ADRA2B

Functionⁱ

Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is clonidine > norepinephrine > epinephrine = oxymetazoline > dopamine > p-tyramine = phenylephrine > serotonin > p-synephrine / p-octopamine. For antagonists, the rank order is yohimbine > chlorpromazine > phentolamine > mianserine > spiperone > prazosin > alprenolol > propanolol > pindolol.1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Length
Siteⁱ	92	Implicated in ligand bindingBy similarity	1
Siteⁱ	176	Implicated in catechol agonist bindingBy similarity	1
Siteⁱ	180	Implicated in catechol agonist bindingBy similarity	1

GO - Molecular functionⁱ

alpha2-adrenergic receptor activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 17215105
epinephrine binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 17215105

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

activation of MAPK activity Source: Ensembl
activation of protein kinase B activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 17215105
adenylate cyclase-activating adrenergic receptor signaling pathway Source: GO_Central
adrenergic receptor signaling pathway
Source: BHF-UCL
Inferred from direct assayⁱ
- 17215105
cell-cell signaling
Source: ProtInc
Traceable author statementⁱ
- 2164221
female pregnancy Source: Ensembl
G-protein coupled receptor signaling pathway
Source: BHF-UCL
Inferred from direct assayⁱ
- 17215105
negative regulation of epinephrine secretion
Source: BHF-UCL
Non-traceable author statementⁱ
- 16531006
negative regulation of norepinephrine secretion
Source: BHF-UCL
Traceable author statementⁱ
- 19477270
platelet activation Source: InterPro
positive regulation of blood pressure Source: Ensembl
positive regulation of MAPK cascade
Source: BHF-UCL
Inferred from direct assayⁱ
- 17215105
positive regulation of neuron differentiation
Source: BHF-UCL
Inferred from direct assayⁱ
- 17215105
positive regulation of uterine smooth muscle contraction Source: Ensembl
receptor transactivation
Source: BHF-UCL
Inferred from direct assayⁱ
- 17215105
regulation of vascular smooth muscle contraction Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	G-protein coupled receptor, Receptor, Transducer

Molecular function

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Reactomeⁱ	R-HSA-390696 Adrenoceptors R-HSA-392023 Adrenaline signalling through Alpha-2 adrenergic receptor R-HSA-418594 G alpha (i) signalling events R-HSA-418597 G alpha (z) signalling events
SignaLinkⁱ	P18089

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Alpha-2B adrenergic receptor Alternative name(s): Alpha-2 adrenergic receptor subtype C2 Alpha-2B adrenoreceptor Short name: Alpha-2B adrenoceptor Short name: Alpha-2BAR
Gene namesⁱ	Name:ADRA2B Synonyms:ADRA2L1, ADRA2RL1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 2

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000274286.1
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:282 ADRA2B
MIMⁱ	104260 gene
neXtProtⁱ	NX_P18089

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 12	ExtracellularBy similarityAdd BLAST	12
Transmembraneⁱ	13 – 38	Helical; Name=1By similarityAdd BLAST	26
Topological domainⁱ	39 – 48	CytoplasmicBy similarity	10
Transmembraneⁱ	49 – 69	Helical; Name=2By similarityAdd BLAST	21
Topological domainⁱ	70 – 86	ExtracellularBy similarityAdd BLAST	17
Transmembraneⁱ	87 – 107	Helical; Name=3By similarityAdd BLAST	21
Topological domainⁱ	108 – 128	CytoplasmicBy similarityAdd BLAST	21
Transmembraneⁱ	129 – 149	Helical; Name=4By similarityAdd BLAST	21
Topological domainⁱ	150 – 172	ExtracellularBy similarityAdd BLAST	23
Transmembraneⁱ	173 – 193	Helical; Name=5By similarityAdd BLAST	21
Topological domainⁱ	194 – 368	CytoplasmicBy similarityAdd BLAST	175
Transmembraneⁱ	369 – 389	Helical; Name=6By similarityAdd BLAST	21
Topological domainⁱ	390 – 405	ExtracellularBy similarityAdd BLAST	16
Transmembraneⁱ	406 – 426	Helical; Name=7By similarityAdd BLAST	21
Topological domainⁱ	427 – 450	CytoplasmicBy similarityAdd BLAST	24

