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Protein

Complement receptor type 1

Gene

CR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Membrane immune adherence receptor that plays a critical role in the capture and clearance of complement-opsonized pathogens by erythrocytes and monocytes/macrophages (PubMed:2963069). Mediates the binding by these cells of particles and immune complexes that have activated complement to eliminate them from the circulation (PubMed:2963069). Acts also in the inhibition of spontaneous complement activation by impairing the formation and function of the alternative and classical pathway C3/C5 convertases, and by serving as a cofactor for the cleavage by factor I of C3b to iC3b, C3c and C3d,g, and of C4b to C4c and C4d (PubMed:2972794, PubMed:8175757). Plays also a role in immune regulation by contributing, upon ligand binding, to the generation of regulatory T cells from activated helper T cells (PubMed:25742728).4 Publications
(Microbial infection) Acts as a receptor for Epstein-Barr virus.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionBlood group antigen, Host cell receptor for virus entry, Receptor
Biological processComplement pathway, Host-virus interaction, Immunity, Innate immunity

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6798695 Neutrophil degranulation
R-HSA-8877330 RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)
R-HSA-977606 Regulation of Complement cascade

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Complement receptor type 1
Alternative name(s):
C3b/C4b receptor
CD_antigen: CD35
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CR1
Synonyms:C3BR
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000203710.10

Human Gene Nomenclature Database

More...
HGNCi
HGNC:2334 CR1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
120620 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P17927

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini42 – 1971ExtracellularSequence analysisAdd BLAST1930
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1972 – 1996HelicalSequence analysisAdd BLAST25
Topological domaini1997 – 2039CytoplasmicSequence analysisAdd BLAST43

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
1378

MalaCards human disease database

More...
MalaCardsi
CR1
MIMi607486 phenotype
611162 phenotype

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA26855

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3713643

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CR1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
290457678

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 41Add BLAST41
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000600942 – 2039Complement receptor type 1Add BLAST1998

