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Protein

Vascular endothelial growth factor receptor 1

Gene

FLT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. May play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells. Can promote endothelial cell proliferation, survival and angiogenesis in adulthood. Its function in promoting cell proliferation seems to be cell-type specific. Promotes PGF-mediated proliferation of endothelial cells, proliferation of some types of cancer cells, but does not promote proliferation of normal fibroblasts (in vitro). Has very high affinity for VEGFA and relatively low protein kinase activity; may function as a negative regulator of VEGFA signaling by limiting the amount of free VEGFA and preventing its binding to KDR. Likewise, isoforms lacking a transmembrane domain, such as isoform 2, isoform 3 and isoform 4, may function as decoy receptors for VEGFA. Modulates KDR signaling by forming heterodimers with KDR. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leading to activation of phosphatidylinositol kinase and the downstream signaling pathway. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Phosphorylates SRC and YES1, and may also phosphorylate CBL. Isoform 1 phosphorylates PLCG. Promotes phosphorylation of AKT1 at 'Ser-473'. Promotes phosphorylation of PTK2/FAK1. Isoform 7 has a truncated kinase domain; it increases phosphorylation of SRC at 'Tyr-418' by unknown means and promotes tumor cell invasion.18 Publications

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation5 Publications

Activity regulationi

Present in an inactive conformation in the absence of bound ligand. Binding of VEGFA, VEGFB or PGF leads to dimerization and activation by autophosphorylation on tyrosine residues.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei861ATPPROSITE-ProRule annotation1
Active sitei1022Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi833 – 841ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, Kinase, Receptor, Transferase, Tyrosine-protein kinase
Biological processAngiogenesis, Chemotaxis, Differentiation
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.1 2681
ReactomeiR-HSA-194306 Neurophilin interactions with VEGF and VEGFR
R-HSA-195399 VEGF binds to VEGFR leading to receptor dimerization
SignaLinkiP17948
SIGNORiP17948

Names & Taxonomyi

Protein namesi
Recommended name:
Vascular endothelial growth factor receptor 1 (EC:2.7.10.1)
Short name:
VEGFR-1
Alternative name(s):
Fms-like tyrosine kinase 1
Short name:
FLT-1
Tyrosine-protein kinase FRT
Tyrosine-protein kinase receptor FLT
Short name:
FLT
Vascular permeability factor receptor
Gene namesi
Name:FLT1
Synonyms:FLT, FRT, VEGFR1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000102755.10
HGNCiHGNC:3763 FLT1
MIMi165070 gene
neXtProtiNX_P17948

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini27 – 758ExtracellularSequence analysisAdd BLAST732
Transmembranei759 – 780HelicalSequence analysisAdd BLAST22
Topological domaini781 – 1338CytoplasmicSequence analysisAdd BLAST558

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Endosome, Membrane, Secreted

Pathology & Biotechi

Involvement in diseasei

Can contribute to cancer cell survival, proliferation, migration, and invasion, and tumor angiogenesis and metastasis. May contribute to cancer pathogenesis by promoting inflammatory responses and recruitment of tumor-infiltrating macrophages.
Abnormally high expression of soluble isoforms (isoform 2, isoform 3 or isoform 4) may be a cause of preeclampsia.

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi767V → A: Abolishes proteolytic cleavage by PSEN1. 1 Publication1
Mutagenesisi861K → M: Abolishes enzyme activity. Abolishes interaction with PLCG. 1 Publication1
Mutagenesisi914Y → F: Reduces phosphorylation at other tyrosine residues. 1 Publication1
Mutagenesisi1050N → D: Strongly increases kinase activity. Increases activity in promoting proliferation of endothelial cells. 1 Publication1
Mutagenesisi1169Y → F: Loss of phosphorylation site. Abolishes interaction with PLCG. 1 Publication1
Mutagenesisi1213Y → F: Loss of phosphorylation site. Abolishes interaction with PIK3R1. 1 Publication1
Mutagenesisi1242Y → F: Loss of phosphorylation site. 1 Publication1
Mutagenesisi1327Y → F: Loss of phosphorylation site. 1 Publication1
Mutagenesisi1333Y → F: Loss of phosphorylation site. Abolishes interaction with CBL. 2 Publications1