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Epilepsy, familial adult myoclonic, 2 (FAME2)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA form of cortical myoclonic tremor with epilepsy, a syndrome characterized by cortical myoclonus and variable occurrence of epileptic seizures. Usually, myoclonic tremor is the presenting symptom, characterized by tremulous finger movements and myoclonic jerks of the limbs increased by action and posture. In a minority of patients, seizures are the presenting symptom; both complex partial as well as generalized tonic clonic seizures are described. Some patients exhibit mild cognitive impairment.

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_073953	225 – 229	HGGAL → QFGR in FAME2; gain of function; decreases interaction with PPP1R9B upon activation by neurotransmitter. 1 Publication		5

Keywords - Diseaseⁱ

Epilepsy

Organism-specific databases

DisGeNET More...DisGeNETⁱ	151
MalaCards human disease database More...MalaCardsⁱ	ADRA2B
MIMⁱ	607876 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000274286
Orphanetⁱ	86814 Benign adult familial myoclonic epilepsy
PharmGKBⁱ	PA36

Chemistry databases

ChEMBLⁱ	CHEMBL1942
Drug and drug target database More...DrugBankⁱ	DB00543 Amoxapine DB00182 Amphetamine DB00714 Apomorphine DB00964 Apraclonidine DB01238 Aripiprazole DB06216 Asenapine DB00217 Bethanidine DB00484 Brimonidine DB01200 Bromocriptine DB00248 Cabergoline DB01136 Carvedilol DB00477 Chlorpromazine DB09202 Cirazoline DB00575 Clonidine DB00363 Clozapine DB01151 Desipramine DB01142 Doxepin DB04855 Dronedarone DB06262 Droxidopa DB01363 Ephedra DB05492 Epicept NP-1 DB00668 Epinephrine DB01049 Ergoloid mesylate DB00696 Ergotamine DB06678 Esmirtazapine DB00292 Etomidate DB00800 Fenoldopam DB00629 Guanabenz DB01018 Guanfacine DB06707 Levonordefrin DB00589 Lisuride DB00408 Loxapine DB00934 Maprotiline DB01365 Mephentermine DB01577 Methamphetamine DB01403 Methotrimeprazine DB06148 Mianserin DB00368 Norepinephrine DB00540 Nortriptyline DB00334 Olanzapine DB05461 OPC-28326 DB00935 Oxymetazoline DB01267 Paliperidone DB01186 Pergolide DB00925 Phenoxybenzamine DB00413 Pramipexole DB00457 Prazosin DB01224 Quetiapine DB00734 Risperidone DB00268 Ropinirole DB05271 Rotigotine DB13025 Tiapride DB00697 Tizanidine DB00797 Tolazoline DB00726 Trimipramine DB06694 Xylometazoline DB01392 Yohimbine DB00246 Ziprasidone
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	26

Polymorphism and mutation databases

BioMutaⁱ	ADRA2B
DMDMⁱ	27151763

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000069094	1 – 450	Alpha-2B adrenergic receptorAdd BLAST		450

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Disulfide bondⁱ	85 ↔ 164	PROSITE-ProRule annotation
Lipidationⁱ	442	S-palmitoyl cysteineSequence analysis		1

Keywords - PTMⁱ

Disulfide bond, Lipoprotein, Palmitate

Proteomic databases

PaxDbⁱ	P18089
PeptideAtlas More...PeptideAtlasⁱ	P18089
PRIDEⁱ	P18089
ProteomicsDBⁱ	53548

PTM databases

PhosphoSitePlusⁱ	P18089

PhosphoSitePlusⁱ

P18089

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000274286 Expressed in 84 organ(s), highest expression level in apex of heart
CleanExⁱ	HS_ADRA2B

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA066029

HPAⁱ

HPA066029

Interactionⁱ

Subunit structureⁱ

Interacts with RAB26 (PubMed:23105096). Interacts with PPP1R9B (PubMed:24114805).2 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
RAB26	Q9ULW5	4	EBI-9077302,EBI-958239

With

Entry

#Exp.