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei42Pyrrolidone carboxylic acidSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi43 ↔ 86PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi56N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi73 ↔ 99PROSITE-ProRule annotation
Disulfide bondi104 ↔ 145PROSITE-ProRule annotation
Disulfide bondi131 ↔ 161PROSITE-ProRule annotation
Disulfide bondi166 ↔ 215PROSITE-ProRule annotation
Disulfide bondi195 ↔ 232PROSITE-ProRule annotation
Disulfide bondi238 ↔ 280PROSITE-ProRule annotation
Glycosylationi252N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi266 ↔ 293PROSITE-ProRule annotation
Disulfide bondi297 ↔ 340PROSITE-ProRule annotation
Disulfide bondi326 ↔ 353PROSITE-ProRule annotation
Disulfide bondi358 ↔ 400PROSITE-ProRule annotation
Disulfide bondi386 ↔ 416PROSITE-ProRule annotation
Glycosylationi410N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi421 ↔ 470PROSITE-ProRule annotation
Glycosylationi447N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi450 ↔ 487PROSITE-ProRule annotation
Disulfide bondi493 ↔ 536PROSITE-ProRule annotation
Glycosylationi509N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi523 ↔ 549PROSITE-ProRule annotation
Disulfide bondi554 ↔ 595PROSITE-ProRule annotation
Glycosylationi578N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi581 ↔ 611PROSITE-ProRule annotation
Disulfide bondi616 ↔ 665PROSITE-ProRule annotation
Disulfide bondi645 ↔ 682PROSITE-ProRule annotation
Disulfide bondi688 ↔ 730PROSITE-ProRule annotation
Glycosylationi702N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi716 ↔ 743PROSITE-ProRule annotation
Disulfide bondi747 ↔ 790PROSITE-ProRule annotation
Disulfide bondi776 ↔ 803PROSITE-ProRule annotation
Disulfide bondi808 ↔ 850PROSITE-ProRule annotation
Disulfide bondi836 ↔ 866PROSITE-ProRule annotation
Glycosylationi860N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi871 ↔ 920PROSITE-ProRule annotation
Glycosylationi897N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi900 ↔ 937PROSITE-ProRule annotation
Disulfide bondi943 ↔ 986PROSITE-ProRule annotation
Glycosylationi959N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi973 ↔ 999PROSITE-ProRule annotation
Disulfide bondi1004 ↔ 1045
Glycosylationi1028N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1031 ↔ 1061
Disulfide bondi1066 ↔ 1115
Disulfide bondi1095 ↔ 1132
Disulfide bondi1138 ↔ 1180PROSITE-ProRule annotation
Glycosylationi1152N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1166 ↔ 1193PROSITE-ProRule annotation
Disulfide bondi1197 ↔ 1240PROSITE-ProRule annotation
Disulfide bondi1226 ↔ 1253PROSITE-ProRule annotation
Disulfide bondi1258 ↔ 1300PROSITE-ProRule annotation
Disulfide bondi1286 ↔ 1316PROSITE-ProRule annotation
Glycosylationi1310N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1321 ↔ 1370PROSITE-ProRule annotation
Disulfide bondi1350 ↔ 1387PROSITE-ProRule annotation
Disulfide bondi1396 ↔ 1439PROSITE-ProRule annotation
Disulfide bondi1426 ↔ 1452PROSITE-ProRule annotation
Disulfide bondi1457 ↔ 1498PROSITE-ProRule annotation
Glycosylationi1481N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1484 ↔ 1514PROSITE-ProRule annotation
Glycosylationi1504N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1519 ↔ 1568PROSITE-ProRule annotation
Glycosylationi1534N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1540N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1548 ↔ 1585PROSITE-ProRule annotation
Disulfide bondi1591 ↔ 1633PROSITE-ProRule annotation
Glycosylationi1605N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1619 ↔ 1646PROSITE-ProRule annotation
Disulfide bondi1650 ↔ 1693PROSITE-ProRule annotation
Disulfide bondi1679 ↔ 1706PROSITE-ProRule annotation
Disulfide bondi1711 ↔ 1753PROSITE-ProRule annotation
Disulfide bondi1739 ↔ 1769PROSITE-ProRule annotation
Glycosylationi1763N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1774 ↔ 1823PROSITE-ProRule annotation
Disulfide bondi1803 ↔ 1840PROSITE-ProRule annotation
Disulfide bondi1848 ↔ 1891PROSITE-ProRule annotation
Disulfide bondi1877 ↔ 1904PROSITE-ProRule annotation
Glycosylationi1908N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1909 ↔ 1952PROSITE-ProRule annotation
Disulfide bondi1938 ↔ 1965PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein, Pyrrolidone carboxylic acid

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P17927

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P17927

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P17927

PeptideAtlas

More...
PeptideAtlasi
P17927

PRoteomics IDEntifications database

More...
PRIDEi
P17927

ProteomicsDB human proteome resource

More...
ProteomicsDBi
53525

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1929

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P17927

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P17927

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Present on erythrocytes, a subset of T cells, mature B cells, follicular dendritic cells, monocytes and granulocytes.3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000203710 Expressed in 135 organ(s), highest expression level in blood

CleanEx database of gene expression profiles

More...
CleanExi
HS_CR1

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P17927 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P17927 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB002491
CAB016271
HPA042455
HPA043579
HPA049348

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via Sushi 1 and Sushi 2 domains) with complement factor C4b (PubMed:2972794, PubMed:8175757). Interacts (via Sushi 8 and Sushi 9 domains) with complement factor C3b (PubMed:2972794, PubMed:8175757). Interacts (via Sushi 24 and Sushi 25 domains) with MBL2 (PubMed:23460739, PubMed:29563915). Interacts with FCN2 (PubMed:2972794). Interacts (via Sushi 24 and Sushi 25 domains) with C1QA (PubMed:9324355, PubMed:29563915).5 Publications
(Microbial infection) Interacts with Epstein-Barr virus gp350.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
107769, 1 interactor

Protein interaction database and analysis system

More...
IntActi
P17927, 7 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000356016

