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Entry version 150 (29 Sep 2021)
Sequence version 3 (04 Dec 2007)
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Protein

Dual specificity protein kinase splA

Gene

splA

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Essential for spore differentiation.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei2142ATPPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei2243Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi2121 – 2129ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Transferase, Tyrosine-protein kinase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.7.12.1, 1939

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Dual specificity protein kinase splA (EC:2.7.10.2)
Alternative name(s):
Non-receptor tyrosine kinase spore lysis A
Tyrosine-protein kinase 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:splA
Synonyms:DpyK1, pyK1, pykA
ORF Names:DDB_G0283385
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDictyostelium discoideum (Slime mold)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri44689 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaAmoebozoaEvoseaEumycetozoaDictyosteliaDictyostelialesDictyosteliaceaeDictyostelium
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002195 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componentsi: Chromosome 4, Unassembled WGS sequence

Organism-specific databases

Dictyostelium discoideum online informatics resource

More...
dictyBasei
DDB_G0283385, splA

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000881211 – 2410Dual specificity protein kinase splAAdd BLAST2410

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Tyrosine kinase domain is capable of autophosphorylation, in vitro; however it is also autophosphorylated on serine and threonine residues.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P18160

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in vegetative cells and throughout development with a peak during the mound stage of morphogenesis.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
44689.DDB0252636

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P18160

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini822 – 1004B30.2/SPRY 1PROSITE-ProRule annotationAdd BLAST183
Domaini1020 – 1209B30.2/SPRY 2PROSITE-ProRule annotationAdd BLAST190
Domaini1481 – 1703B30.2/SPRY 3PROSITE-ProRule annotationAdd BLAST223
Domaini1734 – 1798SAMPROSITE-ProRule annotationAdd BLAST65
Domaini2115 – 2387Protein kinasePROSITE-ProRule annotationAdd BLAST273

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni29 – 48DisorderedSequence analysisAdd BLAST20
Regioni66 – 103DisorderedSequence analysisAdd BLAST38
Regioni116 – 158DisorderedSequence analysisAdd BLAST43
Regioni187 – 252DisorderedSequence analysisAdd BLAST66
Regioni508 – 647DisorderedSequence analysisAdd BLAST140
Regioni659 – 820DisorderedSequence analysisAdd BLAST162
Regioni1228 – 1428DisorderedSequence analysisAdd BLAST201
Regioni1493 – 1512DisorderedSequence analysisAdd BLAST20
Regioni1862 – 2105DisorderedSequence analysisAdd BLAST244

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi139 – 158Polar residuesSequence analysisAdd BLAST20
Compositional biasi525 – 579Polar residuesSequence analysisAdd BLAST55
Compositional biasi580 – 596Pro residuesSequence analysisAdd BLAST17
Compositional biasi597 – 616Polar residuesSequence analysisAdd BLAST20
Compositional biasi617 – 644Pro residuesSequence analysisAdd BLAST28
Compositional biasi659 – 734Polar residuesSequence analysisAdd BLAST76
Compositional biasi735 – 749Pro residuesSequence analysisAdd BLAST15
Compositional biasi750 – 764Polar residuesSequence analysisAdd BLAST15
Compositional biasi777 – 820Polar residuesSequence analysisAdd BLAST44
Compositional biasi1228 – 1406Polar residuesSequence analysisAdd BLAST179
Compositional biasi1414 – 1428Polar residuesSequence analysisAdd BLAST15
Compositional biasi1863 – 1881Basic and acidic residuesSequence analysisAdd BLAST19
Compositional biasi1916 – 1930Polar residuesSequence analysisAdd BLAST15
Compositional biasi1939 – 1977Polar residuesSequence analysisAdd BLAST39
Compositional biasi1984 – 2005Polar residuesSequence analysisAdd BLAST22
Compositional biasi2015 – 2086Polar residuesSequence analysisAdd BLAST72
Compositional biasi2087 – 2104Pro residuesSequence analysisAdd BLAST18