IntAct

Notes

RAB26

Q9ULW5

4

EBI-9077302,EBI-958239

Protein-protein interaction databases

BioGridⁱ	106660, 3 interactors
Database of interacting proteins More...DIPⁱ	DIP-61453N
IntActⁱ	P18089, 3 interactors
STRINGⁱ	9606.ENSP00000387281

Chemistry databases

BindingDBⁱ

P18089

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P18089
SMRⁱ	P18089
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	294 – 311	Asp/Glu-rich (acidic)Add BLAST		18

Sequence similaritiesⁱ

Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2B sub-subfamily.PROSITE-ProRule annotation

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3656 Eukaryota ENOG410XRW9 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118795
HOGENOMⁱ	HOG000239242
HOVERGENⁱ	HBG106962
InParanoidⁱ	P18089
KEGG Orthology (KO) More...KOⁱ	K04139
OMAⁱ	WCEVYLA
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G06VI
PhylomeDBⁱ	P18089
TreeFamⁱ	TF316350

Family and domain databases

InterProⁱ	View protein in InterPro IPR002233 ADR_fam IPR000207 ADRA2B_rcpt IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR01103 ADRENERGICR PR00559 ADRENRGCA2BR PR00237 GPCRRHODOPSN
SMARTⁱ	View protein in SMART SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P18089-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MDHQDPYSVQ ATAAIAAAIT FLILFTIFGN ALVILAVLTS RSLRAPQNLF 
        60         70         80         90        100
LVSLAAADIL VATLIIPFSL ANELLGYWYF RRTWCEVYLA LDVLFCTSSI 
       110        120        130        140        150
VHLCAISLDR YWAVSRALEY NSKRTPRRIK CIILTVWLIA AVISLPPLIY 
       160        170        180        190        200
KGDQGPQPRG RPQCKLNQEA WYILASSIGS FFAPCLIMIL VYLRIYLIAK 
       210        220        230        240        250
RSNRRGPRAK GGPGQGESKQ PRPDHGGALA SAKLPALASV ASAREVNGHS 
       260        270        280        290        300
KSTGEKEEGE TPEDTGTRAL PPSWAALPNS GQGQKEGVCG ASPEDEAEEE 
       310        320        330        340        350
EEEEEEEEEC EPQAVPVSPA SACSPPLQQP QGSRVLATLR GQVLLGRGVG 
       360        370        380        390        400
AIGGQWWRRR AQLTREKRFT FVLAVVIGVF VLCWFPFFFS YSLGAICPKH 
       410        420        430        440        450
CKVPHGLFQF FFWIGYCNSS LNPVIYTIFN QDFRRAFRRI LCRPWTQTAW

Length:450

Mass (Da):49,954

Last modified:March 15, 2017 - v4

Checksum:ⁱ06E43857152A68ED

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	362 – 363	QL → HV in AAA51666 (PubMed:2164221).Curated		2
Sequence conflictⁱ	362 – 363	QL → HV no nucleotide entry (PubMed:2172775).Curated		2

Polymorphismⁱ

A rare polymorphic frameshift in position 451 produces a protein of 545 residues.1 Publication

