UniProtKB - P18089 (ADA2B_HUMAN)
Protein
Alpha-2B adrenergic receptor
Gene
ADRA2B
Organism
Homo sapiens (Human)
Status
Functioni
Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is clonidine > norepinephrine > epinephrine = oxymetazoline > dopamine > p-tyramine = phenylephrine > serotonin > p-synephrine / p-octopamine. For antagonists, the rank order is yohimbine > chlorpromazine > phentolamine > mianserine > spiperone > prazosin > alprenolol > propanolol > pindolol.1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 92 | Implicated in ligand bindingBy similarity | 1 | |
Sitei | 176 | Implicated in catechol agonist bindingBy similarity | 1 | |
Sitei | 180 | Implicated in catechol agonist bindingBy similarity | 1 |
GO - Molecular functioni
- alpha2-adrenergic receptor activity Source: BHF-UCL
- epinephrine binding Source: BHF-UCL
- G protein-coupled receptor activity Source: GO_Central
GO - Biological processi
- activation of MAPK activity Source: Ensembl
- activation of protein kinase B activity Source: BHF-UCL
- adenylate cyclase-activating adrenergic receptor signaling pathway Source: GO_Central
- adrenergic receptor signaling pathway Source: BHF-UCL
- cell-cell signaling Source: ProtInc
- female pregnancy Source: Ensembl
- G protein-coupled receptor signaling pathway Source: BHF-UCL
- negative regulation of epinephrine secretion Source: BHF-UCL
- negative regulation of norepinephrine secretion Source: BHF-UCL
- platelet activation Source: InterPro
- positive regulation of blood pressure Source: Ensembl
- positive regulation of MAPK cascade Source: BHF-UCL
- positive regulation of neuron differentiation Source: BHF-UCL
- positive regulation of uterine smooth muscle contraction Source: Ensembl
- receptor transactivation Source: BHF-UCL
- regulation of vascular associated smooth muscle contraction Source: Ensembl
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
PathwayCommonsi | P18089 |
Reactomei | R-HSA-390696, Adrenoceptors R-HSA-392023, Adrenaline signalling through Alpha-2 adrenergic receptor R-HSA-418594, G alpha (i) signalling events R-HSA-418597, G alpha (z) signalling events |
SignaLinki | P18089 |
SIGNORi | P18089 |
Names & Taxonomyi
Protein namesi | Recommended name: Alpha-2B adrenergic receptorAlternative name(s): Alpha-2 adrenergic receptor subtype C2 Alpha-2B adrenoreceptor Short name: Alpha-2B adrenoceptor Short name: Alpha-2BAR |
Gene namesi | Name:ADRA2B Synonyms:ADRA2L1, ADRA2RL1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000274286.1 |
HGNCi | HGNC:282, ADRA2B |
MIMi | 104260, gene |
neXtProti | NX_P18089 |
Subcellular locationi
Plasma membrane
- Cell membrane 3 Publications; Multi-pass membrane protein 1 Publication
Note: Interaction with RAB26, GGA1, GGA2 and GGA3 mediates transport from the Golgi to the cell membrane.3 Publications
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
- plasma membrane Source: Reactome
Other locations
- cell surface Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 12 | ExtracellularBy similarityAdd BLAST | 12 | |
Transmembranei | 13 – 38 | Helical; Name=1By similarityAdd BLAST | 26 | |
Topological domaini | 39 – 48 | CytoplasmicBy similarity | 10 | |
Transmembranei | 49 – 69 | Helical; Name=2By similarityAdd BLAST | 21 | |
Topological domaini | 70 – 86 | ExtracellularBy similarityAdd BLAST | 17 | |
