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UniProtKB - P17921 (SYFA_BACSU)
Protein
Phenylalanine--tRNA ligase alpha subunit
Gene
pheS
Organism
Bacillus subtilis (strain 168)
Status
Functioni
Catalytic activityi
- EC:6.1.1.20
Cofactori
Mg2+By similarityNote: Binds 2 magnesium ions per tetramer.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 256 | MagnesiumBy similarity | 1 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-UniRule
- magnesium ion binding Source: UniProtKB-UniRule
- phenylalanine-tRNA ligase activity Source: GO_Central
- tRNA binding Source: InterPro
GO - Biological processi
- phenylalanyl-tRNA aminoacylation Source: GO_Central
Keywordsi
Molecular function | Aminoacyl-tRNA synthetase, Ligase |
Biological process | Protein biosynthesis |
Ligand | ATP-binding, Magnesium, Metal-binding, Nucleotide-binding |
Enzyme and pathway databases
BioCyci | BSUB:BSU28640-MONOMER |
SABIO-RKi | P17921 |
Names & Taxonomyi
Protein namesi | Recommended name: Phenylalanine--tRNA ligase alpha subunit (EC:6.1.1.20)Alternative name(s): Phenylalanyl-tRNA synthetase alpha subunit Short name: PheRS |
Gene namesi | Name:pheS Ordered Locus Names:BSU28640 |
Organismi | Bacillus subtilis (strain 168) |
Taxonomic identifieri | 224308 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus › |
Proteomesi |
|
Subcellular locationi
Cytoplasm and Cytosol
Other locations
- cytoplasm Source: GO_Central
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000126666 | 1 – 344 | Phenylalanine--tRNA ligase alpha subunitAdd BLAST | 344 |
Proteomic databases
jPOSTi | P17921 |
PaxDbi | P17921 |
PRIDEi | P17921 |
Interactioni
Subunit structurei
Tetramer of two alpha and two beta subunits.
By similarityProtein-protein interaction databases
STRINGi | 224308.BSU28640 |
Family & Domainsi
Sequence similaritiesi
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.Curated
Phylogenomic databases
eggNOGi | COG0016, Bacteria |
InParanoidi | P17921 |
OMAi | DWHNFTA |
PhylomeDBi | P17921 |
Family and domain databases
Gene3Di | 3.30.930.10, 1 hit |
HAMAPi | MF_00281, Phe_tRNA_synth_alpha1, 1 hit |
InterProi | View protein in InterPro IPR006195, aa-tRNA-synth_II IPR045864, aa-tRNA-synth_II/BPL/LPL IPR004529, Phe-tRNA-synth_IIc_asu IPR004530, Phe-tRNA-synth_IIc_mito IPR004188, Phe-tRNA_ligase_II_N IPR022911, Phe_tRNA_ligase_alpha1_bac IPR002319, Phenylalanyl-tRNA_Synthase IPR010978, tRNA-bd_arm |
PANTHERi | PTHR11538:SF41, PTHR11538:SF41, 1 hit |
Pfami | View protein in Pfam PF02912, Phe_tRNA-synt_N, 1 hit PF01409, tRNA-synt_2d, 1 hit |
SUPFAMi | SSF46589, SSF46589, 1 hit SSF55681, SSF55681, 1 hit |
TIGRFAMsi | TIGR00468, pheS, 1 hit |
PROSITEi | View protein in PROSITE PS50862, AA_TRNA_LIGASE_II, 1 hit |
i Sequence
Sequence statusi: Complete.
