UniProtKB - P17948 (VGFR1_HUMAN)
Vascular endothelial growth factor receptor 1
FLT1
Functioni
Catalytic activityi
- ATP + L-tyrosyl-[protein] = ADP + H+ + O-phospho-L-tyrosyl-[protein]PROSITE-ProRule annotation5 PublicationsEC:2.7.10.1PROSITE-ProRule annotation5 Publications
Activity regulationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 861 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 1022 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 833 – 841 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- growth factor binding Source: UniProtKB
- placental growth factor-activated receptor activity Source: UniProtKB
- transmembrane receptor protein tyrosine kinase activity Source: GO_Central
- vascular endothelial growth factor-activated receptor activity Source: UniProtKB
- vascular endothelial growth factor binding Source: GO_Central
- VEGF-A-activated receptor activity Source: UniProtKB
- VEGF-B-activated receptor activity Source: UniProtKB
GO - Biological processi
- blood vessel morphogenesis Source: UniProtKB
- cell differentiation Source: UniProtKB-KW
- cell migration Source: UniProtKB
- cellular response to vascular endothelial growth factor stimulus Source: UniProtKB
- embryonic morphogenesis Source: UniProtKB
- monocyte chemotaxis Source: UniProtKB
- negative regulation of vascular endothelial cell proliferation Source: BHF-UCL
- peptidyl-tyrosine phosphorylation Source: UniProtKB
- positive regulation of angiogenesis Source: UniProtKB
- positive regulation of cell migration Source: UniProtKB
- positive regulation of cell population proliferation Source: ProtInc
- positive regulation of MAPK cascade Source: UniProtKB
- positive regulation of MAP kinase activity Source: UniProtKB
- positive regulation of phosphatidylinositol 3-kinase activity Source: UniProtKB
- positive regulation of phosphatidylinositol 3-kinase signaling Source: UniProtKB
- positive regulation of phospholipase C activity Source: UniProtKB
- positive regulation of vascular endothelial growth factor receptor signaling pathway Source: BHF-UCL
- protein autophosphorylation Source: UniProtKB
- sprouting angiogenesis Source: GO_Central
- transmembrane receptor protein tyrosine kinase signaling pathway Source: GO_Central
- vascular endothelial growth factor receptor-1 signaling pathway Source: UniProtKB
- vascular endothelial growth factor receptor signaling pathway Source: UniProtKB
Keywordsi
Molecular function | Developmental protein, Kinase, Receptor, Transferase, Tyrosine-protein kinase |
Biological process | Angiogenesis, Chemotaxis, Differentiation |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 2.7.10.1 2681 |
Reactomei | R-HSA-194306 Neurophilin interactions with VEGF and VEGFR R-HSA-195399 VEGF binds to VEGFR leading to receptor dimerization |
SignaLinki | P17948 |
SIGNORi | P17948 |
Names & Taxonomyi
Protein namesi | Recommended name: Vascular endothelial growth factor receptor 1 (EC:2.7.10.1)Short name: VEGFR-1 Alternative name(s): Fms-like tyrosine kinase 1 Short name: FLT-1 Tyrosine-protein kinase FRT Tyrosine-protein kinase receptor FLT Short name: FLT Vascular permeability factor receptor |
Gene namesi | Name:FLT1 Synonyms:FLT, FRT, VEGFR1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:3763 FLT1 |
MIMi | 165070 gene |
neXtProti | NX_P17948 |
Subcellular locationi
Plasma membrane
Endosome
Note: Autophosphorylation promotes ubiquitination and endocytosis.