Transmembranei | 87 – 107 | Helical; Name=3By similarityAdd BLAST | 21 | |
Topological domaini | 108 – 128 | CytoplasmicBy similarityAdd BLAST | 21 | |
Transmembranei | 129 – 149 | Helical; Name=4By similarityAdd BLAST | 21 | |
Topological domaini | 150 – 172 | ExtracellularBy similarityAdd BLAST | 23 | |
Transmembranei | 173 – 193 | Helical; Name=5By similarityAdd BLAST | 21 | |
Topological domaini | 194 – 368 | CytoplasmicBy similarityAdd BLAST | 175 | |
Transmembranei | 369 – 389 | Helical; Name=6By similarityAdd BLAST | 21 | |
Topological domaini | 390 – 405 | ExtracellularBy similarityAdd BLAST | 16 | |
Transmembranei | 406 – 426 | Helical; Name=7By similarityAdd BLAST | 21 | |
Topological domaini | 427 – 450 | CytoplasmicBy similarityAdd BLAST | 24 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Involvement in diseasei
Epilepsy, familial adult myoclonic, 2 (FAME2)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of familial myoclonic epilepsy, a neurologic disorder characterized by cortical hand tremors, myoclonic jerks and occasional generalized or focal seizures with a non-progressive or very slowly progressive disease course. Usually, myoclonic tremor is the presenting symptom, characterized by tremulous finger movements and myoclonic jerks of the limbs increased by action and posture. In a minority of patients, seizures are the presenting symptom. Some patients exhibit mild cognitive impairment. FAME2 inheritance is autosomal dominant.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_073953 | 225 – 229 | HGGAL → QFGR in FAME2; gain of function; decreases interaction with PPP1R9B upon activation by neurotransmitter. 1 Publication | 5 |
Keywords - Diseasei
EpilepsyOrganism-specific databases
DisGeNETi | 151 |
MalaCardsi | ADRA2B |
MIMi | 607876, phenotype |
OpenTargetsi | ENSG00000274286 |
Orphaneti | 86814, Benign adult familial myoclonic epilepsy |
PharmGKBi | PA36 |
Miscellaneous databases
Pharosi | P18089, Tclin |
Chemistry databases
ChEMBLi | CHEMBL1942 |
DrugBanki | DB00543, Amoxapine DB00182, Amphetamine DB00714, Apomorphine DB00964, Apraclonidine DB09229, Aranidipine DB01238, Aripiprazole DB14185, Aripiprazole lauroxil DB06216, Asenapine DB00217, Bethanidine DB00484, Brimonidine DB01200, Bromocriptine DB00248, Cabergoline DB01136, Carvedilol DB04846, Celiprolol DB00477, Chlorpromazine DB09202, Cirazoline DB00575, Clonidine DB00363, Clozapine DB01151, Desipramine DB01576, Dextroamphetamine DB11273, Dihydroergocornine DB13345, Dihydroergocristine DB11278, DL-Methylephedrine DB09167, Dosulepin DB04855, Dronedarone DB06262, Droxidopa DB01363, Ephedra sinica root DB05492, Epicept NP-1 DB00668, Epinephrine DB01049, Ergoloid mesylate DB01175, Escitalopram DB06678, Esmirtazapine DB00292, Etomidate DB09194, Etoperidone DB00800, Fenoldopam DB00629, Guanabenz DB01018, Guanfacine DB00502, Haloperidol DB11577, Indigotindisulfonic acid DB06707, Levonordefrin DB00589, Lisuride DB09195, Lorpiprazole DB00408, Loxapine DB00934, Maprotiline DB01365, Mephentermine DB01577, Metamfetamine DB01403, Methotrimeprazine DB06148, Mianserin DB09205, Moxisylyte DB00368, Norepinephrine DB00540, Nortriptyline DB06229, Ocaperidone DB05461, OPC-28326 DB00935, Oxymetazoline DB01267, Paliperidone DB00715, Paroxetine DB01186, Pergolide DB00925, Phenoxybenzamine DB00397, Phenylpropanolamine DB06153, Pizotifen DB00457, Prazosin DB00433, Prochlorperazine DB01069, Promethazine DB01224, Quetiapine DB11124, Racepinephrine DB00734, Risperidone DB00268, Ropinirole DB05271, Rotigotine DB09304, Setiptiline DB13025, Tiapride DB00697, Tizanidine DB00797, Tolazoline DB00193, Tramadol DB00726, Trimipramine DB11477, Xylazine DB06694, Xylometazoline DB01392, Yohimbine DB00246, Ziprasidone |
