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Protein

Insulin-like growth factor-binding protein 2

Gene

IGFBP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Inhibits IGF-mediated growth and developmental rates. IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • insulin-like growth factor I binding Source: UniProtKB
  • insulin-like growth factor II binding Source: UniProtKB
  • signaling receptor binding Source: ParkinsonsUK-UCL

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGrowth factor binding
Biological processGrowth regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P18065

Protein family/group databases

MEROPS protease database

More...
MEROPSi
I31.953

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Insulin-like growth factor-binding protein 2
Short name:
IBP-2
Short name:
IGF-binding protein 2
Short name:
IGFBP-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IGFBP2
Synonyms:BP2, IBP2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000115457.9

Human Gene Nomenclature Database

More...
HGNCi
HGNC:5471 IGFBP2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
146731 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P18065

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi216 – 219KKLR → NNLA: Does not disrupt growth-inhibiting activity. 1 Publication4
Mutagenesisi303D → E: Does not disrupt growth-inhibiting activity. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
3485

Open Targets

More...
OpenTargetsi
ENSG00000115457

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA29704

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3088

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
IGFBP2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
290457647

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 35Add BLAST35
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001437036 – 325Insulin-like growth factor-binding protein 2Add BLAST290

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi227 ↔ 261PROSITE-ProRule annotation1 Publication
Disulfide bondi272 ↔ 283PROSITE-ProRule annotation1 Publication
Disulfide bondi285 ↔ 306PROSITE-ProRule annotation1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

O-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P18065

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P18065

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P18065

PeptideAtlas

More...
PeptideAtlasi
P18065

PRoteomics IDEntifications database

More...
PRIDEi
P18065

ProteomicsDB human proteome resource

More...
ProteomicsDBi
53541

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P18065

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P18065

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
P18065

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000115457 Expressed in 195 organ(s), highest expression level in decidua

CleanEx database of gene expression profiles

More...
CleanExi
HS_IGFBP2

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P18065 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P18065 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA077723

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds IGF2 more than IGF1.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
INO80BQ9C0864EBI-2504392,EBI-715611

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
109706, 6 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
P18065

Protein interaction database and analysis system

More...
IntActi
P18065, 3 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000233809

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P18065

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1325
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2H7TNMR-A220-325[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P18065

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P18065

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P18065

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini38 – 134IGFBP N-terminalPROSITE-ProRule annotationAdd BLAST97
Domaini224 – 306Thyroglobulin type-1PROSITE-ProRule annotationAdd BLAST83

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi301 – 303Cell attachment site3

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The C-terminus is required for IGF-binding and growth inhibition.1 Publication

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IHUR Eukaryota
ENOG4111GWQ LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158542

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000253012

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG002631

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P18065

Identification of Orthologs from Complete Genome Data

More...
OMAi
DGTMNML

Database of Orthologous Groups

More...
OrthoDBi
979270at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P18065

TreeFam database of animal gene trees

More...
TreeFami
TF331211

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00191 TY, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
4.10.800.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009030 Growth_fac_rcpt_cys_sf
IPR012210 IGFBP-2
IPR000867 IGFBP-like
IPR009168 IGFBP1-6
IPR022321 IGFBP_1-6_chordata
IPR017891 Insulin_GF-bd_Cys-rich_CS
IPR000716 Thyroglobulin_1
IPR036857 Thyroglobulin_1_sf

The PANTHER Classification System

More...
PANTHERi
PTHR11551 PTHR11551, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00219 IGFBP, 1 hit
PF00086 Thyroglobulin_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01976 IGFBPFAMILY
PR01978 IGFBPFAMILY2

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00121 IB, 1 hit
SM00211 TY, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57184 SSF57184, 1 hit
SSF57610 SSF57610, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00222 IGFBP_N_1, 1 hit
PS51323 IGFBP_N_2, 1 hit
PS00484 THYROGLOBULIN_1_1, 1 hit
PS51162 THYROGLOBULIN_1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

