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UniProtKB - P18124 (RL7_HUMAN)

Entry version 220 (07 Apr 2021)
Sequence version 1 (01 Nov 1990)
Previous versions | rss
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Protein

60S ribosomal protein L7

Gene

RPL7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the large ribosomal subunit (PubMed:12962325). Binds to G-rich structures in 28S rRNA and in mRNAs. Plays a regulatory role in the translation apparatus; inhibits cell-free translation of mRNAs.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein, RNA-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P18124

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-156827, L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902, Peptide chain elongation
R-HSA-1799339, SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823, Viral mRNA Translation
R-HSA-2408557, Selenocysteine synthesis
R-HSA-6791226, Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72689, Formation of a pool of free 40S subunits
R-HSA-72706, GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764, Eukaryotic Translation Termination
R-HSA-9010553, Regulation of expression of SLITs and ROBOs
R-HSA-9633012, Response of EIF2AK4 (GCN2) to amino acid deficiency
R-HSA-975956, Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

SIGNOR Signaling Network Open Resource

More...SIGNORi		P18124

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
60S ribosomal protein L7
Alternative name(s):
Large ribosomal subunit protein uL301 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RPL7
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:10363, RPL7

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		604166, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P18124

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000147604.13

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		6129

Open Targets

More...OpenTargetsi		ENSG00000147604

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA34759

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P18124, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		RPL7

Domain mapping of disease mutations (DMDM)

More...DMDMi		133021

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001046331 – 24860S ribosomal protein L7Add BLAST248

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources2 Publications1
Modified residuei17PhosphothreonineCombined sources1
Modified residuei124N6-acetyllysineCombined sources1
Modified residuei127N6-succinyllysineBy similarity1
Modified residuei139PhosphotyrosineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P18124

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P18124

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P18124

MaxQB - The MaxQuant DataBase

More...MaxQBi		P18124

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P18124

PeptideAtlas

More...PeptideAtlasi		P18124

PRoteomics IDEntifications database

More...PRIDEi		P18124

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		53549

Consortium for Top Down Proteomics

More...TopDownProteomicsi		P18124

2D gel databases

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

More...SWISS-2DPAGEi		P18124

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P18124

MetOSite database of methionine sulfoxide sites

More...MetOSitei		P18124

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P18124

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P18124

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000147604, Expressed in subventricular zone (outer) (primate) and 196 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P18124, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P18124, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000147604, Tissue enhanced (blood)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the large ribosomal subunit (Probable). Homodimer.

Interacts with DHX33 (PubMed:26100019).

1 Publication1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		112049, 337 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-5183, 60S cytosolic large ribosomal subunit

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P18124

Protein interaction database and analysis system

More...IntActi		P18124, 104 interactors

Molecular INTeraction database

More...MINTi		P18124

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000339795

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P18124, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P18124

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati7 – 181Add BLAST12
Repeati19 – 302Add BLAST12
Repeati31 – 423Add BLAST12
Repeati43 – 544Add BLAST12

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni7 – 544 X 12 AA tandem repeatsAdd BLAST48

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the universal ribosomal protein uL30 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3184, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00950000182878

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P18124

Identification of Orthologs from Complete Genome Data

More...OMAi		KFKHYIE

Database of Orthologous Groups

More...OrthoDBi		1544778at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P18124

TreeFam database of animal gene trees

More...TreeFami		TF300740

Family and domain databases

Conserved Domains Database

More...CDDi		cd01657, Ribosomal_L7_archeal_euk, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.15.30, 1 hit
3.30.1390.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR036919, L30_ferredoxin-like_sf
IPR023106, Ribosomal_L30_central_dom_arc
IPR018038, Ribosomal_L30_CS
IPR016082, Ribosomal_L30_ferredoxin-like
IPR012988, Ribosomal_L30_N
IPR039699, Ribosomal_L7/L30
IPR005998, Ribosomal_L7_euk
IPR035808, Ribosomal_L7_euk_arc

The PANTHER Classification System

More...PANTHERi		PTHR11524, PTHR11524, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00327, Ribosomal_L30, 1 hit
PF08079, Ribosomal_L30_N, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF55129, SSF55129, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR01310, uL30_euk, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00634, RIBOSOMAL_L30, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

