UniProtKB - P18124 (RL7_HUMAN)
Protein
60S ribosomal protein L7
Gene
RPL7
Organism
Homo sapiens (Human)
Status
Functioni
Component of the large ribosomal subunit (PubMed:12962325). Binds to G-rich structures in 28S rRNA and in mRNAs. Plays a regulatory role in the translation apparatus; inhibits cell-free translation of mRNAs.1 Publication
GO - Molecular functioni
- DNA binding Source: MGI
- mRNA binding Source: MGI
- protein homodimerization activity Source: MGI
- RNA binding Source: UniProtKB
- structural constituent of ribosome Source: GO_Central
GO - Biological processi
- maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: GO_Central
- nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: Reactome
- ribosomal large subunit biogenesis Source: UniProtKB
- rRNA processing Source: UniProtKB
- SRP-dependent cotranslational protein targeting to membrane Source: Reactome
- translation Source: ProtInc
- translational initiation Source: Reactome
- viral transcription Source: Reactome
Keywordsi
Molecular function | Ribonucleoprotein, Ribosomal protein, RNA-binding |
Enzyme and pathway databases
Reactomei | R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156902 Peptide chain elongation R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane R-HSA-192823 Viral mRNA Translation R-HSA-2408557 Selenocysteine synthesis R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-72689 Formation of a pool of free 40S subunits R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72764 Eukaryotic Translation Termination R-HSA-9010553 Regulation of expression of SLITs and ROBOs R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
Names & Taxonomyi
Protein namesi | Recommended name: 60S ribosomal protein L7Alternative name(s): Large ribosomal subunit protein uL301 Publication |
Gene namesi | Name:RPL7 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:10363 RPL7 |
MIMi | 604166 gene |
neXtProti | NX_P18124 |
Subcellular locationi
Cytosol
- cytosol Source: Reactome
- cytosolic large ribosomal subunit Source: UniProtKB
Nucleus
Other locations
- cytoplasm Source: UniProtKB
- focal adhesion Source: UniProtKB
- membrane Source: UniProtKB
- polysome Source: Ensembl
- postsynaptic density Source: SynGO
- ribonucleoprotein complex Source: MGI
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 6129 |
OpenTargetsi | ENSG00000147604 |
PharmGKBi | PA34759 |
Miscellaneous databases
Pharosi | P18124 |
Polymorphism and mutation databases
BioMutai | RPL7 |
DMDMi | 133021 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000104633 | 1 – 248 | 60S ribosomal protein L7Add BLAST | 248 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineCombined sources2 Publications | 1 | |
Modified residuei | 17 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 124 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 127 | N6-succinyllysineBy similarity | 1 | |
Modified residuei | 139 | PhosphotyrosineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | P18124 |
jPOSTi | P18124 |
MassIVEi | P18124 |
MaxQBi | P18124 |
PaxDbi | P18124 |
PeptideAtlasi | P18124 |
PRIDEi | P18124 |
ProteomicsDBi | 53549 |
TopDownProteomicsi | P18124 |
2D gel databases
SWISS-2DPAGEi | P18124 |
PTM databases
iPTMneti | P18124 |
PhosphoSitePlusi | P18124 |
SwissPalmi | P18124 |
Expressioni
Gene expression databases
Bgeei | ENSG00000147604 Expressed in 180 organ(s), highest expression level in colon |
ExpressionAtlasi | P18124 baseline and differential |
Genevisiblei | P18124 HS |
Organism-specific databases
HPAi | HPA058373 |
Interactioni
Subunit structurei
Component of the large ribosomal subunit (Probable). Homodimer.
Interacts with DHX33 (PubMed:26100019).
