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Protein

Galectin-3

Gene

LGALS3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells. Together with TRIM16, coordinates the recognition of membrane damage with mobilization of the core autophagy regulators ATG16L1 and BECN1 in response to damaged endomembranes.By similarity4 Publications

GO - Molecular functioni

  • carbohydrate binding Source: ProtInc
  • chemoattractant activity Source: BHF-UCL
  • IgE binding Source: BHF-UCL
  • laminin binding Source: BHF-UCL
  • oligosaccharide binding Source: UniProtKB
  • protein phosphatase binding Source: ARUK-UCL
  • protein phosphatase inhibitor activity Source: ARUK-UCL
  • RNA binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionIgE-binding protein
Biological processDifferentiation, Immunity, Innate immunity, mRNA processing, mRNA splicing
LigandLectin

Enzyme and pathway databases

ReactomeiR-HSA-6798695 Neutrophil degranulation
R-HSA-879415 Advanced glycosylation endproduct receptor signaling
R-HSA-8939246 RUNX1 regulates transcription of genes involved in differentiation of myeloid cells
R-HSA-8941333 RUNX2 regulates genes involved in differentiation of myeloid cells
SIGNORiP17931

Protein family/group databases

MoonDBiP17931 Curated
UniLectiniP17931

Names & Taxonomyi

Protein namesi
Recommended name:
Galectin-3
Short name:
Gal-3
Alternative name(s):
35 kDa lectin
Carbohydrate-binding protein 35
Short name:
CBP 35
Galactose-specific lectin 3
Galactoside-binding protein
Short name:
GALBP
IgE-binding protein
L-31
Laminin-binding protein
Lectin L-29
Mac-2 antigen
Gene namesi
Name:LGALS3
Synonyms:MAC2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000131981.15
HGNCiHGNC:6563 LGALS3
MIMi153619 gene
neXtProtiNX_P17931

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Secreted, Spliceosome

Pathology & Biotechi

Organism-specific databases

DisGeNETi3958
OpenTargetsiENSG00000131981
PharmGKBiPA30340

Chemistry databases

ChEMBLiCHEMBL4531

Polymorphism and mutation databases

BioMutaiLGALS3
DMDMi215274262

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000769302 – 250Galectin-3Add BLAST249

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei6Phosphoserine1 Publication1
Modified residuei12Phosphoserine1 Publication1
Disulfide bondi173InterchainBy similarity
Modified residuei188PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Disulfide bond, Phosphoprotein

Proteomic databases

EPDiP17931
MaxQBiP17931
PaxDbiP17931
PeptideAtlasiP17931
PRIDEiP17931
ProteomicsDBi53526

2D gel databases

DOSAC-COBS-2DPAGEiP17931
REPRODUCTION-2DPAGEiIPI00465431
UCD-2DPAGEiP17931

PTM databases

iPTMnetiP17931
PhosphoSitePlusiP17931

Miscellaneous databases

PMAP-CutDBiP17931

Expressioni

Tissue specificityi

A major expression is found in the colonic epithelium. It is also abundant in the activated macrophages. Expressed in fetal membranes.1 Publication

Gene expression databases

BgeeiENSG00000131981 Expressed in 239 organ(s), highest expression level in colonic mucosa
CleanExiHS_LGALS3
ExpressionAtlasiP17931 baseline and differential
GenevisibleiP17931 HS

Organism-specific databases

HPAiCAB005191
HPA003162

Interactioni

Subunit structurei

Probably forms homo- or heterodimers. Interacts with DMBT1 (By similarity). Interacts with CD6 and ALCAM (PubMed:24945728). Forms a complex with the ITGA3, ITGB1 and CSPG4. Interacts with LGALS3BP, LYPD3, CYHR1 and UACA. Interacts with TRIM16; this interaction mediates autophagy of damage endomembranes.By similarity4 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi110149, 210 interactors
CORUMiP17931
DIPiDIP-45623N
IntActiP17931, 65 interactors
MINTiP17931
STRINGi9606.ENSP00000254301

Chemistry databases

BindingDBiP17931

Structurei

Secondary structure

1250
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP17931
SMRiP17931
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP17931

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati36 – 4419
Repeati45 – 5329
Repeati54 – 6239
Repeati63 – 694; approximate7
Repeati70 – 7859
Repeati79 – 886; approximate10
Repeati89 – 1007; approximateAdd BLAST12
Repeati101 – 1098; approximate9
Domaini118 – 248GalectinPROSITE-ProRule annotationAdd BLAST131

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni36 – 1098 X 9 AA tandem repeats of Y-P-G-X(3)-P-G-AAdd BLAST74
Regioni181 – 187Beta-galactoside bindingBy similarity7

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi226 – 241Nuclear export signalBy similarityAdd BLAST16

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3587 Eukaryota
ENOG4111EA0 LUCA
GeneTreeiENSGT00760000119105
HOVERGENiHBG006255
InParanoidiP17931
KOiK06831
OMAiYWGPEER
OrthoDBiEOG091G0WP8
PhylomeDBiP17931
TreeFamiTF315551