Organism-specific databases

DisGeNETi2321
MalaCardsiFLT1
OpenTargetsiENSG00000102755
PharmGKBiPA28180

Chemistry databases

ChEMBLiCHEMBL1868
DrugBankiDB06080 ABT-869
DB06626 Axitinib
DB06101 IMC-1C11
DB09078 Lenvatinib
DB07288 N-(4-chlorophenyl)-2-[(pyridin-4-ylmethyl)amino]benzamide
DB09079 Nintedanib
DB05913 OSI-930
DB06589 Pazopanib
DB08896 Regorafenib
DB00398 Sorafenib
DB01268 Sunitinib
DB05075 TG100801
DB04879 Vatalanib
GuidetoPHARMACOLOGYi1812

Polymorphism and mutation databases

BioMutaiFLT1
DMDMi143811474

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 261 PublicationAdd BLAST26
ChainiPRO_000001676827 – 1338Vascular endothelial growth factor receptor 1Add BLAST1312

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi53 ↔ 107PROSITE-ProRule annotation
Glycosylationi100N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi158 ↔ 207
Glycosylationi164N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi196N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi251N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi252 ↔ 311PROSITE-ProRule annotation
Glycosylationi323N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi402N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi417N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi454 ↔ 535PROSITE-ProRule annotation
Glycosylationi474N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi547N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi577 ↔ 636PROSITE-ProRule annotation
Glycosylationi597N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi620N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi625N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi666N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi682 ↔ 731PROSITE-ProRule annotation
Modified residuei914Phosphotyrosine; by autocatalysis1 Publication1
Modified residuei1053Phosphotyrosine; by autocatalysisBy similarity1
Modified residuei1169Phosphotyrosine; by autocatalysis1 Publication1
Modified residuei1213Phosphotyrosine; by autocatalysis5 Publications1
Modified residuei1242Phosphotyrosine; by autocatalysis1 Publication1
Modified residuei1309Phosphotyrosine; by autocatalysis1 Publication1
Modified residuei1327Phosphotyrosine; by autocatalysis2 Publications1
Modified residuei1333Phosphotyrosine; by autocatalysis1 Publication1

Post-translational modificationi

N-glycosylated.2 Publications
Ubiquitinated after VEGFA-mediated autophosphorylation, leading to proteolytic degradation.1 Publication
Autophosphorylated on tyrosine residues upon ligand binding. Autophosphorylation occurs in trans, i.e. one subunit of the dimeric receptor phosphorylates tyrosine residues on the other subunit. Phosphorylation at Tyr-1169 is important for interaction with PLCG. Phosphorylation at Tyr-1213 is important for interaction with PIK3R1, PTPN11, GRB2, and PLCG. Phosphorylation at Tyr-1333 is important for endocytosis and for interaction with CBL, NCK1 and CRK. Is probably dephosphorylated by PTPRB.5 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei767 – 768Cleavage; by PSEN1Curated2

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP17948
MaxQBiP17948
PaxDbiP17948
PeptideAtlasiP17948
PRIDEiP17948
ProteomicsDBi53530
53531 [P17948-2]
53532 [P17948-3]
53533 [P17948-4]
53534 [P17948-5]
53535 [P17948-6]
53536 [P17948-7]

PTM databases

GlyConnecti771
iPTMnetiP17948
PhosphoSitePlusiP17948
UniCarbKBiP17948

Expressioni

Tissue specificityi

Detected in normal lung, but also in placenta, liver, kidney, heart and brain tissues. Specifically expressed in most of the vascular endothelial cells, and also expressed in peripheral blood monocytes. Isoform 2 is strongly expressed in placenta. Isoform 3 is expressed in corneal epithelial cells (at protein level). Isoform 3 is expressed in vascular smooth muscle cells (VSMC).2 Publications

Inductioni

Up-regulated in coculture of VSMC/endothelial cell (EC) or by direct exposure to VEGF of VSMC monoculture. Up-regulated from the second trimester of pregnancy to the term and in the placenta of women with preeclampsia (PE). Up-regulated in monocytes exposed to bacterial lipopolysaccharide (LPS).2 Publications

Gene expression databases

BgeeiENSG00000102755 Expressed in 220 organ(s), highest expression level in placenta
CleanExiHS_FLT1
ExpressionAtlasiP17948 baseline and differential
GenevisibleiP17948 HS