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

12039
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1GKGNMR-A1002-1133[»]
1GKNNMR-A942-1065[»]
1GOPmodel-A942-1133[»]
1PPQNMR-A1002-1065[»]
2MCYNMR-A102-233[»]
2MCZNMR-A41-163[»]
2Q7ZX-ray-A42-1972[»]
5FO9X-ray3.30C/F941-1136[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P17927

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P17927

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P17927

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini42 – 101Sushi 1PROSITE-ProRule annotationAdd BLAST60
Domaini102 – 163Sushi 2PROSITE-ProRule annotationAdd BLAST62
Domaini164 – 234Sushi 3PROSITE-ProRule annotationAdd BLAST71
Domaini236 – 295Sushi 4PROSITE-ProRule annotationAdd BLAST60
Domaini295 – 355Sushi 5PROSITE-ProRule annotationAdd BLAST61
Domaini356 – 418Sushi 6PROSITE-ProRule annotationAdd BLAST63
Domaini419 – 489Sushi 7PROSITE-ProRule annotationAdd BLAST71
Domaini491 – 551Sushi 8PROSITE-ProRule annotationAdd BLAST61
Domaini552 – 613Sushi 9PROSITE-ProRule annotationAdd BLAST62
Domaini614 – 684Sushi 10PROSITE-ProRule annotationAdd BLAST71
Domaini686 – 745Sushi 11PROSITE-ProRule annotationAdd BLAST60
Domaini745 – 805Sushi 12PROSITE-ProRule annotationAdd BLAST61
Domaini806 – 868Sushi 13PROSITE-ProRule annotationAdd BLAST63
Domaini869 – 939Sushi 14PROSITE-ProRule annotationAdd BLAST71
Domaini941 – 1001Sushi 15PROSITE-ProRule annotationAdd BLAST61
Domaini1002 – 1063Sushi 16PROSITE-ProRule annotationAdd BLAST62
Domaini1064 – 1134Sushi 17PROSITE-ProRule annotationAdd BLAST71
Domaini1136 – 1195Sushi 18PROSITE-ProRule annotationAdd BLAST60
Domaini1195 – 1255Sushi 19PROSITE-ProRule annotationAdd BLAST61
Domaini1256 – 1318Sushi 20PROSITE-ProRule annotationAdd BLAST63
Domaini1319 – 1389Sushi 21PROSITE-ProRule annotationAdd BLAST71
Domaini1394 – 1454Sushi 22PROSITE-ProRule annotationAdd BLAST61
Domaini1455 – 1516Sushi 23PROSITE-ProRule annotationAdd BLAST62
Domaini1517 – 1587Sushi 24PROSITE-ProRule annotationAdd BLAST71
Domaini1589 – 1648Sushi 25PROSITE-ProRule annotationAdd BLAST60
Domaini1648 – 1708Sushi 26PROSITE-ProRule annotationAdd BLAST61
Domaini1709 – 1771Sushi 27PROSITE-ProRule annotationAdd BLAST63
Domaini1772 – 1842Sushi 28PROSITE-ProRule annotationAdd BLAST71
Domaini1846 – 1906Sushi 29PROSITE-ProRule annotationAdd BLAST61
Domaini1907 – 1967Sushi 30PROSITE-ProRule annotationAdd BLAST61

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat, Signal, Sushi, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410KDF5 Eukaryota
ENOG410YE3Q LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000139590

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG005397

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P17927

KEGG Orthology (KO)

More...
KOi
K04011

Database of Orthologous Groups

More...
OrthoDBi
46968at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P17927

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00033 CCP, 30 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00084 Sushi, 30 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00032 CCP, 30 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57535 SSF57535, 30 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50923 SUSHI, 30 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

P17927-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGASSPRSPE PVGPPAPGLP FCCGGSLLAV VVLLALPVAW GQCNAPEWLP
60 70 80 90 100
FARPTNLTDE FEFPIGTYLN YECRPGYSGR PFSIICLKNS VWTGAKDRCR
110 120 130 140 150
RKSCRNPPDP VNGMVHVIKG IQFGSQIKYS CTKGYRLIGS SSATCIISGD
160 170 180 190 200
TVIWDNETPI CDRIPCGLPP TITNGDFIST NRENFHYGSV VTYRCNPGSG
210 220 230 240 250
GRKVFELVGE PSIYCTSNDD QVGIWSGPAP QCIIPNKCTP PNVENGILVS
260 270 280 290 300
DNRSLFSLNE VVEFRCQPGF VMKGPRRVKC QALNKWEPEL PSCSRVCQPP
310 320 330 340 350
PDVLHAERTQ RDKDNFSPGQ EVFYSCEPGY DLRGAASMRC TPQGDWSPAA
360 370 380 390 400
PTCEVKSCDD FMGQLLNGRV LFPVNLQLGA KVDFVCDEGF QLKGSSASYC
410 420 430 440 450
VLAGMESLWN SSVPVCEQIF CPSPPVIPNG RHTGKPLEVF PFGKTVNYTC
460 470 480 490 500
DPHPDRGTSF DLIGESTIRC TSDPQGNGVW SSPAPRCGIL GHCQAPDHFL
510 520 530 540 550
FAKLKTQTNA SDFPIGTSLK YECRPEYYGR PFSITCLDNL VWSSPKDVCK
560 570 580 590 600
RKSCKTPPDP VNGMVHVITD IQVGSRINYS CTTGHRLIGH SSAECILSGN
610 620 630 640 650
AAHWSTKPPI CQRIPCGLPP TIANGDFIST NRENFHYGSV VTYRCNPGSG
660 670 680 690 700
GRKVFELVGE PSIYCTSNDD QVGIWSGPAP QCIIPNKCTP PNVENGILVS
710 720 730 740 750
DNRSLFSLNE VVEFRCQPGF VMKGPRRVKC QALNKWEPEL PSCSRVCQPP
760 770 780 790 800
PDVLHAERTQ RDKDNFSPGQ EVFYSCEPGY DLRGAASMRC TPQGDWSPAA
810 820 830 840 850
PTCEVKSCDD FMGQLLNGRV LFPVNLQLGA KVDFVCDEGF QLKGSSASYC
860 870 880 890 900
VLAGMESLWN SSVPVCEQIF CPSPPVIPNG RHTGKPLEVF PFGKAVNYTC
910 920 930 940 950
DPHPDRGTSF DLIGESTIRC TSDPQGNGVW SSPAPRCGIL GHCQAPDHFL
960 970 980 990 1000
FAKLKTQTNA SDFPIGTSLK YECRPEYYGR PFSITCLDNL VWSSPKDVCK
1010 1020 1030 1040 1050
RKSCKTPPDP VNGMVHVITD IQVGSRINYS CTTGHRLIGH SSAECILSGN
1060 1070 1080 1090 1100
TAHWSTKPPI CQRIPCGLPP TIANGDFIST NRENFHYGSV VTYRCNLGSR
1110 1120 1130 1140 1150
GRKVFELVGE PSIYCTSNDD QVGIWSGPAP QCIIPNKCTP PNVENGILVS
1160 1170 1180 1190 1200
DNRSLFSLNE VVEFRCQPGF VMKGPRRVKC QALNKWEPEL PSCSRVCQPP
1210 1220 1230 1240 1250
PEILHGEHTP SHQDNFSPGQ EVFYSCEPGY DLRGAASLHC TPQGDWSPEA
1260 1270 1280 1290 1300
PRCAVKSCDD FLGQLPHGRV LFPLNLQLGA KVSFVCDEGF RLKGSSVSHC
1310 1320 1330 1340 1350
VLVGMRSLWN NSVPVCEHIF CPNPPAILNG RHTGTPSGDI PYGKEISYTC
1360 1370 1380 1390 1400
