UniProtKB - P18052 (PTPRA_MOUSE)

BLAST

>sp|P18052|PTPRA_MOUSE Receptor-type tyrosine-protein phosphatase alpha OS=Mus musculus OX=10090 GN=Ptpra PE=1 SV=3
MDSWFILVLFGSGLIHVSANNATTVSPSLGTTRLIKTSTTELAKEENKTSNSTSSVISLS
VAPTFSPNLTLEPTYVTTVNSSHSDNGTRRAASTESGGTTISPNGSWLIENQFTDAITEP
WEGNSSTAATTPETFPPADETPIIAVMVALSSLLVIVFIIIVLYMLRFKKYKQAGSHSNS
FRLSNGRTEDVEPQSVPLLARSPSTNRKYPPLPVDKLEEEINRRMADDNKLFREEFNALP
ACPIQATCEAASKEENKEKNRYVNILPFLSLAVSKDAVKALNKTTPLLERRFIGKSNSRG
CLSDDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNT
ATIVMVTNLKERKECKCAQYWPDQGCWTYGNVRVSVEDVTVLVDYTVRKFCIQQVGDVTN
RKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFV
VIDAMLDMMHSERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELEVTS
LETHLQKIYNKIPGTSNNGLEEEFKKLTSIKIQNDKMRTGNLPANMKKNRVLQIIPYEFN
RVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLT
ELEERGQEKCAQYWPSDGLVSYGDITVELKKEEECESYTVRDLLVTNTRENKSRQIRQFH
FHGWPEVGIPSDGKGMINIIAAVQKQQQQSGNHPITVHCSAGAGRTGTFCALSTVLERVK
AEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYIDAFSDYANFK

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History
Entry version 180 (07 Nov 2018)
Sequence version 3 (27 Jul 2011)
Previous versions | rss
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Protein

Receptor-type tyrosine-protein phosphatase alpha

Gene

Ptpra

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Catalytic activityⁱ

Protein tyrosine phosphate + H₂O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	437	SubstrateBy similarity	1
Active siteⁱ	469	Phosphocysteine intermediateBy similarity	1
Binding siteⁱ	513	SubstrateBy similarity	1
Active siteⁱ	759	Phosphocysteine intermediateBy similarity	1

GO - Molecular functionⁱ

protein-containing complex binding Source: MGI
protein tyrosine phosphatase activity Source: MGI

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

insulin receptor signaling pathway
Source: MGI
Inferred from mutant phenotypeⁱ
- 14733908
modulation of chemical synaptic transmission
Source: SynGO
Inferred from mutant phenotypeⁱ
- 12912911
positive regulation of oligodendrocyte differentiation Source: MGI
protein phosphorylation
Source: MGI
Inferred from direct assayⁱ
- 14733908

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hydrolase, Protein phosphatase

Molecular function

Hydrolase, Protein phosphatase

Enzyme and pathway databases

Reactomeⁱ	R-MMU-375165 NCAM signaling for neurite out-growth R-MMU-5673001 RAF/MAP kinase cascade

Reactomeⁱ

R-MMU-375165 NCAM signaling for neurite out-growth
R-MMU-5673001 RAF/MAP kinase cascade

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Receptor-type tyrosine-protein phosphatase alpha (EC:3.1.3.48) Short name: Protein-tyrosine phosphatase alpha Short name: R-PTP-alpha Alternative name(s): LCA-related phosphatase PTPTY-28
Gene namesⁱ	Name:Ptpra Synonyms:Lrp, Ptpa
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 2

Organism-specific databases

MGIⁱ	MGI:97808 Ptpra

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	20 – 142	ExtracellularSequence analysisAdd BLAST	123
Transmembraneⁱ	143 – 166	HelicalSequence analysisAdd BLAST	24
Topological domainⁱ	167 – 829	CytoplasmicSequence analysisAdd BLAST	663