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_025099	211	G → A1 PublicationCorresponds to variant dbSNP:rs9333568Ensembl.	1
Natural variantⁱVAR_073953	225 – 229	HGGAL → QFGR in FAME2; gain of function; decreases interaction with PPP1R9B upon activation by neurotransmitter. 1 Publication	5
Natural variantⁱVAR_070775	301 – 303	Missing Polymorphism; found with a frequency of 0.31 in Caucasians and 0.12 in African-Americans; exhibits impaired phosphorylation and desensitization by G protein-coupled receptor kinases; does not affect ligand-binding. 2 Publications	3
Natural variantⁱVAR_033462	376	V → I. Corresponds to variant dbSNP:rs29000569Ensembl.	1
Natural variantⁱVAR_025100	379	V → G1 PublicationCorresponds to variant dbSNP:rs527655811Ensembl.	1
Natural variantⁱVAR_033463	379	V → I. Corresponds to variant dbSNP:rs29000569Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M34041 Genomic DNA Translation: AAA51666.1 AF316895 Genomic DNA Translation: AAK01635.1 AF005900 Genomic DNA Translation: AAB62558.1 AY548167 Genomic DNA Translation: AAS55646.1 DQ057076 Genomic DNA Translation: AAY43127.1 EU332847 Genomic DNA Translation: ABY87536.1 AC092603 Genomic DNA Translation: AAX93218.1 KF573706 Genomic DNA No translation available. CH471207 Genomic DNA Translation: EAW71390.1 BC133021 mRNA Translation: AAI33022.1 BC136537 mRNA Translation: AAI36538.1 M38742 Genomic DNA Translation: AAA62823.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS56129.1
PIRⁱ	A37223
NCBI Reference Sequences More...RefSeqⁱ	NP_000673.2, NM_000682.6
UniGeneⁱ	Hs.247686

Genome annotation databases

Ensemblⁱ	ENST00000620793; ENSP00000480573; ENSG00000274286
GeneIDⁱ	151
KEGGⁱ	hsa:151
UCSC genome browser More...UCSCⁱ	uc032nvj.2 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P18089	Uncharacterized protein		PAPAN		524	UniRef90_P18089
Uncharacterized protein (Fragment)		MACFA		68
Adrenoceptor alpha 2B		GORGO		454
Uncharacterized protein		COLAP		452
ADRA2B isoform 1		PONAB		452
+48

Protein	Similar proteins		Species	Score	Length	Source
P18089	Alpha-2A adrenergic receptor		BOVIN		452	UniRef50_P18089
Uncharacterized protein		PAPAN		524
Uncharacterized protein (Fragment)		MACFA		68
Adrenoceptor alpha 2B		GORGO		454
Alpha-2B adrenergic receptor		CASCN		452
+130

Cross-referencesⁱ

Web resourcesⁱ

SeattleSNPs

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M34041 Genomic DNA Translation: AAA51666.1 AF316895 Genomic DNA Translation: AAK01635.1 AF005900 Genomic DNA Translation: AAB62558.1 AY548167 Genomic DNA Translation: AAS55646.1 DQ057076 Genomic DNA Translation: AAY43127.1 EU332847 Genomic DNA Translation: ABY87536.1 AC092603 Genomic DNA Translation: AAX93218.1 KF573706 Genomic DNA No translation available. CH471207 Genomic DNA Translation: EAW71390.1 BC133021 mRNA Translation: AAI33022.1 BC136537 mRNA Translation: AAI36538.1 M38742 Genomic DNA Translation: AAA62823.1
CCDSⁱ	CCDS56129.1
PIRⁱ	A37223
RefSeqⁱ	NP_000673.2, NM_000682.6
UniGeneⁱ	Hs.247686

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2CVA	model	-	A	97-128	[»]
ProteinModelPortalⁱ	P18089
SMRⁱ	P18089
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	106660, 3 interactors
DIPⁱ	DIP-61453N
IntActⁱ	P18089, 3 interactors
STRINGⁱ	9606.ENSP00000387281

Chemistry databases

BindingDBⁱ	P18089
ChEMBLⁱ	CHEMBL1942
DrugBankⁱ	DB00543 Amoxapine DB00182 Amphetamine DB00714 Apomorphine DB00964 Apraclonidine DB01238 Aripiprazole DB06216 Asenapine DB00217 Bethanidine DB00484 Brimonidine DB01200 Bromocriptine DB00248 Cabergoline DB01136 Carvedilol DB00477 Chlorpromazine DB09202 Cirazoline DB00575 Clonidine DB00363 Clozapine DB01151 Desipramine DB01142 Doxepin DB04855 Dronedarone DB06262 Droxidopa DB01363 Ephedra DB05492 Epicept NP-1 DB00668 Epinephrine DB01049 Ergoloid mesylate DB00696 Ergotamine DB06678 Esmirtazapine DB00292 Etomidate DB00800 Fenoldopam DB00629 Guanabenz DB01018 Guanfacine DB06707 Levonordefrin DB00589 Lisuride DB00408 Loxapine DB00934 Maprotiline DB01365 Mephentermine DB01577 Methamphetamine DB01403 Methotrimeprazine DB06148 Mianserin DB00368 Norepinephrine DB00540 Nortriptyline DB00334 Olanzapine DB05461 OPC-28326 DB00935 Oxymetazoline DB01267 Paliperidone DB01186 Pergolide DB00925 Phenoxybenzamine DB00413 Pramipexole DB00457 Prazosin DB01224 Quetiapine DB00734 Risperidone DB00268 Ropinirole DB05271 Rotigotine DB13025 Tiapride DB00697 Tizanidine DB00797 Tolazoline DB00726 Trimipramine DB06694 Xylometazoline DB01392 Yohimbine DB00246 Ziprasidone
GuidetoPHARMACOLOGYⁱ	26