P18065-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLPRVGCPAL PLPPPPLLPL LLLLLGASGG GGGARAEVLF RCPPCTPERL
60 70 80 90 100
AACGPPPVAP PAAVAAVAGG ARMPCAELVR EPGCGCCSVC ARLEGEACGV
110 120 130 140 150
YTPRCGQGLR CYPHPGSELP LQALVMGEGT CEKRRDAEYG ASPEQVADNG
160 170 180 190 200
DDHSEGGLVE NHVDSTMNML GGGGSAGRKP LKSGMKELAV FREKVTEQHR
210 220 230 240 250
QMGKGGKHHL GLEEPKKLRP PPARTPCQQE LDQVLERIST MRLPDERGPL
260 270 280 290 300
EHLYSLHIPN CDKHGLYNLK QCKMSLNGQR GECWCVNPNT GKLIQGAPTI
310 320
RGDPECHLFY NEQQEARGVH TQRMQ
Length:325
Mass (Da):34,814
Last modified:March 2, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9E1436DBCCC6EA2A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JMY1C9JMY1_HUMAN
Insulin-like growth factor-binding ...
IGFBP2
181Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JW52C9JW52_HUMAN
Insulin-like growth factor-binding ...
IGFBP2
78Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C1H0H7C1H0_HUMAN
Insulin-like growth factor-binding ...
IGFBP2
98Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti15P → PPLL in CAA34373 (PubMed:2479552).Curated1
Sequence conflicti15P → PPLL in AAA36048 (PubMed:1710112).Curated1
Sequence conflicti15P → PPLL in AAA03246 (PubMed:1712312).Curated1
Sequence conflicti15P → PPLL in AAB22308 (PubMed:1376411).Curated1
Sequence conflicti15P → PPLL in AAQ87876 (Ref. 7) Curated1
Sequence conflicti15P → PPLL in AAH04312 (PubMed:15489334).Curated1
Sequence conflicti15P → PPLL in AAH09902 (PubMed:15489334).Curated1
Sequence conflicti15P → PPLL in AAH12769 (PubMed:15489334).Curated1
Sequence conflicti15P → PPLL in AAH71967 (PubMed:15489334).Curated1
Sequence conflicti57P → R in AAA36048 (PubMed:1710112).Curated1
Sequence conflicti317R → C in CAA34373 (PubMed:2479552).Curated1
Sequence conflicti320H → D in AAA36048 (PubMed:1710112).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_018871137A → D1 PublicationCorresponds to variant dbSNP:rs9341096Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X16302 mRNA Translation: CAA34373.1
M69241
, M69237, M69239, M69240 Genomic DNA Translation: AAA36048.1
M35410 mRNA Translation: AAA03246.1
S37730
, S37712, S37722, S37726 Genomic DNA Translation: AAB22308.1
CR610845 mRNA No translation available.
AY398667 Genomic DNA Translation: AAQ87876.1
AC073321 Genomic DNA No translation available.
AC007563 Genomic DNA No translation available.
BC004312 mRNA Translation: AAH04312.1
BC009902 mRNA Translation: AAH09902.1
BC012769 mRNA Translation: AAH12769.1
BC071967 mRNA Translation: AAH71967.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS42815.1

Protein sequence database of the Protein Information Resource

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PIRi
A41927

NCBI Reference Sequences

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RefSeqi
NP_000588.2, NM_000597.2
NP_001300919.1, NM_001313990.1
NP_001300921.1, NM_001313992.1
NP_001300922.1, NM_001313993.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.438102

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000233809; ENSP00000233809; ENSG00000115457