Family and domain databases

CDDicd00070 GLECT, 1 hit
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR015534 Galectin_3
IPR001079 Galectin_CRD
PANTHERiPTHR11346:SF26 PTHR11346:SF26, 1 hit
PfamiView protein in Pfam
PF00337 Gal-bind_lectin, 1 hit
SMARTiView protein in SMART
SM00908 Gal-bind_lectin, 1 hit
SM00276 GLECT, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS51304 GALECTIN, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P17931-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADNFSLHDA LSGSGNPNPQ GWPGAWGNQP AGAGGYPGAS YPGAYPGQAP
60 70 80 90 100
PGAYPGQAPP GAYPGAPGAY PGAPAPGVYP GPPSGPGAYP SSGQPSATGA
110 120 130 140 150
YPATGPYGAP AGPLIVPYNL PLPGGVVPRM LITILGTVKP NANRIALDFQ
160 170 180 190 200
RGNDVAFHFN PRFNENNRRV IVCNTKLDNN WGREERQSVF PFESGKPFKI
210 220 230 240 250
QVLVEPDHFK VAVNDAHLLQ YNHRVKKLNE ISKLGISGDI DLTSASYTMI
Length:250
Mass (Da):26,152
Last modified:November 25, 2008 - v5
Checksum:iC49DDF6D67AE0C88
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V3R6G3V3R6_HUMAN
Galectin
LGALS3
233Annotation score:
G3V407G3V407_HUMAN
Galectin-3
LGALS3
88Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti33 – 52AGGYP…QAPPG → QGLPRGFLSWGLPRAGTPR (PubMed:2402511).CuratedAdd BLAST20
Sequence conflicti88Missing (PubMed:2402511).Curated1
Sequence conflicti232S → R in M64303 (PubMed:2009535).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01298864P → H3 PublicationsCorresponds to variant dbSNP:rs4644Ensembl.1
Natural variantiVAR_01298998T → P4 PublicationsCorresponds to variant dbSNP:rs4652Ensembl.1
Natural variantiVAR_049768183R → K. Corresponds to variant dbSNP:rs10148371Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M57710 mRNA Translation: AAA35607.1
M35368 mRNA Translation: AAA88086.1
M36682 mRNA Translation: AAA36163.1
M64303 mRNA No translation available.
S59012 mRNA Translation: AAB26229.1
AF031425
, AF031422, AF031423, AF031424 Genomic DNA Translation: AAB86584.1
AB006780 mRNA Translation: BAA22164.1
AK314929 mRNA Translation: BAG37435.1
CR456897 mRNA Translation: CAG33178.1
AL139316 Genomic DNA No translation available.
CH471061 Genomic DNA Translation: EAW80658.1
BC001120 mRNA Translation: AAH01120.1
BC053667 mRNA Translation: AAH53667.1
CCDSiCCDS41956.1
PIRiA35820
RefSeqiNP_002297.2, NM_002306.3
UniGeneiHs.531081

Genome annotation databases

EnsembliENST00000254301; ENSP00000254301; ENSG00000131981
GeneIDi3958
KEGGihsa:3958
UCSCiuc001xbr.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

Galectin-3

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M57710 mRNA Translation: AAA35607.1
M35368 mRNA Translation: AAA88086.1
M36682 mRNA Translation: AAA36163.1
M64303 mRNA No translation available.
S59012 mRNA Translation: AAB26229.1
AF031425
, AF031422, AF031423, AF031424 Genomic DNA Translation: AAB86584.1
AB006780 mRNA Translation: BAA22164.1
AK314929 mRNA Translation: BAG37435.1
CR456897 mRNA Translation: CAG33178.1
AL139316 Genomic DNA No translation available.
CH471061 Genomic DNA Translation: EAW80658.1
BC001120 mRNA Translation: AAH01120.1
BC053667 mRNA Translation: AAH53667.1
CCDSiCCDS41956.1
PIRiA35820
RefSeqiNP_002297.2, NM_002306.3
UniGeneiHs.531081