DrugCentrali | P18089 |
GuidetoPHARMACOLOGYi | 26 |
Polymorphism and mutation databases
BioMutai | ADRA2B |
DMDMi | 27151763 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000069094 | 1 – 450 | Alpha-2B adrenergic receptorAdd BLAST | 450 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 85 ↔ 164 | PROSITE-ProRule annotation | ||
Lipidationi | 442 | S-palmitoyl cysteineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, Lipoprotein, PalmitateProteomic databases
PaxDbi | P18089 |
PeptideAtlasi | P18089 |
PRIDEi | P18089 |
ProteomicsDBi | 53548 |
PTM databases
PhosphoSitePlusi | P18089 |
Expressioni
Gene expression databases
Bgeei | ENSG00000274286, Expressed in apex of heart and 101 other tissues |
Organism-specific databases
HPAi | ENSG00000274286, Low tissue specificity |
Interactioni
Subunit structurei
Binary interactionsi
Hide detailsProtein-protein interaction databases
BioGRIDi | 106660, 7 interactors |
DIPi | DIP-61453N |
IntActi | P18089, 5 interactors |
STRINGi | 9606.ENSP00000480573 |
Chemistry databases
BindingDBi | P18089 |
Miscellaneous databases
RNActi | P18089, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P18089 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 294 – 311 | Asp/Glu-rich (acidic)Add BLAST | 18 |
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2B sub-subfamily.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT00940000161915 |
InParanoidi | P18089 |
OMAi | NSGQGQK |
OrthoDBi | 737211at2759 |
PhylomeDBi | P18089 |
TreeFami | TF316350 |
Family and domain databases
InterProi | View protein in InterPro IPR002233, ADR_fam IPR000207, ADRA2B_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR01103, ADRENERGICR PR00559, ADRENRGCA2BR PR00237, GPCRRHODOPSN |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P18089-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDHQDPYSVQ ATAAIAAAIT FLILFTIFGN ALVILAVLTS RSLRAPQNLF
60 70 80 90 100
LVSLAAADIL VATLIIPFSL ANELLGYWYF RRTWCEVYLA LDVLFCTSSI
110 120 130 140 150
VHLCAISLDR YWAVSRALEY NSKRTPRRIK CIILTVWLIA AVISLPPLIY
160 170 180 190 200
KGDQGPQPRG RPQCKLNQEA WYILASSIGS FFAPCLIMIL VYLRIYLIAK
210 220 230 240 250
RSNRRGPRAK GGPGQGESKQ PRPDHGGALA SAKLPALASV ASAREVNGHS
260 270 280 290 300
KSTGEKEEGE TPEDTGTRAL PPSWAALPNS GQGQKEGVCG ASPEDEAEEE
310 320 330 340 350
EEEEEEEEEC EPQAVPVSPA SACSPPLQQP QGSRVLATLR GQVLLGRGVG
360 370 380 390 400
AIGGQWWRRR AQLTREKRFT FVLAVVIGVF VLCWFPFFFS YSLGAICPKH
410 420 430 440 450
CKVPHGLFQF FFWIGYCNSS LNPVIYTIFN QDFRRAFRRI LCRPWTQTAW
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 362 – 363 | QL → HV in AAA51666 (PubMed:2164221).Curated | 2 | |
Sequence conflicti | 362 – 363 | QL → HV no nucleotide entry (PubMed:2172775).Curated | 2 |
Polymorphismi
A rare polymorphic frameshift in position 451 produces a protein of 545 residues.1 Publication
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_025099 | 211 | G → A1 PublicationCorresponds to variant dbSNP:rs9333568Ensembl. | 1 | |
