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Protein

Early growth response protein 1

Gene

EGR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional regulator (PubMed:20121949). Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes (By similarity). Binds double-stranded target DNA, irrespective of the cytosine methylation status (PubMed:25258363, PubMed:25999311). Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Activates expression of p53/TP53 and TGFB1, and thereby helps prevent tumor formation. Required for normal progress through mitosis and normal proliferation of hepatocytes after partial hepatectomy. Mediates responses to ischemia and hypoxia; regulates the expression of proteins such as IL1B and CXCL2 that are involved in inflammatory processes and development of tissue damage after ischemia. Regulates biosynthesis of luteinizing hormone (LHB) in the pituitary (By similarity).By similarity3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri338 – 362C2H2-type 1PROSITE-ProRule annotationCombined sources2 PublicationsAdd BLAST25
Zinc fingeri368 – 390C2H2-type 2PROSITE-ProRule annotationCombined sources2 PublicationsAdd BLAST23
Zinc fingeri396 – 418C2H2-type 3PROSITE-ProRule annotationCombined sources2 PublicationsAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-8943724 Regulation of PTEN gene transcription
R-HSA-909733 Interferon alpha/beta signaling
SignaLinkiP18146
SIGNORiP18146

Names & Taxonomyi

Protein namesi
Recommended name:
Early growth response protein 11 Publication
Short name:
EGR-11 Publication
Alternative name(s):
AT225
Nerve growth factor-induced protein A
Short name:
NGFI-A
Transcription factor ETR103
Transcription factor Zif268
Zinc finger protein 2251 Publication
Zinc finger protein Krox-24
Gene namesi
Name:EGR1
Synonyms:KROX24, ZNF2251 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000120738.7
HGNCiHGNC:3238 EGR1
MIMi128990 gene
neXtProtiNX_P18146

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi1958
OpenTargetsiENSG00000120738
PharmGKBiPA27673

Chemistry databases

ChEMBLiCHEMBL3616355

Polymorphism and mutation databases

BioMutaiEGR1
DMDMi119242

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000471091 – 543Early growth response protein 1Add BLAST543

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki305Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiP18146
PaxDbiP18146
PeptideAtlasiP18146
PRIDEiP18146
ProteomicsDBi53552

PTM databases

iPTMnetiP18146
PhosphoSitePlusiP18146

Expressioni

Tissue specificityi

Detected in neutrophils (at protein level).1 Publication

Inductioni

By growth factors.1 Publication

Gene expression databases

BgeeiENSG00000120738 Expressed in 233 organ(s), highest expression level in epithelium of mammary gland
CleanExiHS_EGR1
HS_ZNF225
ExpressionAtlasiP18146 baseline and differential
GenevisibleiP18146 HS

Organism-specific databases

HPAiCAB019427
HPA029937
HPA029938

Interactioni

Subunit structurei

Interacts with SNAI1 and SP1 upon 12-O-tetradecanoylphorbol-13-acetate (TPA) induction.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei336Interaction with DNACombined sources1 Publication1
Sitei347Interaction with DNABy similarity1
Sitei351Interaction with DNABy similarity1
Sitei357Interaction with DNACombined sources1 Publication1
Sitei375Interaction with DNABy similarity1
Sitei379Interaction with DNACombined sources1 Publication1
Sitei403Interaction with DNACombined sources1 Publication1
Sitei407Interaction with DNACombined sources1 Publication1
Sitei413Interaction with DNACombined sources2 Publications1

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi108278, 39 interactors
CORUMiP18146
IntActiP18146, 23 interactors
MINTiP18146
STRINGi9606.ENSP00000239938

Structurei

Secondary structure

1543
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP18146
SMRiP18146
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi57 – 84Gly/Ser-richAdd BLAST28

Domaini

Binds to DNA motifs with the sequence 5'-GCG(T/G)GGGCG-3' via its C2H2-type zinc fingers (PubMed:25258363, PubMed:25999311). The first, most N-terminal zinc finger binds to the 3'-GCG motif, the middle zinc finger interacts with the central TGG motif, and the C-terminal zinc finger binds to the 5'-GCG motif. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Has reduced affinity for target DNA where the cytosines have been oxidized to 5-hydroxymethylcytosine. Does not bind target DNA where the cytosines have been oxidized to 5-formylcytosine or 5-carboxylcytosine (PubMed:25258363).2 Publications

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri338 – 362C2H2-type 1PROSITE-ProRule annotationCombined sources2 PublicationsAdd BLAST25
Zinc fingeri368 – 390C2H2-type 2PROSITE-ProRule annotationCombined sources2 PublicationsAdd BLAST23
Zinc fingeri396 – 418C2H2-type 3PROSITE-ProRule annotationCombined sources2 PublicationsAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00550000074455
HOGENOMiHOG000036856
HOVERGENiHBG003909
InParanoidiP18146
KOiK09203
OMAiFATQTGS
OrthoDBiEOG091G06VX
PhylomeDBiP18146
TreeFamiTF318980

Family and domain databases

InterProiView protein in InterPro
IPR021849 EGR
IPR021839 EGR1_C
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF11914 DUF3432, 2 hits
PF11928 DUF3446, 1 hit
PF00096 zf-C2H2, 3 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits

Sequencei

Sequence statusi: Complete.

