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Entry version 219 (13 Feb 2019)
Sequence version 5 (25 Nov 2008)
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Protein

Galectin-3

Gene

LGALS3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells. Together with TRIM16, coordinates the recognition of membrane damage with mobilization of the core autophagy regulators ATG16L1 and BECN1 in response to damaged endomembranes.By similarity4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • carbohydrate binding Source: ProtInc
  • chemoattractant activity Source: BHF-UCL
  • IgE binding Source: BHF-UCL
  • laminin binding Source: BHF-UCL
  • oligosaccharide binding Source: UniProtKB
  • protein phosphatase binding Source: ARUK-UCL
  • protein phosphatase inhibitor activity Source: ARUK-UCL
  • RNA binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIgE-binding protein
Biological processDifferentiation, Immunity, Innate immunity, mRNA processing, mRNA splicing
LigandLectin

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6798695 Neutrophil degranulation
R-HSA-879415 Advanced glycosylation endproduct receptor signaling
R-HSA-8939246 RUNX1 regulates transcription of genes involved in differentiation of myeloid cells
R-HSA-8941333 RUNX2 regulates genes involved in differentiation of myeloid cells

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P17931

Protein family/group databases

MoonDB Database of extreme multifunctional and moonlighting proteins

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MoonDBi
P17931 Curated

UniLectin database of carbohydrate-binding proteins

More...
UniLectini
P17931

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Galectin-3
Short name:
Gal-3
Alternative name(s):
35 kDa lectin
Carbohydrate-binding protein 35
Short name:
CBP 35
Galactose-specific lectin 3
Galactoside-binding protein
Short name:
GALBP
IgE-binding protein
L-31
Laminin-binding protein
Lectin L-29
Mac-2 antigen
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LGALS3
Synonyms:MAC2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000131981.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:6563 LGALS3

Online Mendelian Inheritance in Man (OMIM)

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MIMi
153619 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P17931

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Secreted, Spliceosome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
3958

Open Targets

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OpenTargetsi
ENSG00000131981

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30340

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL4531

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
LGALS3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
215274262

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedBy similarity
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000769302 – 250Galectin-3Add BLAST249

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineBy similarity1
Modified residuei6Phosphoserine1 Publication1
Modified residuei12Phosphoserine1 Publication1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi173InterchainBy similarity
Modified residuei188PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Disulfide bond, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P17931

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P17931

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P17931

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P17931

PeptideAtlas

More...
PeptideAtlasi
P17931

PRoteomics IDEntifications database

More...
PRIDEi
P17931

ProteomicsDB human proteome resource

More...
ProteomicsDBi
53526

2D gel databases

DOSAC-COBS 2D-PAGE database

More...
DOSAC-COBS-2DPAGEi
P17931

REPRODUCTION-2DPAGE

More...
REPRODUCTION-2DPAGEi
IPI00465431

University College Dublin 2-DE Proteome Database

More...
UCD-2DPAGEi
P17931

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P17931

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P17931

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
P17931

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

A major expression is found in the colonic epithelium. It is also abundant in the activated macrophages. Expressed in fetal membranes.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000131981 Expressed in 239 organ(s), highest expression level in colonic mucosa

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P17931 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P17931 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB005191
HPA003162

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Probably forms homo- or heterodimers. Interacts with DMBT1 (By similarity). Interacts with CD6 and ALCAM (PubMed:24945728). Forms a complex with the ITGA3, ITGB1 and CSPG4. Interacts with LGALS3BP, LYPD3, CYHR1 and UACA. Interacts with TRIM16; this interaction mediates autophagy of damage endomembranes.By similarity4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
110149, 214 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
P17931

Database of interacting proteins

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DIPi
DIP-45623N

Protein interaction database and analysis system

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IntActi
P17931, 65 interactors

Molecular INTeraction database

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MINTi
P17931

STRING: functional protein association networks

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STRINGi
9606.ENSP00000254301

