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Protein

Insulin-like growth factor-binding protein 2

Gene

IGFBP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibits IGF-mediated growth and developmental rates. IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.1 Publication

GO - Molecular functioni

  • insulin-like growth factor I binding Source: UniProtKB
  • insulin-like growth factor II binding Source: UniProtKB
  • signaling receptor binding Source: ParkinsonsUK-UCL

GO - Biological processi

Keywordsi

Molecular functionGrowth factor binding
Biological processGrowth regulation

Enzyme and pathway databases

ReactomeiR-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
SIGNORiP18065

Protein family/group databases

MEROPSiI31.953

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin-like growth factor-binding protein 2
Short name:
IBP-2
Short name:
IGF-binding protein 2
Short name:
IGFBP-2
Gene namesi
Name:IGFBP2
Synonyms:BP2, IBP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000115457.9
HGNCiHGNC:5471 IGFBP2
MIMi146731 gene
neXtProtiNX_P18065

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi216 – 219KKLR → NNLA: Does not disrupt growth-inhibiting activity. 1 Publication4
Mutagenesisi303D → E: Does not disrupt growth-inhibiting activity. 1 Publication1

Organism-specific databases

DisGeNETi3485
OpenTargetsiENSG00000115457
PharmGKBiPA29704

Chemistry databases

ChEMBLiCHEMBL3088

Polymorphism and mutation databases

BioMutaiIGFBP2
DMDMi290457647

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 35Add BLAST35
ChainiPRO_000001437036 – 325Insulin-like growth factor-binding protein 2Add BLAST290

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi227 ↔ 261PROSITE-ProRule annotation1 Publication
Disulfide bondi272 ↔ 283PROSITE-ProRule annotation1 Publication
Disulfide bondi285 ↔ 306PROSITE-ProRule annotation1 Publication

Post-translational modificationi

O-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiP18065
PaxDbiP18065
PeptideAtlasiP18065
PRIDEiP18065
ProteomicsDBi53541

PTM databases

iPTMnetiP18065
PhosphoSitePlusiP18065

Miscellaneous databases

PMAP-CutDBiP18065

Expressioni

Gene expression databases

BgeeiENSG00000115457 Expressed in 195 organ(s), highest expression level in decidua
CleanExiHS_IGFBP2
ExpressionAtlasiP18065 baseline and differential
GenevisibleiP18065 HS

Organism-specific databases

HPAiHPA077723

Interactioni

Subunit structurei

Binds IGF2 more than IGF1.

Binary interactionsi

WithEntry#Exp.IntActNotes
INO80BQ9C0864EBI-2504392,EBI-715611

GO - Molecular functioni

Protein-protein interaction databases

BioGridi109706, 6 interactors
CORUMiP18065
IntActiP18065, 3 interactors
STRINGi9606.ENSP00000233809

Chemistry databases

BindingDBiP18065

Structurei

Secondary structure

1325
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP18065
SMRiP18065
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP18065

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini38 – 134IGFBP N-terminalPROSITE-ProRule annotationAdd BLAST97
Domaini224 – 306Thyroglobulin type-1PROSITE-ProRule annotationAdd BLAST83

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi301 – 303Cell attachment site3

Domaini

The C-terminus is required for IGF-binding and growth inhibition.1 Publication

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IHUR Eukaryota
ENOG4111GWQ LUCA
GeneTreeiENSGT00550000074457
HOGENOMiHOG000253012
HOVERGENiHBG002631
InParanoidiP18065
OMAiDGTMNML
OrthoDBiEOG091G0EIN
PhylomeDBiP18065
TreeFamiTF331211

Family and domain databases

CDDicd00191 TY, 1 hit
Gene3Di4.10.800.10, 1 hit
InterProiView protein in InterPro
IPR009030 Growth_fac_rcpt_cys_sf
IPR012210 IGFBP-2
IPR000867 IGFBP-like
IPR009168 IGFBP1-6
IPR022321 IGFBP_1-6_chordata
IPR017891 Insulin_GF-bd_Cys-rich_CS
IPR000716 Thyroglobulin_1
IPR036857 Thyroglobulin_1_sf
PANTHERiPTHR11551 PTHR11551, 1 hit
PfamiView protein in Pfam
PF00219 IGFBP, 1 hit
PF00086 Thyroglobulin_1, 1 hit
PRINTSiPR01976 IGFBPFAMILY
PR01978 IGFBPFAMILY2
SMARTiView protein in SMART
SM00121 IB, 1 hit
SM00211 TY, 1 hit
SUPFAMiSSF57184 SSF57184, 1 hit
SSF57610 SSF57610, 1 hit
PROSITEiView protein in PROSITE
PS00222 IGFBP_N_1, 1 hit
PS51323 IGFBP_N_2, 1 hit
PS00484 THYROGLOBULIN_1_1, 1 hit
PS51162 THYROGLOBULIN_1_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