1 Publication1 PublicationBinary interactionsi
GO - Molecular functioni
- protein homodimerization activity Source: MGI
Protein-protein interaction databases
BioGridi | 112049, 276 interactors |
CORUMi | P18124 |
IntActi | P18124, 95 interactors |
MINTi | P18124 |
STRINGi | 9606.ENSP00000339795 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 7 – 18 | 1Add BLAST | 12 | |
Repeati | 19 – 30 | 2Add BLAST | 12 | |
Repeati | 31 – 42 | 3Add BLAST | 12 | |
Repeati | 43 – 54 | 4Add BLAST | 12 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 7 – 54 | 4 X 12 AA tandem repeatsAdd BLAST | 48 |
Sequence similaritiesi
Belongs to the universal ribosomal protein uL30 family.Curated
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG3184 Eukaryota COG1841 LUCA |
GeneTreei | ENSGT00950000182878 |
HOGENOMi | HOG000170917 |
InParanoidi | P18124 |
KOi | K02937 |
OMAi | KFKHYIE |
OrthoDBi | 1544778at2759 |
PhylomeDBi | P18124 |
TreeFami | TF300740 |
Family and domain databases
CDDi | cd01657 Ribosomal_L7_archeal_euk, 1 hit |
Gene3Di | 1.10.15.30, 1 hit 3.30.1390.20, 1 hit |
InterProi | View protein in InterPro IPR036919 L30_ferredoxin-like_sf IPR023106 Ribosomal_L30_central_dom_arc IPR018038 Ribosomal_L30_CS IPR016082 Ribosomal_L30_ferredoxin-like IPR012988 Ribosomal_L30_N IPR039699 Ribosomal_L7/L30 IPR005998 Ribosomal_L7_euk IPR035808 Ribosomal_L7_euk_arc |
PANTHERi | PTHR11524 PTHR11524, 1 hit |
Pfami | View protein in Pfam PF00327 Ribosomal_L30, 1 hit PF08079 Ribosomal_L30_N, 1 hit |
SUPFAMi | SSF55129 SSF55129, 1 hit |
TIGRFAMsi | TIGR01310 uL30_euk, 1 hit |
PROSITEi | View protein in PROSITE PS00634 RIBOSOMAL_L30, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
P18124-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEGVEEKKKE VPAVPETLKK KRRNFAELKI KRLRKKFAQK MLRKARRKLI
60 70 80 90 100
YEKAKHYHKE YRQMYRTEIR MARMARKAGN FYVPAEPKLA FVIRIRGING
110 120 130 140 150
VSPKVRKVLQ LLRLRQIFNG TFVKLNKASI NMLRIVEPYI AWGYPNLKSV
160 170 180 190 200
NELIYKRGYG KINKKRIALT DNALIARSLG KYGIICMEDL IHEIYTVGKR
210 220 230 240
FKEANNFLWP FKLSSPRGGM KKKTTHFVEG GDAGNREDQI NRLIRRMN
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA8MUD9 | A8MUD9_HUMAN | 60S ribosomal protein L7 | RPL7 | 208 | Annotation score: | ||
C9JIJ5 | C9JIJ5_HUMAN | 60S ribosomal protein L7 | RPL7 | 99 | Annotation score: | ||
C9JZ88 | C9JZ88_HUMAN | 60S ribosomal protein L7 | RPL7 | 88 | Annotation score: |
Sequence cautioni
The sequence CAA41026 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 48 | K → E in CAG33054 (Ref. 4) Curated | 1 | |
Sequence conflicti | 157 | R → L in CAA41026 (PubMed:8441630).Curated | 1 | |
Sequence conflicti | 157 | R → L in CAA41027 (PubMed:8441630).Curated | 1 | |
Sequence conflicti | 160 | G → A in CAA41026 (PubMed:8441630).Curated | 1 | |
Sequence conflicti | 166 | R → Q in CAA41026 (PubMed:8441630).Curated | 1 | |
Sequence conflicti | 173 | A → S in AAA03081 (PubMed:8360149).Curated | 1 | |
Sequence conflicti | 192 | H → R in CAG33054 (Ref. 4) Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X57958 mRNA Translation: CAA41026.1 Different initiation. X57959 mRNA Translation: CAA41027.1 L16558 mRNA Translation: AAA03081.1 X52967 mRNA Translation: CAA37139.1 CR456773 mRNA Translation: CAG33054.1 AK291119 mRNA Translation: BAF83808.1 AK313365 mRNA Translation: BAG36165.1 BC006095 mRNA Translation: AAH06095.1 BC008850 mRNA Translation: AAH08850.1 BC009599 mRNA Translation: AAH09599.1 BC071671 mRNA Translation: AAH71671.1 BC071894 mRNA Translation: AAH71894.1 BC071895 mRNA Translation: AAH71895.1 BC087837 mRNA Translation: AAH87837.1 |
CCDSi | CCDS6212.1 |
PIRi | S11709 R5HU7 |
RefSeqi | NP_000962.2, NM_000971.3 |
Genome annotation databases
Ensembli | ENST00000352983; ENSP00000339795; ENSG00000147604 |
GeneIDi | 6129 |
KEGGi | hsa:6129 |
UCSCi | uc003xzg.4 human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X57958 mRNA Translation: CAA41026.1 Different initiation. X57959 mRNA Translation: CAA41027.1 L16558 mRNA Translation: AAA03081.1 X52967 mRNA Translation: CAA37139.1 CR456773 mRNA Translation: CAG33054.1 AK291119 mRNA Translation: BAF83808.1 AK313365 mRNA Translation: BAG36165.1 BC006095 mRNA Translation: AAH06095.1 BC008850 mRNA Translation: AAH08850.1 BC009599 mRNA Translation: AAH09599.1 BC071671 mRNA Translation: AAH71671.1 BC071894 mRNA Translation: AAH71894.1 BC071895 mRNA Translation: AAH71895.1 BC087837 mRNA Translation: AAH87837.1 |
CCDSi | CCDS6212.1 |
PIRi | S11709 R5HU7 |
RefSeqi | NP_000962.2, NM_000971.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4UG0 | electron microscopy | - | LF | 1-248 | [»] | |
