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Protein

5-aminolevulinate synthase, erythroid-specific, mitochondrial

Gene

ALAS2

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Miscellaneous

There are two delta-ALA synthases in vertebrates: an erythroid- specific form and one (housekeeping) which is expressed in all tissues.

Catalytic activityi

Succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2.

Cofactori

Pathwayi: protoporphyrin-IX biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 5-aminolevulinate from glycine.
Proteins known to be involved in this subpathway in this organism are:
  1. 5-aminolevulinate synthase, nonspecific, mitochondrial (ALAS1), 5-aminolevulinate synthase, erythroid-specific, mitochondrial (ALAS2), 5-aminolevulinate synthase (ALAS1), 5-aminolevulinate synthase (ALAS1), 5-aminolevulinate synthase (ALAS1)
This subpathway is part of the pathway protoporphyrin-IX biosynthesis, which is itself part of Porphyrin-containing compound metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-aminolevulinate from glycine, the pathway protoporphyrin-IX biosynthesis and in Porphyrin-containing compound metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei98SubstrateBy similarity1
Binding sitei212SubstrateBy similarity1
Binding sitei231SubstrateBy similarity1
Binding sitei264Pyridoxal phosphateBy similarity1
Binding sitei292Pyridoxal phosphateBy similarity1
Binding sitei320Pyridoxal phosphateBy similarity1
Active sitei323By similarity1
Binding sitei352Pyridoxal phosphate; shared with dimeric partnerBy similarity1
Binding sitei353Pyridoxal phosphate; shared with dimeric partnerBy similarity1
Binding sitei437SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processHeme biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

ReactomeiR-GGA-421525 Heme synthesis
UniPathwayiUPA00251; UER00375

Names & Taxonomyi

Protein namesi
Recommended name:
5-aminolevulinate synthase, erythroid-specific, mitochondrial (EC:2.3.1.37)
Short name:
ALAS-E
Alternative name(s):
5-aminolevulinic acid synthase 2
Delta-ALA synthase 2
Delta-aminolevulinate synthase 2
Gene namesi
Name:ALAS2
Synonyms:ALASE
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 18MitochondrionSequence analysisAdd BLAST18
ChainiPRO_000000122619 – 5135-aminolevulinate synthase, erythroid-specific, mitochondrialAdd BLAST495

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei323N6-(pyridoxal phosphate)lysineBy similarity1

Proteomic databases

PRIDEiP18080

Expressioni

Tissue specificityi

Erythroid specific.

Interactioni

Subunit structurei

Homodimer.

Structurei

3D structure databases

ProteinModelPortaliP18080
SMRiP18080
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOVERGENiHBG005954
InParanoidiP18080
PhylomeDBiP18080

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
InterProiView protein in InterPro
IPR010961 4pyrrol_synth_NH2levulA_synth
IPR001917 Aminotrans_II_pyridoxalP_BS
IPR004839 Aminotransferase_I/II
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00155 Aminotran_1_2, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR01821 5aminolev_synth, 1 hit
PROSITEiView protein in PROSITE
PS00599 AA_TRANSFER_CLASS_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P18080-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAFLRCPLL ARHPPLARAF ATGARCPFMG FAHRAAPELQ EDVERPQIPA
60 70 80 90 100
VEVLEELLRD GGAALNRTVR DCMDEDAFPY EEQFQAQLGA LRRTHTYRVV
110 120 130 140 150
TAVGRRADAP PLGTRGTAPH TSVELWCSSD YLGLSRHPAV LRAARAALDA
160 170 180 190 200
HGLGAGGTRN IGGTSPLHGA LERALALLHR QPRAALFSSC FAANDTALDT
210 220 230 240 250
LARILPGCQV YSDAGNHASM IQGIRRRGVP KFIFRHNDPH HLEQLLGRSP
260 270 280 290 300
PGVPKIVAFE SLHSMDGSIA PLEELCDVAH AYGALTFVDE VHAVGLYGAR
310 320 330 340 350
GAGIAERDGV QHKVDVVSGT LGKALGAVGG YIAGSEALVD AVRSLGPGFI
360 370 380 390 400
FTTALPPQRG GGALAALQVV GSAEGAALRR AHQRHAKHLR VLLRDRGLPA
410 420 430 440 450
LPSHIVPVRW DAEANTRLSR ALLEEHGLYV QAINHPTVPR GQELLLRIAP
460 470 480 490 500
TPHHSPPMLE NLADKLSECW GAVGLPREDP PGPSCSSCHR PLHLSLLSPL
510
ERDQFGVRGA AAG
Length:513
Mass (Da):54,778
Last modified:November 1, 1995 - v2
Checksum:iC319A4DE5294CF74
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M24367 mRNA Translation: AAA20400.1
PIRiA31452 SYCHLE

Similar proteinsi

Entry informationi

Entry nameiHEM0_CHICK
AccessioniPrimary (citable) accession number: P18080
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1995
Last modified: May 23, 2018
This is version 112 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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