P17921-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEEKLKQLEQ EALEQVEAAS SLKVVNDIRV QYLGKKGPIT EVLRGMGKLS
60 70 80 90 100
AEERPKMGAL ANEVRERIAN AIADKNEKLE EEEMKQKLAG QTIDVTLPGN
110 120 130 140 150
PVAVGGRHPL TVVIEEIEDL FIGMGYTVEE GPEVETDYYN FESLNLPKEH
160 170 180 190 200
PARDMQDSFY ITEETLMRTQ TSPVQTRTME KHEGKGPVKI ICPGKVYRRD
210 220 230 240 250
NDDATHSHQF MQIEGLVVDK NISMSDLKGT LELVAKKMFG QDREIRLRPS
260 270 280 290 300
FFPFTEPSVE VDVTCFKCGG NGCSVCKGTG WIEILGAGMV HPNVLKMAGF
310 320 330 340
DPKEYQGFAF GMGVERIAML KYGIDDIRHF YTNDVRFISQ FKQA
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 90 – 105 | GQTID…PVAVG → DRQLTSRCREPCCSR in CAA37224 (PubMed:2127701).CuratedAdd BLAST | 16 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X53057 Genomic DNA Translation: CAA37224.1 Z75208 Genomic DNA Translation: CAA99603.1 AL009126 Genomic DNA Translation: CAB14824.1 |
PIRi | H69675, YFBSA |
RefSeqi | NP_390742.1, NC_000964.3 WP_004398818.1, NZ_JNCM01000036.1 |
Genome annotation databases
EnsemblBacteriai | CAB14824; CAB14824; BSU_28640 |
GeneIDi | 937987 |
KEGGi | bsu:BSU28640 |
PATRICi | fig|224308.179.peg.3111 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X53057 Genomic DNA Translation: CAA37224.1 Z75208 Genomic DNA Translation: CAA99603.1 AL009126 Genomic DNA Translation: CAB14824.1 |
PIRi | H69675, YFBSA |
RefSeqi | NP_390742.1, NC_000964.3 WP_004398818.1, NZ_JNCM01000036.1 |
3D structure databases
SMRi | P17921 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 224308.BSU28640 |
Proteomic databases
jPOSTi | P17921 |
PaxDbi | P17921 |
PRIDEi | P17921 |
Genome annotation databases
EnsemblBacteriai | CAB14824; CAB14824; BSU_28640 |
GeneIDi | 937987 |
KEGGi | bsu:BSU28640 |
PATRICi | fig|224308.179.peg.3111 |
Phylogenomic databases
eggNOGi | COG0016, Bacteria |
InParanoidi | P17921 |
OMAi | DWHNFTA |
PhylomeDBi | P17921 |
Enzyme and pathway databases
BioCyci | BSUB:BSU28640-MONOMER |
SABIO-RKi | P17921 |
Family and domain databases
Gene3Di | 3.30.930.10, 1 hit |
HAMAPi | MF_00281, Phe_tRNA_synth_alpha1, 1 hit |
InterProi | View protein in InterPro IPR006195, aa-tRNA-synth_II IPR045864, aa-tRNA-synth_II/BPL/LPL IPR004529, Phe-tRNA-synth_IIc_asu IPR004530, Phe-tRNA-synth_IIc_mito IPR004188, Phe-tRNA_ligase_II_N IPR022911, Phe_tRNA_ligase_alpha1_bac IPR002319, Phenylalanyl-tRNA_Synthase IPR010978, tRNA-bd_arm |
PANTHERi | PTHR11538:SF41, PTHR11538:SF41, 1 hit |
Pfami | View protein in Pfam PF02912, Phe_tRNA-synt_N, 1 hit PF01409, tRNA-synt_2d, 1 hit |
SUPFAMi | SSF46589, SSF46589, 1 hit SSF55681, SSF55681, 1 hit |
TIGRFAMsi | TIGR00468, pheS, 1 hit |
PROSITEi | View protein in PROSITE PS50862, AA_TRNA_LIGASE_II, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SYFA_BACSU | |
Accessioni | P17921Primary (citable) accession number: P17921 Secondary accession number(s): P94539 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1990 |
Last sequence update: | November 1, 1997 | |
Last modified: | February 23, 2022 | |
This is version 153 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Aminoacyl-tRNA synthetases
List of aminoacyl-tRNA synthetase entries - SIMILARITY comments
Index of protein domains and families