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P17931

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1250
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1A3KX-ray2.10A114-250[»]
1KJLX-ray1.40A105-250[»]
1KJRX-ray1.55A105-250[»]
2NMNX-ray2.45A113-250[»]
2NMOX-ray1.35A113-250[»]
2NN8X-ray1.35A113-250[»]
2XG3X-ray1.20A114-250[»]
3AYAX-ray2.00A/B117-250[»]
3AYCX-ray1.80A/B117-250[»]
3AYDX-ray1.90A117-250[»]
3AYEX-ray2.00A/B117-250[»]
3T1LX-ray1.60A108-250[»]
3T1MX-ray1.55A108-250[»]
3ZSJX-ray0.86A113-250[»]
3ZSKX-ray0.90A114-250[»]
3ZSLX-ray1.08A114-250[»]
3ZSMX-ray1.25A114-250[»]
4BLIX-ray1.08A114-250[»]
4BLJX-ray1.20A114-250[»]
4BM8X-ray0.96A114-250[»]
4JC1X-ray1.50A108-250[»]
4JCKX-ray1.15A108-250[»]
4LBJX-ray1.80A114-250[»]
4LBKX-ray1.60A114-250[»]
4LBLX-ray1.58A114-250[»]
4LBMX-ray1.55A112-250[»]
4LBNX-ray1.70A112-250[»]
4LBOX-ray1.65A113-250[»]
4R9AX-ray1.20A111-250[»]
4R9BX-ray1.20A111-250[»]
4R9CX-ray1.19A111-250[»]
4R9DX-ray1.24A111-250[»]
4RL7X-ray2.00A111-250[»]
4XBNX-ray2.21A113-250[»]
5E88X-ray1.60A114-250[»]
5E89X-ray1.50A114-250[»]
5E8AX-ray1.50A114-250[»]
5EXOX-ray1.50A112-250[»]
5H9PX-ray2.04A113-250[»]
5H9RX-ray1.58A113-250[»]
5IUQX-ray1.12A113-250[»]
5NF7X-ray1.59A106-250[»]
5NF9X-ray1.87A106-250[»]
5NFAX-ray1.59A106-250[»]
5NFBX-ray1.59A106-250[»]
5NFCX-ray1.59A106-250[»]
5OAXX-ray1.20A114-250[»]
5ODYX-ray1.15A113-250[»]
6B8KX-ray1.28A112-250[»]
6EOGX-ray1.20A114-250[»]
6EOLX-ray1.50A114-250[»]
6EXYOther1.10A113-250[»]
6EYMOther1.70A113-250[»]
6F2QOther1.03A113-250[»]
6F6YX-ray1.41A114-250[»]
6FOFX-ray2.20A/B/C/D/E/F/G/H/I/J/K/L2-250[»]
6G0VX-ray1.09A114-250[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P17931

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P17931

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P17931

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati36 – 4419
Repeati45 – 5329
Repeati54 – 6239
Repeati63 – 694; approximate7
Repeati70 – 7859
Repeati79 – 886; approximate10
Repeati89 – 1007; approximateAdd BLAST12
Repeati101 – 1098; approximate9
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini118 – 248GalectinPROSITE-ProRule annotationAdd BLAST131

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni36 – 1098 X 9 AA tandem repeats of Y-P-G-X(3)-P-G-AAdd BLAST74
Regioni181 – 187Beta-galactoside bindingBy similarity7

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi226 – 241Nuclear export signalBy similarityAdd BLAST16

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3587 Eukaryota
ENOG4111EA0 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157224

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG006255

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P17931

KEGG Orthology (KO)

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KOi
K06831

Identification of Orthologs from Complete Genome Data

More...
OMAi
YWGPEER

Database of Orthologous Groups

More...
OrthoDBi
829777at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P17931

TreeFam database of animal gene trees

More...
TreeFami
TF315551

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00070 GLECT, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013320 ConA-like_dom_sf
IPR015534 Galectin_3
IPR001079 Galectin_CRD

