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Protein

Homeobox protein CDX-1

Gene

Cdx1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plays a role in transcriptional regulation. Involved in activated KRAS-mediated transcriptional activation of PRKD1 in colorectal cancer (CRC) cells. Binds to the PRKD1 promoter in colorectal cancer (CRC) cells. Could play a role in the terminal differentiation of the intestine. Binds preferentially to methylated DNA.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi154 – 213HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein CDX-1
Alternative name(s):
Caudal-type homeobox protein 1
Gene namesi
Name:Cdx1
Synonyms:Cdx-1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:88360 Cdx1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000488471 – 268Homeobox protein CDX-1Add BLAST268

Proteomic databases

PaxDbiP18111
PeptideAtlasiP18111
PRIDEiP18111

PTM databases

PhosphoSitePlusiP18111

Expressioni

Tissue specificityi

Intestinal epithelium.

Gene expression databases

BgeeiENSMUSG00000024619 Expressed in 49 organ(s), highest expression level in large intestine
CleanExiMM_CDX1
GenevisibleiP18111 MM

Interactioni

Protein-protein interaction databases

BioGridi198663, 6 interactors
STRINGi10090.ENSMUSP00000025521

Structurei

3D structure databases

ProteinModelPortaliP18111
SMRiP18111
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni157 – 178Interaction with DNABy similarityAdd BLAST22
Regioni196 – 207Interaction with 5-mCpG DNABy similarityAdd BLAST12

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi144 – 149Poly-Gly6
Compositional biasi217 – 221Poly-Gln5

Sequence similaritiesi

Belongs to the Caudal homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0848 Eukaryota
ENOG4111W2J LUCA
GeneTreeiENSGT00910000143983
HOGENOMiHOG000115975
HOVERGENiHBG005302
InParanoidiP18111
KOiK09312
OMAiEDWHSYG
OrthoDBiEOG091G0LXJ
PhylomeDBiP18111
TreeFamiTF351605

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR006820 Caudal_activation_dom
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
IPR000047 HTH_motif
PfamiView protein in Pfam
PF04731 Caudal_act, 1 hit
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
PR00031 HTHREPRESSR
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

P18111-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MYVGYVLDKD SPVYPGPARP SSLGLGPPTY APPGPAPAPP QYPDFAGYTH
60 70 80 90 100
VEPAPAPPPT WAAPFPAPKD DWAAAYGPGP TASAASPAPL AFGPPPDFSP
110 120 130 140 150
VPAPPGPGPG ILAQSLGAPG APSSPGAPRR TPYEWMRRSV AAAGGGGSGK
160 170 180 190 200
TRTKDKYRVV YTDHQRLELE KEFHYSRYIT IRRKSELAAN LGLTERQVKI
210 220 230 240 250
WFQNRRAKER KVNKKKQQQQ QPLPPTQLPL PLDGTPTPSG PPLGSLCPTN
260
AGLLGTPSPV PVKEEFLP
Length:268
Mass (Da):28,436
Last modified:November 1, 1995 - v2
Checksum:i85F45B2A3E12B2AE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti15P → Q in AAH19986 (PubMed:15489334).Curated1
Sequence conflicti146G → C in AAA37412 (PubMed:2905686).Curated1
Sequence conflicti157Y → S in AAA37412 (PubMed:2905686).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M37163 mRNA Translation: AAA37412.1 Sequence problems.
M80463 Unassigned DNA Translation: AAA16447.1 Sequence problems.
BC019986 mRNA Translation: AAH19986.1
CCDSiCCDS29279.1
PIRiA49303
RefSeqiNP_034010.3, NM_009880.3
UniGeneiMm.144448

Genome annotation databases

EnsembliENSMUST00000025521; ENSMUSP00000025521; ENSMUSG00000024619
GeneIDi12590
KEGGimmu:12590
UCSCiuc008fbj.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M37163 mRNA Translation: AAA37412.1 Sequence problems.
M80463 Unassigned DNA Translation: AAA16447.1 Sequence problems.
BC019986 mRNA Translation: AAH19986.1
CCDSiCCDS29279.1
PIRiA49303
RefSeqiNP_034010.3, NM_009880.3
UniGeneiMm.144448

3D structure databases

ProteinModelPortaliP18111
SMRiP18111
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198663, 6 interactors
STRINGi10090.ENSMUSP00000025521

PTM databases

PhosphoSitePlusiP18111

Proteomic databases

PaxDbiP18111
PeptideAtlasiP18111
PRIDEiP18111

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025521; ENSMUSP00000025521; ENSMUSG00000024619
GeneIDi12590
KEGGimmu:12590
UCSCiuc008fbj.2 mouse

Organism-specific databases

CTDi1044
MGIiMGI:88360 Cdx1

Phylogenomic databases

eggNOGiKOG0848 Eukaryota
ENOG4111W2J LUCA
GeneTreeiENSGT00910000143983
HOGENOMiHOG000115975
HOVERGENiHBG005302
InParanoidiP18111
KOiK09312
OMAiEDWHSYG
OrthoDBiEOG091G0LXJ
PhylomeDBiP18111
TreeFamiTF351605

Miscellaneous databases

PROiPR:P18111
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024619 Expressed in 49 organ(s), highest expression level in large intestine
CleanExiMM_CDX1
GenevisibleiP18111 MM

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR006820 Caudal_activation_dom
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
IPR000047 HTH_motif
PfamiView protein in Pfam
PF04731 Caudal_act, 1 hit
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
PR00031 HTHREPRESSR
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCDX1_MOUSE
AccessioniPrimary (citable) accession number: P18111
Secondary accession number(s): Q8VCF7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1995
Last modified: September 12, 2018
This is version 146 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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