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0192, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_229194_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P18160

Identification of Orthologs from Complete Genome Data

More...
OMAi
GWTPPIL

Family and domain databases

Conserved Domains Database

More...
CDDi
cd12885, SPRY_RanBP_like, 3 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.150.50, 1 hit
2.60.120.920, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001870, B30.2/SPRY
IPR043136, B30.2/SPRY_sf
IPR013320, ConA-like_dom_sf
IPR011009, Kinase-like_dom_sf
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR001660, SAM
IPR013761, SAM/pointed_sf
IPR001245, Ser-Thr/Tyr_kinase_cat_dom
IPR003877, SPRY_dom
IPR008266, Tyr_kinase_AS
IPR044736, Vid30/RanBPM/SPLA_SPRY

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07714, PK_Tyr_Ser-Thr, 1 hit
PF07647, SAM_2, 1 hit
PF00622, SPRY, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00454, SAM, 1 hit
SM00449, SPRY, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47769, SSF47769, 1 hit
SSF49899, SSF49899, 3 hits
SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50188, B302_SPRY, 3 hits
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00109, PROTEIN_KINASE_TYR, 1 hit
PS50105, SAM_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P18160-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNSKNDLFIG FFFFFYNYYY YYNNNNNNNN NNNNNNNNNN NNNNNNNNNN
60 70 80 90 100
NNIYIIVIIG LDPQQNHPSL KIPPPPSPTS PYVRRHARQH SRSNSSNSPG
110 120 130 140 150
ELTGGVEIIQ QQNSINTQTS PPTSTSPNTV PPPPPTNTTT SSTTITRNSN
160 170 180 190 200
NINNSNGGII NSSSGSNINN SSSSGVINTN INNSGGNISP TSNSLPSSNN
210 220 230 240 250
NILYTSSGSN SGNNNNNNNT INISSGSSGI NNSSNSNINN NNNNNSSSSS
260 270 280 290 300
GIHASGSLTA IPTNTNSNSS IFHSSNSVNR INKSNYSADS LVLPPNRISQ
310 320 330 340 350
VPQSQTQPQL QISPSTSFSS QQQQQQQLQQ QLQLQQQLQQ QIQQQQQIQQ
360 370 380 390 400
QQNLHFTYSK TFTSGQPNTL VNLSSPPPQS KHLHVSSDHS FFNEVLTPTP
410 420 430 440 450
VIHNSTNQNN QLLFGDSDPL SFLEYNNFIN RYQPALKNNQ PVSSYRQQQQ
460 470 480 490 500
IQHQIQLQQI QQQQQQQQQI QQQQLQQQQQ IQQQQIQQQQ QQIQQQQQQQ
510 520 530 540 550
QQQQQQQQQL QQIQPPPTIQ PPPQQTTPTL RGNRSSGNLS GLNSFSLKQS
560 570 580 590 600
TDSLTPPPNS QQSTVSSNST PIAATPISPL TAPTSPPPPP PPPTNFNSKF
610 620 630 640 650
NNNNNNNINN SSNNNTTVPP SPPPIIVLPK SPSSRSPRPA SAPVPSAPFL
660 670 680 690 700
VNNRVINTSS SSNISTNNTD LNLSSSSSSS PPLNISTASP SKSEDSPPTV
710 720 730 740 750
SPSYKQQQQQ QQQQQQQQQQ LNNSSNSSYS PKPRSPSVSS PPPSSISPNS
760 770 780 790 800
SPIGSPNISF HHHQQHQIPP PPPVLSNTNN NNNNNNNNNN NNNNNNNNNN
810 820 830 840 850
NNNNNNNNNN NTNHTNKKEG DSSWFNMSFK FFKKKLVPSN EYRWDLRKSN
860 870 880 890 900
SLTLNIEDKS RCSYRLPTSG SKGIAKSTQP FSSSFTYFEL FITNGNGDKI
910 920 930 940 950
CFGLTTNDHP IEVYPGNYQG SYGYSGDGKC YFGTNEGRVY GPSFSSGDVV
960 970 980 990 1000
GCGYDSSSKT LYFTKNGVYL GVAAQKVNLI GLYPTVGLQN PGESVVINFF
1010 1020 1030 1040 1050