The PANTHER Classification System

More...
PANTHERi
PTHR11346:SF26 PTHR11346:SF26, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00337 Gal-bind_lectin, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00908 Gal-bind_lectin, 1 hit
SM00276 GLECT, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49899 SSF49899, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51304 GALECTIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P17931-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADNFSLHDA LSGSGNPNPQ GWPGAWGNQP AGAGGYPGAS YPGAYPGQAP
60 70 80 90 100
PGAYPGQAPP GAYPGAPGAY PGAPAPGVYP GPPSGPGAYP SSGQPSATGA
110 120 130 140 150
YPATGPYGAP AGPLIVPYNL PLPGGVVPRM LITILGTVKP NANRIALDFQ
160 170 180 190 200
RGNDVAFHFN PRFNENNRRV IVCNTKLDNN WGREERQSVF PFESGKPFKI
210 220 230 240 250
QVLVEPDHFK VAVNDAHLLQ YNHRVKKLNE ISKLGISGDI DLTSASYTMI
Length:250
Mass (Da):26,152
Last modified:November 25, 2008 - v5
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC49DDF6D67AE0C88
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V3R6G3V3R6_HUMAN
Galectin
LGALS3
233Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V407G3V407_HUMAN
Galectin-3
LGALS3
88Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti33 – 52AGGYP…QAPPG → QGLPRGFLSWGLPRAGTPR (PubMed:2402511).CuratedAdd BLAST20
Sequence conflicti88Missing (PubMed:2402511).Curated1
Sequence conflicti232S → R in M64303 (PubMed:2009535).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01298864P → H3 PublicationsCorresponds to variant dbSNP:rs4644Ensembl.1
Natural variantiVAR_01298998T → P4 PublicationsCorresponds to variant dbSNP:rs4652Ensembl.1
Natural variantiVAR_049768183R → K. Corresponds to variant dbSNP:rs10148371Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
M57710 mRNA Translation: AAA35607.1
M35368 mRNA Translation: AAA88086.1
M36682 mRNA Translation: AAA36163.1
M64303 mRNA No translation available.
S59012 mRNA Translation: AAB26229.1
AF031425
, AF031422, AF031423, AF031424 Genomic DNA Translation: AAB86584.1
AB006780 mRNA Translation: BAA22164.1
AK314929 mRNA Translation: BAG37435.1
CR456897 mRNA Translation: CAG33178.1
AL139316 Genomic DNA No translation available.
CH471061 Genomic DNA Translation: EAW80658.1
BC001120 mRNA Translation: AAH01120.1
BC053667 mRNA Translation: AAH53667.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS41956.1

Protein sequence database of the Protein Information Resource

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PIRi
A35820

NCBI Reference Sequences

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RefSeqi
NP_002297.2, NM_002306.3

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.531081

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000254301; ENSP00000254301; ENSG00000131981

Database of genes from NCBI RefSeq genomes

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GeneIDi
3958

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:3958

UCSC genome browser

More...
UCSCi
uc001xbr.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Functional Glycomics Gateway - Glycan Binding

Galectin-3

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M57710 mRNA Translation: AAA35607.1
M35368 mRNA Translation: AAA88086.1
M36682 mRNA Translation: AAA36163.1
M64303 mRNA No translation available.
S59012 mRNA Translation: AAB26229.1
AF031425
, AF031422, AF031423, AF031424 Genomic DNA Translation: AAB86584.1
AB006780 mRNA Translation: BAA22164.1
AK314929 mRNA Translation: BAG37435.1
CR456897 mRNA Translation: CAG33178.1
AL139316 Genomic DNA No translation available.
CH471061 Genomic DNA Translation: EAW80658.1
BC001120 mRNA Translation: AAH01120.1
BC053667 mRNA Translation: AAH53667.1
CCDSiCCDS41956.1
PIRiA35820
RefSeqiNP_002297.2, NM_002306.3
UniGeneiHs.531081

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1A3KX-ray2.10A114-250[»]
1KJLX-ray1.40A105-250[»]
1KJRX-ray1.55A105-250[»]
2NMNX-ray2.45A113-250[»]
2NMOX-ray1.35A113-250[»]
2NN8X-ray1.35A113-250[»]
2XG3X-ray1.20A114-250[»]
3AYAX-ray2.00A/B117-250[»]
3AYCX-ray1.80A/B117-250[»]
3AYDX-ray1.90A117-250[»]
3AYEX-ray2.00A/B117-250[»]
3T1LX-ray1.60A108-250[»]
3T1MX-ray1.55A108-250[»]
3ZSJX-ray0.86A113-250[»]
3ZSKX-ray0.90A114-250[»]
3ZSLX-ray1.08A114-250[»]
3ZSMX-ray1.25A114-250[»]
4BLIX-ray1.08A114-250[»]
4BLJX-ray1.20A114-250[»]
4BM8X-ray0.96A114-250[»]
4JC1X-ray1.50A108-250[»]
4JCKX-ray1.15A108-250[»]
4LBJX-ray1.80A114-250[»]
4LBKX-ray1.60A114-250[»]
4LBLX-ray1.58A114-250[»]
4LBMX-ray1.55A112-250[»]
4LBNX-ray1.70A112-250[»]
4LBOX-ray1.65A113-250[»]
4R9AX-ray1.20A111-250[»]
4R9BX-ray1.20A111-250[»]
4R9CX-ray1.19A111-250[»]
4R9DX-ray1.24A111-250[»]
4RL7X-ray2.00A111-250[»]
4XBNX-ray2.21A113-250[»]
5E88X-ray1.60A114-250[»]
5E89X-ray1.50A114-250[»]
5E8AX-ray1.50A114-250[»]
5EXOX-ray1.50A112-250[»]
5H9PX-ray2.04A113-250[»]
5H9RX-ray1.58A113-250[»]
5IUQX-ray1.12A113-250[»]
5NF7X-ray1.59A106-250[»]
5NF9X-ray1.87A106-250[»]
5NFAX-ray1.59A106-250[»]
5NFBX-ray1.59A106-250[»]
5NFCX-ray1.59A106-250[»]
5OAXX-ray1.20A114-250[»]
5ODYX-ray1.15A113-250[»]
6B8KX-ray1.28A112-250[»]
6EOGX-ray1.20A114-250[»]
6EOLX-ray1.50A114-250[»]
6EXYOther1.10A113-250[»]
6EYMOther1.70A113-250[»]
6F2QOther1.03A113-250[»]
6F6YX-ray1.41A114-250[»]
6FOFX-ray2.20A/B/C/D/E/F/G/H/I/J/K/L2-250[»]
6G0VX-ray1.09A114-250[»]
ProteinModelPortaliP17931
SMRiP17931
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110149, 214 interactors
CORUMiP17931
DIPiDIP-45623N
IntActiP17931, 65 interactors
MINTiP17931
STRINGi9606.ENSP00000254301

