Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 169 (29 Sep 2021)
Sequence version 1 (01 Nov 1990)
Previous versions | rss
Add a publicationFeedback
Protein

Long-chain-fatty-acid--CoA ligase 1

Gene

Acsl1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:8978480, PubMed:10198260, PubMed:10749848, PubMed:28209804).

Preferentially uses palmitoleate, oleate and linoleate (By similarity).

Preferentially activates arachidonate than epoxyeicosatrienoic acids (EETs) or hydroxyeicosatrienoic acids (HETEs) (PubMed:28209804).

By similarity4 Publications

Miscellaneous

5 rat isozymes encoded by different genes have been described. ACSL6 corresponds to isozyme 2 (ACS2).1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited at high temperature and by arachidonate.1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=649 µM for ATP1 Publication
  2. KM=6.4 µM for CoA1 Publication
  3. KM=5.0 µM for palmitate1 Publication
  4. KM=2.7 µM for palmitate (when expressed in bacteria)1 Publication
  5. KM=6.6 µM for stearate (when expressed in bacteria)1 Publication
  6. KM=6.7 µM for oleate (when expressed in bacteria)1 Publication
  7. KM=5 µM for linoleate (when expressed in bacteria)1 Publication
  8. KM=6.3 µM for arachidonate (when expressed in bacteria)1 Publication
  9. KM=2.1 µM for palmitate (when expressed in mammalian cell)1 Publication
  10. KM=11.5 µM for stearate (when expressed in mammalian cell)1 Publication
  11. KM=14.7 µM for oleate (when expressed in mammalian cell)1 Publication
  12. KM=7 µM for linoleate (when expressed in mammalian cell)1 Publication
  13. KM=7.3 µM for arachidonate (when expressed in mammalian cell)1 Publication
  1. Vmax=1695 nmol/min/mg enzyme with palmitate as substrate1 Publication
  2. Vmax=3068 nmol/min/mg enzyme with palmitate as substrate (when expressed in mammalian cell)1 Publication
  3. Vmax=2342 nmol/min/mg enzyme with stearate as substrate (when expressed in mammalian cell)1 Publication
  4. Vmax=2607 nmol/min/mg enzyme with oleate as substrate (when expressed in mammalian cell)1 Publication
  5. Vmax=2525 nmol/min/mg enzyme with linoleate as substrate (when expressed in mammalian cell)1 Publication
  6. Vmax=1745 nmol/min/mg enzyme with arachidonate as substrate (when expressed in mammalian cell)1 Publication
  7. Vmax=3754 nmol/min/mg enzyme with palmitate as substrate (when expressed in bacteria)1 Publication
  8. Vmax=2874 nmol/min/mg enzyme with stearate as substrate (when expressed in bacteria)1 Publication
  9. Vmax=2089 nmol/min/mg enzyme with oleate as substrate (when expressed in bacteria)1 Publication
  10. Vmax=1635 nmol/min/mg enzyme with linoleate as substrate (when expressed in bacteria)1 Publication
  11. Vmax=3363 nmol/min/mg enzyme with arachidonate as substrate (when expressed in bacteria)1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLigase
Biological processFatty acid metabolism, Lipid metabolism
LigandATP-binding, Magnesium, Nucleotide-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:MONOMER-14442

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
6.2.1.3, 5301

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-2046105, Linoleic acid (LA) metabolism
R-RNO-2046106, alpha-linolenic acid (ALA) metabolism
R-RNO-75876, Synthesis of very long-chain fatty acyl-CoAs

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
P18163

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...
SwissLipidsi
SLP:000001018

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Long-chain-fatty-acid--CoA ligase 1Curated (EC:6.2.1.31 Publication)
Alternative name(s):
Arachidonate--CoA ligase (EC:6.2.1.151 Publication)
Long-chain acyl-CoA synthetase 1
Short name:
LACS 1
Long-chain-fatty-acid--CoA ligase, liver isozyme
Phytanate--CoA ligase (EC:6.2.1.242 Publications)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Acsl1Imported
Synonyms:Acs1, Acsl2, Facl2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Rat genome database

More...
RGDi
2015, Acsl1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei25 – 45Helical; Signal-anchor for type III membrane proteinSequence analysisAdd BLAST21
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini46 – 699CytoplasmicSequence analysisAdd BLAST654

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome, Mitochondrion, Mitochondrion outer membrane, Peroxisome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001931061 – 699Long-chain-fatty-acid--CoA ligase 1Add BLAST699

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionine1 Publication1
Modified residuei93'-nitrotyrosine1 Publication1
Modified residuei85Phosphotyrosine1 Publication1
Modified residuei863'-nitrotyrosine1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi136O-linked (GlcNAc) serine1 Publication1
Modified residuei208N6-acetyllysineBy similarity1
Modified residuei357N6-acetyllysineBy similarity1
Modified residuei387N6-acetyllysineBy similarity1
Modified residuei621PhosphoserineBy similarity1
Modified residuei633N6-acetyllysine1 Publication1

Keywords - PTMi

Acetylation, Glycoprotein, Nitration, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P18163

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P18163

PRoteomics IDEntifications database

More...
PRIDEi
P18163

PTM databases

CarbonylDB database of protein carbonylation sites

More...
CarbonylDBi
P18163

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
P18163, 1 site

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P18163

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P18163

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Liver, heart, epididymal adipose and to a lesser extent brain, small intestine and lung.

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Levels remain constant during development.