GPFSYRGAPE KPSKQSTIKD SGGSSIIPSE DLIPKEEFEV CRWSEKKNYH
1060 1070 1080 1090 1100
GKHVVVRNRT AFLPLDSPKD TIGGVRATQP FGEGFCYFEV IIDQLDKGQL
1110 1120 1130 1140 1150
SIGLANLEYP TFYHVGWMPR SYGYHNDDGR KFRWREEPGV NEGESYGSSY
1160 1170 1180 1190 1200
KKGDIIGCGL SFTSREIFFT KNGMYLGTAF SNVYGVFYPS VAFNEPGISI
1210 1220 1230 1240 1250
TGVFGPPFKF SQVTLMLKNV NSTSILVPNG NNNNNSNNNN NNNNNNIIGN
1260 1270 1280 1290 1300
GKITTTTTTS TSPSSINNNE DISSNNNNNN NNNNNNNNNN NNNNNNNNNN
1310 1320 1330 1340 1350
NNNNSNSSNT NNNNINNTTN NNNSNSNNNN NNNNSNSNSN SNNNNINNNN
1360 1370 1380 1390 1400
NNNNNNNNIY LTKKPSIGST DESSTGSLGG NNSSGNNNSS SGSIGNNSSI
1410 1420 1430 1440 1450
IKQRSPPHSI NGPLMLPPSS TNNNNNIYSS YNSTTAGSST TILPTLNHPI
1460 1470 1480 1490 1500
FGNTTSNNNS SSTLSVGGNN NLLGRHCQSL PITASTNHTL SSSLGVSFSS
1510 1520 1530 1540 1550
PSSSPKTSPR KIVNSSEDLG FVQTFQDQDG QPPSAWRRCG KSIKTKDDIT
1560 1570 1580 1590 1600
LTIIKKKTSV AMADRPFSSN SSSTICYFEV YLEGHDKKGS ITVGLSHSTY
1610 1620 1630 1640 1650
PFIKHIGREP KSYGFSSEGE KYGGSEIGEP YGPFFFFDGD SIASSCVIGC
1660 1670 1680 1690 1700
GINTSTRDIF FTKNGHYLGV AFSRVTSDPL YPSISFRGVV GGLCVATFPG
1710 1720 1730 1740 1750
GHFRFNIEDL PGISPSVWTE ALGPDRQGSG FKNWAPNDVA IWLESFNYGQ
1760 1770 1780 1790 1800
YRKNFRDNNI SGRHLEGITH AMLKNDLGIE PYGHREDIIN RLNRMIQIWN
1810 1820 1830 1840 1850
DKSPDSYPKI AIDSSDKIRW PASGGSSGGI NISGGVVIGS SSGSDDGITE
1860 1870 1880 1890 1900
ISSSSKNIRP YKSYTQKEIE DRNRRSTISG GEKKNKYYID NQMDPHQIGS
1910 1920 1930 1940 1950
MDSDGLLPDF GQGPPDEKNS SKTLSNEQIR YLQQRKDEPP IAISSTGNGG
1960 1970 1980 1990 2000
SVSSTGGSSG FLTFPSSNSL THPPQRDKPT QEFTHLPPIT SNYKGITNTG
2010 2020 2030 2040 2050
QPHKSFDQPL ELFPRHSAFS NNGNNGNNNN NNNNNNIKAN QQQQQQSSYQ
2060 2070 2080 2090 2100
QSQTQQQQQH ITSTSTSTTN KWIDPFGGWE TQSSLSHPPS RPPPPPPPPP
2110 2120 2130 2140 2150
QLPVRSEYEI DFNELEFGQT IGKGFFGEVK RGYWRETDVA IKIIYRDQFK
2160 2170 2180 2190 2200
TKSSLVMFQN EVGILSKLRH PNVVQFLGAC TAGGEDHHCI VTEWMGGGSL
2210 2220 2230 2240 2250
RQFLTDHFNL LEQNPHIRLK LALDIAKGMN YLHGWTPPIL HRDLSSRNIL
2260 2270 2280 2290 2300
LDHNIDPKNP VVSSRQDIKC KISDFGLSRL KMEQASQMTQ SVGCIPYMAP
2310 2320 2330 2340 2350
EVFKGDSNSE KSDVYSYGMV LFELLTSDEP QQDMKPMKMA HLAAYESYRP
2360 2370 2380 2390 2400
PIPLTTSSKW KEILTQCWDS NPDSRPTFKQ IIVHLKEMED QGVSSFASVP
2410
VQTIDTGVYA
Length:2,410
Mass (Da):264,919
Last modified:December 4, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i768EC59E9E05C229
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti2074D → R in AAA33202 (PubMed:1972546).Curated1
Sequence conflicti2261V → L in AAA33202 (PubMed:1972546).Curated1
Sequence conflicti2282M → K in AAB41125 (PubMed:8898241).Curated1
Sequence conflicti2282M → K in AAA33202 (PubMed:1972546).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAFI02000055 Genomic DNA Translation: EAL65677.1
U32174 Genomic DNA Translation: AAB41125.1
M33785 mRNA Translation: AAA33202.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T18276