Chemistry databases

BindingDBiP17931
ChEMBLiCHEMBL4531

Protein family/group databases

MoonDBiP17931 Curated
UniLectiniP17931

PTM databases

iPTMnetiP17931
PhosphoSitePlusiP17931

Polymorphism and mutation databases

BioMutaiLGALS3
DMDMi215274262

2D gel databases

DOSAC-COBS-2DPAGEiP17931
REPRODUCTION-2DPAGEiIPI00465431
UCD-2DPAGEiP17931

Proteomic databases

EPDiP17931
jPOSTiP17931
MaxQBiP17931
PaxDbiP17931
PeptideAtlasiP17931
PRIDEiP17931
ProteomicsDBi53526

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
3958
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000254301; ENSP00000254301; ENSG00000131981
GeneIDi3958
KEGGihsa:3958
UCSCiuc001xbr.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3958
DisGeNETi3958
EuPathDBiHostDB:ENSG00000131981.15

GeneCards: human genes, protein and diseases

More...
GeneCardsi
LGALS3
HGNCiHGNC:6563 LGALS3
HPAiCAB005191
HPA003162
MIMi153619 gene
neXtProtiNX_P17931
OpenTargetsiENSG00000131981
PharmGKBiPA30340

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3587 Eukaryota
ENOG4111EA0 LUCA
GeneTreeiENSGT00940000157224
HOVERGENiHBG006255
InParanoidiP17931
KOiK06831
OMAiYWGPEER
OrthoDBi829777at2759
PhylomeDBiP17931
TreeFamiTF315551

Enzyme and pathway databases

ReactomeiR-HSA-6798695 Neutrophil degranulation
R-HSA-879415 Advanced glycosylation endproduct receptor signaling
R-HSA-8939246 RUNX1 regulates transcription of genes involved in differentiation of myeloid cells
R-HSA-8941333 RUNX2 regulates genes involved in differentiation of myeloid cells
SIGNORiP17931

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
LGALS3 human
EvolutionaryTraceiP17931

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
LGALS3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
3958
PMAP-CutDBiP17931

Protein Ontology

More...
PROi
PR:P17931

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000131981 Expressed in 239 organ(s), highest expression level in colonic mucosa
ExpressionAtlasiP17931 baseline and differential
GenevisibleiP17931 HS

Family and domain databases

CDDicd00070 GLECT, 1 hit
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR015534 Galectin_3
IPR001079 Galectin_CRD
PANTHERiPTHR11346:SF26 PTHR11346:SF26, 1 hit
PfamiView protein in Pfam
PF00337 Gal-bind_lectin, 1 hit
SMARTiView protein in SMART
SM00908 Gal-bind_lectin, 1 hit
SM00276 GLECT, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS51304 GALECTIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLEG3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P17931
Secondary accession number(s): B2RC38
, Q16005, Q6IBA7, Q96J47
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 25, 2008
Last modified: February 13, 2019
This is version 219 of the entry and version 5 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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