Beta-1 adrenergic receptor

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• alpha-2A adrenergic receptor binding Source: RGD
• beta1-adrenergic receptor activity Source: RGD <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Opposite action of beta1- and beta2-adrenergic receptors on Ca(V)1 L-channel current in rat adrenal chromaffin cells."
    Cesetti T., Hernandez-Guijo J.M., Baldelli P., Carabelli V., Carbone E.
    J Neurosci 23:73-83(2003) [PubMed] [Europe PMC] [Abstract]
• G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential Source: RGD
• G protein-coupled receptor activity Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• guanyl-nucleotide exchange factor activity Source: UniProtKB
• PDZ domain binding Source: RGD
• protein heterodimerization activity Source: RGD

GO - Biological processⁱ

• adenylate cyclase-activating adrenergic receptor signaling pathway Source: UniProtKB
• adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: RGD
• aging Source: RGD <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "Age-related increase of beta1-adrenergic receptor gene expression in rat liver: a potential mechanism contributing to increased beta-adrenergic receptor density and responsiveness during aging."
    Jin W.
    J Recept Signal Transduct Res 30:24-30(2010) [PubMed] [Europe PMC] [Abstract]
• apoptotic process Source: RGDInferred from direct assayⁱ
  • "Autoantibody against cardiac beta1-adrenoceptor induces apoptosis in cultured neonatal rat cardiomyocytes."
    Gao Y., Liu H.R., Zhao R.R., Zhi J.M.
    Acta Biochim Biophys Sin (Shanghai) 38:443-449(2006) [PubMed] [Europe PMC] [Abstract]
• brown fat cell differentiation Source: RGD
• diet induced thermogenesis Source: RGD
• fear response Source: RGD
• glycogen catabolic process Source: RGDInferred from direct assayⁱ
  • "Greater glycogen utilization during 1- than 2-adrenergic receptor stimulation in the isolated perfused rat heart."
    McConville P., Lakatta E.G., Spencer R.G.
    Am J Physiol Endocrinol Metab 293:E1828-35(2007) [PubMed] [Europe PMC] [Abstract]
• G protein-coupled receptor signaling pathway Source: RGDInferred from direct assayⁱ
  • "Opposite action of beta1- and beta2-adrenergic receptors on Ca(V)1 L-channel current in rat adrenal chromaffin cells."
    Cesetti T., Hernandez-Guijo J.M., Baldelli P., Carabelli V., Carbone E.
    J Neurosci 23:73-83(2003) [PubMed] [Europe PMC] [Abstract]
• heat generation Source: RGD
• inhibitory postsynaptic potential Source: RGD <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Labetalol facilitates GABAergic transmission to rat periaqueductal gray neurons via antagonizing beta1-adrenergic receptors--a possible mechanism underlying labetalol-induced analgesia."
    Xiao C., Zhou C., Atlas G., Delphin E., Ye J.H.
    Brain Res 1198:34-43(2008) [PubMed] [Europe PMC] [Abstract]
• lipid homeostasis Source: RGDInferred from mutant phenotypeⁱ
  • "Role of beta-adrenergic receptors in regulation of hepatic fat accumulation during aging."
    Ghosh P.M., Shu Z.J., Zhu B., Lu Z., Ikeno Y., Barnes J.L., Yeh C.K., Zhang B.X., Katz M.S., Kamat A.
    J Endocrinol 213:251-261(2012) [PubMed] [Europe PMC] [Abstract]
• memory Source: RGDInferred from mutant phenotypeⁱ
  • "Down-regulation of beta1-adrenoceptors gene expression by short interfering RNA impairs the memory retrieval in the basolateral amygdala of rats."
    Fu A.L., Yan X.B., Sui L.
    Neurosci Lett 428:77-81(2007) [PubMed] [Europe PMC] [Abstract]
• negative regulation of multicellular organism growth Source: RGD
• negative regulation of smooth muscle contraction Source: RGDInferred from mutant phenotypeⁱ
  • "High concentrations of landiolol, a beta(1)-adrenoceptor antagonist, stimulate smooth muscle contraction of the rat trachea through the Rho-kinase pathway."
    Shibata O., Nishioka K., Yamaguchi M., Makita T., Sumikawa K.
    J Anesth 22:21-26(2008) [PubMed] [Europe PMC] [Abstract]
• negative regulation of urine volume Source: RGDInferred from direct assayⁱ
  • "Effects of beta 1- and beta 2-adrenoceptor agonists applied into the hypothalamic paraventricular nuclei of spontaneously hypertensive rats on urine production."
