Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 126 (17 Jun 2020)
Sequence version 2 (22 Jul 2008)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

37 kDa salivary gland allergen Aed a 2

Gene

D7

Organism
Aedes aegypti (Yellowfever mosquito) (Culex aegypti)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Thought to be involved in blood-feeding.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
37 kDa salivary gland allergen Aed a 2
Alternative name(s):
Protein D7
Allergen: Aed a 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:D7
ORF Names:AAEL006424
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAedes aegypti (Yellowfever mosquito) (Culex aegypti)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7159 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraNematoceraCulicoideaCulicidaeCulicinaeAediniAedesStegomyia
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008820 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section is used for proteins that cause an allergic reaction in mammals. We usually specify in which species the protein is allergenic.<p><a href='/help/allergenic_properties' target='_top'>More...</a></p>Allergenic propertiesi

Causes an allergic reaction in human.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergome; a platform for allergen knowledge

More...
Allergomei
3540 Aed a 2.0101
4 Aed a 2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 17Sequence analysisAdd BLAST17
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002105918 – 32137 kDa salivary gland allergen Aed a 2Add BLAST304

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the distal-lateral and medial lobes of the adult female salivary gland.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7159.AAEL006424-PA

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1321
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P18153

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P18153

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_077766_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P18153

Identification of Orthologs from Complete Genome Data

More...
OMAi
TRCMEDN

Database of Orthologous Groups

More...
OrthoDBi
1039968at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P18153

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.238.20, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006170 PBP/GOBP
IPR036728 PBP_GOBP_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01395 PBP_GOBP, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00708 PhBP, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47565 SSF47565, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform A (identifier: P18153-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKLPLLLAIV TTFSVVASTG PFDPEEMLFT FTRCMEDNLE DGPNRLPMLA
60 70 80 90 100
KWKEWINEPV DSPATQCFGK CVLVRTGLYD PVAQKFDASV IQEQFKAYPS
110 120 130 140 150
LGEKSKVEAY ANAVQQLPST NNDCAAVFKA YDPVHKAHKD TSKNLFHGNK
160 170 180 190 200
ELTKGLYEKL GKDIRQKKQS YFEFCENKYY PAGSDKRQQL CKIRQYTVLD
210 220 230 240 250
DALFKEHTDC VMKGIRYITK NNELDAEEVK RDFMQVNKDT KALEKVLNDC
260 270 280 290 300
KSKEPSNAGE KSWHYYKCLV ESSVKDDFKE AFDYREVRSQ IYAFNLPKKQ
310 320
VYSKPAVQSQ VMEIDGKQCP Q
Length:321
Mass (Da):36,895
Last modified:July 22, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9BAF0F0335B93070
GO
Isoform B (identifier: P18153-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     74-87: Missing.
     161-161: G → V
     162-226: Missing.

Show »
Length:242
Mass (Da):27,537
Checksum:i7D95CF83EC782D85
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti4P → L in AAA29347 (PubMed:2052024).Curated1
Sequence conflicti10V → F in AAA29347 (PubMed:2052024).Curated1
Sequence conflicti19T → M in AAA29347 (PubMed:2052024).Curated1
Sequence conflicti19T → M in AAD01849 (PubMed:10436938).Curated1
Sequence conflicti30T → I in AAA29347 (PubMed:2052024).Curated1
Sequence conflicti30T → I in AAD01849 (PubMed:10436938).Curated1
Sequence conflicti43P → A in AAA29347 (PubMed:2052024).Curated1
Sequence conflicti43P → A in AAD01849 (PubMed:10436938).Curated1
Sequence conflicti115Q → K in AAA29347 (PubMed:2052024).Curated1
Sequence conflicti115Q → K in AAD01849 (PubMed:10436938).Curated1
Sequence conflicti169Q → K in AAA29348 (PubMed:2052024).Curated1
Sequence conflicti192K → Q in AAA29347 (PubMed:2052024).Curated1
Sequence conflicti221 – 226NNELDA → DNQLDV in AAA29347 (PubMed:2052024).Curated6
Sequence conflicti234 – 235MQ → KL in AAA29347 (PubMed:2052024).Curated2
Sequence conflicti234 – 235MQ → KL in AAA29348 (PubMed:2052024).Curated2
Sequence conflicti234 – 235MQ → KL in AAD01849 (PubMed:10436938).Curated2
Sequence conflicti259G → K in AAA29347 (PubMed:2052024).Curated1
Sequence conflicti259G → K in AAA29348 (PubMed:2052024).Curated1
Sequence conflicti259G → K in AAD01849 (PubMed:10436938).Curated1
Sequence conflicti301V → A in AAA29347 (PubMed:2052024).Curated1
Sequence conflicti301V → A in AAA29348 (PubMed:2052024).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_03486374 – 87Missing in isoform B. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_034864161G → V in isoform B. 1 Publication1
Alternative sequenceiVSP_034865162 – 226Missing in isoform B. 1 PublicationAdd BLAST65