Keywords - Cellular componentⁱ

Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 19	CuratedAdd BLAST		19
ChainⁱPRO_0000025434	20 – 829	Receptor-type tyrosine-protein phosphatase alphaAdd BLAST		810

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	21	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	47	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	51	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	68	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	80	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	86	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	104	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	124	N-linked (GlcNAc...) asparagineSequence analysis	1
Modified residueⁱ	202	PhosphoserineCombined sources	1
Modified residueⁱ	204	PhosphoserineCombined sources	1
Modified residueⁱ	825	PhosphotyrosineCombined sources	1

Keywords - PTMⁱ

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P18052
PaxDbⁱ	P18052
PeptideAtlas More...PeptideAtlasⁱ	P18052
PRIDEⁱ	P18052

PTM databases

iPTMnetⁱ	P18052
PhosphoSitePlusⁱ	P18052

Expressionⁱ

Tissue specificityⁱ

Widely expressed. Highest expression in brain and kidney.3 Publications

Gene expression databases

Bgeeⁱ	ENSMUSG00000027303 Expressed in 286 organ(s), highest expression level in lens of camera-type eye
CleanExⁱ	MM_PTPRA
ExpressionAtlasⁱ	P18052 baseline and differential
Genevisibleⁱ	P18052 MM

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
Chl1	P70232	4	EBI-6597520,EBI-7703109
Grb2	Q60631	4	EBI-6597520,EBI-1688
Prkcb	P68403	3	EBI-6597520,EBI-397072	From Rattus norvegicus.
Ptprn	Q60673	3	EBI-6597520,EBI-8328895
SRC	P00523	2	EBI-6597520,EBI-848039	From Gallus gallus.
SRC	P12931	3	EBI-6597520,EBI-621482	From Homo sapiens.
Src	P05480	2	EBI-6597520,EBI-298680

Protein-protein interaction databases

BioGridⁱ	202491, 2 interactors
CORUMⁱ	P18052
IntActⁱ	P18052, 12 interactors
Molecular INTeraction database More...MINTⁱ	P18052
STRINGⁱ	10090.ENSMUSP00000076533

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	214 – 238	Combined sources	25
Helixⁱ	249 – 252	Combined sources	4
Helixⁱ	254 – 259	Combined sources	6
Turnⁱ	305 – 307	Combined sources	3
Turnⁱ	318 – 321	Combined sources	4
Beta strandⁱ	324 – 330	Combined sources	7
Beta strandⁱ	333 – 340	Combined sources	8
Helixⁱ	345 – 347	Combined sources	3
Helixⁱ	348 – 357	Combined sources	10
Beta strandⁱ	362 – 365	Combined sources	4
Beta strandⁱ	369 – 371	Combined sources	3
Beta strandⁱ	383 – 389	Combined sources	7
Beta strandⁱ	392 – 401	Combined sources	10
Beta strandⁱ	403 – 413	Combined sources	11
Beta strandⁱ	425 – 432	Combined sources	8
Beta strandⁱ	437 – 439	Combined sources	3
Helixⁱ	445 – 457	Combined sources	13
Beta strandⁱ	465 – 468	Combined sources	4
Beta strandⁱ	470 – 473	Combined sources	4
Helixⁱ	474 – 491	Combined sources	18
Beta strandⁱ	492 – 495	Combined sources	4
Helixⁱ	497 – 504	Combined sources	8
Turnⁱ	505 – 507	Combined sources	3
Helixⁱ	515 – 530	Combined sources	16
Helixⁱ	579 – 581	Combined sources	3
Turnⁱ	583 – 585	Combined sources	3
Beta strandⁱ	608 – 612	Combined sources	5
Beta strandⁱ	617 – 621	Combined sources	5
Beta strandⁱ	630 – 633	Combined sources	4
Beta strandⁱ	638 – 640	Combined sources	3
Helixⁱ	641 – 650	Combined sources	10
Beta strandⁱ	655 – 658	Combined sources	4
Beta strandⁱ	664 – 667	Combined sources	4
Beta strandⁱ	676 – 678	Combined sources	3
Beta strandⁱ	696 – 706	Combined sources	11
Beta strandⁱ	712 – 721	Combined sources	10
Beta strandⁱ	726 – 728	Combined sources	3
Beta strandⁱ	731 – 733	Combined sources	3
Helixⁱ	736 – 746	Combined sources	11
Turnⁱ	747 – 751	Combined sources	5
Beta strandⁱ	755 – 763	Combined sources	9
Helixⁱ	764 – 782	Combined sources	19
Helixⁱ	789 – 795	Combined sources	7
Turnⁱ	805 – 808	Combined sources	4
Helixⁱ	809 – 817	Combined sources	9
Turnⁱ	818 – 820	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	P18052
SMRⁱ	P18052
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