    Tsushima H., Fujimoto S., Matsuda T.
    Jpn J Pharmacol 64:201-207(1994) [PubMed] [Europe PMC] [Abstract]
• norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure Source: RGD
• positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: RGDInferred from mutant phenotypeⁱ
  • "Beta1-adrenoceptors in rat anterior pituitary may be constitutively active. Inverse agonism of CGP 20712A on basal 3',5'-cyclic adenosine 5'-monophosphate levels."
    Janssens K., Boussemaere M., Wagner S., Kopka K., Denef C.
    Endocrinology 149:2391-2402(2008) [PubMed] [Europe PMC] [Abstract]
• positive regulation of adenylate cyclase activity Source: RGDInferred from mutant phenotypeⁱ
  • "beta1-Adrenergic receptors activate two distinct signaling pathways in striatal neurons."
    Meitzen J., Luoma J.I., Stern C.M., Mermelstein P.G.
    J Neurochem 116:984-995(2011) [PubMed] [Europe PMC] [Abstract]
• positive regulation of apoptotic process Source: RGDInferred from mutant phenotypeⁱ
  • "Specific beta1-adrenergic receptor silencing with small interfering RNA lowers high blood pressure and improves cardiac function in myocardial ischemia."
    Arnold A.S., Tang Y.L., Qian K., Shen L., Valencia V., Phillips M.I., Zhang Y.C.
    J Hypertens 25:197-205(2007) [PubMed] [Europe PMC] [Abstract]
• positive regulation of calcium ion import across plasma membrane Source: RGDInferred from direct assayⁱ
  • "Enhanced cardiac L-type calcium current response to beta2-adrenergic stimulation in heart failure."
    Zhang Z.S., Cheng H.J., Ukai T., Tachibana H., Cheng C.P.
    J Pharmacol Exp Ther 298:188-196(2001) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cation channel activity Source: RGDInferred from direct assayⁱ
  • "beta-Adrenergic agonists differentially regulate highly selective and nonselective epithelial sodium channels to promote alveolar fluid clearance in vivo."
    Downs C.A., Kriener L.H., Yu L., Eaton D.C., Jain L., Helms M.N.
    Am J Physiol Lung Cell Mol Physiol 302:L1167-78(2012) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cell growth involved in cardiac muscle cell development Source: RGDInferred from mutant phenotypeⁱ
  • "Endocytosis machinery is required for beta1-adrenergic receptor-induced hypertrophy in neonatal rat cardiac myocytes."
    Morisco C., Marrone C., Galeotti J., Shao D., Vatner D.E., Vatner S.F., Sadoshima J.
    Cardiovasc Res 78:36-44(2008) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cold-induced thermogenesis Source: YuBioLab <p>Inferred from Sequence or Structural Similarity<br />Used for any analysis based on sequence alignment, structure comparison, or evaluation of sequence features such as composition.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iss">GO evidence code guide</a></p> Inferred from sequence or structural similarityⁱ
  • "Beta(1)/beta(2)/beta(3)-adrenoceptor knockout mice are obese and cold-sensitive but have normal lipolytic responses to fasting."
    Jimenez M., Leger B., Canola K., Lehr L., Arboit P., Seydoux J., Russell A.P., Giacobino J.P., Muzzin P., Preitner F.
    FEBS Lett 530:37-40(2002) [PubMed] [Europe PMC] [Abstract]
  • "beta(1) Adrenergic receptor is key to cold- and diet-induced thermogenesis in mice."
    Ueta C.B., Fernandes G.W., Capelo L.P., Fonseca T.L., Maculan F.D., Gouveia C.H., Brum P.C., Christoffolete M.A., Aoki M.S., Lancellotti C.L., Kim B., Bianco A.C., Ribeiro M.O.
    J Endocrinol 214:359-365(2012) [PubMed] [Europe PMC] [Abstract]
• positive regulation of GTPase activity Source: UniProtKB
• positive regulation of heart rate Source: RGDInferred from mutant phenotypeⁱ
  • "Role of beta-adrenergic and cholinergic systems in acclimatization to hypoxia in the rat."
    Clancy R.L., Moue Y., Erwig L.P., Smith P.G., Gonzalez N.C.
    Respir Physiol 107:75-84(1997) [PubMed] [Europe PMC] [Abstract]
• positive regulation of heart rate by epinephrine-norepinephrine Source: RGD
• positive regulation of long-term synaptic potentiation Source: RGDInferred from direct assayⁱ