P18124-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEGVEEKKKE VPAVPETLKK KRRNFAELKI KRLRKKFAQK MLRKARRKLI 
        60         70         80         90        100
YEKAKHYHKE YRQMYRTEIR MARMARKAGN FYVPAEPKLA FVIRIRGING 
       110        120        130        140        150
VSPKVRKVLQ LLRLRQIFNG TFVKLNKASI NMLRIVEPYI AWGYPNLKSV 
       160        170        180        190        200
NELIYKRGYG KINKKRIALT DNALIARSLG KYGIICMEDL IHEIYTVGKR 
       210        220        230        240 
FKEANNFLWP FKLSSPRGGM KKKTTHFVEG GDAGNREDQI NRLIRRMN
Length:248
Mass (Da):29,226
Last modified:November 1, 1990 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i070EB4C904E6795A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A8MUD9A8MUD9_HUMAN
60S ribosomal protein L7
RPL7
208Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JIJ5C9JIJ5_HUMAN
60S ribosomal protein L7
RPL7
99Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JZ88C9JZ88_HUMAN
60S ribosomal protein L7
RPL7
88Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAA41026 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti48K → E in CAG33054 (Ref. 4) Curated1
Sequence conflicti157R → L in CAA41026 (PubMed:8441630).Curated1
Sequence conflicti157R → L in CAA41027 (PubMed:8441630).Curated1
Sequence conflicti160G → A in CAA41026 (PubMed:8441630).Curated1
Sequence conflicti166R → Q in CAA41026 (PubMed:8441630).Curated1
Sequence conflicti173A → S in AAA03081 (PubMed:8360149).Curated1
Sequence conflicti192H → R in CAG33054 (Ref. 4) Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X57958 mRNA Translation: CAA41026.1 Different initiation.
X57959 mRNA Translation: CAA41027.1
L16558 mRNA Translation: AAA03081.1
X52967 mRNA Translation: CAA37139.1
CR456773 mRNA Translation: CAG33054.1
AK291119 mRNA Translation: BAF83808.1
AK313365 mRNA Translation: BAG36165.1
BC006095 mRNA Translation: AAH06095.1
BC008850 mRNA Translation: AAH08850.1
BC009599 mRNA Translation: AAH09599.1
BC071671 mRNA Translation: AAH71671.1
BC071894 mRNA Translation: AAH71894.1
BC071895 mRNA Translation: AAH71895.1
BC087837 mRNA Translation: AAH87837.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS6212.1

Protein sequence database of the Protein Information Resource

More...PIRi		S11709, R5HU7

NCBI Reference Sequences

More...RefSeqi		NP_000962.2, NM_000971.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000352983; ENSP00000339795; ENSG00000147604

Database of genes from NCBI RefSeq genomes

More...GeneIDi		6129

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:6129

UCSC genome browser

More...UCSCi		uc003xzg.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57958 mRNA Translation: CAA41026.1 Different initiation.
X57959 mRNA Translation: CAA41027.1
L16558 mRNA Translation: AAA03081.1
X52967 mRNA Translation: CAA37139.1
CR456773 mRNA Translation: CAG33054.1
AK291119 mRNA Translation: BAF83808.1
AK313365 mRNA Translation: BAG36165.1
BC006095 mRNA Translation: AAH06095.1
BC008850 mRNA Translation: AAH08850.1
BC009599 mRNA Translation: AAH09599.1
BC071671 mRNA Translation: AAH71671.1
BC071894 mRNA Translation: AAH71894.1
BC071895 mRNA Translation: AAH71895.1
BC087837 mRNA Translation: AAH87837.1
CCDSiCCDS6212.1
PIRiS11709, R5HU7
RefSeqiNP_000962.2, NM_000971.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-LF1-248[»]
4V6Xelectron microscopy5.00CF1-248[»]
5AJ0electron microscopy3.50AF1-248[»]
5LKSelectron microscopy3.60LF1-248[»]
5T2Celectron microscopy3.60m1-248[»]
6EK0electron microscopy2.90LF1-248[»]
6IP5electron microscopy3.902A1-248[»]
6IP6electron microscopy4.502A1-248[»]
6IP8electron microscopy3.902A1-248[»]
6LQMelectron microscopy3.09w1-248[»]
6LSRelectron microscopy3.13w1-248[»]
6LSSelectron microscopy3.23p1-248[»]
6LU8electron microscopy3.13p1-248[»]
6OLEelectron microscopy3.10H24-248[»]
6OLFelectron microscopy3.90H24-248[»]
6OLGelectron microscopy3.40AF15-248[»]
6OLIelectron microscopy3.50H24-248[»]
6OLZelectron microscopy3.90AF15-248[»]
6OM0electron microscopy3.10H24-248[»]
6OM7electron microscopy3.70H24-248[»]
6QZPelectron microscopy2.90LF24-248[»]
6W6Lelectron microscopy3.84H1-248[»]
6XA1electron microscopy2.80LF24-248[»]
6Y0Gelectron microscopy3.20LF1-248[»]
6Y2Lelectron microscopy3.00LF1-248[»]
6Y57electron microscopy3.50LF1-248[»]
6Y6Xelectron microscopy2.80LF24-248[»]
6Z6Lelectron microscopy3.00LF1-248[»]
6Z6Melectron microscopy3.10LF1-248[»]
6Z6Nelectron microscopy2.90LF1-248[»]
6ZM7electron microscopy2.70LF1-248[»]
6ZMEelectron microscopy3.00LF1-248[»]
6ZMIelectron microscopy2.60LF1-248[»]
6ZMOelectron microscopy3.10LF1-248[»]
SMRiP18124
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi112049, 337 interactors
ComplexPortaliCPX-5183, 60S cytosolic large ribosomal subunit
CORUMiP18124
IntActiP18124, 104 interactors
MINTiP18124
STRINGi9606.ENSP00000339795