P18052

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	232 – 528	Tyrosine-protein phosphatase 1PROSITE-ProRule annotationAdd BLAST		297
Domainⁱ	560 – 818	Tyrosine-protein phosphatase 2PROSITE-ProRule annotationAdd BLAST		259

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	469 – 475	Substrate bindingBy similarity		7

Sequence similaritiesⁱ

Belongs to the protein-tyrosine phosphatase family. Receptor class 4 subfamily.Curated

Keywords - Domainⁱ

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG4228 Eukaryota COG5599 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118900
HOGENOMⁱ	HOG000231464
HOVERGENⁱ	HBG053758
InParanoidⁱ	P18052
KEGG Orthology (KO) More...KOⁱ	K18032
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G02ID
TreeFamⁱ	TF351829

Family and domain databases

Gene3Dⁱ	3.90.190.10, 1 hit
InterProⁱ	View protein in InterPro IPR029021 Prot-tyrosine_phosphatase-like IPR000242 PTPase_domain IPR016130 Tyr_Pase_AS IPR003595 Tyr_Pase_cat IPR016336 Tyr_Pase_rcpt_a/e-type IPR027262 Tyr_Pase_rcpt_alpha IPR000387 TYR_PHOSPHATASE_dom
PANTHERⁱ	PTHR19134:SF433 PTHR19134:SF433, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00102 Y_phosphatase, 2 hits
PIRSFⁱ	PIRSF500808 PTPR_alpha, 1 hit PIRSF002006 PTPR_alpha_epsilon, 1 hit
PRINTSⁱ	PR00700 PRTYPHPHTASE
SMARTⁱ	View protein in SMART SM00194 PTPc, 2 hits SM00404 PTPc_motif, 2 hits
SUPFAMⁱ	SSF52799 SSF52799, 2 hits
PROSITEⁱ	View protein in PROSITE PS00383 TYR_PHOSPHATASE_1, 2 hits PS50056 TYR_PHOSPHATASE_2, 2 hits PS50055 TYR_PHOSPHATASE_PTP, 2 hits

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P18052-1) [UniParc]FASTA Add to basket

Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDSWFILVLF GSGLIHVSAN NATTVSPSLG TTRLIKTSTT ELAKEENKTS 
        60         70         80         90        100
NSTSSVISLS VAPTFSPNLT LEPTYVTTVN SSHSDNGTRR AASTESGGTT 
       110        120        130        140        150
ISPNGSWLIE NQFTDAITEP WEGNSSTAAT TPETFPPADE TPIIAVMVAL 
       160        170        180        190        200
SSLLVIVFII IVLYMLRFKK YKQAGSHSNS FRLSNGRTED VEPQSVPLLA 
       210        220        230        240        250
RSPSTNRKYP PLPVDKLEEE INRRMADDNK LFREEFNALP ACPIQATCEA 
       260        270        280        290        300
ASKEENKEKN RYVNILPFLS LAVSKDAVKA LNKTTPLLER RFIGKSNSRG 
       310        320        330        340        350
CLSDDHSRVH LTPVEGVPDS DYINASFING YQEKNKFIAA QGPKEETVND 
       360        370        380        390        400
FWRMIWEQNT ATIVMVTNLK ERKECKCAQY WPDQGCWTYG NVRVSVEDVT 
       410        420        430        440        450
VLVDYTVRKF CIQQVGDVTN RKPQRLITQF HFTSWPDFGV PFTPIGMLKF 
       460        470        480        490        500
LKKVKACNPQ YAGAIVVHCS AGVGRTGTFV VIDAMLDMMH SERKVDVYGF 
       510        520        530        540        550
VSRIRAQRCQ MVQTDMQYVF IYQALLEHYL YGDTELEVTS LETHLQKIYN 
       560        570        580        590        600
KIPGTSNNGL EEEFKKLTSI KIQNDKMRTG NLPANMKKNR VLQIIPYEFN 
       610        620        630        640        650
RVIIPVKRGE ENTDYVNASF IDGYRQKDSY IASQGPLLHT IEDFWRMIWE 
       660        670        680        690        700
WKSCSIVMLT ELEERGQEKC AQYWPSDGLV SYGDITVELK KEEECESYTV 
       710        720        730        740        750
RDLLVTNTRE NKSRQIRQFH FHGWPEVGIP SDGKGMINII AAVQKQQQQS 
       760        770        780        790        800
GNHPITVHCS AGAGRTGTFC ALSTVLERVK AEGILDVFQT VKSLRLQRPH 
       810        820 
MVQTLEQYEF CYKVVQEYID AFSDYANFK

Length:829

Mass (Da):93,698

Last modified:July 27, 2011 - v3

Checksum:ⁱ4724A0F477D304B5

Isoform 2 (identifier: P18052-2) [UniParc]FASTA Add to basket

Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
268-268: F → Y
269-303: Missing.

« Hide

        10         20         30         40         50
MDSWFILVLF GSGLIHVSAN NATTVSPSLG TTRLIKTSTT ELAKEENKTS 
        60         70         80         90        100
NSTSSVISLS VAPTFSPNLT LEPTYVTTVN SSHSDNGTRR AASTESGGTT 
       110        120        130        140        150
ISPNGSWLIE NQFTDAITEP WEGNSSTAAT TPETFPPADE TPIIAVMVAL 
       160        170        180        190        200
SSLLVIVFII IVLYMLRFKK YKQAGSHSNS FRLSNGRTED VEPQSVPLLA 
       210        220        230        240        250
RSPSTNRKYP PLPVDKLEEE INRRMADDNK LFREEFNALP ACPIQATCEA 
       260        270        280        290        300
ASKEENKEKN RYVNILPYDD HSRVHLTPVE GVPDSDYINA SFINGYQEKN 
       310        320        330        340        350
KFIAAQGPKE ETVNDFWRMI WEQNTATIVM VTNLKERKEC KCAQYWPDQG 
       360        370        380        390        400
CWTYGNVRVS VEDVTVLVDY TVRKFCIQQV GDVTNRKPQR LITQFHFTSW 
       410        420        430        440        450
PDFGVPFTPI GMLKFLKKVK ACNPQYAGAI VVHCSAGVGR TGTFVVIDAM 
       460        470        480        490        500
LDMMHSERKV DVYGFVSRIR AQRCQMVQTD MQYVFIYQAL LEHYLYGDTE 
       510        520        530        540        550
LEVTSLETHL QKIYNKIPGT SNNGLEEEFK KLTSIKIQND KMRTGNLPAN 
       560        570        580        590        600
MKKNRVLQII PYEFNRVIIP VKRGEENTDY VNASFIDGYR QKDSYIASQG 
       610        620        630        640        650
PLLHTIEDFW RMIWEWKSCS IVMLTELEER GQEKCAQYWP SDGLVSYGDI 
       660        670        680        690        700
TVELKKEEEC ESYTVRDLLV TNTRENKSRQ IRQFHFHGWP EVGIPSDGKG 
       710        720        730        740        750
MINIIAAVQK QQQQSGNHPI TVHCSAGAGR TGTFCALSTV LERVKAEGIL 
       760        770        780        790 
DVFQTVKSLR LQRPHMVQTL EQYEFCYKVV QEYIDAFSDY ANFK