Natural variantiVAR_073953 | 225 – 229 | HGGAL → QFGR in FAME2; gain of function; decreases interaction with PPP1R9B upon activation by neurotransmitter. 1 Publication | 5 | |
Natural variantiVAR_070775 | 301 – 303 | Missing Polymorphism; found with a frequency of 0.31 in Caucasians and 0.12 in African-Americans; exhibits impaired phosphorylation and desensitization by G protein-coupled receptor kinases; does not affect ligand-binding. 2 Publications | 3 | |
Natural variantiVAR_033462 | 376 | V → I. Corresponds to variant dbSNP:rs1431850417Ensembl. | 1 | |
Natural variantiVAR_025100 | 379 | V → G1 PublicationCorresponds to variant dbSNP:rs527655811Ensembl. | 1 | |
Natural variantiVAR_033463 | 379 | V → I. Corresponds to variant dbSNP:rs29000569EnsemblClinVar. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M34041 Genomic DNA Translation: AAA51666.1 AF316895 Genomic DNA Translation: AAK01635.1 AF005900 Genomic DNA Translation: AAB62558.1 AY548167 Genomic DNA Translation: AAS55646.1 DQ057076 Genomic DNA Translation: AAY43127.1 EU332847 Genomic DNA Translation: ABY87536.1 AC092603 Genomic DNA Translation: AAX93218.1 KF573706 Genomic DNA No translation available. CH471207 Genomic DNA Translation: EAW71390.1 BC133021 mRNA Translation: AAI33022.1 BC136537 mRNA Translation: AAI36538.1 M38742 Genomic DNA Translation: AAA62823.1 |
CCDSi | CCDS56129.1 |
PIRi | A37223 |
RefSeqi | NP_000673.2, NM_000682.6 |
Genome annotation databases
Ensembli | ENST00000620793; ENSP00000480573; ENSG00000274286 |
GeneIDi | 151 |
KEGGi | hsa:151 |
UCSCi | uc032nvj.2, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
SeattleSNPs |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M34041 Genomic DNA Translation: AAA51666.1 AF316895 Genomic DNA Translation: AAK01635.1 AF005900 Genomic DNA Translation: AAB62558.1 AY548167 Genomic DNA Translation: AAS55646.1 DQ057076 Genomic DNA Translation: AAY43127.1 EU332847 Genomic DNA Translation: ABY87536.1 AC092603 Genomic DNA Translation: AAX93218.1 KF573706 Genomic DNA No translation available. CH471207 Genomic DNA Translation: EAW71390.1 BC133021 mRNA Translation: AAI33022.1 BC136537 mRNA Translation: AAI36538.1 M38742 Genomic DNA Translation: AAA62823.1 |
CCDSi | CCDS56129.1 |
PIRi | A37223 |
RefSeqi | NP_000673.2, NM_000682.6 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2CVA | model | - | A | 97-128 | [»] | |
6K41 | electron microscopy | 2.90 | R | 9-450 | [»] | |
6K42 | electron microscopy | 4.10 | R | 7-450 | [»] | |
SMRi | P18089 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 106660, 7 interactors |
DIPi | DIP-61453N |
IntActi | P18089, 5 interactors |
STRINGi | 9606.ENSP00000480573 |
Chemistry databases
BindingDBi | P18089 |
ChEMBLi | CHEMBL1942 |
DrugBanki | DB00543, Amoxapine DB00182, Amphetamine DB00714, Apomorphine DB00964, Apraclonidine DB09229, Aranidipine DB01238, Aripiprazole DB14185, Aripiprazole lauroxil DB06216, Asenapine DB00217, Bethanidine DB00484, Brimonidine DB01200, Bromocriptine DB00248, Cabergoline DB01136, Carvedilol DB04846, Celiprolol DB00477, Chlorpromazine DB09202, Cirazoline DB00575, Clonidine DB00363, Clozapine DB01151, Desipramine DB01576, Dextroamphetamine DB11273, Dihydroergocornine DB13345, Dihydroergocristine DB11278, DL-Methylephedrine DB09167, Dosulepin DB04855, Dronedarone DB06262, Droxidopa DB01363, Ephedra sinica root DB05492, Epicept NP-1 DB00668, Epinephrine DB01049, Ergoloid mesylate DB01175, Escitalopram