DPHPDRGMTF NLIGESTIRC TSDPHGNGVW SSPAPRCELS VRAGHCKTPE
1410 1420 1430 1440 1450
QFPFASPTIP INDFEFPVGT SLNYECRPGY FGKMFSISCL ENLVWSSVED
1460 1470 1480 1490 1500
NCRRKSCGPP PEPFNGMVHI NTDTQFGSTV NYSCNEGFRL IGSPSTTCLV
1510 1520 1530 1540 1550
SGNNVTWDKK APICEIISCE PPPTISNGDF YSNNRTSFHN GTVVTYQCHT
1560 1570 1580 1590 1600
GPDGEQLFEL VGERSIYCTS KDDQVGVWSS PPPRCISTNK CTAPEVENAI
1610 1620 1630 1640 1650
RVPGNRSFFS LTEIIRFRCQ PGFVMVGSHT VQCQTNGRWG PKLPHCSRVC
1660 1670 1680 1690 1700
QPPPEILHGE HTLSHQDNFS PGQEVFYSCE PSYDLRGAAS LHCTPQGDWS
1710 1720 1730 1740 1750
PEAPRCTVKS CDDFLGQLPH GRVLLPLNLQ LGAKVSFVCD EGFRLKGRSA
1760 1770 1780 1790 1800
SHCVLAGMKA LWNSSVPVCE QIFCPNPPAI LNGRHTGTPF GDIPYGKEIS
1810 1820 1830 1840 1850
YACDTHPDRG MTFNLIGESS IRCTSDPQGN GVWSSPAPRC ELSVPAACPH
1860 1870 1880 1890 1900
PPKIQNGHYI GGHVSLYLPG MTISYICDPG YLLVGKGFIF CTDQGIWSQL
1910 1920 1930 1940 1950
DHYCKEVNCS FPLFMNGISK ELEMKKVYHY GDYVTLKCED GYTLEGSPWS
1960 1970 1980 1990 2000
QCQADDRWDP PLAKCTSRTH DALIVGTLSG TIFFILLIIF LSWIILKHRK
2010 2020 2030
GNNAHENPKE VAIHLHSQGG SSVHPRTLQT NEENSRVLP
Length:2,039
Mass (Da):223,663
Last modified:March 2, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFB01870F19D5E6DD
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PDY4E9PDY4_HUMAN
Complement receptor type 1
CR1
2,489Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5SR44Q5SR44_HUMAN
Complement receptor type 1
CR1
2,039Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YE06H0YE06_HUMAN
Complement receptor type 1
CR1
660Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PQN4E9PQN4_HUMAN
Complement receptor type 1
CR1
604Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti173T → A in CAI16042 (PubMed:16710414).Curated1
Sequence conflicti173T → A in CAI16723 (PubMed:16710414).Curated1
Sequence conflicti445T → A in CAA68755 (PubMed:2972794).Curated1
Sequence conflicti445T → A in AAB60694 (PubMed:8245463).Curated1
Sequence conflicti445T → A in CAA32541 (PubMed:2971757).Curated1
Sequence conflicti1876I → T in CAA68755 (PubMed:2972794).Curated1
Sequence conflicti1876I → T in CAA28933 (PubMed:2951479).Curated1