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By high fat and high carbohydrate diets.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000010633, Expressed in liver and 20 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P18163, RN

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
247327, 1 interactor

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
P18163

Protein interaction database and analysis system

More...
IntActi
P18163, 29 interactors

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000014235

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1256, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154508

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000022_45_4_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P18163

Identification of Orthologs from Complete Genome Data

More...
OMAi
EWIVRDS

Database of Orthologous Groups

More...
OrthoDBi
630541at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P18163

TreeFam database of animal gene trees

More...
TreeFami
TF313877

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR020845, AMP-binding_CS
IPR000873, AMP-dep_Synth/Lig

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00501, AMP-binding, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00455, AMP_BINDING, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P18163-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEVHELFRYF RMPELIDIRQ YVRTLPTNTL MGFGAFAALT TFWYATRPKA
60 70 80 90 100
LKPPCDLSMQ SVEVTGTTEG VRRSAVLEDD KLLLYYYDDV RTMYDGFQRG
110 120 130 140 150
IQVSNDGPCL GSRKPNQPYE WISYKQVAEM AECIGSALIQ KGFKPCSEQF
160 170 180 190 200
IGIFSQNRPE WVTIEQGCFT YSMVVVPLYD TLGTDAITYI VNKAELSVIF
210 220 230 240 250
ADKPEKAKLL LEGVENKLTP CLKIIVIMDS YDNDLVERGQ KCGVEIIGLK
260 270 280 290 300
ALEDLGRVNR TKPKPPEPED LAIICFTSGT TGNPKGAMVT HQNIMNDCSG
310 320 330 340 350
FIKATESAFI ASPEDVLISF LPLAHMFETV VECVMLCHGA KIGFFQGDIR
360 370 380 390 400
LLMDDLKVLQ PTIFPVVPRL LNRMFDRIFG QANTSVKRWL LDFASKRKEA
410 420 430 440 450
ELRSGIVRNN SLWDKLIFHK IQSSLGGKVR LMITGAAPVS ATVLTFLRAA
460 470 480 490 500
LGCQFYEGYG QTECTAGCCL SLPGDWTAGH VGAPMPCNYI KLVDVEDMNY
510 520 530 540 550
QAAKGEGEVC VKGANVFKGY LKDPARTAEA LDKDGWLHTG DIGKWLPNGT
560 570 580 590 600
LKIIDRKKHI FKLAQGEYIA PEKIENIYLR SEAVAQVFVH GESLQAFLIA
610 620 630 640 650
IVVPDVEILP SWAQKRGFQG SFEELCRNKD INKAILEDMV KLGKNAGLKP
660 670 680 690
FEQVKGIAVH PELFSIDNGL LTPTLKAKRP ELRNYFRSQI DELYSTIKI
Length:699
Mass (Da):78,179
Last modified:November 1, 1990 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6E1EACE0EAE8A85C
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
D90109 mRNA Translation: BAA14136.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A36275

NCBI Reference Sequences

More...
RefSeqi
NP_036952.1, NM_012820.1
XP_006253184.1, XM_006253122.1
XP_006253185.1, XM_006253123.1
XP_006253186.1, XM_006253124.2
XP_006253187.1, XM_006253125.3
XP_006253188.1, XM_006253126.2
XP_006253189.1, XM_006253127.1
XP_008769476.1, XM_008771254.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000014235; ENSRNOP00000014235; ENSRNOG00000010633
ENSRNOT00000089501; ENSRNOP00000072677; ENSRNOG00000010633

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
25288

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:25288

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D90109 mRNA Translation: BAA14136.1
PIRiA36275
RefSeqiNP_036952.1, NM_012820.1
XP_006253184.1, XM_006253122.1
XP_006253185.1, XM_006253123.1
XP_006253186.1, XM_006253124.2
XP_006253187.1, XM_006253125.3
XP_006253188.1, XM_006253126.2
XP_006253189.1, XM_006253127.1
XP_008769476.1, XM_008771254.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi247327, 1 interactor
CORUMiP18163
IntActiP18163, 29 interactors
STRINGi10116.ENSRNOP00000014235

Chemistry databases

SwissLipidsiSLP:000001018

PTM databases

CarbonylDBiP18163
GlyGeniP18163, 1 site
iPTMnetiP18163
PhosphoSitePlusiP18163

Proteomic databases

jPOSTiP18163
PaxDbiP18163
PRIDEiP18163

Genome annotation databases

EnsembliENSRNOT00000014235; ENSRNOP00000014235; ENSRNOG00000010633
ENSRNOT00000089501; ENSRNOP00000072677; ENSRNOG00000010633
GeneIDi25288
KEGGirno:25288

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
2180
RGDi2015, Acsl1

Phylogenomic databases

eggNOGiKOG1256, Eukaryota
GeneTreeiENSGT00940000154508
HOGENOMiCLU_000022_45_4_1
InParanoidiP18163
OMAiEWIVRDS
OrthoDBi630541at2759
PhylomeDBiP18163
TreeFamiTF313877

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-14442
BRENDAi6.2.1.3, 5301
ReactomeiR-RNO-2046105, Linoleic acid (LA) metabolism
R-RNO-2046106, alpha-linolenic acid (ALA) metabolism
R-RNO-75876, Synthesis of very long-chain fatty acyl-CoAs
SABIO-RKiP18163

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P18163

Gene expression databases

BgeeiENSRNOG00000010633, Expressed in liver and 20 other tissues
GenevisibleiP18163, RN

Family and domain databases

InterProiView protein in InterPro
IPR020845, AMP-binding_CS
IPR000873, AMP-dep_Synth/Lig
PfamiView protein in Pfam
PF00501, AMP-binding, 1 hit
PROSITEiView protein in PROSITE
PS00455, AMP_BINDING, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiACSL1_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P18163
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: September 29, 2021
This is version 169 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again