Protein family/group databases

GPCRDBⁱ	Search...

GPCRDBⁱ

Search...

PTM databases

PhosphoSitePlusⁱ	P18089

PhosphoSitePlusⁱ

P18089

Polymorphism and mutation databases

BioMutaⁱ	ADRA2B
DMDMⁱ	27151763

Proteomic databases

PaxDbⁱ	P18089
PeptideAtlasⁱ	P18089
PRIDEⁱ	P18089
ProteomicsDBⁱ	53548

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	151
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000620793; ENSP00000480573; ENSG00000274286
GeneIDⁱ	151
KEGGⁱ	hsa:151
UCSCⁱ	uc032nvj.2 human

Organism-specific databases

CTDⁱ	151
DisGeNETⁱ	151
EuPathDBⁱ	HostDB:ENSG00000274286.1
GeneCardsⁱ	ADRA2B
H-InvDBⁱ	HIX0161945
HGNCⁱ	HGNC:282 ADRA2B
HPAⁱ	HPA066029
MalaCardsⁱ	ADRA2B
MIMⁱ	104260 gene 607876 phenotype
neXtProtⁱ	NX_P18089
OpenTargetsⁱ	ENSG00000274286
Orphanetⁱ	86814 Benign adult familial myoclonic epilepsy
PharmGKBⁱ	PA36
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3656 Eukaryota ENOG410XRW9 LUCA
GeneTreeⁱ	ENSGT00760000118795
HOGENOMⁱ	HOG000239242
HOVERGENⁱ	HBG106962
InParanoidⁱ	P18089
KOⁱ	K04139
OMAⁱ	WCEVYLA
OrthoDBⁱ	EOG091G06VI
PhylomeDBⁱ	P18089
TreeFamⁱ	TF316350

Enzyme and pathway databases

Reactomeⁱ	R-HSA-390696 Adrenoceptors R-HSA-392023 Adrenaline signalling through Alpha-2 adrenergic receptor R-HSA-418594 G alpha (i) signalling events R-HSA-418597 G alpha (z) signalling events
SignaLinkⁱ	P18089

Miscellaneous databases

GeneWikiⁱ	Alpha-2B_adrenergic_receptor
GenomeRNAiⁱ	151
Protein Ontology More...PROⁱ	PR:P18089
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000274286 Expressed in 84 organ(s), highest expression level in apex of heart
CleanExⁱ	HS_ADRA2B

Family and domain databases

InterProⁱ	View protein in InterPro IPR002233 ADR_fam IPR000207 ADRA2B_rcpt IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM
Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR01103 ADRENERGICR PR00559 ADRENRGCA2BR PR00237 GPCRRHODOPSN
SMARTⁱ	View protein in SMART SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ADA2B_HUMAN
Accessionⁱ	P18089Primary (citable) accession number: P18089 Secondary accession number(s): A2RUS0 , Q4TUH9, Q53RF2, Q9BZK0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1990
	Last sequence update:	March 15, 2017
	Last modified:	September 12, 2018
	This is version 187 of the entry and version 4 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries

UniProtKB

UniParc

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UniRef

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Supporting data

UniProtKB - P18089 (ADA2B_HUMAN)

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Alpha-2B adrenergic receptor

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