<p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

CR1 contains a system of antigens called the Knops blood group system. Polymorphisms within this system are involved in malarial rosetting, a process associated with cerebral malaria, the major cause of mortality in Plasmodium falciparum malaria. Common Knops system antigens include McCoy (McC) and Sl(a)/Vil (Kn4, or Swain-Langley; Vil or Villien). Sl(a-) phenotype is more common in persons of African descent and may protect against fatal malaria.
Other polymorphic forms of CR1 contain 23, 37 or 44 Sushi (CCP/SCR) domains instead of the 30 Sushi (CCP/SCR) domains. The most frequent alleles are the F allotype (shown here) and the S allotype (37 repeat Sushi domains). The gene frequencies of the F allotype and S allotype are 0.87 and 0.11 in Caucasians, 0.82 and 0.11 in African Americans, 0.89 and 0.11 in Mexicans.
Genetic variations in CR1 resulting in CR1 deficiency are involved in protection against severe malaria [MIMi:611162]. Parasitized red blood cells (RBCs) from children suffering from severe malaria often adhere to complement receptor 1 (CR1) on uninfected RBCs to form clumps of cells known as rosettes. CR1-deficient red blood cells show greatly reduced rosetting and CR1 deficiency occurs in healthy individuals from malaria-endemic regions.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0138191208H → R1 PublicationCorresponds to variant dbSNP:rs2274567Ensembl.1
Natural variantiVAR_0138201408T → I. 1
Natural variantiVAR_0202631408T → M. Corresponds to variant dbSNP:rs3737002Ensembl.1
Natural variantiVAR_0556851540N → S. Corresponds to variant dbSNP:rs17259045Ensembl.1
Natural variantiVAR_0138211590K → E in MCC(b) antigen. 1 PublicationCorresponds to variant dbSNP:rs17047660Ensembl.1
Natural variantiVAR_0138221601R → G in Sl(2)/Vil antigen and Sl(3) antigen. 2 PublicationsCorresponds to variant dbSNP:rs17047661Ensembl.1
Natural variantiVAR_0138231610S → T in Sl(3) antigen. 3 PublicationsCorresponds to variant dbSNP:rs4844609Ensembl.1
Natural variantiVAR_0138241615I → V2 PublicationsCorresponds to variant dbSNP:rs6691117Ensembl.1
Natural variantiVAR_0138251827P → R2 PublicationsCorresponds to variant dbSNP:rs3811381Ensembl.1
Natural variantiVAR_0138261850H → D2 Publications1
Natural variantiVAR_0556861969T → A2 PublicationsCorresponds to variant dbSNP:rs2296160Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Y00816 mRNA Translation: CAA68755.1
L17418
, L17390, L17399, L17409, L17419, L17420, L17421, L17422, L17423, L17391, L17392, L17393, L17394, L17395, L17396, L17397, L17398, L17400, L17401, L17402, L17403, L17404, L17405, L17406, L17407, L17408, L17410, L17411, L17412, L17413, L17414, L17415, L17416, L17417 Genomic DNA Translation: AAB60694.1
L17418
, L17390, L17391, L17392, L17393, L17394, L17395, L17396, L17397, L17398, L17399, L17400, L17401, L17402, L17403, L17404, L17405, L17406, L17407, L17408, L17409, L17410, L17411, L17412, L17413, L17414, L17415, L17416, L17417, L17419, L17420, L17421, L17422, L17423, L17424, L17425, L17426, L17427, L17428, L17429, L17430 Genomic DNA Translation: AAB60695.1
AL137789, AL691452 Genomic DNA Translation: CAI16042.1
AL137789, AL691452 Genomic DNA Translation: CAI16043.1
AL691452, AL137789 Genomic DNA Translation: CAI16723.1
AL691452, AL137789 Genomic DNA Translation: CAI16725.1
X14362 mRNA Translation: CAA32541.1
X05309 mRNA Translation: CAA28933.1
M11569 mRNA Translation: AAA52297.1
M11617 mRNA Translation: AAA52298.1
M11618 mRNA Translation: AAA52299.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS44309.1

Protein sequence database of the Protein Information Resource

More...
PIRi
I73012

NCBI Reference Sequences

More...
RefSeqi
NP_000564.2, NM_000573.3
NP_000642.3, NM_000651.4

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.334019

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000367051; ENSP00000356018; ENSG00000203710
ENST00000367053; ENSP00000356020; ENSG00000203710
ENST00000400960; ENSP00000383744; ENSG00000203710

