTLESFREN LNDPRFDYNK FFRKRMEIIY DKQKNFINYY KAQREENPEL
210 220 230 240 250
IIDDIVKTYL SNEYSKEIDE LNTYIEESLN KITQNSGNDV RNFEEFKNGE
260 270 280 290 300
SFNLYEQELV ERWNLAAASD ILRISALKEI GGMYLDVDML PGIQPDLFES
310 320 330 340 350
IEKPSSVTVD FWEMTKLEAI MKYKEYIPEY TSEHFDMLDE EVQSSFESVL
360 370 380 390 400
ASKSDKSEIF SSLGDMEASP LEVKIAFNSK GIINQGLISV KDSYCSNLIV
410 420 430 440 450
KQIENRYKIL NNSLNPAISE DNDFNTTTNT FIDSIMAEAN ADNGRFMMEL
460 470 480 490 500
GKYLRVGFFP DVKTTINLSG PEAYAAAYQD LLMFKEGSMN IHLIEADLRN
510 520 530 540 550
FEISKTNISQ STEQEMASLW SFDDARAKAQ FEEYKRNYFE GSLGEDDNLD
560 570 580 590 600
FSQNIVVDKE YLLEKISSLA RSSERGYIHY IVQLQGDKIS YEAACNLFAK
610 620 630 640 650
TPYDSVLFQK NIEDSEIAYY YNPGDGEIQE IDKYKIPSII SDRPKIKLTF
660 670 680 690 700
IGHGKDEFNT DIFAGFDVDS LSTEIEAAID LAKEDISPKS IEINLLGCNM
710 720 730 740 750
FSYSINVEET YPGKLLLKVK DKISELMPSI SQDSIIVSAN QYEVRINSEG
760 770 780 790 800
RRELLDHSGE WINKEESIIK DISSKEYISF NPKENKITVK SKNLPELSTL
810 820 830 840 850
LQEIRNNSNS SDIELEEKVM LTECEINVIS NIDTQIVEER IEEAKNLTSD
860 870 880 890 900
SINYIKDEFK LIESISDALC DLKQQNELED SHFISFEDIS ETDEGFSIRF
910 920 930 940 950
INKETGESIF VETEKTIFSE YANHITEEIS KIKGTIFDTV NGKLVKKVNL
960 970 980 990 1000
DTTHEVNTLN AAFFIQSLIE YNSSKESLSN LSVAMKVQVY AQLFSTGLNT
1010 1020 1030 1040 1050
ITDAAKVVEL VSTALDETID LLPTLSEGLP IIATIIDGVS LGAAIKELSE
1060 1070 1080 1090 1100
TSDPLLRQEI EAKIGIMAVN LTTATTAIIT SSLGIASGFS ILLVPLAGIS
1110 1120 1130 1140 1150
AGIPSLVNNE LVLRDKATKV VDYFKHVSLV ETEGVFTLLD DKIMMPQDDL
1160 1170 1180 1190 1200
VISEIDFNNN SIVLGKCEIW RMEGGSGHTV TDDIDHFFSA PSITYREPHL
1210 1220 1230 1240 1250
SIYDVLEVQK EELDLSKDLM VLPNAPNRVF AWETGWTPGL RSLENDGTKL
1260 1270 1280 1290 1300
LDRIRDNYEG EFYWRYFAFI ADALITTLKP RYEDTNIRIN LDSNTRSFIV
1310 1320 1330 1340 1350
PIITTEYIRE KLSYSFYGSG GTYALSLSQY NMGINIELSE SDVWIIDVDN
1360 1370 1380 1390 1400
VVRDVTIESD KIKKGDLIEG ILSTLSIEEN KIILNSHEIN FSGEVNGSNG
1410 1420 1430 1440 1450
FVSLTFSILE GINAIIEVDL LSKSYKLLIS GELKILMLNS NHIQQKIDYI
1460 1470 1480 1490 1500
GFNSELQKNI PYSFVDSEGK ENGFINGSTK EGLFVSELPD VVLISKVYMD
1510 1520 1530 1540 1550
DSKPSFGYYS NNLKDVKVIT KDNVNILTGY YLKDDIKISL SLTLQDEKTI
1560 1570 1580 1590 1600
KLNSVHLDES GVAEILKFMN RKGNTNTSDS LMSFLESMNI KSIFVNFLQS
1610 1620 1630 1640 1650
NIKFILDANF IISGTTSIGQ FEFICDENDN IQPYFIKFNT LETNYTLYVG
1660 1670 1680 1690 1700
NRQNMIVEPN YDLDDSGDIS STVINFSQKY LYGIDSCVNK VVISPNIYTD
1710 1720 1730 1740 1750
EINITPVYET NNTYPEVIVL DANYINEKIN VNINDLSIRY VWSNDGNDFI
1760 1770 1780 1790 1800
LMSTSEENKV SQVKIRFVNV FKDKTLANKL SFNFSDKQDV PVSEIILSFT
1810 1820 1830 1840 1850
PSYYEDGLIG YDLGLVSLYN EKFYINNFGM MVSGLIYIND SLYYFKPPVN
1860 1870 1880 1890 1900
NLITGFVTVG DDKYYFNPIN GGAASIGETI IDDKNYYFNQ SGVLQTGVFS
1910 1920 1930 1940 1950
TEDGFKYFAP ANTLDENLEG EAIDFTGKLI IDENIYYFDD NYRGAVEWKE
1960 1970 1980 1990 2000
LDGEMHYFSP ETGKAFKGLN QIGDYKYYFN SDGVMQKGFV SINDNKHYFD
2010 2020 2030 2040 2050
DSGVMKVGYT EIDGKHFYFA ENGEMQIGVF NTEDGFKYFA HHNEDLGNEE
2060 2070 2080 2090 2100
GEEISYSGIL NFNNKIYYFD DSFTAVVGWK DLEDGSKYYF DEDTAEAYIG
2110 2120 2130 2140 2150
LSLINDGQYY FNDDGIMQVG FVTINDKVFY FSDSGIIESG VQNIDDNYFY
2160 2170 2180 2190 2200
IDDNGIVQIG VFDTSDGYKY FAPANTVNDN IYGQAVEYSG LVRVGEDVYY
2210 2220 2230 2240 2250
FGETYTIETG WIYDMENESD KYYFNPETKK ACKGINLIDD IKYYFDEKGI
2260 2270 2280 2290 2300
MRTGLISFEN NNYYFNENGE MQFGYINIED KMFYFGEDGV MQIGVFNTPD
2310 2320 2330 2340 2350
GFKYFAHQNT LDENFEGESI NYTGWLDLDE KRYYFTDEYI AATGSVIIDG
2360
EEYYFDPDTA QLVISE
Length:2,366
Mass (Da):269,712
Last modified:January 23, 2007 - v3
Checksum:iE1024BD8B8A56ADF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53138 Genomic DNA Translation: CAA37298.1
X92982 Genomic DNA Translation: CAA63562.1
X60984 Genomic DNA Translation: CAA43299.1
PIRiA27636
S10317
RefSeqiWP_009902069.1, NZ_NBTS02000002.1