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3485

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:3485

UCSC genome browser

More...
UCSCi
uc061sgd.1 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16302 mRNA Translation: CAA34373.1
M69241
, M69237, M69239, M69240 Genomic DNA Translation: AAA36048.1
M35410 mRNA Translation: AAA03246.1
S37730
, S37712, S37722, S37726 Genomic DNA Translation: AAB22308.1
CR610845 mRNA No translation available.
AY398667 Genomic DNA Translation: AAQ87876.1
AC073321 Genomic DNA No translation available.
AC007563 Genomic DNA No translation available.
BC004312 mRNA Translation: AAH04312.1
BC009902 mRNA Translation: AAH09902.1
BC012769 mRNA Translation: AAH12769.1
BC071967 mRNA Translation: AAH71967.1
CCDSiCCDS42815.1
PIRiA41927
RefSeqiNP_000588.2, NM_000597.2
NP_001300919.1, NM_001313990.1
NP_001300921.1, NM_001313992.1
NP_001300922.1, NM_001313993.1
UniGeneiHs.438102

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2H7TNMR-A220-325[»]
ProteinModelPortaliP18065
SMRiP18065
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109706, 6 interactors
CORUMiP18065
IntActiP18065, 3 interactors
STRINGi9606.ENSP00000233809

Chemistry databases

BindingDBiP18065
ChEMBLiCHEMBL3088

Protein family/group databases

MEROPSiI31.953

PTM databases

iPTMnetiP18065
PhosphoSitePlusiP18065

Polymorphism and mutation databases

BioMutaiIGFBP2
DMDMi290457647

Proteomic databases

EPDiP18065
jPOSTiP18065
PaxDbiP18065
PeptideAtlasiP18065
PRIDEiP18065
ProteomicsDBi53541

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
3485
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000233809; ENSP00000233809; ENSG00000115457
GeneIDi3485
KEGGihsa:3485
UCSCiuc061sgd.1 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3485
DisGeNETi3485
EuPathDBiHostDB:ENSG00000115457.9

GeneCards: human genes, protein and diseases

More...
GeneCardsi
IGFBP2
HGNCiHGNC:5471 IGFBP2
HPAiHPA077723
MIMi146731 gene
neXtProtiNX_P18065
OpenTargetsiENSG00000115457
PharmGKBiPA29704

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IHUR Eukaryota
ENOG4111GWQ LUCA
GeneTreeiENSGT00940000158542
HOGENOMiHOG000253012
HOVERGENiHBG002631
InParanoidiP18065
OMAiDGTMNML
OrthoDBi979270at2759
PhylomeDBiP18065
TreeFamiTF331211

Enzyme and pathway databases

ReactomeiR-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
SIGNORiP18065

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
IGFBP2 human
EvolutionaryTraceiP18065

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
IGFBP2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
3485
PMAP-CutDBiP18065

Protein Ontology

More...
PROi
PR:P18065

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000115457 Expressed in 195 organ(s), highest expression level in decidua
CleanExiHS_IGFBP2
ExpressionAtlasiP18065 baseline and differential
GenevisibleiP18065 HS

Family and domain databases

CDDicd00191 TY, 1 hit
Gene3Di4.10.800.10, 1 hit
InterProiView protein in InterPro
IPR009030 Growth_fac_rcpt_cys_sf
IPR012210 IGFBP-2
IPR000867 IGFBP-like
IPR009168 IGFBP1-6
IPR022321 IGFBP_1-6_chordata
IPR017891 Insulin_GF-bd_Cys-rich_CS
IPR000716 Thyroglobulin_1
IPR036857 Thyroglobulin_1_sf
PANTHERiPTHR11551 PTHR11551, 1 hit
PfamiView protein in Pfam
PF00219 IGFBP, 1 hit
PF00086 Thyroglobulin_1, 1 hit
PRINTSiPR01976 IGFBPFAMILY
PR01978 IGFBPFAMILY2
SMARTiView protein in SMART
SM00121 IB, 1 hit
SM00211 TY, 1 hit
SUPFAMiSSF57184 SSF57184, 1 hit
SSF57610 SSF57610, 1 hit
PROSITEiView protein in PROSITE
PS00222 IGFBP_N_1, 1 hit
PS51323 IGFBP_N_2, 1 hit
PS00484 THYROGLOBULIN_1_1, 1 hit
PS51162 THYROGLOBULIN_1_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIBP2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P18065
Secondary accession number(s): Q14619, Q9UCL3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: March 2, 2010
Last modified: January 16, 2019
This is version 192 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
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