NCBI Reference Sequences

More...
RefSeqi
XP_639040.1, XM_633948.1

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
EAL65677; EAL65677; DDB_G0283385

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
8624065

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ddi:DDB_G0283385

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000055 Genomic DNA Translation: EAL65677.1
U32174 Genomic DNA Translation: AAB41125.1
M33785 mRNA Translation: AAA33202.1
PIRiT18276
RefSeqiXP_639040.1, XM_633948.1

3D structure databases

SMRiP18160
ModBaseiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0252636

Proteomic databases

PaxDbiP18160

Genome annotation databases

EnsemblProtistsiEAL65677; EAL65677; DDB_G0283385
GeneIDi8624065
KEGGiddi:DDB_G0283385

Organism-specific databases

dictyBaseiDDB_G0283385, splA

Phylogenomic databases

eggNOGiKOG0192, Eukaryota
HOGENOMiCLU_229194_0_0_1
InParanoidiP18160
OMAiGWTPPIL

Enzyme and pathway databases

BRENDAi2.7.12.1, 1939

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P18160

Family and domain databases

CDDicd12885, SPRY_RanBP_like, 3 hits
Gene3Di1.10.150.50, 1 hit
2.60.120.920, 3 hits
InterProiView protein in InterPro
IPR001870, B30.2/SPRY
IPR043136, B30.2/SPRY_sf
IPR013320, ConA-like_dom_sf
IPR011009, Kinase-like_dom_sf
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR001660, SAM
IPR013761, SAM/pointed_sf
IPR001245, Ser-Thr/Tyr_kinase_cat_dom
IPR003877, SPRY_dom
IPR008266, Tyr_kinase_AS
IPR044736, Vid30/RanBPM/SPLA_SPRY
PfamiView protein in Pfam
PF07714, PK_Tyr_Ser-Thr, 1 hit
PF07647, SAM_2, 1 hit
PF00622, SPRY, 3 hits
SMARTiView protein in SMART
SM00454, SAM, 1 hit
SM00449, SPRY, 3 hits
SUPFAMiSSF47769, SSF47769, 1 hit
SSF49899, SSF49899, 3 hits
SSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50188, B302_SPRY, 3 hits
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00109, PROTEIN_KINASE_TYR, 1 hit
PS50105, SAM_DOMAIN, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSPLA_DICDI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P18160
Secondary accession number(s): Q54R51
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: December 4, 2007
Last modified: September 29, 2021
This is version 150 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families
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