4V6X | electron microscopy | 5.00 | CF | 1-248 | [»] | |
5AJ0 | electron microscopy | 3.50 | AF | 1-248 | [»] | |
5LKS | electron microscopy | 3.60 | LF | 1-248 | [»] | |
5T2C | electron microscopy | 3.60 | m | 1-248 | [»] | |
6EK0 | electron microscopy | 2.90 | LF | 1-248 | [»] | |
6IP5 | electron microscopy | 3.90 | 2A | 1-248 | [»] | |
6IP6 | electron microscopy | 4.50 | 2A | 1-248 | [»] | |
6IP8 | electron microscopy | 3.90 | 2A | 1-248 | [»] | |
6OLE | electron microscopy | 3.10 | H | 24-248 | [»] | |
6OLF | electron microscopy | 3.90 | H | 24-248 | [»] | |
6OLG | electron microscopy | 3.40 | AF | 15-248 | [»] | |
6OLI | electron microscopy | 3.50 | H | 24-248 | [»] | |
6OLZ | electron microscopy | 3.90 | AF | 15-248 | [»] | |
6OM0 | electron microscopy | 3.10 | H | 24-248 | [»] | |
6OM7 | electron microscopy | 3.70 | H | 24-248 | [»] | |
6QZP | electron microscopy | 2.90 | LF | 24-248 | [»] | |
SMRi | P18124 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGridi | 112049, 276 interactors |
CORUMi | P18124 |
IntActi | P18124, 95 interactors |
MINTi | P18124 |
STRINGi | 9606.ENSP00000339795 |
PTM databases
iPTMneti | P18124 |
PhosphoSitePlusi | P18124 |
SwissPalmi | P18124 |
Polymorphism and mutation databases
BioMutai | RPL7 |
DMDMi | 133021 |
2D gel databases
SWISS-2DPAGEi | P18124 |
Proteomic databases
EPDi | P18124 |
jPOSTi | P18124 |
MassIVEi | P18124 |
MaxQBi | P18124 |
PaxDbi | P18124 |
PeptideAtlasi | P18124 |
PRIDEi | P18124 |
ProteomicsDBi | 53549 |
TopDownProteomicsi | P18124 |
Protocols and materials databases
DNASUi | 6129 |
Genome annotation databases
Ensembli | ENST00000352983; ENSP00000339795; ENSG00000147604 |
GeneIDi | 6129 |
KEGGi | hsa:6129 |
UCSCi | uc003xzg.4 human |
Organism-specific databases
CTDi | 6129 |
DisGeNETi | 6129 |
GeneCardsi | RPL7 |
HGNCi | HGNC:10363 RPL7 |
HPAi | HPA058373 |
MIMi | 604166 gene |
neXtProti | NX_P18124 |
OpenTargetsi | ENSG00000147604 |
PharmGKBi | PA34759 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3184 Eukaryota COG1841 LUCA |
GeneTreei | ENSGT00950000182878 |
HOGENOMi | HOG000170917 |
InParanoidi | P18124 |
KOi | K02937 |
OMAi | KFKHYIE |
OrthoDBi | 1544778at2759 |
PhylomeDBi | P18124 |
TreeFami | TF300740 |
Enzyme and pathway databases
Reactomei | R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156902 Peptide chain elongation R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane R-HSA-192823 Viral mRNA Translation R-HSA-2408557 Selenocysteine synthesis R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-72689 Formation of a pool of free 40S subunits R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72764 Eukaryotic Translation Termination R-HSA-9010553 Regulation of expression of SLITs and ROBOs R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
Miscellaneous databases
ChiTaRSi | RPL7 human |
GeneWikii | RPL7 |
GenomeRNAii | 6129 |
Pharosi | P18124 |
PROi | PR:P18124 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000147604 Expressed in 180 organ(s), highest expression level in colon |
ExpressionAtlasi | P18124 baseline and differential |
Genevisiblei | P18124 HS |
Family and domain databases
CDDi | cd01657 Ribosomal_L7_archeal_euk, 1 hit |
Gene3Di | 1.10.15.30, 1 hit 3.30.1390.20, 1 hit |
InterProi | View protein in InterPro IPR036919 L30_ferredoxin-like_sf IPR023106 Ribosomal_L30_central_dom_arc IPR018038 Ribosomal_L30_CS IPR016082 Ribosomal_L30_ferredoxin-like IPR012988 Ribosomal_L30_N IPR039699 Ribosomal_L7/L30 IPR005998 Ribosomal_L7_euk IPR035808 Ribosomal_L7_euk_arc |
PANTHERi | PTHR11524 PTHR11524, 1 hit |
Pfami | View protein in Pfam PF00327 Ribosomal_L30, 1 hit PF08079 Ribosomal_L30_N, 1 hit |
SUPFAMi | SSF55129 SSF55129, 1 hit |
TIGRFAMsi | TIGR01310 uL30_euk, 1 hit |
PROSITEi | View protein in PROSITE PS00634 RIBOSOMAL_L30, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RL7_HUMAN | |
Accessioni | P18124Primary (citable) accession number: P18124 Secondary accession number(s): A8K504 Q6IBM9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1990 |
Last sequence update: | November 1, 1990 | |
Last modified: | November 13, 2019 | |
This is version 211 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Complete proteome, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 8
Human chromosome 8: entries, gene names and cross-references to MIM - Ribosomal proteins
Ribosomal proteins families and list of entries - SIMILARITY comments
Index of protein domains and families - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references