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Entry version 154 (12 Aug 2020)
Sequence version 2 (15 Jul 1998)
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Protein

Phenylalanine--tRNA ligase beta subunit

Gene

pheT

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+By similarityNote: Binds 2 magnesium ions per tetramer.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi462MagnesiumBy similarity1
Metal bindingi468Magnesium; via carbonyl oxygenBy similarity1
Metal bindingi471MagnesiumBy similarity1
Metal bindingi472MagnesiumBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase, RNA-binding, tRNA-binding
Biological processProtein biosynthesis
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
BSUB:BSU28630-MONOMER

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
P17922

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Phenylalanine--tRNA ligase beta subunit (EC:6.1.1.20)
Alternative name(s):
Phenylalanyl-tRNA synthetase beta subunit
Short name:
PheRS
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:pheT
Ordered Locus Names:BSU28630
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBacillus subtilis (strain 168)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri224308 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001570 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001268441 – 804Phenylalanine--tRNA ligase beta subunitAdd BLAST804

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P17922

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P17922

PRoteomics IDEntifications database

More...
PRIDEi
P17922

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Tetramer of two alpha and two beta subunits.

By similarity

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
P17922, 1 interactor

Molecular INTeraction database

More...
MINTi
P17922

STRING: functional protein association networks

More...
STRINGi
224308.BSU28630

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P17922

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini40 – 155tRNA-bindingAdd BLAST116
Domaini409 – 484B5Add BLAST76
Domaini710 – 803FDX-ACBAdd BLAST94

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG0072, Bacteria
COG0073, Bacteria

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P17922

KEGG Orthology (KO)

More...
KOi
K01890

Identification of Orthologs from Complete Genome Data

More...
OMAi
ISYNWLK

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P17922

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00769, PheRS_beta_core, 1 hit
cd02796, tRNA_bind_bactPheRS, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.70.380, 1 hit
3.50.40.10, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_00283, Phe_tRNA_synth_beta1, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005146, B3/B4_tRNA-bd
IPR009061, DNA-bd_dom_put_sf
IPR005121, Fdx_antiC-bd
IPR036690, Fdx_antiC-bd_sf
IPR012340, NA-bd_OB-fold
IPR004532, Phe-tRNA-ligase_IIc_bsu
IPR020825, Phe-tRNA_synthase_B3/B4
IPR041616, PheRS_beta_core
IPR002547, tRNA-bd_dom
IPR033714, tRNA_bind_bactPheRS
IPR005147, tRNA_synthase_B5-dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03483, B3_4, 1 hit
PF03484, B5, 1 hit
PF03147, FDX-ACB, 1 hit
PF01588, tRNA_bind, 1 hit
PF17759, tRNA_synthFbeta, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00873, B3_4, 1 hit
SM00874, B5, 1 hit
SM00896, FDX-ACB, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46955, SSF46955, 1 hit
SSF50249, SSF50249, 1 hit
SSF54991, SSF54991, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00472, pheT_bact, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51483, B5, 1 hit
PS51447, FDX_ACB, 1 hit
PS50886, TRBD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P17922-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFVSYKWLED YVDLKGMDPA VLAEKITRAG IEVEGIEYKG EGIKGVVIGH
60 70 80 90 100
VLEREQHPNA DKLNKCLVDI GAEAPVQIIC GAPNVDKGQK VAVATVGAVL
110 120 130 140 150
PGNFKIKKAK LRGEESNGMI CSLQELGIES KLVAKEYAEG IFVFPNDAET
160 170 180 190 200
GSDALAALQL DDAILELGLT PNRADAMNML GVAYEVAAIL DTEVKLPQTD
210 220 230 240 250
YPAASEQASD YISVKIEDQE ANPLYTAKII KNVTIAPSPL WMQTKLMNAG
260 270 280 290 300
IRPHNNVVDI TNFVLLEYGQ PLHAFDYDRF GSKEVVVRKA AENEMIVTLD
310 320 330 340 350
DQERKLSADH LVITNGTKAQ AVAGVMGGAE SEVQEDTKTI LLEAAYFNGQ
360 370 380 390 400
KVRKASKDLG LRSESSVRFE KGIDPARVRL AAERAAQLIH LYAGGEVLAG
410 420 430 440 450
TVEEDHLTIE ANNIHVSADK VSSVLGLTIS KEELISIYKR LGFTVGEADD
460 470 480 490 500
LLVVTVPSRR GDITIEEDLI EEAARLYGYD NIPSTLPETA GTTGGLTPYQ
510 520 530 540 550
AKRRKVRRFL EGAGLSQAIT YSLTNEKKAT AFAIEKSLNT VLALPMSEER
560 570 580 590 600
SILRHSLVPN LLDSVSYNLA RQTDSVALYE VGSVFLTKEE DTKPVETERV
610 620 630 640 650
AGAVTGLWRK QLWQGEKKPV DFFVVKGIVE GLLDKLNVLD SIEFVQSERK
660 670 680 690 700
QLHPGRTANI LLNGSLIGFI GQVHPSLEKE LDIKETYVFE LDLHALLAAE
710 720 730 740 750
TAPLVYTAIP KYPSVTRDIA LVTDKTVTSG QLESVIKEAG GKLLKEVTVF
760 770 780 790 800
DVYEGEHMEE GKKSVAFSLQ YVNPEQTLTE EEVTKAHSKV LKALEDTYQA