P18065-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLPRVGCPAL PLPPPPLLPL LLLLLGASGG GGGARAEVLF RCPPCTPERL
60 70 80 90 100
AACGPPPVAP PAAVAAVAGG ARMPCAELVR EPGCGCCSVC ARLEGEACGV
110 120 130 140 150
YTPRCGQGLR CYPHPGSELP LQALVMGEGT CEKRRDAEYG ASPEQVADNG
160 170 180 190 200
DDHSEGGLVE NHVDSTMNML GGGGSAGRKP LKSGMKELAV FREKVTEQHR
210 220 230 240 250
QMGKGGKHHL GLEEPKKLRP PPARTPCQQE LDQVLERIST MRLPDERGPL
260 270 280 290 300
EHLYSLHIPN CDKHGLYNLK QCKMSLNGQR GECWCVNPNT GKLIQGAPTI
310 320
RGDPECHLFY NEQQEARGVH TQRMQ
Length:325
Mass (Da):34,814
Last modified:March 2, 2010 - v2
Checksum:i9E1436DBCCC6EA2A
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JMY1C9JMY1_HUMAN
Insulin-like growth factor-binding ...
IGFBP2
181Annotation score:
C9JW52C9JW52_HUMAN
Insulin-like growth factor-binding ...
IGFBP2
78Annotation score:
H7C1H0H7C1H0_HUMAN
Insulin-like growth factor-binding ...
IGFBP2
98Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti15P → PPLL in CAA34373 (PubMed:2479552).Curated1
Sequence conflicti15P → PPLL in AAA36048 (PubMed:1710112).Curated1
Sequence conflicti15P → PPLL in AAA03246 (PubMed:1712312).Curated1
Sequence conflicti15P → PPLL in AAB22308 (PubMed:1376411).Curated1
Sequence conflicti15P → PPLL in AAQ87876 (Ref. 7) Curated1
Sequence conflicti15P → PPLL in AAH04312 (PubMed:15489334).Curated1
Sequence conflicti15P → PPLL in AAH09902 (PubMed:15489334).Curated1
Sequence conflicti15P → PPLL in AAH12769 (PubMed:15489334).Curated1
Sequence conflicti15P → PPLL in AAH71967 (PubMed:15489334).Curated1
Sequence conflicti57P → R in AAA36048 (PubMed:1710112).Curated1
Sequence conflicti317R → C in CAA34373 (PubMed:2479552).Curated1
Sequence conflicti320H → D in AAA36048 (PubMed:1710112).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_018871137A → D1 PublicationCorresponds to variant dbSNP:rs9341096Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16302 mRNA Translation: CAA34373.1
M69241
, M69237, M69239, M69240 Genomic DNA Translation: AAA36048.1
M35410 mRNA Translation: AAA03246.1
S37730
, S37712, S37722, S37726 Genomic DNA Translation: AAB22308.1
CR610845 mRNA No translation available.
AY398667 Genomic DNA Translation: AAQ87876.1
AC073321 Genomic DNA No translation available.
AC007563 Genomic DNA No translation available.
BC004312 mRNA Translation: AAH04312.1
BC009902 mRNA Translation: AAH09902.1
BC012769 mRNA Translation: AAH12769.1
BC071967 mRNA Translation: AAH71967.1
CCDSiCCDS42815.1
PIRiA41927
RefSeqiNP_000588.2, NM_000597.2
NP_001300919.1, NM_001313990.1
NP_001300921.1, NM_001313992.1
NP_001300922.1, NM_001313993.1
UniGeneiHs.438102