  • "Hidden prenatal malnutrition in the rat: role of beta(1)-adrenoceptors on synaptic plasticity in the frontal cortex."
    Flores O., Perez H., Valladares L., Morgan C., Gatica A., Burgos H., Olivares R., Hernandez A.
    J Neurochem 119:314-323(2011) [PubMed] [Europe PMC] [Abstract]
• positive regulation of renin secretion into blood stream Source: RGDInferred from mutant phenotypeⁱ
  • "Renal denervation causes chronic hypotension in rats: role of beta1-adrenoceptor activity."
    Jacob F., LaBine B.G., Ariza P., Katz S.A., Osborn J.W.
    Clin Exp Pharmacol Physiol 32:255-262(2005) [PubMed] [Europe PMC] [Abstract]
• positive regulation of saliva secretion Source: RGDInferred from mutant phenotypeⁱ
  • "Beta-adrenoceptor alterations coupled with secretory response and experimental periodontitis in rat submandibular glands."
    Busch L., Sterin-Borda L., Borda E.
    Arch Oral Biol 53:509-516(2008) [PubMed] [Europe PMC] [Abstract]
• positive regulation of systemic arterial blood pressure Source: RGDInferred from mutant phenotypeⁱ
  • "Effect of stellate ganglionectomy on basal cardiovascular function and responses to beta1-adrenoceptor blockade in the rat."
    Yoshimoto M., Wehrwein E.A., Novotny M., Swain G.M., Kreulen D.L., Osborn J.W.
    Am J Physiol Heart Circ Physiol 295:H2447-54(2008) [PubMed] [Europe PMC] [Abstract]
• positive regulation of the force of heart contraction by epinephrine-norepinephrine Source: RGD
• positive regulation of the force of heart contraction by norepinephrine Source: RGDInferred from direct assayⁱ
  • "Inotropy and L-type Ca2+ current, activated by beta1- and beta2-adrenoceptors, are differently controlled by phosphodiesterases 3 and 4 in rat heart."
    Christ T., Galindo-Tovar A., Thoms M., Ravens U., Kaumann A.J.
    Br J Pharmacol 156:62-83(2009) [PubMed] [Europe PMC] [Abstract]
• protein localization to organelle Source: RGDInferred from direct assayⁱ
  • "Crosstalk between adenosine A1 and beta1-adrenergic receptors regulates translocation of PKCepsilon in isolated rat cardiomyocytes."
    Komatsu S., Dobson J.G. Jr., Ikebe M., Shea L.G., Fenton R.A.
    J Cell Physiol 227:3201-3207(2012) [PubMed] [Europe PMC] [Abstract]
• regulation of calcium ion transport Source: RGDInferred from direct assayⁱ
  • "Inotropy and L-type Ca2+ current, activated by beta1- and beta2-adrenoceptors, are differently controlled by phosphodiesterases 3 and 4 in rat heart."
    Christ T., Galindo-Tovar A., Thoms M., Ravens U., Kaumann A.J.
    Br J Pharmacol 156:62-83(2009) [PubMed] [Europe PMC] [Abstract]
• regulation of cardiac muscle cell contraction Source: RGDInferred from direct assayⁱ
  • "Adenoprotection of the heart involves phospholipase C-induced activation and translocation of PKC-epsilon to RACK2 in adult rat and mouse."
    Fenton R.A., Komatsu S., Ikebe M., Shea L.G., Dobson J.G. Jr.
    Am J Physiol Heart Circ Physiol 297:H718-25(2009) [PubMed] [Europe PMC] [Abstract]
• regulation of circadian sleep/wake cycle, sleep Source: UniProtKB
• response to cold Source: RGD
• Rho protein signal transduction Source: RGDInferred from mutant phenotypeⁱ
  • "High concentrations of landiolol, a beta(1)-adrenoceptor antagonist, stimulate smooth muscle contraction of the rat trachea through the Rho-kinase pathway."
    Shibata O., Nishioka K., Yamaguchi M., Makita T., Sumikawa K.
    J Anesth 22:21-26(2008) [PubMed] [Europe PMC] [Abstract]
• sensory perception of pain Source: RGDInferred from mutant phenotypeⁱ
  • "Mechanisms underlying the nociceptive responses induced by platelet-activating factor (PAF) in the rat paw."
    Marotta D.M., Costa R., Motta E.M., Fernandes E.S., Medeiros R., Quintao N.L., Campos M.M., Calixto J.B.
    Biochem Pharmacol 77:1223-1235(2009) [PubMed] [Europe PMC] [Abstract]
• wound healing Source: RGDInferred from mutant phenotypeⁱ
  • "beta-1 and beta-2, but not alpha-1 and alpha-2, adrenoceptor blockade delays rat cutaneous wound healing."
    Romana-Souza B., Santos J.S., Monte-Alto-Costa A.
    Wound Repair Regen 17:230-239(2009) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Topology