Show »

Length:794

Mass (Da):89,957

Checksum:ⁱ5A282BF9347D18A8

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

Q91V35	Q91V35_MOUSE	Receptor-type tyrosine-protein phos... Receptor-type tyrosine-protein phosphatase alpha, EC 3.1.3.48	Ptpra	793	Annotation score:
A0A2R8VHH6	A0A2R8VHH6_MOUSE	Receptor-type tyrosine-protein phos... Receptor-type tyrosine-protein phosphatase alpha	Ptpra	374	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	231	L → I in AAA39448 (PubMed:2162042).Curated	1
Sequence conflictⁱ	326	S → G (PubMed:1590786).Curated	1
Sequence conflictⁱ	411	C → S (PubMed:2166945).Curated	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_011880	268	F → Y in isoform 2. 2 Publications		1
Alternative sequenceⁱVSP_005146	269 – 303	Missing in isoform 2. 2 PublicationsAdd BLAST		35

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M36033 mRNA Translation: AAA39448.1 M36034 Genomic DNA Translation: AAA39449.2 L13607 Genomic DNA No translation available. AL731707 Genomic DNA Translation: CAM13265.1 CH466519 Genomic DNA Translation: EDL28272.1 Z23054 mRNA Translation: CAA80589.1 Z23055 mRNA Translation: CAA80590.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS16743.1 [P18052-1]
PIRⁱ	A47373
NCBI Reference Sequences More...RefSeqⁱ	NP_033006.2, NM_008980.2 [P18052-1]
UniGeneⁱ	Mm.224246

Genome annotation databases

Ensemblⁱ	ENSMUST00000077303; ENSMUSP00000076533; ENSMUSG00000027303 [P18052-1]
GeneIDⁱ	19262
KEGGⁱ	mmu:19262
UCSC genome browser More...UCSCⁱ	uc008mjc.2 mouse [P18052-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P18052	Receptor-type tyrosine-protein phosphatase alpha		LOXAF		831	UniRef90_P18052
P18052-2	Receptor-type tyrosine-protein phosphatase alpha		HUMAN		802	UniRef90_P18052-2
Receptor-type tyrosine-protein phosphatase alpha		RAT		796
Receptor-type tyrosine-protein phosphatase alpha		MYODS		947
Uncharacterized protein		PAPAN		845
Uncharacterized protein		MACMU		845
+331

Protein	Similar proteins		Species	Score	Length	Source
P18052	Receptor-type tyrosine-protein phosphatase alpha		LOXAF		831	UniRef50_P18052
Protein tyrosine phosphatase, receptor type, A (Fragment)		CALMI		330
receptor-type tyrosine-protein phosphatase alpha-like isoform X1		SALSA		852
Receptor-type tyrosine-protein phosphatase alpha		ONCMY		809
Receptor-type tyrosine-protein phosphatase alpha		MONDO		831
+180
P18052-2	Receptor-type tyrosine-protein phosphatase alpha		HUMAN		802	UniRef50_P18052-2
Receptor-type tyrosine-protein phosphatase alpha		RAT		796
Receptor-type tyrosine-protein phosphatase alpha		MYODS		947
Uncharacterized protein		MACMU		845
Uncharacterized protein		PAPAN		845
+466

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M36033 mRNA Translation: AAA39448.1 M36034 Genomic DNA Translation: AAA39449.2 L13607 Genomic DNA No translation available. AL731707 Genomic DNA Translation: CAM13265.1 CH466519 Genomic DNA Translation: EDL28272.1 Z23054 mRNA Translation: CAA80589.1 Z23055 mRNA Translation: CAA80590.1
CCDSⁱ	CCDS16743.1 [P18052-1]
PIRⁱ	A47373
RefSeqⁱ	NP_033006.2, NM_008980.2 [P18052-1]
UniGeneⁱ	Mm.224246

