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Protein

T-complex protein 1 subunit alpha

Gene

TCP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). The TRiC complex plays a role in the folding of actin and tubulin (Probable).Curated2 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-389957 Prefoldin mediated transfer of substrate to CCT/TriC
R-HSA-389960 Formation of tubulin folding intermediates by CCT/TriC
R-HSA-390450 Folding of actin by CCT/TriC
R-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis
R-HSA-5620922 BBSome-mediated cargo-targeting to cilium
R-HSA-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
R-HSA-8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation

Names & Taxonomyi

Protein namesi
Recommended name:
T-complex protein 1 subunit alpha
Short name:
TCP-1-alpha
Alternative name(s):
CCT-alpha
Gene namesi
Name:TCP1
Synonyms:CCT1, CCTA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000120438.11
HGNCiHGNC:11655 TCP1
MIMi186980 gene
neXtProtiNX_P17987

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

DisGeNETi6950
OpenTargetsiENSG00000120438
PharmGKBiPA36406

Polymorphism and mutation databases

BioMutaiTCP1
DMDMi135538

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001283021 – 556T-complex protein 1 subunit alphaAdd BLAST556

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1 Publication1
Modified residuei6PhosphoserineCombined sources1
Modified residuei181PhosphotyrosineCombined sources1
Modified residuei199N6-acetyllysineCombined sources1
Modified residuei400N6-acetyllysineCombined sources1
Modified residuei491PhosphoserineCombined sources1
Modified residuei494N6-acetyllysineBy similarity1
Modified residuei544PhosphoserineCombined sources1
Modified residuei551PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP17987
MaxQBiP17987
PaxDbiP17987
PeptideAtlasiP17987
PRIDEiP17987
ProteomicsDBi53538

2D gel databases

OGPiP17987
REPRODUCTION-2DPAGEiIPI00290566
P17987
UCD-2DPAGEiP17987

PTM databases

iPTMnetiP17987
PhosphoSitePlusiP17987
SwissPalmiP17987

Expressioni

Gene expression databases

BgeeiENSG00000120438 Expressed in 230 organ(s), highest expression level in testis
CleanExiHS_TCP1
ExpressionAtlasiP17987 baseline and differential
GenevisibleiP17987 HS

Organism-specific databases

HPAiCAB017460
HPA027337
HPA031082

Interactioni

Subunit structurei

Component of the chaperonin-containing T-complex (TRiC), a heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter (PubMed:1630492, PubMed:20080638, PubMed:25467444). Interacts with PACRG (PubMed:14532270).4 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi112810, 238 interactors
CORUMiP17987
DIPiDIP-33676N
IntActiP17987, 135 interactors
MINTiP17987
STRINGi9606.ENSP00000317334

Structurei

3D structure databases

ProteinModelPortaliP17987
SMRiP17987
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TCP-1 chaperonin family.Curated

Phylogenomic databases

eggNOGiKOG0360 Eukaryota
COG0459 LUCA
GeneTreeiENSGT00550000074878
HOGENOMiHOG000226729
HOVERGENiHBG001052
InParanoidiP17987
KOiK09493
OMAiIMRIDTL
OrthoDBiEOG091G04HL
PhylomeDBiP17987
TreeFamiTF106331

Family and domain databases

CDDicd03335 TCP1_alpha, 1 hit
Gene3Di1.10.560.10, 2 hits
3.30.260.10, 2 hits
3.50.7.10, 1 hit
InterProiView protein in InterPro
IPR012715 Chap_CCT_alpha
IPR017998 Chaperone_TCP-1
IPR002194 Chaperonin_TCP-1_CS
IPR002423 Cpn60/TCP-1
IPR027409 GroEL-like_apical_dom_sf
IPR027413 GROEL-like_equatorial_sf
IPR027410 TCP-1-like_intermed_sf
PfamiView protein in Pfam
PF00118 Cpn60_TCP1, 1 hit
PRINTSiPR00304 TCOMPLEXTCP1
SUPFAMiSSF48592 SSF48592, 2 hits
SSF52029 SSF52029, 1 hit
SSF54849 SSF54849, 2 hits
TIGRFAMsiTIGR02340 chap_CCT_alpha, 1 hit
PROSITEiView protein in PROSITE
PS00750 TCP1_1, 1 hit
PS00751 TCP1_2, 1 hit
PS00995 TCP1_3, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 10 potential isoforms that are computationally mapped.iShow all