Cytoskeleton
- actin cytoskeleton Source: HPA
Endosome
- endosome Source: UniProtKB-SubCell
Extracellular region or secreted
- extracellular space Source: ProtInc
Plasma Membrane
- integral component of plasma membrane Source: UniProtKB
- plasma membrane Source: HPA
Other locations
- focal adhesion Source: UniProtKB
- receptor complex Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 27 – 758 | ExtracellularSequence analysisAdd BLAST | 732 | |
Transmembranei | 759 – 780 | HelicalSequence analysisAdd BLAST | 22 | |
Topological domaini | 781 – 1338 | CytoplasmicSequence analysisAdd BLAST | 558 |
Keywords - Cellular componenti
Cell membrane, Cytoplasm, Endosome, Membrane, SecretedPathology & Biotechi
Involvement in diseasei
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 767 | V → A: Abolishes proteolytic cleavage by PSEN1. 1 Publication | 1 | |
Mutagenesisi | 861 | K → M: Abolishes enzyme activity. Abolishes interaction with PLCG. 1 Publication | 1 | |
Mutagenesisi | 914 | Y → F: Reduces phosphorylation at other tyrosine residues. 1 Publication | 1 | |
Mutagenesisi | 1050 | N → D: Strongly increases kinase activity. Increases activity in promoting proliferation of endothelial cells. 1 Publication | 1 | |
Mutagenesisi | 1169 | Y → F: Loss of phosphorylation site. Abolishes interaction with PLCG. 1 Publication | 1 | |
Mutagenesisi | 1213 | Y → F: Loss of phosphorylation site. Abolishes interaction with PIK3R1. 1 Publication | 1 | |
Mutagenesisi | 1242 | Y → F: Loss of phosphorylation site. 1 Publication | 1 | |
Mutagenesisi | 1327 | Y → F: Loss of phosphorylation site. 1 Publication | 1 | |
Mutagenesisi | 1333 | Y → F: Loss of phosphorylation site. Abolishes interaction with CBL. 2 Publications | 1 |
Organism-specific databases
DisGeNETi | 2321 |
MalaCardsi | FLT1 |
OpenTargetsi | ENSG00000102755 |
Orphaneti | 275555 Preeclampsia |
PharmGKBi | PA28180 |
Miscellaneous databases
Pharosi | P17948 |
Chemistry databases
ChEMBLi | CHEMBL1868 |
DrugBanki | DB06080 ABT-869 DB06626 Axitinib DB05932 Denibulin DB10770 Foreskin fibroblast (neonatal) DB12010 Fostamatinib DB06101 IMC-1C11 DB09078 Lenvatinib DB07288 N-(4-chlorophenyl)-2-[(pyridin-4-ylmethyl)amino]benzamide DB09079 Nintedanib DB05913 OSI-930 DB06589 Pazopanib DB09221 Polaprezinc DB08896 Regorafenib DB00398 Sorafenib DB01268 Sunitinib DB05075 TG-100801 DB04879 Vatalanib |
DrugCentrali | P17948 |
GuidetoPHARMACOLOGYi | 1812 |
Polymorphism and mutation databases
BioMutai | FLT1 |
DMDMi | 143811474 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 26 | 1 PublicationAdd BLAST | 26 | |
ChainiPRO_0000016768 | 27 – 1338 | Vascular endothelial growth factor receptor 1Add BLAST | 1312 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 53 ↔ 107 | PROSITE-ProRule annotation | ||
Glycosylationi | 100 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 158 ↔ 207 | |||
Glycosylationi | 164 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 196 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 251 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 252 ↔ 311 | PROSITE-ProRule annotation | ||
Glycosylationi | 323 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 402 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 417 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 454 ↔ 535 | PROSITE-ProRule annotation | ||
Glycosylationi | 474 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 547 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 577 ↔ 636 | PROSITE-ProRule annotation | ||
Glycosylationi | 597 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 620 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 625 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 666 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 682 ↔ 731 | PROSITE-ProRule annotation | ||
Modified residuei | 914 | Phosphotyrosine; by autocatalysis1 Publication | 1 | |
Modified residuei | 1053 | Phosphotyrosine; by autocatalysisBy similarity | 1 | |
Modified residuei | 1169 | Phosphotyrosine; by autocatalysis1 Publication | 1 | |
Modified residuei | 1213 | Phosphotyrosine; by autocatalysis5 Publications | 1 | |
Modified residuei | 1242 | Phosphotyrosine; by autocatalysis1 Publication | 1 | |
Modified residuei | 1309 | Phosphotyrosine; by autocatalysis1 Publication | 1 | |
Modified residuei | 1327 | Phosphotyrosine; by autocatalysis2 Publications | 1 | |
Modified residuei | 1333 | Phosphotyrosine; by autocatalysis1 Publication | 1 |
Post-translational modificationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 767 – 768 | Cleavage; by PSEN1Curated | 2 |
Keywords - PTMi
Disulfide bond, Glycoprotein, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | P17948 |
jPOSTi | P17948 |
MassIVEi | P17948 |
MaxQBi | P17948 |
PaxDbi | P17948 |
PeptideAtlasi | P17948 |
PRIDEi | P17948 |
ProteomicsDBi | 3403 53530 [P17948-1] 53531 [P17948-2] 53532 [P17948-3] 53533 [P17948-4] 53534 [P17948-5] 53535 [P17948-6] 53536 [P17948-7] |
PTM databases
GlyConnecti | 771 |
iPTMneti | P17948 |
PhosphoSitePlusi | P17948 |
UniCarbKBi | P17948 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000102755 Expressed in 220 organ(s), highest expression level in placenta |
ExpressionAtlasi | P17948 baseline and differential |
Genevisiblei | P17948 HS |
Organism-specific databases
HPAi | CAB068189 CAB068190 HPA011740 HPA014290 |
Interactioni
Subunit structurei
Interacts with VEGFA, VEGFB and PGF. Monomer in the absence of bound VEGFA, VEGFB or PGF. Homodimer in the presence of bound VEGFA, VEGFB and PGF. Can also form a heterodimer with KDR.
Interacts (when tyrosine phosphorylated) with CBL, CRK, GRB2, NCK1, PIK3R1, PLCG, PSEN1 and PTPN11. Probably interacts also with PTPRB.
Interacts with RACK1.
Identified in a complex with CBL and CD2AP.
16 PublicationsBinary interactionsi
GO - Molecular functioni
- growth factor binding Source: UniProtKB
- vascular endothelial growth factor binding Source: GO_Central
Protein-protein interaction databases
BioGridi | 108609, 15 interactors |
DIPi | DIP-643N |
IntActi | P17948, 33 interactors |
MINTi | P17948 |
STRINGi | 9606.ENSP00000282397 |
Chemistry databases
BindingDBi | P17948 |
Structurei
Secondary structure
3D structure databases
SMRi | P17948 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P17948 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 32 – 123 | Ig-like C2-type 1Add BLAST | 92 | |
Domaini | 151 – 214 | Ig-like C2-type 2Add BLAST | 64 | |
Domaini | 230 – 327 | Ig-like C2-type 3Add BLAST | 98 | |
Domaini | 335 – 421 | Ig-like C2-type 4Add BLAST | 87 | |
Domaini | 428 – 553 | Ig-like C2-type 5Add BLAST | 126 | |
Domaini | 556 – 654 | Ig-like C2-type 6Add BLAST | 99 | |
Domaini | 661 – 747 | Ig-like C2-type 7Add BLAST | 87 | |
Domaini | 827 – 1158 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 332 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0200 Eukaryota COG0515 LUCA |
GeneTreei | ENSGT00940000158713 |
HOGENOMi | HOG000037949 |
InParanoidi | P17948 |
KOi | K05096 |
OMAi | FVEMHSD |
OrthoDBi | 1377476at2759 |
PhylomeDBi | P17948 |
TreeFami | TF325768 |
Family and domain databases
Gene3Di | 2.60.40.10, 7 hits |
InterProi | View protein in InterPro IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR013098 Ig_I-set IPR003599 Ig_sub IPR003598 Ig_sub2 IPR013106 Ig_V-set IPR013151 Immunoglobulin IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR001245 Ser-Thr/Tyr_kinase_cat_dom IPR008266 Tyr_kinase_AS IPR020635 Tyr_kinase_cat_dom IPR001824 Tyr_kinase_rcpt_3_CS IPR041348 VEGFR-2_TMD IPR009135 VEGFR1_rcpt |
Pfami | View protein in Pfam PF07679 I-set, 2 hits PF00047 ig, 1 hit PF07714 Pkinase_Tyr, 1 hit PF17988 VEGFR-2_TMD, 1 hit |
PRINTSi | PR01833 VEGFRECEPTR1 |
SMARTi | View protein in SMART SM00409 IG, 7 hits SM00408 IGc2, 5 hits SM00406 IGv, 2 hits SM00219 TyrKc, 1 hit |
SUPFAMi | SSF48726 SSF48726, 7 hits SSF56112 SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50835 IG_LIKE, 6 hits PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00109 PROTEIN_KINASE_TYR, 1 hit PS00240 RECEPTOR_TYR_KIN_III, 1 hit |
s (8+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 8 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 8 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MVSYWDTGVL LCALLSCLLL TGSSSGSKLK DPELSLKGTQ HIMQAGQTLH
60 70 80 90 100
LQCRGEAAHK WSLPEMVSKE SERLSITKSA CGRNGKQFCS TLTLNTAQAN
110 120 130 140 150
HTGFYSCKYL AVPTSKKKET ESAIYIFISD TGRPFVEMYS EIPEIIHMTE
160 170 180 190 200
GRELVIPCRV TSPNITVTLK KFPLDTLIPD GKRIIWDSRK GFIISNATYK
210 220 230 240 250
EIGLLTCEAT VNGHLYKTNY LTHRQTNTII DVQISTPRPV KLLRGHTLVL
260 270 280 290 300
NCTATTPLNT RVQMTWSYPD EKNKRASVRR RIDQSNSHAN IFYSVLTIDK
310 320 330 340 350
MQNKDKGLYT CRVRSGPSFK SVNTSVHIYD KAFITVKHRK QQVLETVAGK
360 370 380 390 400
RSYRLSMKVK AFPSPEVVWL KDGLPATEKS ARYLTRGYSL IIKDVTEEDA
410 420 430 440 450
GNYTILLSIK QSNVFKNLTA TLIVNVKPQI YEKAVSSFPD PALYPLGSRQ
460 470 480 490 500
ILTCTAYGIP QPTIKWFWHP CNHNHSEARC DFCSNNEESF ILDADSNMGN
510 520 530 540 550
RIESITQRMA IIEGKNKMAS TLVVADSRIS GIYICIASNK VGTVGRNISF
560 570 580 590 600
YITDVPNGFH VNLEKMPTEG EDLKLSCTVN KFLYRDVTWI LLRTVNNRTM
610 620 630 640 650
HYSISKQKMA ITKEHSITLN LTIMNVSLQD SGTYACRARN VYTGEEILQK
660 670 680 690 700
KEITIRDQEA PYLLRNLSDH TVAISSSTTL DCHANGVPEP QITWFKNNHK
710 720 730 740 750
IQQEPGIILG PGSSTLFIER VTEEDEGVYH CKATNQKGSV ESSAYLTVQG
760 770 780 790 800
TSDKSNLELI TLTCTCVAAT LFWLLLTLFI RKMKRSSSEI KTDYLSIIMD
810 820 830 840 850
PDEVPLDEQC ERLPYDASKW EFARERLKLG KSLGRGAFGK VVQASAFGIK
860 870 880 890 900
KSPTCRTVAV KMLKEGATAS EYKALMTELK ILTHIGHHLN VVNLLGACTK
910 920 930 940 950
QGGPLMVIVE YCKYGNLSNY LKSKRDLFFL NKDAALHMEP KKEKMEPGLE
960 970 980 990 1000
QGKKPRLDSV TSSESFASSG FQEDKSLSDV EEEEDSDGFY KEPITMEDLI
1010 1020 1030 1040 1050
SYSFQVARGM EFLSSRKCIH RDLAARNILL SENNVVKICD FGLARDIYKN
1060 1070 1080 1090 1100
PDYVRKGDTR LPLKWMAPES IFDKIYSTKS DVWSYGVLLW EIFSLGGSPY
1110 1120 1130 1140 1150
PGVQMDEDFC SRLREGMRMR APEYSTPEIY QIMLDCWHRD PKERPRFAEL
1160 1170 1180 1190 1200
VEKLGDLLQA NVQQDGKDYI PINAILTGNS GFTYSTPAFS EDFFKESISA
1210 1220 1230 1240 1250
PKFNSGSSDD VRYVNAFKFM SLERIKTFEE LLPNATSMFD DYQGDSSTLL
1260 1270 1280 1290 1300
ASPMLKRFTW TDSKPKASLK IDLRVTSKSK ESGLSDVSRP SFCHSSCGHV
1310 1320 1330
SEGKRRFTYD HAELERKIAC CSPPPDYNSV VLYSTPPI
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A1W2PNW4 | A0A1W2PNW4_HUMAN | Vascular endothelial growth factor ... | FLT1 | 665 | Annotation score: | ||
H9N1E7 | H9N1E7_HUMAN | Vascular endothelial growth factor ... | FLT1 | 433 | Annotation score: | ||
H9N1E8 | H9N1E8_HUMAN | Vascular endothelial growth factor ... | FLT1 | 85 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 490 | F → S in AAC16449 (PubMed:10471394).Curated | 1 | |
Sequence conflicti | 779 | F → L in CAA35946 (PubMed:2158038).Curated | 1 | |
Sequence conflicti | 1029 | L → F in ABI53803 (PubMed:20512933).Curated | 1 | |
Sequence conflicti | 1029 | L → F in ABI53804 (PubMed:20512933).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_042045 | 60 | K → T1 PublicationCorresponds to variant dbSNP:rs56409818Ensembl. | 1 | |
Natural variantiVAR_049719 | 128 | I → L. Corresponds to variant dbSNP:rs35073261Ensembl. | 1 | |
Natural variantiVAR_042046 | 144 | E → K1 PublicationCorresponds to variant dbSNP:rs55974987Ensembl. | 1 | |
Natural variantiVAR_042047 | 281 | R → Q1 PublicationCorresponds to variant dbSNP:rs55687105Ensembl. | 1 | |
Natural variantiVAR_042048 | 422 | L → I in a lung adenocarcinoma sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_042049 | 781 | R → Q in a glioma low grade oligodendroglioma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs553261958Ensembl. | 1 | |
Natural variantiVAR_042050 | 938 | M → V1 PublicationCorresponds to variant dbSNP:rs35549791Ensembl. | 1 | |
Natural variantiVAR_042051 | 982 | E → A1 PublicationCorresponds to variant dbSNP:rs35832528Ensembl. | 1 | |
Natural variantiVAR_042052 | 1061 | L → V in a bladder transitional cell carcinoma sample; somatic mutation. 1 Publication | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_041983 | 1 – 995 | Missing in isoform 7. 1 PublicationAdd BLAST | 995 | |
Alternative sequenceiVSP_041984 | 1 – 875 | Missing in isoform 6. 1 PublicationAdd BLAST | 875 | |
Alternative sequenceiVSP_041985 | 1 – 782 | Missing in isoform 5. 1 PublicationAdd BLAST | 782 | |
Alternative sequenceiVSP_047759 | 1 – 7 | MVSYWDT → MNSDLLV in isoform 8. 1 Publication | 7 | |
Alternative sequenceiVSP_047760 | 8 – 984 | Missing in isoform 8. 1 PublicationAdd BLAST | 977 | |
Alternative sequenceiVSP_041929 | 518 – 541 | MASTL…ASNKV → LPPANSSFMLPPTSFSSNYF HFLP in isoform 4. 1 PublicationAdd BLAST | 24 | |
Alternative sequenceiVSP_041930 | 542 – 1338 | Missing in isoform 4. 1 PublicationAdd BLAST | 797 | |
Alternative sequenceiVSP_002955 | 657 – 687 | DQEAP…HANGV → GEHCNKKAVFSRISKFKSTR NDCTTQSNVKH in isoform 2. 3 PublicationsAdd BLAST | 31 | |
Alternative sequenceiVSP_002956 | 688 – 1338 | Missing in isoform 2. 3 PublicationsAdd BLAST | 651 | |
Alternative sequenceiVSP_041927 | 706 – 733 | GIILG…YHCKA → ELYTSTSPSSSSSSPLSSSS SSSSSSSS in isoform 3. 3 PublicationsAdd BLAST | 28 | |
Alternative sequenceiVSP_041928 | 734 – 1338 | Missing in isoform 3. 3 PublicationsAdd BLAST | 605 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X51602 mRNA Translation: CAA35946.1 U01134 mRNA Translation: AAC50060.1 AF063657 mRNA Translation: AAC16449.2 EU826561 mRNA Translation: ACF47597.1 EU368830 mRNA Translation: ACA62948.1 DQ836394 mRNA Translation: ABI53803.1 DQ836395 mRNA Translation: ABI53804.1 DQ836396 mRNA Translation: ABI53805.1 EF491868 mRNA Translation: ABS32268.1 EF491869 mRNA Translation: ABS32269.1 EF491870 mRNA Translation: ABS32270.1 EU360600 mRNA Translation: ACB05747.1 EU332841 Genomic DNA Translation: ABY87530.1 AK292936 mRNA Translation: BAF85625.1 AK300392 mRNA Translation: BAG62125.1 AL138712 Genomic DNA No translation available. AL139005 Genomic DNA No translation available. CH471075 Genomic DNA Translation: EAX08431.1 CH471075 Genomic DNA Translation: EAX08432.1 BC039007 mRNA Translation: AAH39007.1 D00133 Genomic DNA Translation: BAA00080.1 |
CCDSi | CCDS53860.1 [P17948-3] CCDS53861.1 [P17948-4] CCDS73556.1 [P17948-2] CCDS9330.1 [P17948-1] |
PIRi | A49636 S09982 |
RefSeqi | NP_001153392.1, NM_001159920.1 [P17948-2] NP_001153502.1, NM_001160030.1 [P17948-3] NP_001153503.1, NM_001160031.1 [P17948-4] NP_002010.2, NM_002019.4 [P17948-1] |
Genome annotation databases
Ensembli | ENST00000282397; ENSP00000282397; ENSG00000102755 [P17948-1] ENST00000539099; ENSP00000442630; ENSG00000102755 [P17948-4] ENST00000541932; ENSP00000437631; ENSG00000102755 [P17948-3] ENST00000543394; ENSP00000437841; ENSG00000102755 [P17948-8] ENST00000615840; ENSP00000484039; ENSG00000102755 [P17948-2] |
GeneIDi | 2321 |
KEGGi | hsa:2321 |
UCSCi | uc001usb.4 human [P17948-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X51602 mRNA Translation: CAA35946.1 U01134 mRNA Translation: AAC50060.1 AF063657 mRNA Translation: AAC16449.2 EU826561 mRNA Translation: ACF47597.1 EU368830 mRNA Translation: ACA62948.1 DQ836394 mRNA Translation: ABI53803.1 DQ836395 mRNA Translation: ABI53804.1 DQ836396 mRNA Translation: ABI53805.1 EF491868 mRNA Translation: ABS32268.1 EF491869 mRNA Translation: ABS32269.1 EF491870 mRNA Translation: ABS32270.1 EU360600 mRNA Translation: ACB05747.1 EU332841 Genomic DNA Translation: ABY87530.1 AK292936 mRNA Translation: BAF85625.1 AK300392 mRNA Translation: BAG62125.1 AL138712 Genomic DNA No translation available. AL139005 Genomic DNA No translation available. CH471075 Genomic DNA Translation: EAX08431.1 CH471075 Genomic DNA Translation: EAX08432.1 BC039007 mRNA Translation: AAH39007.1 D00133 Genomic DNA Translation: BAA00080.1 |
CCDSi | CCDS53860.1 [P17948-3] CCDS53861.1 [P17948-4] CCDS73556.1 [P17948-2] CCDS9330.1 [P17948-1] |
PIRi | A49636 S09982 |
RefSeqi | NP_001153392.1, NM_001159920.1 [P17948-2] NP_001153502.1, NM_001160030.1 [P17948-3] NP_001153503.1, NM_001160031.1 [P17948-4] NP_002010.2, NM_002019.4 [P17948-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1FLT | X-ray | 1.70 | X/Y | 132-226 | [»] | |
1QSV | NMR | - | A | 129-229 | [»] | |
1QSZ | NMR | - | A | 129-229 | [»] | |
1QTY | X-ray | 2.70 | T/U/X/Y | 129-229 | [»] | |
1RV6 | X-ray | 2.45 | X/Y | 130-229 | [»] | |
2XAC | X-ray | 2.71 | C/X | 129-226 | [»] | |
3HNG | X-ray | 2.70 | A | 801-1158 | [»] | |
4CKV | X-ray | 2.06 | X | 132-225 | [»] | |
4CL7 | X-ray | 2.00 | A/B/C/D | 132-225 | [»] | |
5ABD | X-ray | 2.00 | E/I/X | 132-226 | [»] | |
5EX3 | X-ray | 2.41 | D | 827-835 | [»] | |
5T89 | X-ray | 4.00 | X/Y | 27-656 | [»] | |
SMRi | P17948 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGridi | 108609, 15 interactors |
DIPi | DIP-643N |
IntActi | P17948, 33 interactors |
MINTi | P17948 |
STRINGi | 9606.ENSP00000282397 |
Chemistry databases
BindingDBi | P17948 |
ChEMBLi | CHEMBL1868 |
DrugBanki | DB06080 ABT-869 DB06626 Axitinib DB05932 Denibulin DB10770 Foreskin fibroblast (neonatal) DB12010 Fostamatinib DB06101 IMC-1C11 DB09078 Lenvatinib DB07288 N-(4-chlorophenyl)-2-[(pyridin-4-ylmethyl)amino]benzamide DB09079 Nintedanib DB05913 OSI-930 DB06589 Pazopanib DB09221 Polaprezinc DB08896 Regorafenib DB00398 Sorafenib DB01268 Sunitinib DB05075 TG-100801 DB04879 Vatalanib |
DrugCentrali | P17948 |
GuidetoPHARMACOLOGYi | 1812 |
PTM databases
GlyConnecti | 771 |
iPTMneti | P17948 |
PhosphoSitePlusi | P17948 |
UniCarbKBi | P17948 |
Polymorphism and mutation databases
BioMutai | FLT1 |
DMDMi | 143811474 |
Proteomic databases
EPDi | P17948 |
jPOSTi | P17948 |
MassIVEi | P17948 |
MaxQBi | P17948 |
PaxDbi | P17948 |
PeptideAtlasi | P17948 |
PRIDEi | P17948 |
ProteomicsDBi | 3403 53530 [P17948-1] 53531 [P17948-2] 53532 [P17948-3] 53533 [P17948-4] 53534 [P17948-5] 53535 [P17948-6] 53536 [P17948-7] |
Protocols and materials databases
ABCDi | P17948 |
DNASUi | 2321 |
Genome annotation databases
Ensembli | ENST00000282397; ENSP00000282397; ENSG00000102755 [P17948-1] ENST00000539099; ENSP00000442630; ENSG00000102755 [P17948-4] ENST00000541932; ENSP00000437631; ENSG00000102755 [P17948-3] ENST00000543394; ENSP00000437841; ENSG00000102755 [P17948-8] ENST00000615840; ENSP00000484039; ENSG00000102755 [P17948-2] |
GeneIDi | 2321 |
KEGGi | hsa:2321 |
UCSCi | uc001usb.4 human [P17948-1] |
Organism-specific databases
CTDi | 2321 |
DisGeNETi | 2321 |
GeneCardsi | FLT1 |
HGNCi | HGNC:3763 FLT1 |
HPAi | CAB068189 CAB068190 HPA011740 HPA014290 |
MalaCardsi | FLT1 |
MIMi | 165070 gene |
neXtProti | NX_P17948 |
OpenTargetsi | ENSG00000102755 |
Orphaneti | 275555 Preeclampsia |
PharmGKBi | PA28180 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0200 Eukaryota COG0515 LUCA |
GeneTreei | ENSGT00940000158713 |
HOGENOMi | HOG000037949 |
InParanoidi | P17948 |
KOi | K05096 |
OMAi | FVEMHSD |
OrthoDBi | 1377476at2759 |
PhylomeDBi | P17948 |
TreeFami | TF325768 |
Enzyme and pathway databases
BRENDAi | 2.7.10.1 2681 |
Reactomei | R-HSA-194306 Neurophilin interactions with VEGF and VEGFR R-HSA-195399 VEGF binds to VEGFR leading to receptor dimerization |
SignaLinki | P17948 |
SIGNORi | P17948 |
Miscellaneous databases
ChiTaRSi | FLT1 human |
EvolutionaryTracei | P17948 |
GeneWikii | FLT1 |
GenomeRNAii | 2321 |
Pharosi | P17948 |
PROi | PR:P17948 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000102755 Expressed in 220 organ(s), highest expression level in placenta |
ExpressionAtlasi | P17948 baseline and differential |
Genevisiblei | P17948 HS |
Family and domain databases
Gene3Di | 2.60.40.10, 7 hits |
InterProi | View protein in InterPro IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR013098 Ig_I-set IPR003599 Ig_sub IPR003598 Ig_sub2 IPR013106 Ig_V-set IPR013151 Immunoglobulin IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR001245 Ser-Thr/Tyr_kinase_cat_dom IPR008266 Tyr_kinase_AS IPR020635 Tyr_kinase_cat_dom IPR001824 Tyr_kinase_rcpt_3_CS IPR041348 VEGFR-2_TMD IPR009135 VEGFR1_rcpt |
Pfami | View protein in Pfam PF07679 I-set, 2 hits PF00047 ig, 1 hit PF07714 Pkinase_Tyr, 1 hit PF17988 VEGFR-2_TMD, 1 hit |
PRINTSi | PR01833 VEGFRECEPTR1 |
SMARTi | View protein in SMART SM00409 IG, 7 hits SM00408 IGc2, 5 hits SM00406 IGv, 2 hits SM00219 TyrKc, 1 hit |
SUPFAMi | SSF48726 SSF48726, 7 hits SSF56112 SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50835 IG_LIKE, 6 hits PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00109 PROTEIN_KINASE_TYR, 1 hit PS00240 RECEPTOR_TYR_KIN_III, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | VGFR1_HUMAN | |
Accessioni | P17948Primary (citable) accession number: P17948 Secondary accession number(s): A3E342 Q12954 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1990 |
Last sequence update: | April 3, 2007 | |
Last modified: | October 16, 2019 | |
This is version 229 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Complete proteome, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 13
Human chromosome 13: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - Human and mouse protein kinases
Human and mouse protein kinases: classification and index - SIMILARITY comments
Index of protein domains and families - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references