PTM databases

iPTMnetiP18124
MetOSiteiP18124
PhosphoSitePlusiP18124
SwissPalmiP18124

Genetic variation databases

BioMutaiRPL7
DMDMi133021

2D gel databases

SWISS-2DPAGEiP18124

Proteomic databases

EPDiP18124
jPOSTiP18124
MassIVEiP18124
MaxQBiP18124
PaxDbiP18124
PeptideAtlasiP18124
PRIDEiP18124
ProteomicsDBi53549
TopDownProteomicsiP18124

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		25169, 245 antibodies

The DNASU plasmid repository

More...DNASUi		6129

Genome annotation databases

EnsembliENST00000352983; ENSP00000339795; ENSG00000147604
GeneIDi6129
KEGGihsa:6129
UCSCiuc003xzg.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		6129
DisGeNETi6129

GeneCards: human genes, protein and diseases

More...GeneCardsi		RPL7
HGNCiHGNC:10363, RPL7
HPAiENSG00000147604, Tissue enhanced (blood)
MIMi604166, gene
neXtProtiNX_P18124
OpenTargetsiENSG00000147604
PharmGKBiPA34759
VEuPathDBiHostDB:ENSG00000147604.13

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3184, Eukaryota
GeneTreeiENSGT00950000182878
InParanoidiP18124
OMAiKFKHYIE
OrthoDBi1544778at2759
PhylomeDBiP18124
TreeFamiTF300740

Enzyme and pathway databases

PathwayCommonsiP18124
ReactomeiR-HSA-156827, L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902, Peptide chain elongation
R-HSA-1799339, SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823, Viral mRNA Translation
R-HSA-2408557, Selenocysteine synthesis
R-HSA-6791226, Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72689, Formation of a pool of free 40S subunits
R-HSA-72706, GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764, Eukaryotic Translation Termination
R-HSA-9010553, Regulation of expression of SLITs and ROBOs
R-HSA-9633012, Response of EIF2AK4 (GCN2) to amino acid deficiency
R-HSA-975956, Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
SIGNORiP18124

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		6129, 787 hits in 971 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		RPL7, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		RPL7

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		6129
PharosiP18124, Tbio

Protein Ontology

More...PROi		PR:P18124
RNActiP18124, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000147604, Expressed in subventricular zone (outer) (primate) and 196 other tissues
ExpressionAtlasiP18124, baseline and differential
GenevisibleiP18124, HS

Family and domain databases

CDDicd01657, Ribosomal_L7_archeal_euk, 1 hit
Gene3Di1.10.15.30, 1 hit
3.30.1390.20, 1 hit
InterProiView protein in InterPro
IPR036919, L30_ferredoxin-like_sf
IPR023106, Ribosomal_L30_central_dom_arc
IPR018038, Ribosomal_L30_CS
IPR016082, Ribosomal_L30_ferredoxin-like
IPR012988, Ribosomal_L30_N
IPR039699, Ribosomal_L7/L30
IPR005998, Ribosomal_L7_euk
IPR035808, Ribosomal_L7_euk_arc
PANTHERiPTHR11524, PTHR11524, 1 hit
PfamiView protein in Pfam
PF00327, Ribosomal_L30, 1 hit
PF08079, Ribosomal_L30_N, 1 hit
SUPFAMiSSF55129, SSF55129, 1 hit
TIGRFAMsiTIGR01310, uL30_euk, 1 hit
PROSITEiView protein in PROSITE
PS00634, RIBOSOMAL_L30, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRL7_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P18124
Secondary accession number(s): A8K504
, Q15289, Q3KQU0, Q5I0X1, Q6IBM9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: April 7, 2021
This is version 220 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Ribosomal proteins
    Ribosomal proteins families and list of entries
  2. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families
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