DB06678, Esmirtazapine DB00292, Etomidate DB09194, Etoperidone DB00800, Fenoldopam DB00629, Guanabenz DB01018, Guanfacine DB00502, Haloperidol DB11577, Indigotindisulfonic acid DB06707, Levonordefrin DB00589, Lisuride DB09195, Lorpiprazole DB00408, Loxapine DB00934, Maprotiline DB01365, Mephentermine DB01577, Metamfetamine DB01403, Methotrimeprazine DB06148, Mianserin DB09205, Moxisylyte DB00368, Norepinephrine DB00540, Nortriptyline DB06229, Ocaperidone DB05461, OPC-28326 DB00935, Oxymetazoline DB01267, Paliperidone DB00715, Paroxetine DB01186, Pergolide DB00925, Phenoxybenzamine DB00397, Phenylpropanolamine DB06153, Pizotifen DB00457, Prazosin DB00433, Prochlorperazine DB01069, Promethazine DB01224, Quetiapine DB11124, Racepinephrine DB00734, Risperidone DB00268, Ropinirole DB05271, Rotigotine DB09304, Setiptiline DB13025, Tiapride DB00697, Tizanidine DB00797, Tolazoline DB00193, Tramadol DB00726, Trimipramine DB11477, Xylazine DB06694, Xylometazoline DB01392, Yohimbine DB00246, Ziprasidone |
DrugCentrali | P18089 |
GuidetoPHARMACOLOGYi | 26 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
PhosphoSitePlusi | P18089 |
Polymorphism and mutation databases
BioMutai | ADRA2B |
DMDMi | 27151763 |
Proteomic databases
PaxDbi | P18089 |
PeptideAtlasi | P18089 |
PRIDEi | P18089 |
ProteomicsDBi | 53548 |
Protocols and materials databases
Antibodypediai | 72874, 112 antibodies |
DNASUi | 151 |
Genome annotation databases
Ensembli | ENST00000620793; ENSP00000480573; ENSG00000274286 |
GeneIDi | 151 |
KEGGi | hsa:151 |
UCSCi | uc032nvj.2, human |
Organism-specific databases
CTDi | 151 |
DisGeNETi | 151 |
EuPathDBi | HostDB:ENSG00000274286.1 |
GeneCardsi | ADRA2B |
HGNCi | HGNC:282, ADRA2B |
HPAi | ENSG00000274286, Low tissue specificity |
MalaCardsi | ADRA2B |
MIMi | 104260, gene 607876, phenotype |
neXtProti | NX_P18089 |
OpenTargetsi | ENSG00000274286 |
Orphaneti | 86814, Benign adult familial myoclonic epilepsy |
PharmGKBi | PA36 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT00940000161915 |
InParanoidi | P18089 |
OMAi | NSGQGQK |
OrthoDBi | 737211at2759 |
PhylomeDBi | P18089 |
TreeFami | TF316350 |
Enzyme and pathway databases
PathwayCommonsi | P18089 |
Reactomei | R-HSA-390696, Adrenoceptors R-HSA-392023, Adrenaline signalling through Alpha-2 adrenergic receptor R-HSA-418594, G alpha (i) signalling events R-HSA-418597, G alpha (z) signalling events |
SignaLinki | P18089 |
SIGNORi | P18089 |
Miscellaneous databases
BioGRID-ORCSi | 151, 2 hits in 846 CRISPR screens |
ChiTaRSi | ADRA2B, human |
GeneWikii | Alpha-2B_adrenergic_receptor |
GenomeRNAii | 151 |
Pharosi | P18089, Tclin |
PROi | PR:P18089 |
RNActi | P18089, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000274286, Expressed in apex of heart and 101 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR002233, ADR_fam IPR000207, ADRA2B_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR01103, ADRENERGICR PR00559, ADRENRGCA2BR PR00237, GPCRRHODOPSN |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ADA2B_HUMAN | |
Accessioni | P18089Primary (citable) accession number: P18089 Secondary accession number(s): A2RUS0 Q9BZK0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1990 |
Last sequence update: | March 15, 2017 | |
Last modified: | December 2, 2020 | |
This is version 204 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries