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UniProtKB - P18089 (ADA2B_HUMAN)

Entry version 206 (07 Apr 2021)
Sequence version 4 (15 Mar 2017)
Previous versions | rss
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Protein

Alpha-2B adrenergic receptor

Gene

ADRA2B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is clonidine > norepinephrine > epinephrine = oxymetazoline > dopamine > p-tyramine = phenylephrine > serotonin > p-synephrine / p-octopamine. For antagonists, the rank order is yohimbine > chlorpromazine > phentolamine > mianserine > spiperone > prazosin > alprenolol > propanolol > pindolol.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei92Implicated in ligand bindingBy similarity1
Sitei176Implicated in catechol agonist bindingBy similarity1
Sitei180Implicated in catechol agonist bindingBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P18089

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-390696, Adrenoceptors
R-HSA-392023, Adrenaline signalling through Alpha-2 adrenergic receptor
R-HSA-418594, G alpha (i) signalling events
R-HSA-418597, G alpha (z) signalling events

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P18089

SIGNOR Signaling Network Open Resource

More...SIGNORi		P18089

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Alpha-2B adrenergic receptor
Alternative name(s):
Alpha-2 adrenergic receptor subtype C2
Alpha-2B adrenoreceptor
Short name:
Alpha-2B adrenoceptor
Short name:
Alpha-2BAR
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ADRA2B
Synonyms:ADRA2L1, ADRA2RL1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:282, ADRA2B

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		104260, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P18089

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000274286.1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 12ExtracellularBy similarityAdd BLAST12
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei13 – 38Helical; Name=1By similarityAdd BLAST26
Topological domaini39 – 48CytoplasmicBy similarity10
Transmembranei49 – 69Helical; Name=2By similarityAdd BLAST21
Topological domaini70 – 86ExtracellularBy similarityAdd BLAST17
Transmembranei87 – 107Helical; Name=3By similarityAdd BLAST21
Topological domaini108 – 128CytoplasmicBy similarityAdd BLAST21
Transmembranei129 – 149Helical; Name=4By similarityAdd BLAST21
Topological domaini150 – 172ExtracellularBy similarityAdd BLAST23
Transmembranei173 – 193Helical; Name=5By similarityAdd BLAST21
Topological domaini194 – 368CytoplasmicBy similarityAdd BLAST175
Transmembranei369 – 389Helical; Name=6By similarityAdd BLAST21
Topological domaini390 – 405ExtracellularBy similarityAdd BLAST16
Transmembranei406 – 426Helical; Name=7By similarityAdd BLAST21
Topological domaini427 – 450CytoplasmicBy similarityAdd BLAST24

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Epilepsy, familial adult myoclonic, 2 (FAME2)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA form of familial myoclonic epilepsy, a neurologic disorder characterized by cortical hand tremors, myoclonic jerks and occasional generalized or focal seizures with a non-progressive or very slowly progressive disease course. Usually, myoclonic tremor is the presenting symptom, characterized by tremulous finger movements and myoclonic jerks of the limbs increased by action and posture. In a minority of patients, seizures are the presenting symptom. Some patients exhibit mild cognitive impairment. FAME2 inheritance is autosomal dominant.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_073953225 – 229HGGAL → QFGR in FAME2; gain of function; decreases interaction with PPP1R9B upon activation by neurotransmitter. 1 Publication5

Keywords - Diseasei

Epilepsy

Organism-specific databases

DisGeNET

More...DisGeNETi		151

MalaCards human disease database

More...MalaCardsi		ADRA2B
MIMi607876, phenotype

Open Targets

More...OpenTargetsi		ENSG00000274286

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		86814, Benign adult familial myoclonic epilepsy

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA36

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P18089, Tclin

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL1942

Drug and drug target database

More...DrugBanki		DB00543, Amoxapine
DB00182, Amphetamine
DB00714, Apomorphine
DB00964, Apraclonidine
DB09229, Aranidipine
DB01238, Aripiprazole
DB14185, Aripiprazole lauroxil
DB06216, Asenapine
DB00217, Bethanidine
DB00484, Brimonidine
DB01200, Bromocriptine
DB00248, Cabergoline
DB01136, Carvedilol
DB04846, Celiprolol
DB00477, Chlorpromazine
DB09202, Cirazoline
DB00575, Clonidine
DB00363, Clozapine
DB01151, Desipramine
DB01576, Dextroamphetamine
DB11273, Dihydroergocornine
DB13345, Dihydroergocristine
DB11278, DL-Methylephedrine
DB09167, Dosulepin
DB04855, Dronedarone
DB06262, Droxidopa
DB01363, Ephedra sinica root
DB05492, Epicept NP-1
DB00668, Epinephrine
DB01049, Ergoloid mesylate
DB01175, Escitalopram
DB06678, Esmirtazapine
DB00292, Etomidate
DB09194, Etoperidone
DB00800, Fenoldopam
DB00629, Guanabenz
DB01018, Guanfacine
DB00502, Haloperidol
DB11577, Indigotindisulfonic acid
DB06707, Levonordefrin
DB00589, Lisuride
DB09195, Lorpiprazole
DB00408, Loxapine
DB00934, Maprotiline
DB01365, Mephentermine
DB01577, Metamfetamine
DB01403, Methotrimeprazine
DB06148, Mianserin
DB09205, Moxisylyte
DB00368, Norepinephrine
DB00540, Nortriptyline
DB06229, Ocaperidone
DB05461, OPC-28326
DB00935, Oxymetazoline
DB01267, Paliperidone
DB00715, Paroxetine
DB01186, Pergolide
DB00925, Phenoxybenzamine
DB00397, Phenylpropanolamine
DB06153, Pizotifen
DB00457, Prazosin
DB00433, Prochlorperazine
DB01069, Promethazine
DB01224, Quetiapine
DB11124, Racepinephrine
DB00734, Risperidone
DB00268, Ropinirole
DB05271, Rotigotine
DB09304, Setiptiline
DB13025, Tiapride
DB00697, Tizanidine
DB00797, Tolazoline
DB00193, Tramadol
DB00726, Trimipramine
DB11477, Xylazine
DB06694, Xylometazoline
DB01392, Yohimbine
DB00246, Ziprasidone

DrugCentral

More...DrugCentrali		P18089

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		26

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ADRA2B

Domain mapping of disease mutations (DMDM)

More...DMDMi		27151763

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000690941 – 450Alpha-2B adrenergic receptorAdd BLAST450

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi85 ↔ 164PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi442S-palmitoyl cysteineSequence analysis1

Keywords - PTMi

Disulfide bond, Lipoprotein, Palmitate

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P18089

PeptideAtlas

More...PeptideAtlasi		P18089

PRoteomics IDEntifications database

More...PRIDEi		P18089

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		53548

PTM databases

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P18089

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000274286, Expressed in apex of heart and 101 other tissues

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000274286, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with RAB26 (PubMed:23105096).

Interacts with PPP1R9B (PubMed:24114805).

Interacts with GGA1, GGA2 and GGA3 (PubMed:27901063, PubMed:26811329).

4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		106660, 7 interactors

Database of interacting proteins

More...DIPi		DIP-61453N

Protein interaction database and analysis system

More...IntActi		P18089, 5 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000480573

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P18089

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P18089, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1450
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P18089

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi294 – 311Asp/Glu-rich (acidic)Add BLAST18

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2B sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3656, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000161915

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P18089

Identification of Orthologs from Complete Genome Data

More...OMAi		NSGQGQK

Database of Orthologous Groups

More...OrthoDBi		737211at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P18089

TreeFam database of animal gene trees

More...TreeFami		TF316350

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002233, ADR_fam
IPR000207, ADRA2B_rcpt
IPR000276, GPCR_Rhodpsn
IPR017452, GPCR_Rhodpsn_7TM

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00001, 7tm_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01103, ADRENERGICR
PR00559, ADRENRGCA2BR
PR00237, GPCRRHODOPSN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01381, 7TM_GPCR_Srsx, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00237, G_PROTEIN_RECEP_F1_1, 1 hit
PS50262, G_PROTEIN_RECEP_F1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P18089-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDHQDPYSVQ ATAAIAAAIT FLILFTIFGN ALVILAVLTS RSLRAPQNLF 
        60         70         80         90        100
LVSLAAADIL VATLIIPFSL ANELLGYWYF RRTWCEVYLA LDVLFCTSSI 
       110        120        130        140        150
VHLCAISLDR YWAVSRALEY NSKRTPRRIK CIILTVWLIA AVISLPPLIY 
       160        170        180        190        200
KGDQGPQPRG RPQCKLNQEA WYILASSIGS FFAPCLIMIL VYLRIYLIAK 
       210        220        230        240        250
RSNRRGPRAK GGPGQGESKQ PRPDHGGALA SAKLPALASV ASAREVNGHS 
       260        270        280        290        300
KSTGEKEEGE TPEDTGTRAL PPSWAALPNS GQGQKEGVCG ASPEDEAEEE 
       310        320        330        340        350
EEEEEEEEEC EPQAVPVSPA SACSPPLQQP QGSRVLATLR GQVLLGRGVG 
       360        370        380        390        400
AIGGQWWRRR AQLTREKRFT FVLAVVIGVF VLCWFPFFFS YSLGAICPKH 
       410        420        430        440        450
CKVPHGLFQF FFWIGYCNSS LNPVIYTIFN QDFRRAFRRI LCRPWTQTAW
Length:450
Mass (Da):49,954
Last modified:March 15, 2017 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i06E43857152A68ED
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti362 – 363QL → HV in AAA51666 (PubMed:2164221).Curated2
Sequence conflicti362 – 363QL → HV no nucleotide entry (PubMed:2172775).Curated2

<p>This subsection of the 'Sequence' section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement%5Fin%5Fdisease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

A rare polymorphic frameshift in position 451 produces a protein of 545 residues.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_025099211G → A1 PublicationCorresponds to variant dbSNP:rs9333568Ensembl.1
Natural variantiVAR_073953225 – 229HGGAL → QFGR in FAME2; gain of function; decreases interaction with PPP1R9B upon activation by neurotransmitter. 1 Publication5
Natural variantiVAR_070775301 – 303Missing Found with a frequency of 0.31 in Caucasians and 0.12 in African-Americans; exhibits impaired phosphorylation and desensitization by G protein-coupled receptor kinases; does not affect ligand-binding. 2 Publications3
Natural variantiVAR_033462376V → I. Corresponds to variant dbSNP:rs1431850417Ensembl.1
Natural variantiVAR_025100379V → G1 PublicationCorresponds to variant dbSNP:rs527655811Ensembl.1
Natural variantiVAR_033463379V → I. Corresponds to variant dbSNP:rs29000569EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M34041 Genomic DNA Translation: AAA51666.1
AF316895 Genomic DNA Translation: AAK01635.1
AF005900 Genomic DNA Translation: AAB62558.1
AY548167 Genomic DNA Translation: AAS55646.1
DQ057076 Genomic DNA Translation: AAY43127.1
EU332847 Genomic DNA Translation: ABY87536.1
AC092603 Genomic DNA Translation: AAX93218.1
KF573706 Genomic DNA No translation available.
CH471207 Genomic DNA Translation: EAW71390.1
BC133021 mRNA Translation: AAI33022.1
BC136537 mRNA Translation: AAI36538.1
M38742 Genomic DNA Translation: AAA62823.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS56129.1

Protein sequence database of the Protein Information Resource

More...PIRi		A37223

NCBI Reference Sequences

More...RefSeqi		NP_000673.2, NM_000682.6

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000620793; ENSP00000480573; ENSG00000274286

Database of genes from NCBI RefSeq genomes

More...GeneIDi		151

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:151

UCSC genome browser

More...UCSCi		uc032nvj.2, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M34041 Genomic DNA Translation: AAA51666.1
AF316895 Genomic DNA Translation: AAK01635.1
AF005900 Genomic DNA Translation: AAB62558.1
AY548167 Genomic DNA Translation: AAS55646.1
DQ057076 Genomic DNA Translation: AAY43127.1
EU332847 Genomic DNA Translation: ABY87536.1
AC092603 Genomic DNA Translation: AAX93218.1
KF573706 Genomic DNA No translation available.
CH471207 Genomic DNA Translation: EAW71390.1
BC133021 mRNA Translation: AAI33022.1
BC136537 mRNA Translation: AAI36538.1
M38742 Genomic DNA Translation: AAA62823.1
CCDSiCCDS56129.1
PIRiA37223
RefSeqiNP_000673.2, NM_000682.6

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CVAmodel-A97-128[»]
6K41electron microscopy2.90R9-450[»]
6K42electron microscopy4.10R7-450[»]
SMRiP18089
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi106660, 7 interactors
DIPiDIP-61453N
IntActiP18089, 5 interactors
STRINGi9606.ENSP00000480573

Chemistry databases

BindingDBiP18089
ChEMBLiCHEMBL1942
DrugBankiDB00543, Amoxapine
DB00182, Amphetamine
DB00714, Apomorphine
DB00964, Apraclonidine
DB09229, Aranidipine
DB01238, Aripiprazole
DB14185, Aripiprazole lauroxil
DB06216, Asenapine
DB00217, Bethanidine
DB00484, Brimonidine
DB01200, Bromocriptine
DB00248, Cabergoline
DB01136, Carvedilol
DB04846, Celiprolol
DB00477, Chlorpromazine
DB09202, Cirazoline
DB00575, Clonidine
DB00363, Clozapine
DB01151, Desipramine
DB01576, Dextroamphetamine
DB11273, Dihydroergocornine
DB13345, Dihydroergocristine
DB11278, DL-Methylephedrine
DB09167, Dosulepin
DB04855, Dronedarone
DB06262, Droxidopa
DB01363, Ephedra sinica root
DB05492, Epicept NP-1
DB00668, Epinephrine
DB01049, Ergoloid mesylate
DB01175, Escitalopram
DB06678, Esmirtazapine
DB00292, Etomidate
DB09194, Etoperidone
DB00800, Fenoldopam
DB00629, Guanabenz
DB01018, Guanfacine
DB00502, Haloperidol
DB11577, Indigotindisulfonic acid
DB06707, Levonordefrin
DB00589, Lisuride
DB09195, Lorpiprazole
DB00408, Loxapine
DB00934, Maprotiline
DB01365, Mephentermine
DB01577, Metamfetamine
DB01403, Methotrimeprazine
DB06148, Mianserin
DB09205, Moxisylyte
DB00368, Norepinephrine
DB00540, Nortriptyline
DB06229, Ocaperidone
DB05461, OPC-28326
DB00935, Oxymetazoline
DB01267, Paliperidone
DB00715, Paroxetine
DB01186, Pergolide
DB00925, Phenoxybenzamine
DB00397, Phenylpropanolamine
DB06153, Pizotifen
DB00457, Prazosin
DB00433, Prochlorperazine
DB01069, Promethazine
DB01224, Quetiapine
DB11124, Racepinephrine
DB00734, Risperidone
DB00268, Ropinirole
DB05271, Rotigotine
DB09304, Setiptiline
DB13025, Tiapride
DB00697, Tizanidine
DB00797, Tolazoline
DB00193, Tramadol
DB00726, Trimipramine
DB11477, Xylazine
DB06694, Xylometazoline
DB01392, Yohimbine
DB00246, Ziprasidone
DrugCentraliP18089
GuidetoPHARMACOLOGYi26

Protein family/group databases

Information system for G protein-coupled receptors (GPCRs)

More...GPCRDBi		Search...

PTM databases

PhosphoSitePlusiP18089

Genetic variation databases

BioMutaiADRA2B
DMDMi27151763

Proteomic databases

PaxDbiP18089
PeptideAtlasiP18089
PRIDEiP18089
ProteomicsDBi53548

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		72874, 116 antibodies

The DNASU plasmid repository

More...DNASUi		151

Genome annotation databases

EnsembliENST00000620793; ENSP00000480573; ENSG00000274286
GeneIDi151
KEGGihsa:151
UCSCiuc032nvj.2, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		151
DisGeNETi151

GeneCards: human genes, protein and diseases

More...GeneCardsi		ADRA2B
HGNCiHGNC:282, ADRA2B
HPAiENSG00000274286, Low tissue specificity
MalaCardsiADRA2B
MIMi104260, gene
607876, phenotype
neXtProtiNX_P18089
OpenTargetsiENSG00000274286
Orphaneti86814, Benign adult familial myoclonic epilepsy
PharmGKBiPA36
VEuPathDBiHostDB:ENSG00000274286.1

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3656, Eukaryota
GeneTreeiENSGT00940000161915
InParanoidiP18089
OMAiNSGQGQK
OrthoDBi737211at2759
PhylomeDBiP18089
TreeFamiTF316350

Enzyme and pathway databases

PathwayCommonsiP18089
ReactomeiR-HSA-390696, Adrenoceptors
R-HSA-392023, Adrenaline signalling through Alpha-2 adrenergic receptor
R-HSA-418594, G alpha (i) signalling events
R-HSA-418597, G alpha (z) signalling events
SignaLinkiP18089
SIGNORiP18089

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		151, 2 hits in 986 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ADRA2B, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Alpha-2B_adrenergic_receptor

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		151
PharosiP18089, Tclin

Protein Ontology

More...PROi		PR:P18089
RNActiP18089, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000274286, Expressed in apex of heart and 101 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR002233, ADR_fam
IPR000207, ADRA2B_rcpt
IPR000276, GPCR_Rhodpsn
IPR017452, GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001, 7tm_1, 1 hit
PRINTSiPR01103, ADRENERGICR
PR00559, ADRENRGCA2BR
PR00237, GPCRRHODOPSN
SMARTiView protein in SMART
SM01381, 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237, G_PROTEIN_RECEP_F1_1, 1 hit
PS50262, G_PROTEIN_RECEP_F1_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiADA2B_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P18089
Secondary accession number(s): A2RUS0
, Q4TUH9, Q53RF2, Q9BZK0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: March 15, 2017
Last modified: April 7, 2021
This is version 206 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with genetic variants
    List of human entries with genetic variants
  4. Human variants curated from literature reports
    Index of human variants curated from literature reports
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families
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