P18146-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAAKAEMQL MSPLQISDPF GSFPHSPTMD NYPKLEEMML LSNGAPQFLG
60 70 80 90 100
AAGAPEGSGS NSSSSSSGGG GGGGGGSNSS SSSSTFNPQA DTGEQPYEHL
110 120 130 140 150
TAESFPDISL NNEKVLVETS YPSQTTRLPP ITYTGRFSLE PAPNSGNTLW
160 170 180 190 200
PEPLFSLVSG LVSMTNPPAS SSSAPSPAAS SASASQSPPL SCAVPSNDSS
210 220 230 240 250
PIYSAAPTFP TPNTDIFPEP QSQAFPGSAG TALQYPPPAY PAAKGGFQVP
260 270 280 290 300
MIPDYLFPQQ QGDLGLGTPD QKPFQGLESR TQQPSLTPLS TIKAFATQSG
310 320 330 340 350
SQDLKALNTS YQSQLIKPSR MRKYPNRPSK TPPHERPYAC PVESCDRRFS
360 370 380 390 400
RSDELTRHIR IHTGQKPFQC RICMRNFSRS DHLTTHIRTH TGEKPFACDI
410 420 430 440 450
CGRKFARSDE RKRHTKIHLR QKDKKADKSV VASSATSSLS SYPSPVATSY
460 470 480 490 500
PSPVTTSYPS PATTSYPSPV PTSFSSPGSS TYPSPVHSGF PSPSVATTYS
510 520 530 540
SVPPAFPAQV SSFPSSAVTN SFSASTGLSD MTATFSPRTI EIC
Length:543
Mass (Da):57,507
Last modified:November 1, 1990 - v1
Checksum:i768CE670D9743E4E
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05271228T → I. Corresponds to variant dbSNP:rs13181973Ensembl.1
Natural variantiVAR_029330144N → K. Corresponds to variant dbSNP:rs28365166Ensembl.1
Natural variantiVAR_029331145S → R. Corresponds to variant dbSNP:rs28365164Ensembl.1
Natural variantiVAR_029332219E → D. Corresponds to variant dbSNP:rs28365165Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52541 mRNA Translation: CAA36777.1
M62829 mRNA Translation: AAA35815.1
M80583 mRNA No translation available.
BC073983 mRNA Translation: AAH73983.1
CCDSiCCDS4206.1
PIRiA41211
RefSeqiNP_001955.1, NM_001964.2
UniGeneiHs.326035
Hs.708393

Genome annotation databases

EnsembliENST00000239938; ENSP00000239938; ENSG00000120738
GeneIDi1958
KEGGihsa:1958

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52541 mRNA Translation: CAA36777.1
M62829 mRNA Translation: AAA35815.1
M80583 mRNA No translation available.
BC073983 mRNA Translation: AAH73983.1
CCDSiCCDS4206.1
PIRiA41211
RefSeqiNP_001955.1, NM_001964.2
UniGeneiHs.326035
Hs.708393

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4R2AX-ray1.59A335-423[»]
4R2CX-ray1.89A335-423[»]
4R2DX-ray2.09A335-423[»]
4X9JX-ray1.41A335-423[»]
5N14NMR-A395-408[»]
ProteinModelPortaliP18146
SMRiP18146
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108278, 39 interactors
CORUMiP18146
IntActiP18146, 23 interactors
MINTiP18146
STRINGi9606.ENSP00000239938

Chemistry databases

ChEMBLiCHEMBL3616355

PTM databases

iPTMnetiP18146
PhosphoSitePlusiP18146

Polymorphism and mutation databases

BioMutaiEGR1
DMDMi119242

Proteomic databases

EPDiP18146
PaxDbiP18146
PeptideAtlasiP18146
PRIDEiP18146
ProteomicsDBi53552

Protocols and materials databases

DNASUi1958
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000239938; ENSP00000239938; ENSG00000120738
GeneIDi1958
KEGGihsa:1958

Organism-specific databases

CTDi1958
DisGeNETi1958
EuPathDBiHostDB:ENSG00000120738.7
GeneCardsiEGR1
HGNCiHGNC:3238 EGR1
HPAiCAB019427
HPA029937
HPA029938
MIMi128990 gene
neXtProtiNX_P18146
OpenTargetsiENSG00000120738
PharmGKBiPA27673
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00550000074455
HOGENOMiHOG000036856
HOVERGENiHBG003909
InParanoidiP18146
KOiK09203
OMAiFATQTGS
OrthoDBiEOG091G06VX
PhylomeDBiP18146
TreeFamiTF318980

Enzyme and pathway databases

ReactomeiR-HSA-8943724 Regulation of PTEN gene transcription
R-HSA-909733 Interferon alpha/beta signaling
SignaLinkiP18146
SIGNORiP18146

Miscellaneous databases

ChiTaRSiEGR1 human
GeneWikiiEGR1
GenomeRNAii1958
PROiPR:P18146
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000120738 Expressed in 233 organ(s), highest expression level in epithelium of mammary gland
CleanExiHS_EGR1
HS_ZNF225
ExpressionAtlasiP18146 baseline and differential
GenevisibleiP18146 HS

Family and domain databases

InterProiView protein in InterPro
IPR021849 EGR
IPR021839 EGR1_C
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF11914 DUF3432, 2 hits
PF11928 DUF3446, 1 hit
PF00096 zf-C2H2, 3 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiEGR1_HUMAN
AccessioniPrimary (citable) accession number: P18146
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: November 7, 2018
This is version 185 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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