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M33156 Genomic DNA Translation: AAA29347.1
M33157 mRNA Translation: AAA29348.1
EF173376 Genomic DNA Translation: ABM68616.1
CH477389 Genomic DNA Translation: EAT41994.1
AF027814 mRNA Translation: AAD01849.1

NCBI Reference Sequences

More...
RefSeqi
XP_001657779.1, XM_001657729.1 [P18153-1]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
AAEL006424-RA; AAEL006424-PA; AAEL006424 [P18153-1]
AAEL026087-RA; AAEL026087-PA; AAEL026087 [P18153-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
5567958

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
aag:5567958

Bioinformatics Resource for Invertebrate Vectors of Human Pathogens

More...
VectorBasei
AAEL006424-RA; AAEL006424-PA; AAEL006424
AAEL026087-RA; AAEL026087-PA; AAEL026087

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M33156 Genomic DNA Translation: AAA29347.1
M33157 mRNA Translation: AAA29348.1
EF173376 Genomic DNA Translation: ABM68616.1
CH477389 Genomic DNA Translation: EAT41994.1
AF027814 mRNA Translation: AAD01849.1
RefSeqiXP_001657779.1, XM_001657729.1 [P18153-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3DXLX-ray1.30A20-321[»]
3DY9X-ray1.70A20-321[»]
3DYEX-ray1.75A20-321[»]
3DZTX-ray1.80A20-321[»]
SMRiP18153
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

STRINGi7159.AAEL006424-PA

Protein family/group databases

Allergomei3540 Aed a 2.0101
4 Aed a 2

Genome annotation databases

EnsemblMetazoaiAAEL006424-RA; AAEL006424-PA; AAEL006424 [P18153-1]
AAEL026087-RA; AAEL026087-PA; AAEL026087 [P18153-1]
GeneIDi5567958
KEGGiaag:5567958
VectorBaseiAAEL006424-RA; AAEL006424-PA; AAEL006424
AAEL026087-RA; AAEL026087-PA; AAEL026087

Phylogenomic databases

HOGENOMiCLU_077766_0_0_1
InParanoidiP18153
OMAiTRCMEDN
OrthoDBi1039968at2759
PhylomeDBiP18153

Miscellaneous databases

EvolutionaryTraceiP18153

Family and domain databases

Gene3Di1.10.238.20, 2 hits
InterProiView protein in InterPro
IPR006170 PBP/GOBP
IPR036728 PBP_GOBP_sf
PfamiView protein in Pfam
PF01395 PBP_GOBP, 2 hits
SMARTiView protein in SMART
SM00708 PhBP, 2 hits
SUPFAMiSSF47565 SSF47565, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiALL2_AEDAE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P18153
Secondary accession number(s): O96364, Q0IF92
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: July 22, 2008
Last modified: June 17, 2020
This is version 126 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Allergens
    Nomenclature of allergens and list of entries
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again