Organism-specific databases

HPAiCAB068189
CAB068190
HPA011740
HPA014290

Interactioni

Subunit structurei

Interacts with VEGFA, VEGFB and PGF. Monomer in the absence of bound VEGFA, VEGFB or PGF. Homodimer in the presence of bound VEGFA, VEGFB and PGF. Can also form a heterodimer with KDR. Interacts (when tyrosine phosphorylated) with CBL, CRK, GRB2, NCK1, PIK3R1, PLCG, PSEN1 and PTPN11. Probably interacts also with PTPRB. Interacts with RACK1. Identified in a complex with CBL and CD2AP.16 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi108609, 14 interactors
DIPiDIP-643N
IntActiP17948, 32 interactors
MINTiP17948
STRINGi9606.ENSP00000282397

Chemistry databases

BindingDBiP17948

Structurei

Secondary structure

11338
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP17948
SMRiP17948
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP17948

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 123Ig-like C2-type 1Add BLAST92
Domaini151 – 214Ig-like C2-type 2Add BLAST64
Domaini230 – 327Ig-like C2-type 3Add BLAST98
Domaini335 – 421Ig-like C2-type 4Add BLAST87
Domaini428 – 553Ig-like C2-type 5Add BLAST126
Domaini556 – 654Ig-like C2-type 6Add BLAST99
Domaini661 – 747Ig-like C2-type 7Add BLAST87
Domaini827 – 1158Protein kinasePROSITE-ProRule annotationAdd BLAST332

Domaini

The second and third Ig-like C2-type (immunoglobulin-like) domains are sufficient for VEGFA binding.2 Publications

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0200 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00760000118923
HOGENOMiHOG000037949
HOVERGENiHBG080796
InParanoidiP17948
KOiK05096
OMAiITLTCTC
OrthoDBiEOG091G01TL
PhylomeDBiP17948
TreeFamiTF325768

Family and domain databases

Gene3Di2.60.40.10, 7 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
IPR013151 Immunoglobulin
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
IPR001824 Tyr_kinase_rcpt_3_CS
IPR009135 VEGFR1_rcpt
PfamiView protein in Pfam
PF07679 I-set, 2 hits
PF00047 ig, 1 hit
PF07714 Pkinase_Tyr, 1 hit
PRINTSiPR01833 VEGFRECEPTR1
SMARTiView protein in SMART
SM00409 IG, 7 hits
SM00408 IGc2, 5 hits
SM00406 IGv, 2 hits
SM00219 TyrKc, 1 hit
SUPFAMiSSF48726 SSF48726, 8 hits
SSF56112 SSF56112, 2 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 6 hits
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit
PS00240 RECEPTOR_TYR_KIN_III, 1 hit

Sequences (8+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 8 isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 8 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P17948-1) [UniParc]FASTAAdd to basket
Also known as: Flt1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVSYWDTGVL LCALLSCLLL TGSSSGSKLK DPELSLKGTQ HIMQAGQTLH
60 70 80 90 100
LQCRGEAAHK WSLPEMVSKE SERLSITKSA CGRNGKQFCS TLTLNTAQAN
110 120 130 140 150
HTGFYSCKYL AVPTSKKKET ESAIYIFISD TGRPFVEMYS EIPEIIHMTE
160 170 180 190 200
GRELVIPCRV TSPNITVTLK KFPLDTLIPD GKRIIWDSRK GFIISNATYK
210 220 230 240 250
EIGLLTCEAT VNGHLYKTNY LTHRQTNTII DVQISTPRPV KLLRGHTLVL
260 270 280 290 300
NCTATTPLNT RVQMTWSYPD EKNKRASVRR RIDQSNSHAN IFYSVLTIDK
310 320 330 340 350
MQNKDKGLYT CRVRSGPSFK SVNTSVHIYD KAFITVKHRK QQVLETVAGK
360 370 380 390 400
RSYRLSMKVK AFPSPEVVWL KDGLPATEKS ARYLTRGYSL IIKDVTEEDA
410 420 430 440 450
GNYTILLSIK QSNVFKNLTA TLIVNVKPQI YEKAVSSFPD PALYPLGSRQ
460 470 480 490 500
ILTCTAYGIP QPTIKWFWHP CNHNHSEARC DFCSNNEESF ILDADSNMGN
510 520 530 540 550
RIESITQRMA IIEGKNKMAS TLVVADSRIS GIYICIASNK VGTVGRNISF
560 570 580 590 600
YITDVPNGFH VNLEKMPTEG EDLKLSCTVN KFLYRDVTWI LLRTVNNRTM
610 620 630 640 650
HYSISKQKMA ITKEHSITLN LTIMNVSLQD SGTYACRARN VYTGEEILQK
660 670 680 690 700
KEITIRDQEA PYLLRNLSDH TVAISSSTTL DCHANGVPEP QITWFKNNHK
710 720 730 740 750
IQQEPGIILG PGSSTLFIER VTEEDEGVYH CKATNQKGSV ESSAYLTVQG
760 770 780 790 800
TSDKSNLELI TLTCTCVAAT LFWLLLTLFI RKMKRSSSEI KTDYLSIIMD
810 820 830 840 850
PDEVPLDEQC ERLPYDASKW EFARERLKLG KSLGRGAFGK VVQASAFGIK
860 870 880 890 900
KSPTCRTVAV KMLKEGATAS EYKALMTELK ILTHIGHHLN VVNLLGACTK
910 920 930 940 950
QGGPLMVIVE YCKYGNLSNY LKSKRDLFFL NKDAALHMEP KKEKMEPGLE
960 970 980 990 1000
QGKKPRLDSV TSSESFASSG FQEDKSLSDV EEEEDSDGFY KEPITMEDLI
1010 1020 1030 1040 1050
SYSFQVARGM EFLSSRKCIH RDLAARNILL SENNVVKICD FGLARDIYKN
1060 1070 1080 1090 1100
PDYVRKGDTR LPLKWMAPES IFDKIYSTKS DVWSYGVLLW EIFSLGGSPY
1110 1120 1130 1140 1150
PGVQMDEDFC SRLREGMRMR APEYSTPEIY QIMLDCWHRD PKERPRFAEL
1160 1170 1180 1190 1200
VEKLGDLLQA NVQQDGKDYI PINAILTGNS GFTYSTPAFS EDFFKESISA
1210 1220 1230 1240 1250
PKFNSGSSDD VRYVNAFKFM SLERIKTFEE LLPNATSMFD DYQGDSSTLL
1260 1270 1280 1290 1300
ASPMLKRFTW TDSKPKASLK IDLRVTSKSK ESGLSDVSRP SFCHSSCGHV
1310 1320 1330
SEGKRRFTYD HAELERKIAC CSPPPDYNSV VLYSTPPI
Length:1,338
Mass (Da):150,769
Last modified:April 3, 2007 - v2
Checksum:iFF3381EEFAF0787C
GO
Isoform 2 (identifier: P17948-2) [UniParc]FASTAAdd to basket
Also known as: sFlt1

The sequence of this isoform differs from the canonical sequence as follows:
     657-687: DQEAPYLLRNLSDHTVAISSSTTLDCHANGV → GEHCNKKAVFSRISKFKSTRNDCTTQSNVKH
     688-1338: Missing.

Show »
Length:687
Mass (Da):77,474
Checksum:i3F73F4942469DA36
GO
Isoform 3 (identifier: P17948-3) [UniParc]FASTAAdd to basket
Also known as: sFlt1-14

The sequence of this isoform differs from the canonical sequence as follows:
     706-733: GIILGPGSSTLFIERVTEEDEGVYHCKA → ELYTSTSPSSSSSSPLSSSSSSSSSSSS
     734-1338: Missing.

Show »
Length:733
Mass (Da):82,124
Checksum:i67B7F8BC1D30CD9E
GO
Isoform 4 (identifier: P17948-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     518-541: MASTLVVADSRISGIYICIASNKV → LPPANSSFMLPPTSFSSNYFHFLP
     542-1338: Missing.

Show »
Length:541
Mass (Da):60,917
Checksum:i50BCDAACB69B0EA2
GO
Isoform 5 (identifier: P17948-5) [UniParc]FASTAAdd to basket
Also known as: i15

The sequence of this isoform differs from the canonical sequence as follows:
     1-782: Missing.

Show »
Length:556
Mass (Da):62,954
Checksum:i9150507FBDF43B24
GO
Isoform 6 (identifier: P17948-6) [UniParc]FASTAAdd to basket
Also known as: i18

The sequence of this isoform differs from the canonical sequence as follows:
     1-875: Missing.