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1A3KX-ray2.10A114-250[»]
1KJLX-ray1.40A105-250[»]
1KJRX-ray1.55A105-250[»]
2NMNX-ray2.45A113-250[»]
2NMOX-ray1.35A113-250[»]
2NN8X-ray1.35A113-250[»]
2XG3X-ray1.20A114-250[»]
3AYAX-ray2.00A/B117-250[»]
3AYCX-ray1.80A/B117-250[»]
3AYDX-ray1.90A117-250[»]
3AYEX-ray2.00A/B117-250[»]
3T1LX-ray1.60A108-250[»]
3T1MX-ray1.55A108-250[»]
3ZSJX-ray0.86A113-250[»]
3ZSKX-ray0.90A114-250[»]
3ZSLX-ray1.08A114-250[»]
3ZSMX-ray1.25A114-250[»]
4BLIX-ray1.08A114-250[»]
4BLJX-ray1.20A114-250[»]
4BM8X-ray0.96A114-250[»]
4JC1X-ray1.50A108-250[»]
4JCKX-ray1.15A108-250[»]
4LBJX-ray1.80A114-250[»]
4LBKX-ray1.60A114-250[»]
4LBLX-ray1.58A114-250[»]
4LBMX-ray1.55A112-250[»]
4LBNX-ray1.70A112-250[»]
4LBOX-ray1.65A113-250[»]
4R9AX-ray1.20A111-250[»]
4R9BX-ray1.20A111-250[»]
4R9CX-ray1.19A111-250[»]
4R9DX-ray1.24A111-250[»]
4RL7X-ray2.00A111-250[»]
4XBNX-ray2.21A113-250[»]
5E88X-ray1.60A114-250[»]
5E89X-ray1.50A114-250[»]
5E8AX-ray1.50A114-250[»]
5EXOX-ray1.50A112-250[»]
5H9PX-ray2.04A113-250[»]
5H9RX-ray1.58A113-250[»]
5IUQX-ray1.12A113-250[»]
5NF7X-ray1.59A106-250[»]
5NF9X-ray1.87A106-250[»]
5NFAX-ray1.59A106-250[»]
5NFBX-ray1.59A106-250[»]
5NFCX-ray1.59A106-250[»]
5OAXX-ray1.20A114-250[»]
5ODYX-ray1.15A113-250[»]
6EOGX-ray1.20A114-250[»]
6EOLX-ray1.50A114-250[»]
6EXYOther1.10A113-250[»]
6EYMOther1.70A113-250[»]
6F2QOther1.03A113-250[»]
6FOFX-ray2.20A/B/C/D/E/F/G/H/I/J/K/L2-250[»]
6G0VX-ray1.09A114-250[»]
ProteinModelPortaliP17931
SMRiP17931
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110149, 210 interactors
CORUMiP17931
DIPiDIP-45623N
IntActiP17931, 65 interactors
MINTiP17931
STRINGi9606.ENSP00000254301

Chemistry databases

BindingDBiP17931
ChEMBLiCHEMBL4531

Protein family/group databases

MoonDBiP17931 Curated
UniLectiniP17931

PTM databases

iPTMnetiP17931
PhosphoSitePlusiP17931

Polymorphism and mutation databases

BioMutaiLGALS3
DMDMi215274262

2D gel databases

DOSAC-COBS-2DPAGEiP17931
REPRODUCTION-2DPAGEiIPI00465431
UCD-2DPAGEiP17931

Proteomic databases

EPDiP17931
MaxQBiP17931
PaxDbiP17931
PeptideAtlasiP17931
PRIDEiP17931
ProteomicsDBi53526

Protocols and materials databases

DNASUi3958
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000254301; ENSP00000254301; ENSG00000131981
GeneIDi3958
KEGGihsa:3958
UCSCiuc001xbr.4 human

Organism-specific databases

CTDi3958
DisGeNETi3958
EuPathDBiHostDB:ENSG00000131981.15
GeneCardsiLGALS3
HGNCiHGNC:6563 LGALS3
HPAiCAB005191
HPA003162
MIMi153619 gene
neXtProtiNX_P17931
OpenTargetsiENSG00000131981
PharmGKBiPA30340
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3587 Eukaryota
ENOG4111EA0 LUCA
GeneTreeiENSGT00760000119105
HOVERGENiHBG006255
InParanoidiP17931
KOiK06831
OMAiYWGPEER
OrthoDBiEOG091G0WP8
PhylomeDBiP17931
TreeFamiTF315551

Enzyme and pathway databases

ReactomeiR-HSA-6798695 Neutrophil degranulation
R-HSA-879415 Advanced glycosylation endproduct receptor signaling
R-HSA-8939246 RUNX1 regulates transcription of genes involved in differentiation of myeloid cells
R-HSA-8941333 RUNX2 regulates genes involved in differentiation of myeloid cells
SIGNORiP17931

Miscellaneous databases

ChiTaRSiLGALS3 human
EvolutionaryTraceiP17931
GeneWikiiLGALS3
GenomeRNAii3958
PMAP-CutDBiP17931
PROiPR:P17931
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000131981 Expressed in 239 organ(s), highest expression level in colonic mucosa
CleanExiHS_LGALS3
ExpressionAtlasiP17931 baseline and differential
GenevisibleiP17931 HS

Family and domain databases

CDDicd00070 GLECT, 1 hit
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR015534 Galectin_3
IPR001079 Galectin_CRD
PANTHERiPTHR11346:SF26 PTHR11346:SF26, 1 hit
PfamiView protein in Pfam
PF00337 Gal-bind_lectin, 1 hit
SMARTiView protein in SMART
SM00908 Gal-bind_lectin, 1 hit
SM00276 GLECT, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS51304 GALECTIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLEG3_HUMAN
AccessioniPrimary (citable) accession number: P17931
Secondary accession number(s): B2RC38
, Q16005, Q6IBA7, Q96J47
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 25, 2008
Last modified: November 7, 2018
This is version 216 of the entry and version 5 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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