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Entry version 106 (31 Jul 2019)
Sequence version 2 (27 May 2002)
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Protein

RNA replication polyprotein

Gene

ORF1

Organism
Potato virus M (strain Russian) (PVM)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

RNA replication polyprotein: RNA-directed RNA polymerase involved in viral RNA replication.PROSITE-ProRule annotationBy similarity
Protease: Thiol protease that cleaves the polyprotein.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei994By similarity1
Active sitei1075By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi1166 – 1173ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDioxygenase, Helicase, Hydrolase, Methyltransferase, Multifunctional enzyme, Nucleotidyltransferase, Oxidoreductase, Protease, RNA-directed RNA polymerase, Thiol protease, Transferase
Biological processViral RNA replication
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RNA replication polyproteinBy similarity
Alternative name(s):
ORF1 proteinBy similarity
Cleaved into the following chain:
HelicaseBy similarity (EC:3.6.4.13Curated)
Including the following 4 domains:
Viral methyltransferaseSequence analysis (EC:2.1.1.-Curated)
Putative Fe(2+) 2-oxoglutarate dioxygenaseSequence analysis (EC:1.14.11.-PROSITE-ProRule annotation)
ProteaseBy similarity (EC:3.4.22.-By similarity)
RNA-directed RNA polymerasePROSITE-ProRule annotation (EC:2.7.7.48PROSITE-ProRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:ORF1By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPotato virus M (strain Russian) (PVM)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri12168 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesRiboviriaTymoviralesBetaflexiviridaeQuinvirinaeCarlavirus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiSolanum tuberosum (Potato) [TaxID: 4113]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000677 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002225631 – 1968RNA replication polyproteinAdd BLAST1968
ChainiPRO_00004319081473 – 1968HelicaseBy similarityAdd BLAST496

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Specific enzymatic cleavages by the viral protease yield mature proteins.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei1472 – 1473Cleavage; by viral proteaseBy similarity2

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
P17965

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini63 – 254Alphavirus-like MTPROSITE-ProRule annotationAdd BLAST192
Domaini883 – 991OTUPROSITE-ProRule annotationAdd BLAST109
Domaini990 – 1080Peptidase C23PROSITE-ProRule annotationAdd BLAST91
Domaini1134 – 1316(+)RNA virus helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST183
Domaini1317 – 1454(+)RNA virus helicase C-terminalAdd BLAST138
Domaini1749 – 1856RdRp catalyticPROSITE-ProRule annotationAdd BLAST108

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027351 (+)RNA_virus_helicase_core_dom
IPR002588 Alphavirus-like_MT_dom
IPR003323 OTU_dom
IPR027417 P-loop_NTPase
IPR008041 Peptidase_C23
IPR007094 RNA-dir_pol_PSvirus
IPR001788 Tymovirus_RNA-dep_RNA_pol