Show »
Length:463
Mass (Da):52,613
Checksum:i7D3D572623A1124E
GO
Isoform 7 (identifier: P17948-7) [UniParc]FASTAAdd to basket
Also known as: i21

The sequence of this isoform differs from the canonical sequence as follows:
     1-995: Missing.

Show »
Length:343
Mass (Da):39,148
Checksum:iB7800AF7311BF0D6
GO
Isoform 8 (identifier: P17948-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-7: MVSYWDT → MNSDLLV
     8-984: Missing.

Show »
Length:361
Mass (Da):41,175
Checksum:i34E2B38DE128BA53
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1W2PNW4A0A1W2PNW4_HUMAN
Vascular endothelial growth factor ...
FLT1
665Annotation score:
H9N1E7H9N1E7_HUMAN
Vascular endothelial growth factor ...
FLT1
433Annotation score:
H9N1E8H9N1E8_HUMAN
Vascular endothelial growth factor ...
FLT1
85Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti490F → S in AAC16449 (PubMed:10471394).Curated1
Sequence conflicti779F → L in CAA35946 (PubMed:2158038).Curated1
Sequence conflicti1029L → F in ABI53803 (PubMed:20512933).Curated1
Sequence conflicti1029L → F in ABI53804 (PubMed:20512933).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04204560K → T1 PublicationCorresponds to variant dbSNP:rs56409818Ensembl.1
Natural variantiVAR_049719128I → L. Corresponds to variant dbSNP:rs35073261Ensembl.1
Natural variantiVAR_042046144E → K1 PublicationCorresponds to variant dbSNP:rs55974987Ensembl.1
Natural variantiVAR_042047281R → Q1 PublicationCorresponds to variant dbSNP:rs55687105Ensembl.1
Natural variantiVAR_042048422L → I in a lung adenocarcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_042049781R → Q in a glioma low grade oligodendroglioma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs553261958Ensembl.1
Natural variantiVAR_042050938M → V1 PublicationCorresponds to variant dbSNP:rs35549791Ensembl.1
Natural variantiVAR_042051982E → A1 PublicationCorresponds to variant dbSNP:rs35832528Ensembl.1
Natural variantiVAR_0420521061L → V in a bladder transitional cell carcinoma sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0419831 – 995Missing in isoform 7. 1 PublicationAdd BLAST995
Alternative sequenceiVSP_0419841 – 875Missing in isoform 6. 1 PublicationAdd BLAST875
Alternative sequenceiVSP_0419851 – 782Missing in isoform 5. 1 PublicationAdd BLAST782
Alternative sequenceiVSP_0477591 – 7MVSYWDT → MNSDLLV in isoform 8. 1 Publication7
Alternative sequenceiVSP_0477608 – 984Missing in isoform 8. 1 PublicationAdd BLAST977
Alternative sequenceiVSP_041929518 – 541MASTL…ASNKV → LPPANSSFMLPPTSFSSNYF HFLP in isoform 4. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_041930542 – 1338Missing in isoform 4. 1 PublicationAdd BLAST797
Alternative sequenceiVSP_002955657 – 687DQEAP…HANGV → GEHCNKKAVFSRISKFKSTR NDCTTQSNVKH in isoform 2. 3 PublicationsAdd BLAST31
Alternative sequenceiVSP_002956688 – 1338Missing in isoform 2. 3 PublicationsAdd BLAST651
Alternative sequenceiVSP_041927706 – 733GIILG…YHCKA → ELYTSTSPSSSSSSPLSSSS SSSSSSSS in isoform 3. 3 PublicationsAdd BLAST28
Alternative sequenceiVSP_041928734 – 1338Missing in isoform 3. 3 PublicationsAdd BLAST605

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51602 mRNA Translation: CAA35946.1
U01134 mRNA Translation: AAC50060.1
AF063657 mRNA Translation: AAC16449.2
EU826561 mRNA Translation: ACF47597.1
EU368830 mRNA Translation: ACA62948.1
DQ836394 mRNA Translation: ABI53803.1
DQ836395 mRNA Translation: ABI53804.1
DQ836396 mRNA Translation: ABI53805.1
EF491868 mRNA Translation: ABS32268.1
EF491869 mRNA Translation: ABS32269.1
EF491870 mRNA Translation: ABS32270.1
EU360600 mRNA Translation: ACB05747.1
EU332841 Genomic DNA Translation: ABY87530.1
AK292936 mRNA Translation: BAF85625.1
AK300392 mRNA Translation: BAG62125.1
AL138712 Genomic DNA No translation available.
AL139005 Genomic DNA No translation available.
CH471075 Genomic DNA Translation: EAX08431.1
CH471075 Genomic DNA Translation: EAX08432.1
BC039007 mRNA Translation: AAH39007.1
D00133 Genomic DNA Translation: BAA00080.1
CCDSiCCDS53860.1 [P17948-3]
CCDS53861.1 [P17948-4]
CCDS73556.1 [P17948-2]
CCDS9330.1 [P17948-1]
PIRiA49636
S09982
RefSeqiNP_001153392.1, NM_001159920.1 [P17948-2]
NP_001153502.1, NM_001160030.1 [P17948-3]
NP_001153503.1, NM_001160031.1 [P17948-4]
NP_002010.2, NM_002019.4 [P17948-1]
UniGeneiHs.594454

Genome annotation databases

EnsembliENST00000282397; ENSP00000282397; ENSG00000102755 [P17948-1]
ENST00000539099; ENSP00000442630; ENSG00000102755 [P17948-4]
ENST00000541932; ENSP00000437631; ENSG00000102755 [P17948-3]
ENST00000543394; ENSP00000437841; ENSG00000102755 [P17948-8]
ENST00000615840; ENSP00000484039; ENSG00000102755 [P17948-2]
GeneIDi2321
KEGGihsa:2321
UCSCiuc001usb.4 human [P17948-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51602 mRNA Translation: CAA35946.1
U01134 mRNA Translation: AAC50060.1
AF063657 mRNA Translation: AAC16449.2
EU826561 mRNA Translation: ACF47597.1
EU368830 mRNA Translation: ACA62948.1
DQ836394 mRNA Translation: ABI53803.1
DQ836395 mRNA Translation: ABI53804.1
DQ836396 mRNA Translation: ABI53805.1
EF491868 mRNA Translation: ABS32268.1
EF491869 mRNA Translation: ABS32269.1
EF491870 mRNA Translation: ABS32270.1
EU360600 mRNA Translation: ACB05747.1
EU332841 Genomic DNA Translation: ABY87530.1
AK292936 mRNA Translation: BAF85625.1
AK300392 mRNA Translation: BAG62125.1
AL138712 Genomic DNA No translation available.
AL139005 Genomic DNA No translation available.
CH471075 Genomic DNA Translation: EAX08431.1
CH471075 Genomic DNA Translation: EAX08432.1
BC039007 mRNA Translation: AAH39007.1
D00133 Genomic DNA Translation: BAA00080.1
CCDSiCCDS53860.1 [P17948-3]
CCDS53861.1 [P17948-4]
CCDS73556.1 [P17948-2]
CCDS9330.1 [P17948-1]
PIRiA49636
S09982
RefSeqiNP_001153392.1, NM_001159920.1 [P17948-2]
NP_001153502.1, NM_001160030.1 [P17948-3]
NP_001153503.1, NM_001160031.1 [P17948-4]
NP_002010.2, NM_002019.4 [P17948-1]
UniGeneiHs.594454

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1FLTX-ray1.70X/Y132-226[»]
1QSVNMR-A129-229[»]
1QSZNMR-A129-229[»]
1QTYX-ray2.70T/U/X/Y129-229[»]
1RV6X-ray2.45X/Y130-229[»]
2XACX-ray2.71C/X129-226[»]
3HNGX-ray2.70A801-1158[»]
4CKVX-ray2.06X132-225[»]
4CL7X-ray2.00A/B/C/D132-225[»]
5ABDX-ray2.00E/I/X132-226[»]
5EX3X-ray2.41D827-835[»]
5T89X-ray4.00X/Y27-656[»]
ProteinModelPortaliP17948
SMRiP17948
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108609, 14 interactors
DIPiDIP-643N
IntActiP17948, 32 interactors
MINTiP17948
STRINGi9606.ENSP00000282397