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1378

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:1378

UCSC genome browser

More...
UCSCi
uc057ozo.1 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

dbRBC/BGMUT

Blood group antigen gene mutation database

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00816 mRNA Translation: CAA68755.1
L17418
, L17390, L17399, L17409, L17419, L17420, L17421, L17422, L17423, L17391, L17392, L17393, L17394, L17395, L17396, L17397, L17398, L17400, L17401, L17402, L17403, L17404, L17405, L17406, L17407, L17408, L17410, L17411, L17412, L17413, L17414, L17415, L17416, L17417 Genomic DNA Translation: AAB60694.1
L17418
, L17390, L17391, L17392, L17393, L17394, L17395, L17396, L17397, L17398, L17399, L17400, L17401, L17402, L17403, L17404, L17405, L17406, L17407, L17408, L17409, L17410, L17411, L17412, L17413, L17414, L17415, L17416, L17417, L17419, L17420, L17421, L17422, L17423, L17424, L17425, L17426, L17427, L17428, L17429, L17430 Genomic DNA Translation: AAB60695.1
AL137789, AL691452 Genomic DNA Translation: CAI16042.1
AL137789, AL691452 Genomic DNA Translation: CAI16043.1
AL691452, AL137789 Genomic DNA Translation: CAI16723.1
AL691452, AL137789 Genomic DNA Translation: CAI16725.1
X14362 mRNA Translation: CAA32541.1
X05309 mRNA Translation: CAA28933.1
M11569 mRNA Translation: AAA52297.1
M11617 mRNA Translation: AAA52298.1
M11618 mRNA Translation: AAA52299.1
CCDSiCCDS44309.1
PIRiI73012
RefSeqiNP_000564.2, NM_000573.3
NP_000642.3, NM_000651.4
UniGeneiHs.334019

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1GKGNMR-A1002-1133[»]
1GKNNMR-A942-1065[»]
1GOPmodel-A942-1133[»]
1PPQNMR-A1002-1065[»]
2MCYNMR-A102-233[»]
2MCZNMR-A41-163[»]
2Q7ZX-ray-A42-1972[»]
5FO9X-ray3.30C/F941-1136[»]
ProteinModelPortaliP17927
SMRiP17927
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107769, 1 interactor
IntActiP17927, 7 interactors
STRINGi9606.ENSP00000356016

Chemistry databases

ChEMBLiCHEMBL3713643

PTM databases

GlyConnecti1929
iPTMnetiP17927
PhosphoSitePlusiP17927

Polymorphism and mutation databases

BioMutaiCR1
DMDMi290457678

Proteomic databases

EPDiP17927
jPOSTiP17927
PaxDbiP17927
PeptideAtlasiP17927
PRIDEiP17927
ProteomicsDBi53525

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367051; ENSP00000356018; ENSG00000203710
ENST00000367053; ENSP00000356020; ENSG00000203710
ENST00000400960; ENSP00000383744; ENSG00000203710
GeneIDi1378
KEGGihsa:1378
UCSCiuc057ozo.1 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1378
DisGeNETi1378
EuPathDBiHostDB:ENSG00000203710.10

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CR1
HGNCiHGNC:2334 CR1
HPAiCAB002491
CAB016271
HPA042455
HPA043579
HPA049348
MalaCardsiCR1
MIMi120620 gene
607486 phenotype
611162 phenotype
neXtProtiNX_P17927
PharmGKBiPA26855

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410KDF5 Eukaryota
ENOG410YE3Q LUCA
HOGENOMiHOG000139590
HOVERGENiHBG005397
InParanoidiP17927
KOiK04011
OrthoDBi46968at2759
PhylomeDBiP17927

Enzyme and pathway databases

ReactomeiR-HSA-6798695 Neutrophil degranulation
R-HSA-8877330 RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)
R-HSA-977606 Regulation of Complement cascade

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CR1 human
EvolutionaryTraceiP17927

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Complement_receptor_1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
1378

Protein Ontology

More...
PROi
PR:P17927

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000203710 Expressed in 135 organ(s), highest expression level in blood
CleanExiHS_CR1
ExpressionAtlasiP17927 baseline and differential
GenevisibleiP17927 HS

Family and domain databases

CDDicd00033 CCP, 30 hits
InterProiView protein in InterPro
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom
PfamiView protein in Pfam
PF00084 Sushi, 30 hits
SMARTiView protein in SMART
SM00032 CCP, 30 hits
SUPFAMiSSF57535 SSF57535, 30 hits
PROSITEiView protein in PROSITE
PS50923 SUSHI, 30 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCR1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P17927
Secondary accession number(s): Q16744
, Q16745, Q5SR43, Q5SR45, Q9UQV2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: March 2, 2010
Last modified: January 16, 2019
This is version 187 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Blood group antigen proteins
    Nomenclature of blood group antigens and list of entries
  2. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  7. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  8. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
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