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Entry version 191 (02 Jun 2021)
Sequence version 3 (21 Jun 2005)
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Protein

Protein serrate

Gene

Ser

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a ligand for Notch (N) receptor. Essential for proper ectodermal development. Serrate represents an element in a network of interacting molecules operating at the cell surface during the differentiation of certain tissues.

Miscellaneous

Separation of neuroblasts from the ectoderm into the inner part of embryo is one of the first steps of CNS development in insects, this process is under control of the neurogenic genes.
Notch and Serrate may interact at the protein level, it is conceivable that the Serrate and Delta proteins may compete for binding with the Notch protein.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
P18168

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein serrate
Alternative name(s):
Protein beaded
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ser
Synonyms:Bd
ORF Names:CG6127
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0004197, Ser

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini80 – 1219ExtracellularSequence analysisAdd BLAST1140
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1220 – 1245HelicalSequence analysisAdd BLAST26
Topological domaini1246 – 1404CytoplasmicSequence analysisAdd BLAST159

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 79Sequence analysisAdd BLAST79
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000771880 – 1404Protein serrateAdd BLAST1325

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi148N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi192N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi237 ↔ 246By similarity
Glycosylationi243N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi250 ↔ 262By similarity
Disulfide bondi270 ↔ 279By similarity
Disulfide bondi284 ↔ 295By similarity
Disulfide bondi288 ↔ 301By similarity
Disulfide bondi303 ↔ 312By similarity
Disulfide bondi315 ↔ 326By similarity
Disulfide bondi321 ↔ 333By similarity
Glycosylationi327N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi335 ↔ 344By similarity
Disulfide bondi351 ↔ 363By similarity
Disulfide bondi357 ↔ 373By similarity
Disulfide bondi375 ↔ 384By similarity
Disulfide bondi391 ↔ 402By similarity
Disulfide bondi396 ↔ 473By similarity
Glycosylationi408N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi448N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi475 ↔ 484By similarity
Disulfide bondi491 ↔ 502By similarity
Disulfide bondi496 ↔ 511By similarity
Disulfide bondi513 ↔ 522By similarity
Disulfide bondi529 ↔ 584By similarity
Glycosylationi554N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi578 ↔ 593By similarity
Disulfide bondi595 ↔ 604By similarity
Disulfide bondi611 ↔ 621By similarity
Disulfide bondi615 ↔ 630By similarity
Disulfide bondi632 ↔ 641By similarity
Disulfide bondi648 ↔ 659By similarity
Disulfide bondi653 ↔ 668By similarity
Disulfide bondi670 ↔ 679By similarity
Disulfide bondi686 ↔ 696By similarity
Disulfide bondi691 ↔ 705By similarity
Disulfide bondi707 ↔ 716By similarity
Glycosylationi735N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi766 ↔ 781By similarity
Disulfide bondi783 ↔ 792By similarity
Disulfide bondi799 ↔ 810By similarity
Disulfide bondi804 ↔ 819By similarity
Disulfide bondi821 ↔ 830By similarity
Disulfide bondi837 ↔ 848By similarity
Disulfide bondi842 ↔ 861By similarity
Disulfide bondi863 ↔ 872By similarity
Disulfide bondi879 ↔ 890By similarity
Disulfide bondi884 ↔ 899By similarity
Disulfide bondi901 ↔ 910By similarity
Disulfide bondi917 ↔ 928By similarity
Disulfide bondi922 ↔ 937By similarity
Disulfide bondi939 ↔ 948By similarity
Glycosylationi961N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi973N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1000N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1026N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1146N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1292Phosphoserine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Ubiquitinated by mind-bomb, leading to its endocytosis and subsequent degradation.Curated

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P18168

PRoteomics IDEntifications database

More...
PRIDEi
P18168

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P18168

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Restricted exclusively to cells of ectodermal origin.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0004197, Expressed in wing disc (Drosophila) and 35 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P18168, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P18168, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
68163, 36 interactors

Protein interaction database and analysis system

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IntActi
P18168, 2 interactors

Molecular INTeraction database

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MINTi
P18168

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0084498

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P18168

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini235 – 279DSLPROSITE-ProRule annotationAdd BLAST45
Domaini280 – 313EGF-like 1PROSITE-ProRule annotationAdd BLAST34
Domaini311 – 345EGF-like 2PROSITE-ProRule annotationAdd BLAST35
Domaini347 – 385EGF-like 3PROSITE-ProRule annotationAdd BLAST39
Domaini387 – 485EGF-like 4PROSITE-ProRule annotationAdd BLAST99
Domaini487 – 523EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini525 – 605EGF-like 6; calcium-bindingPROSITE-ProRule annotationAdd BLAST81
Domaini607 – 642EGF-like 7; calcium-bindingPROSITE-ProRule annotationAdd BLAST36
Domaini644 – 680EGF-like 8; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini682 – 717EGF-like 9PROSITE-ProRule annotationAdd BLAST36
Domaini719 – 793EGF-like 10PROSITE-ProRule annotationAdd BLAST75
Domaini795 – 831EGF-like 11; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini833 – 873EGF-like 12PROSITE-ProRule annotationAdd BLAST41
Domaini875 – 911EGF-like 13PROSITE-ProRule annotationAdd BLAST37
Domaini913 – 949EGF-like 14; calcium-bindingPROSITE-ProRule annotationAdd BLAST37