P17987-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEGPLSVFGD RSTGETIRSQ NVMAAASIAN IVKSSLGPVG LDKMLVDDIG
60 70 80 90 100
DVTITNDGAT ILKLLEVEHP AAKVLCELAD LQDKEVGDGT TSVVIIAAEL
110 120 130 140 150
LKNADELVKQ KIHPTSVISG YRLACKEAVR YINENLIVNT DELGRDCLIN
160 170 180 190 200
AAKTSMSSKI IGINGDFFAN MVVDAVLAIK YTDIRGQPRY PVNSVNILKA
210 220 230 240 250
HGRSQMESML ISGYALNCVV GSQGMPKRIV NAKIACLDFS LQKTKMKLGV
260 270 280 290 300
QVVITDPEKL DQIRQRESDI TKERIQKILA TGANVILTTG GIDDMCLKYF
310 320 330 340 350
VEAGAMAVRR VLKRDLKRIA KASGATILST LANLEGEETF EAAMLGQAEE
360 370 380 390 400
VVQERICDDE LILIKNTKAR TSASIILRGA NDFMCDEMER SLHDALCVVK
410 420 430 440 450
RVLESKSVVP GGGAVEAALS IYLENYATSM GSREQLAIAE FARSLLVIPN
460 470 480 490 500
TLAVNAAQDS TDLVAKLRAF HNEAQVNPER KNLKWIGLDL SNGKPRDNKQ
510 520 530 540 550
AGVFEPTIVK VKSLKFATEA AITILRIDDL IKLHPESKDD KHGSYEDAVH

SGALND
Length:556
Mass (Da):60,344
Last modified:November 1, 1990 - v1
Checksum:i486ECA836EA258A1
GO

Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7ERF2E7ERF2_HUMAN
T-complex protein 1 subunit alpha
TCP1
433Annotation score:
F5H136F5H136_HUMAN
T-complex protein 1 subunit alpha
TCP1
136Annotation score:
F5H676F5H676_HUMAN
T-complex protein 1 subunit alpha
TCP1
111Annotation score:
F5GZI8F5GZI8_HUMAN
T-complex protein 1 subunit alpha
TCP1
100Annotation score:
F5H726F5H726_HUMAN
T-complex protein 1 subunit alpha
TCP1
91Annotation score:
E7EQR6E7EQR6_HUMAN
T-complex protein 1 subunit alpha
TCP1
401Annotation score:
F5GYL4F5GYL4_HUMAN
T-complex protein 1 subunit alpha
TCP1
65Annotation score:
F5H282F5H282_HUMAN
T-complex protein 1 subunit alpha
TCP1
332Annotation score:
F5GZ03F5GZ03_HUMAN
T-complex protein 1 subunit alpha
TCP1
221Annotation score:
F5H7Y1F5H7Y1_HUMAN
T-complex protein 1 subunit alpha
TCP1
59Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti480R → S in AAA61060 (PubMed:3653076).Curated1
Sequence conflicti537 – 540SKDD → ILRI in CAA37064 (PubMed:2377466).Curated4

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0362587V → L in a breast cancer sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52882 mRNA Translation: CAA37064.1
BT006969 mRNA Translation: AAP35615.1
AL135914 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW47616.1
CH471051 Genomic DNA Translation: EAW47618.1
BC000665 mRNA Translation: AAH00665.1
M26885 Genomic DNA Translation: AAA61059.1
M27272, M26889 Genomic DNA Translation: AAA61060.1
CCDSiCCDS5269.1
PIRiS10486
RefSeqiNP_110379.2, NM_030752.2
UniGeneiHs.363137

Genome annotation databases

EnsembliENST00000321394; ENSP00000317334; ENSG00000120438
GeneIDi6950
KEGGihsa:6950
UCSCiuc003qsr.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTCPA_HUMAN
AccessioniPrimary (citable) accession number: P17987
Secondary accession number(s): E1P5B2, Q15556, Q5TCM3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: September 12, 2018
This is version 197 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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