VLRG
Length:804
Mass (Da):87,945
Last modified:July 15, 1998 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD2337DEAE639E651
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti110 – 111KL → NV in CAA37225 (PubMed:2127701).Curated2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X53057 Genomic DNA Translation: CAA37225.1
Z75208 Genomic DNA Translation: CAA99564.1
AL009126 Genomic DNA Translation: CAB14823.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A69676, YFBSB

NCBI Reference Sequences

More...
RefSeqi
NP_390741.1, NC_000964.3
WP_004398979.1, NZ_JNCM01000036.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
CAB14823; CAB14823; BSU28630

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
937445

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
bsu:BSU28630

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|224308.179.peg.3110

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53057 Genomic DNA Translation: CAA37225.1
Z75208 Genomic DNA Translation: CAA99564.1
AL009126 Genomic DNA Translation: CAB14823.1
PIRiA69676, YFBSB
RefSeqiNP_390741.1, NC_000964.3
WP_004398979.1, NZ_JNCM01000036.1

3D structure databases

SMRiP17922
ModBaseiSearch...

Protein-protein interaction databases

IntActiP17922, 1 interactor
MINTiP17922
STRINGi224308.BSU28630

Proteomic databases

jPOSTiP17922
PaxDbiP17922
PRIDEiP17922

Genome annotation databases

EnsemblBacteriaiCAB14823; CAB14823; BSU28630
GeneIDi937445
KEGGibsu:BSU28630
PATRICifig|224308.179.peg.3110

Phylogenomic databases

eggNOGiCOG0072, Bacteria
COG0073, Bacteria
InParanoidiP17922
KOiK01890
OMAiISYNWLK
PhylomeDBiP17922

Enzyme and pathway databases

BioCyciBSUB:BSU28630-MONOMER
SABIO-RKiP17922

Family and domain databases

CDDicd00769, PheRS_beta_core, 1 hit
cd02796, tRNA_bind_bactPheRS, 1 hit
Gene3Di3.30.70.380, 1 hit
3.50.40.10, 1 hit
HAMAPiMF_00283, Phe_tRNA_synth_beta1, 1 hit
InterProiView protein in InterPro
IPR005146, B3/B4_tRNA-bd
IPR009061, DNA-bd_dom_put_sf
IPR005121, Fdx_antiC-bd
IPR036690, Fdx_antiC-bd_sf
IPR012340, NA-bd_OB-fold
IPR004532, Phe-tRNA-ligase_IIc_bsu
IPR020825, Phe-tRNA_synthase_B3/B4
IPR041616, PheRS_beta_core
IPR002547, tRNA-bd_dom
IPR033714, tRNA_bind_bactPheRS
IPR005147, tRNA_synthase_B5-dom
PfamiView protein in Pfam
PF03483, B3_4, 1 hit
PF03484, B5, 1 hit
PF03147, FDX-ACB, 1 hit
PF01588, tRNA_bind, 1 hit
PF17759, tRNA_synthFbeta, 1 hit
SMARTiView protein in SMART
SM00873, B3_4, 1 hit
SM00874, B5, 1 hit
SM00896, FDX-ACB, 1 hit
SUPFAMiSSF46955, SSF46955, 1 hit
SSF50249, SSF50249, 1 hit
SSF54991, SSF54991, 1 hit
TIGRFAMsiTIGR00472, pheT_bact, 1 hit
PROSITEiView protein in PROSITE
PS51483, B5, 1 hit
PS51447, FDX_ACB, 1 hit
PS50886, TRBD, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSYFB_BACSU
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P17922
Secondary accession number(s): P94540
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: July 15, 1998
Last modified: August 12, 2020
This is version 154 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  3. SIMILARITY comments
    Index of protein domains and families
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