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 44DisorderedSequence analysisAdd BLAST44
Regioni417 – 436DisorderedSequence analysisAdd BLAST20
Regioni1267 – 1287DisorderedSequence analysisAdd BLAST21
Regioni1360 – 1404DisorderedSequence analysisAdd BLAST45

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi12 – 32Polar residuesSequence analysisAdd BLAST21

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1217, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000170138

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_004732_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P18168

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P18168

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001774, DSL
IPR001881, EGF-like_Ca-bd_dom
IPR013032, EGF-like_CS
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR009030, Growth_fac_rcpt_cys_sf
IPR026219, Jagged/Serrate
IPR011651, Notch_ligand_N
IPR001007, VWF_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01414, DSL, 1 hit
PF00008, EGF, 6 hits
PF07645, EGF_CA, 1 hit
PF12661, hEGF, 2 hits
PF07657, MNNL, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR02059, JAGGEDFAMILY

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00051, DSL, 1 hit
SM00181, EGF, 14 hits
SM00179, EGF_CA, 9 hits
SM00215, VWC_out, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57184, SSF57184, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00010, ASX_HYDROXYL, 7 hits
PS51051, DSL, 1 hit
PS00022, EGF_1, 14 hits
PS01186, EGF_2, 8 hits
PS50026, EGF_3, 13 hits
PS01187, EGF_CA, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P18168-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFRKHFRRKP ATSSSLESTI ESADSLGMSK KTATKRQRPR HRVPKIATLP
60 70 80 90 100
STIRDCRSLK SACNLIALIL ILLVHKISAA GNFELEILEI SNTNSHLLNG
110 120 130 140 150
YCCGMPAELR ATKTIGCSPC TTAFRLCLKE YQTTEQGASI STGCSFGNAT
160 170 180 190 200
TKILGGSSFV LSDPGVGAIV LPFTFRWTKS FTLILQALDM YNTSYPDAER
210 220 230 240 250
LIEETSYSGV ILPSPEWKTL DHIGRNARIT YRVRVQCAVT YYNTTCTTFC
260 270 280 290 300
RPRDDQFGHY ACGSEGQKLC LNGWQGVNCE EAICKAGCDP VHGKCDRPGE
310 320 330 340 350
CECRPGWRGP LCNECMVYPG CKHGSCNGSA WKCVCDTNWG GILCDQDLNF
360 370 380 390 400
CGTHEPCKHG GTCENTAPDK YRCTCAEGLS GEQCEIVEHP CATRPCRNGG
410 420 430 440 450
TCTLKTSNRT QAQVYRTSHG RSNMGRPVRR SSSMRSLDHL RPEGQALNGS
460 470 480 490 500
SSPGLVSLGS LQLQQQLAPD FTCDCAAGWT GPTCEINIDE CAGGPCEHGG
510 520 530 540 550
TCIDLIGGFR CECPPEWHGD VCQVDVNECE APHSAGIAAN ALLTTTATAI
560 570 580 590 600
IGSNLSSTAL LAALTSAVAS TSLAIGPCIN AKECRNQPGS FACICKEGWG
610 620 630 640 650
GVTCAENLDD CVGQCRNGAT CIDLVNDYRC ACASGFKGRD CETDIDECAT
660 670 680 690 700
SPCRNGGECV DMVGKFNCIC PLGYSGSLCE EAKENCTPSP CLEGHCLNTP
710 720 730 740 750
EGYYCHCPPD RAGKHCEQLR PLCSQPPCNE GCFANVSLAT SATTTTTTTT
760 770 780 790 800
TATTTRKMAK PSGLPCSGHG SCEMSDVGTF CKCHVGHTGT FCEHNLNECS
810 820 830 840 850
PNPCRNGGIC LDGDGDFTCE CMSGWTGKRC SERATGCYAG QCQNGGTCMP
860 870 880 890 900
GAPDKALQPH CRCAPGWTGL FCAEAIDQCR GQPCHNGGTC ESGAGWFRCV
910 920 930 940 950
CAQGFSGPDC RINVNECSPQ PCQGGATCID GIGGYSCICP PGRHGLRCEI
960 970 980 990 1000
LLSDPKSACQ NASNTISPYT ALNRSQNWLD IALTGRTEDD ENCNACVCEN
1010 1020 1030 1040 1050
GTSRCTNLWC GLPNCYKVDP LSKSSNLSGV CKQHEVCVPA LSETCLSSPC
1060 1070 1080 1090 1100
NVRGDCRALE PSRRVAPPRL PAKSSCWPNQ AVVNENCARL TILLALERVG
1110 1120 1130 1140 1150
KGASVEGLCS LVRVLLAAQL IKKPASTFGQ DPGMLMVLCD LKTGTNDTVE
1160 1170 1180 1190 1200
LTVSSSKLND PQLPVAVGLL GELLSFRQLN GIQRRKELEL QHAKLAALTS
1210 1220 1230 1240 1250
IVEVKLETAR VADGSGHSLL IGVLCGVFIV LVGFSVFISL YWKQRLAYRT
1260 1270 1280 1290 1300
SSGMNLTPSL DALRHEEEKS NNLQNEENLR RYTNPLKGST SSLRAATGME
1310 1320 1330 1340 1350
LSLNPAPELA ASAASSSALH RSQPLFPPCD FERELDSSTG LKQAHKRSSQ
1360 1370 1380 1390 1400
ILLHKTQNSD MRKNTVGSLD SPRKDFGKRS INCKSMPPSS GDEGSDVLAT

