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Protein

Deoxycytidylate 5-hydroxymethyltransferase

Gene

42

Organism
Enterobacteria phage T6 (Bacteriophage T6)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

5,10-methylenetetrahydrofolate + H2O + deoxycytidylate = tetrahydrofolate + 5-hydroxymethyldeoxycytidylate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei148Sequence analysis1

GO - Molecular functioni

Keywordsi

Molecular functionTransferase

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxycytidylate 5-hydroxymethyltransferase (EC:2.1.2.8)
Short name:
Deoxycytidylate hydroxymethylase
Alternative name(s):
dCMP hydroxymethylase
Short name:
dCMP HMase
Gene namesi
Name:42
OrganismiEnterobacteria phage T6 (Bacteriophage T6)
Taxonomic identifieri10666 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageCaudoviralesMyoviridaeTevenvirinaeT4virus
Virus hostiEscherichia coli [TaxID: 562]

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001410691 – 246Deoxycytidylate 5-hydroxymethyltransferaseAdd BLAST246

Structurei

3D structure databases

ProteinModelPortaliP18030
SMRiP18030
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidylate synthase family.Curated

Family and domain databases

Gene3Di3.30.572.10, 1 hit
InterProiView protein in InterPro
IPR014619 Deoxycytidylate_hydroxyMease
IPR023451 Thymidate_synth/dCMP_Mease
IPR036926 Thymidate_synth/dCMP_Mease_sf
PfamiView protein in Pfam
PF00303 Thymidylat_synt, 1 hit
PIRSFiPIRSF036750 dCMP_HMase, 1 hit
SUPFAMiSSF55831 SSF55831, 1 hit

Sequencei

Sequence statusi: Complete.

P18030-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MISDSMTVEE IRLHLGLALK EKDFVVDKTG VKTIEIIGAS FVADEPFIFG
60 70 80 90 100
ALNDEYIQRE LEWYKSKSLF VKDIPGETPK IWQQVASSKG EINSNYGWAI
110 120 130 140 150
WSEDNYAQYD MCLAELGQNP DSRRGIMIYT RPSMQFDYNK DGMSDFMCTN
160 170 180 190 200
TVQYLIRDKK INAVVNMRSN DVVFGFRNDY AWQKYVLDKL VSDLNAGDPT
210 220 230 240
RQYKAGSIIW NVGSLHVYSR HFYLVDHWWK TGETHIVKKD YKGEWK
Length:246
Mass (Da):28,621
Last modified:November 1, 1990 - v1
Checksum:iA370095E32451E8D
GO

Sequence databases

PIRiB34273 SZBPT6

Similar proteinsi

Cross-referencesi

Sequence databases

PIRiB34273 SZBPT6

3D structure databases

ProteinModelPortaliP18030
SMRiP18030
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di3.30.572.10, 1 hit
InterProiView protein in InterPro
IPR014619 Deoxycytidylate_hydroxyMease
IPR023451 Thymidate_synth/dCMP_Mease
IPR036926 Thymidate_synth/dCMP_Mease_sf
PfamiView protein in Pfam
PF00303 Thymidylat_synt, 1 hit
PIRSFiPIRSF036750 dCMP_HMase, 1 hit
SUPFAMiSSF55831 SSF55831, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDCHM_BPT6
AccessioniPrimary (citable) accession number: P18030
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: October 25, 2017
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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