Chemistry databases

BindingDBiP17948
ChEMBLiCHEMBL1868
DrugBankiDB06080 ABT-869
DB06626 Axitinib
DB06101 IMC-1C11
DB09078 Lenvatinib
DB07288 N-(4-chlorophenyl)-2-[(pyridin-4-ylmethyl)amino]benzamide
DB09079 Nintedanib
DB05913 OSI-930
DB06589 Pazopanib
DB08896 Regorafenib
DB00398 Sorafenib
DB01268 Sunitinib
DB05075 TG100801
DB04879 Vatalanib
GuidetoPHARMACOLOGYi1812

PTM databases

GlyConnecti771
iPTMnetiP17948
PhosphoSitePlusiP17948
UniCarbKBiP17948

Polymorphism and mutation databases

BioMutaiFLT1
DMDMi143811474

Proteomic databases

EPDiP17948
MaxQBiP17948
PaxDbiP17948
PeptideAtlasiP17948
PRIDEiP17948
ProteomicsDBi53530
53531 [P17948-2]
53532 [P17948-3]
53533 [P17948-4]
53534 [P17948-5]
53535 [P17948-6]
53536 [P17948-7]

Protocols and materials databases

DNASUi2321
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000282397; ENSP00000282397; ENSG00000102755 [P17948-1]
ENST00000539099; ENSP00000442630; ENSG00000102755 [P17948-4]
ENST00000541932; ENSP00000437631; ENSG00000102755 [P17948-3]
ENST00000543394; ENSP00000437841; ENSG00000102755 [P17948-8]
ENST00000615840; ENSP00000484039; ENSG00000102755 [P17948-2]
GeneIDi2321
KEGGihsa:2321
UCSCiuc001usb.4 human [P17948-1]

Organism-specific databases

CTDi2321
DisGeNETi2321
EuPathDBiHostDB:ENSG00000102755.10
GeneCardsiFLT1
H-InvDBiHIX0130593
HGNCiHGNC:3763 FLT1
HPAiCAB068189
CAB068190
HPA011740
HPA014290
MalaCardsiFLT1
MIMi165070 gene
neXtProtiNX_P17948
OpenTargetsiENSG00000102755
PharmGKBiPA28180
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0200 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00760000118923
HOGENOMiHOG000037949
HOVERGENiHBG080796
InParanoidiP17948
KOiK05096
OMAiITLTCTC
OrthoDBiEOG091G01TL
PhylomeDBiP17948
TreeFamiTF325768

Enzyme and pathway databases

BRENDAi2.7.10.1 2681
ReactomeiR-HSA-194306 Neurophilin interactions with VEGF and VEGFR
R-HSA-195399 VEGF binds to VEGFR leading to receptor dimerization
SignaLinkiP17948
SIGNORiP17948

Miscellaneous databases

ChiTaRSiFLT1 human
EvolutionaryTraceiP17948
GeneWikiiFLT1
GenomeRNAii2321
PROiPR:P17948
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000102755 Expressed in 220 organ(s), highest expression level in placenta
CleanExiHS_FLT1
ExpressionAtlasiP17948 baseline and differential
GenevisibleiP17948 HS

Family and domain databases

Gene3Di2.60.40.10, 7 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
IPR013151 Immunoglobulin
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
IPR001824 Tyr_kinase_rcpt_3_CS
IPR009135 VEGFR1_rcpt
PfamiView protein in Pfam
PF07679 I-set, 2 hits
PF00047 ig, 1 hit
PF07714 Pkinase_Tyr, 1 hit
PRINTSiPR01833 VEGFRECEPTR1
SMARTiView protein in SMART
SM00409 IG, 7 hits
SM00408 IGc2, 5 hits
SM00406 IGv, 2 hits
SM00219 TyrKc, 1 hit
SUPFAMiSSF48726 SSF48726, 8 hits
SSF56112 SSF56112, 2 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 6 hits
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit
PS00240 RECEPTOR_TYR_KIN_III, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiVGFR1_HUMAN
AccessioniPrimary (citable) accession number: P17948
Secondary accession number(s): A3E342
, A3E344, A8KA71, B0LPF1, B2BF46, B2BF47, B2BF48, B3FR89, B5A923, F5H5L6, O60722, P16057, Q12954
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: April 3, 2007
Last modified: October 10, 2018
This is version 220 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  6. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  7. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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