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1P15	X-ray	2.00	A/B	577-829	[»]
	1YFO	X-ray	2.25	A/B	202-539	[»]
ProteinModelPortalⁱ	P18052
SMRⁱ	P18052
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	202491, 2 interactors
CORUMⁱ	P18052
IntActⁱ	P18052, 12 interactors
MINTⁱ	P18052
STRINGⁱ	10090.ENSMUSP00000076533

PTM databases

iPTMnetⁱ	P18052
PhosphoSitePlusⁱ	P18052

Proteomic databases

MaxQBⁱ	P18052
PaxDbⁱ	P18052
PeptideAtlasⁱ	P18052
PRIDEⁱ	P18052

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000077303; ENSMUSP00000076533; ENSMUSG00000027303 [P18052-1]
GeneIDⁱ	19262
KEGGⁱ	mmu:19262
UCSCⁱ	uc008mjc.2 mouse [P18052-1]

Organism-specific databases

CTDⁱ	5786
MGIⁱ	MGI:97808 Ptpra

Phylogenomic databases

eggNOGⁱ	KOG4228 Eukaryota COG5599 LUCA
GeneTreeⁱ	ENSGT00760000118900
HOGENOMⁱ	HOG000231464
HOVERGENⁱ	HBG053758
InParanoidⁱ	P18052
KOⁱ	K18032
OrthoDBⁱ	EOG091G02ID
TreeFamⁱ	TF351829

Enzyme and pathway databases

Reactomeⁱ	R-MMU-375165 NCAM signaling for neurite out-growth R-MMU-5673001 RAF/MAP kinase cascade

Reactomeⁱ

R-MMU-375165 NCAM signaling for neurite out-growth
R-MMU-5673001 RAF/MAP kinase cascade

Miscellaneous databases

EvolutionaryTraceⁱ	P18052
Protein Ontology More...PROⁱ	PR:P18052
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000027303 Expressed in 286 organ(s), highest expression level in lens of camera-type eye
CleanExⁱ	MM_PTPRA
ExpressionAtlasⁱ	P18052 baseline and differential
Genevisibleⁱ	P18052 MM

Family and domain databases

Gene3Dⁱ	3.90.190.10, 1 hit
InterProⁱ	View protein in InterPro IPR029021 Prot-tyrosine_phosphatase-like IPR000242 PTPase_domain IPR016130 Tyr_Pase_AS IPR003595 Tyr_Pase_cat IPR016336 Tyr_Pase_rcpt_a/e-type IPR027262 Tyr_Pase_rcpt_alpha IPR000387 TYR_PHOSPHATASE_dom
PANTHERⁱ	PTHR19134:SF433 PTHR19134:SF433, 1 hit
Pfamⁱ	View protein in Pfam PF00102 Y_phosphatase, 2 hits
PIRSFⁱ	PIRSF500808 PTPR_alpha, 1 hit PIRSF002006 PTPR_alpha_epsilon, 1 hit
PRINTSⁱ	PR00700 PRTYPHPHTASE
SMARTⁱ	View protein in SMART SM00194 PTPc, 2 hits SM00404 PTPc_motif, 2 hits
SUPFAMⁱ	SSF52799 SSF52799, 2 hits
PROSITEⁱ	View protein in PROSITE PS00383 TYR_PHOSPHATASE_1, 2 hits PS50056 TYR_PHOSPHATASE_2, 2 hits PS50055 TYR_PHOSPHATASE_PTP, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PTPRA_MOUSE
Accessionⁱ	P18052Primary (citable) accession number: P18052 Secondary accession number(s): A2AHF2, Q61808
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1990
	Last sequence update:	July 27, 2011
	Last modified:	November 7, 2018
	This is version 180 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

UniParc

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UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P18052 (PTPRA_MOUSE)

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Receptor-type tyrosine-protein phosphatase alpha

Ptpra

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