TVMV
Length:1,404
Mass (Da):150,344
Last modified:June 21, 2005 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE988604001DAAC84
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0B4LIS1A0A0B4LIS1_DROME
Delta-like protein
Ser Bd, CT18858, Dmel\CG6127, mel(3)8, Rpw
1,407Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF56678 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti15S → SSLSS in CAA40148 (PubMed:1840519).Curated1
Sequence conflicti23A → P in CAA40148 (PubMed:1840519).Curated1
Sequence conflicti453P → S in AAA28938 (PubMed:2125287).Curated1
Sequence conflicti453P → S in CAA40148 (PubMed:1840519).Curated1
Sequence conflicti637K → T in AAA28938 (PubMed:2125287).Curated1
Sequence conflicti637K → T in CAA40148 (PubMed:1840519).Curated1
Sequence conflicti1176F → S in AAA28938 (PubMed:2125287).Curated1
Sequence conflicti1176F → S in CAA40148 (PubMed:1840519).Curated1
Sequence conflicti1348S → T in CAA40148 (PubMed:1840519).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
M35759 mRNA Translation: AAA28938.1
X56811 mRNA Translation: CAA40148.1
AE014297 Genomic DNA Translation: AAF56678.2 Different initiation.

Protein sequence database of the Protein Information Resource

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PIRi
S16148

NCBI Reference Sequences

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RefSeqi
NP_001287558.1, NM_001300629.1
NP_524527.3, NM_079803.3

Genome annotation databases

Ensembl metazoan genome annotation project

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EnsemblMetazoai
FBtr0085128; FBpp0084498; FBgn0004197

Database of genes from NCBI RefSeq genomes

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GeneIDi
43275

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
dme:Dmel_CG6127

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M35759 mRNA Translation: AAA28938.1
X56811 mRNA Translation: CAA40148.1
AE014297 Genomic DNA Translation: AAF56678.2 Different initiation.
PIRiS16148
RefSeqiNP_001287558.1, NM_001300629.1
NP_524527.3, NM_079803.3

3D structure databases

SMRiP18168
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi68163, 36 interactors
IntActiP18168, 2 interactors
MINTiP18168
STRINGi7227.FBpp0084498

PTM databases

iPTMnetiP18168

Proteomic databases

PaxDbiP18168
PRIDEiP18168

Genome annotation databases

EnsemblMetazoaiFBtr0085128; FBpp0084498; FBgn0004197
GeneIDi43275
KEGGidme:Dmel_CG6127

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
107980446
FlyBaseiFBgn0004197, Ser

Phylogenomic databases

eggNOGiKOG1217, Eukaryota
GeneTreeiENSGT00940000170138
HOGENOMiCLU_004732_0_0_1
InParanoidiP18168
PhylomeDBiP18168

Enzyme and pathway databases

SignaLinkiP18168

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
43275, 0 hits in 3 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
43275

Protein Ontology

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PROi
PR:P18168

Gene expression databases

BgeeiFBgn0004197, Expressed in wing disc (Drosophila) and 35 other tissues
ExpressionAtlasiP18168, baseline and differential
GenevisibleiP18168, DM

Family and domain databases

InterProiView protein in InterPro
IPR001774, DSL
IPR001881, EGF-like_Ca-bd_dom
IPR013032, EGF-like_CS
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR009030, Growth_fac_rcpt_cys_sf
IPR026219, Jagged/Serrate
IPR011651, Notch_ligand_N
IPR001007, VWF_dom
PfamiView protein in Pfam
PF01414, DSL, 1 hit
PF00008, EGF, 6 hits
PF07645, EGF_CA, 1 hit
PF12661, hEGF, 2 hits
PF07657, MNNL, 1 hit
PRINTSiPR02059, JAGGEDFAMILY
SMARTiView protein in SMART
SM00051, DSL, 1 hit
SM00181, EGF, 14 hits
SM00179, EGF_CA, 9 hits
SM00215, VWC_out, 1 hit
SUPFAMiSSF57184, SSF57184, 1 hit
PROSITEiView protein in PROSITE
PS00010, ASX_HYDROXYL, 7 hits
PS51051, DSL, 1 hit
PS00022, EGF_1, 14 hits
PS01186, EGF_2, 8 hits
PS50026, EGF_3, 13 hits
PS01187, EGF_CA, 5 hits

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSERR_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P18168
Secondary accession number(s): Q9VB65
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: June 21, 2005
Last modified: June 2, 2021
This is version 191 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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