Genome annotation databases

GeneIDi31352216

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53138 Genomic DNA Translation: CAA37298.1
X92982 Genomic DNA Translation: CAA63562.1
X60984 Genomic DNA Translation: CAA43299.1
PIRiA27636
S10317
RefSeqiWP_009902069.1, NZ_NBTS02000002.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2BVLX-ray2.20A2-541[»]
2BVMX-ray2.55A2-542[»]
4NC2X-ray2.50A2248-2366[»]
4NP4X-ray2.89A1834-2099[»]
5UQMX-ray2.03A1-543[»]
5UQNX-ray2.06A1-543[»]
5UQTX-ray2.75A/B1-543[»]
6AR6electron microscopy9.00A4-2099[»]
ProteinModelPortaliP18177
SMRiP18177
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP18177, 3 interactors
MINTiP18177

Chemistry databases

ChEMBLiCHEMBL3580505

Protein family/group databases

CAZyiGT44 Glycosyltransferase Family 44
MEROPSiC80.003
TCDBi1.C.57.1.1 the clostridial cytotoxin (cct) family

Proteomic databases

PRIDEiP18177

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi31352216

Phylogenomic databases

eggNOGiENOG4108N67 Bacteria
COG5263 LUCA

Enzyme and pathway databases

BRENDAi2.4.1.B62 13625

Miscellaneous databases

EvolutionaryTraceiP18177

Family and domain databases

Gene3Di3.40.50.11050, 1 hit
InterProiView protein in InterPro
IPR018337 Cell_wall/Cho-bd_repeat
IPR020974 CPD_dom
IPR038383 CPD_dom_sf
IPR029044 Nucleotide-diphossugar_trans
IPR024770 TcdA/TcdB_cat
IPR024772 TcdA/TcdB_N
IPR024769 TcdA/TcdB_pore_forming
PfamiView protein in Pfam
PF01473 CW_binding_1, 4 hits
PF11713 Peptidase_C80, 1 hit
PF12919 TcdA_TcdB, 1 hit
PF12920 TcdA_TcdB_pore, 1 hit
PF12918 TcdB_N, 1 hit
SUPFAMiSSF53448 SSF53448, 1 hit
PROSITEiView protein in PROSITE
PS51771 CGT_MARTX_CPD, 1 hit
PS51170 CW, 18 hits
ProtoNetiSearch...

Entry informationi

Entry nameiTOXB_CLODI
AccessioniPrimary (citable) accession number: P18177
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: January 23, 2007
Last modified: October 10, 2018
This is version 115 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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