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05379 Peptidase_C23, 1 hit
PF00978 RdRP_2, 1 hit
PF01443 Viral_helicase1, 1 hit
PF01660 Vmethyltransf, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51743 ALPHAVIRUS_MT, 1 hit
PS50802 OTU, 1 hit
PS51492 PEPTIDASE_C23, 1 hit
PS51657 PSRV_HELICASE, 1 hit
PS50507 RDRP_SSRNA_POS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P17965-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAVTYRTPME DIVNCFEPAT QAVIANSAAT LYKNFEEQHC QYFNYYLSPL
60 70 80 90 100
AKRKLSMAGI YLSPYSAVVH SHPVCKTLEN YILYSVLPSY INSSFYFVGI
110 120 130 140 150
KERKLQLLKS KCKNLDSVQV VNRYVTSADR MRYTNDFVPY GSYEHECLVH
160 170 180 190 200
KGVGLDNEAL RGLVGPLRRH KAKNLFFHDE LHYWSSKVLI DFLDVMRPDK
210 220 230 240 250
LLGTVVYPPE LLFKPTRSLN EWCYTYDIVG DTLMFFPDGV QSEGYQQPLK
260 270 280 290 300
GGYLLGARSL KLPDGTVYMV DVLCSKFPHH LISITKGEAA APTHRAFGPF
310 320 330 340 350
EAVASEALKA TLSPDYPCAF PVSYEVVNKI YRYLRTLKKP DEQSAIAKLS
360 370 380 390 400
QIIAEPSGRE IDFVECFARL VIHNSSMCAT IMPEQLKEFM GNWLGKMPSV
410 420 430 440 450
LARRFSSVRA VCVNKFIRGL KPYSFTLRLN EITWWNIWEN SYAWFFDTDA
460 470 480 490 500
EVDVPEKLDS LFMGEGAGLV AHITSRPYVG TVPLADREWN ALLCMDSQKL
510 520 530 540 550
LHAMRRMFMR GAWGAHMCVI SREFLLKYVE ARLKSSCLIA KARRRGQHKE
560 570 580 590 600
KLEAWEVLGL KSSDALFRAM TYLCNARLEP MFSESGLRFF LTRGRNNLYG
610 620 630 640 650
LTNYTEGKRA VTGVQNLWSN VVHEVSTKRH KGMIRLEKAR VTEQPRSEFA
660 670 680 690 700
SCVLEPEVWR DVEAALDIEL GEVACACNAR FVQGVVLSNQ AGLNVREQVA
710 720 730 740 750
GASVGLYTKD RSNLKWGNSE LLSNGWGRSL SVWMEINSVS QKFDVAVRLS
760 770 780 790 800
YSKETQMNVL LPSLDGIERG AGATVVNLRK CGAFIVRCAR GWRLALAWMD
810 820 830 840 850
HICLEVMANV AYGHECYMRS WGTMDVVVFL KRATVSEQVT FESAQEVGPI
860 870 880 890 900
EGKSDSGAPG VGVNLDLGGV VGSEYPANGA ERYKRVSGPG DGCCCWHSFA
910 920 930 940 950
YLVGMHHMEL KRLCTSHVFE NAALNVELEQ CKASGAFVTH AAILATALRL
960 970 980 990 1000
RAEIRVHNAG TGRVHRFAPK QKNMALDLWL ESEHYEPQVL RNGCVIESVA
1010 1020 1030 1040 1050
QALGTRNADI LAVVEERCCE EVVESVQAGL GLNLHHVEIV LQCFDIVGHC
1060 1070 1080 1090 1100
NLGDKEITLN AGGKMPFCFD ISDEHMSFCG RRKDPICKLV SGALHGKMFA
1110 1120 1130 1140 1150
ESALLDLENC GLKIDFEPNW NRAGMLADSM YQGATGVLGS ALFNNKRNMR
1160 1170 1180 1190 1200
EKFVRNVSLS LHAIVGTFGS GKSTLFKNLL KYGAGKSLDF VSPRRALAED
1210 1220 1230 1240 1250
FKRTVGMNER GGRAKAGQEN WRVTTLETFL ARVEFLTEGQ VVILDEMQLY
1260 1270 1280 1290 1300
PPGYFDLVVS MLKVDVRLFL VGDPAQSDYD SEKDRLVLGA MEENMSVVLG
1310 1320 1330 1340 1350
AREYNYKVRS HRFLNCNFIG RLPCEINKDD CTIDEPHIMR MHLENLLDVA
1360 1370 1380 1390 1400
EEYKSVVLVS SFDEKMVVCA HLPEAKVLTF GESTGLTFMH GTIYISAVSE
1410 1420 1430 1440 1450
RTNERRWITA LRRFRFNLCF VNCSGMDYQQ LAGRYKGRVR SKFLCKTAIP
1460 1470 1480 1490 1500
DDLNSMLPGQ ALFKSEYPRL IGKDEGVREE KLAGDPWLKT MINLYQAPEV
1510 1520 1530 1540 1550
EIAEEPEVVM QEEWFRTHLP RDELESVRAQ WVHKILAKEY REVRMGDMVS
1560 1570 1580 1590 1600
EQFTHDHTKQ LGAKQLTNAA ERFETIYPRH RASDTVTFLM AVKKRLSFSN
1610 1620 1630 1640 1650
PGKEKGNLFH AASYGKALLS EFLKRVPLKP NHNVRFMEEA LWNFEEKKLS
1660 1670 1680 1690 1700
KSAATIENHS GRSCRDWPTD VAQIFSKSQL CTKFDNRFRV AKAAQSIVCF
1710 1720 1730 1740 1750
QHAVLCRFAP YMRYIEMKVH EVLPKNYYIH SGKGLEELDA WVKKGKFDRI
1760 1770 1780 1790 1800
CTESDYEAFD ASQDEFIMAF ELELMKYLRL PSDLIEDYKF IKTSLGSKLG
1810 1820 1830 1840 1850
NFAIMRFSGE ASTFLFNTLA NMLFTFMRYN IRGDEFICFA GDDMCASRRL
1860 1870 1880 1890 1900
QPTKKFAHFL DKLKLKAKVQ FVQFVNKPTF CGWHLCPDGI YKKPQLVLER
1910 1920 1930 1940 1950
MCIAKEMNNL SNCIDNYAIE VAYAYKLGEK AVNRMDEEEV AAFYNCVRII
1960
VRNKHLIRSD VKQVFEVL
Length:1,968
Mass (Da):223,386
Last modified:May 27, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6F15A79E1AD96AAC
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
D14449 Genomic RNA Translation: BAA03339.1

Protein sequence database of the Protein Information Resource

More...
PIRi
PN0093

NCBI Reference Sequences

More...
RefSeqi
NP_056767.1, NC_001361.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1493995

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
vg:1493995

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D14449 Genomic RNA Translation: BAA03339.1
PIRiPN0093
RefSeqiNP_056767.1, NC_001361.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PRIDEiP17965

Genome annotation databases

GeneIDi1493995
KEGGivg:1493995

Family and domain databases

InterProiView protein in InterPro
IPR027351 (+)RNA_virus_helicase_core_dom
IPR002588 Alphavirus-like_MT_dom
IPR003323 OTU_dom
IPR027417 P-loop_NTPase
IPR008041 Peptidase_C23
IPR007094 RNA-dir_pol_PSvirus
IPR001788 Tymovirus_RNA-dep_RNA_pol
PfamiView protein in Pfam
PF05379 Peptidase_C23, 1 hit
PF00978 RdRP_2, 1 hit
PF01443 Viral_helicase1, 1 hit
PF01660 Vmethyltransf, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51743 ALPHAVIRUS_MT, 1 hit
PS50802 OTU, 1 hit
PS51492 PEPTIDASE_C23, 1 hit
PS51657 PSRV_HELICASE, 1 hit
PS50507 RDRP_SSRNA_POS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRDRP_PVMR
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P17965
Secondary accession number(s): Q89548
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: May 27, 2002
Last modified: July 31, 2019
This is version 106 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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