Genome annotation databases

EnsembliENST00000233809; ENSP00000233809; ENSG00000115457
GeneIDi3485
KEGGihsa:3485
UCSCiuc061sgd.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16302 mRNA Translation: CAA34373.1
M69241
, M69237, M69239, M69240 Genomic DNA Translation: AAA36048.1
M35410 mRNA Translation: AAA03246.1
S37730
, S37712, S37722, S37726 Genomic DNA Translation: AAB22308.1
CR610845 mRNA No translation available.
AY398667 Genomic DNA Translation: AAQ87876.1
AC073321 Genomic DNA No translation available.
AC007563 Genomic DNA No translation available.
BC004312 mRNA Translation: AAH04312.1
BC009902 mRNA Translation: AAH09902.1
BC012769 mRNA Translation: AAH12769.1
BC071967 mRNA Translation: AAH71967.1
CCDSiCCDS42815.1
PIRiA41927
RefSeqiNP_000588.2, NM_000597.2
NP_001300919.1, NM_001313990.1
NP_001300921.1, NM_001313992.1
NP_001300922.1, NM_001313993.1
UniGeneiHs.438102

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2H7TNMR-A220-325[»]
ProteinModelPortaliP18065
SMRiP18065
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109706, 6 interactors
CORUMiP18065
IntActiP18065, 3 interactors
STRINGi9606.ENSP00000233809

Chemistry databases

BindingDBiP18065
ChEMBLiCHEMBL3088

Protein family/group databases

MEROPSiI31.953

PTM databases

iPTMnetiP18065
PhosphoSitePlusiP18065

Polymorphism and mutation databases

BioMutaiIGFBP2
DMDMi290457647

Proteomic databases

EPDiP18065
PaxDbiP18065
PeptideAtlasiP18065
PRIDEiP18065
ProteomicsDBi53541

Protocols and materials databases

DNASUi3485
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000233809; ENSP00000233809; ENSG00000115457
GeneIDi3485
KEGGihsa:3485
UCSCiuc061sgd.1 human

Organism-specific databases

CTDi3485
DisGeNETi3485
EuPathDBiHostDB:ENSG00000115457.9
GeneCardsiIGFBP2
HGNCiHGNC:5471 IGFBP2
HPAiHPA077723
MIMi146731 gene
neXtProtiNX_P18065
OpenTargetsiENSG00000115457
PharmGKBiPA29704
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHUR Eukaryota
ENOG4111GWQ LUCA
GeneTreeiENSGT00550000074457
HOGENOMiHOG000253012
HOVERGENiHBG002631
InParanoidiP18065
OMAiDGTMNML
OrthoDBiEOG091G0EIN
PhylomeDBiP18065
TreeFamiTF331211

Enzyme and pathway databases

ReactomeiR-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
SIGNORiP18065

Miscellaneous databases

ChiTaRSiIGFBP2 human
EvolutionaryTraceiP18065
GeneWikiiIGFBP2
GenomeRNAii3485
PMAP-CutDBiP18065
PROiPR:P18065
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000115457 Expressed in 195 organ(s), highest expression level in decidua
CleanExiHS_IGFBP2
ExpressionAtlasiP18065 baseline and differential
GenevisibleiP18065 HS

Family and domain databases

CDDicd00191 TY, 1 hit
Gene3Di4.10.800.10, 1 hit
InterProiView protein in InterPro
IPR009030 Growth_fac_rcpt_cys_sf
IPR012210 IGFBP-2
IPR000867 IGFBP-like
IPR009168 IGFBP1-6
IPR022321 IGFBP_1-6_chordata
IPR017891 Insulin_GF-bd_Cys-rich_CS
IPR000716 Thyroglobulin_1
IPR036857 Thyroglobulin_1_sf
PANTHERiPTHR11551 PTHR11551, 1 hit
PfamiView protein in Pfam
PF00219 IGFBP, 1 hit
PF00086 Thyroglobulin_1, 1 hit
PRINTSiPR01976 IGFBPFAMILY
PR01978 IGFBPFAMILY2
SMARTiView protein in SMART
SM00121 IB, 1 hit
SM00211 TY, 1 hit
SUPFAMiSSF57184 SSF57184, 1 hit
SSF57610 SSF57610, 1 hit
PROSITEiView protein in PROSITE
PS00222 IGFBP_N_1, 1 hit
PS51323 IGFBP_N_2, 1 hit
PS00484 THYROGLOBULIN_1_1, 1 hit
PS51162 THYROGLOBULIN_1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIBP2_HUMAN
AccessioniPrimary (citable) accession number: P18065
Secondary accession number(s): Q14619, Q9UCL3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: March 2, 2010
Last modified: November 7, 2018
This is version 190 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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