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Mutagenesis

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• alpha-2A adrenergic receptor binding Source: RGD
• PDZ domain binding Source: RGD
• protein heterodimerization activity Source: RGD

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Region

Motif

Compositional bias

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domainⁱ

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

        10         20         30         40         50
MGAGALALGA SEPCNLSSAA PLPDGAATAA RLLVLASPPA SLLPPASEGS 
        60         70         80         90        100
APLSQQWTAG MGLLLALIVL LIVVGNVLVI VAIAKTPRLQ TLTNLFIMSL 
       110        120        130        140        150
ASADLVMGLL VVPFGATIVV WGRWEYGSFF CELWTSVDVL CVTASIETLC 
       160        170        180        190        200
VIALDRYLAI TLPFRYQSLL TRARARALVC TVWAISALVS FLPILMHWWR 
       210        220        230        240        250
AESDEARRCY NDPKCCDFVT NRAYAIASSV VSFYVPLCIM AFVYLRVFRE 
       260        270        280        290        300
AQKQVKKIDS CERRFLTGPP RPPSPAPSPS PGPPRPADSL ANGRSSKRRP 
       310        320        330        340        350
SRLVALREQK ALKTLGIIMG VFTLCWLPFF LANVVKAFHR DLVPDRLFVF 
       360        370        380        390        400
FNWLGYANSA FNPIIYCRSP DFRKAFQRLL CCARRAACRR RAAHGDRPRA 
       410        420        430        440        450
SGCLARAGPP PSPGAPSDDD DDDAGATPPA RLLEPWAGCN GGTTTVDSDS 
       460 
SLDEPGRQGF SSESKV                                      

Experimental Info

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. 7-transmembrane G-linked receptors
   List of 7-transmembrane G-linked receptor entries
2. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references
3. SIMILARITY comments
   Index of protein domains and families