Hoxb1

Functionⁱ

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures.

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
DNA bindingⁱ	199 – 258	HomeoboxPROSITE-ProRule annotationAdd BLAST		60

GO - Molecular functionⁱ

DNA binding
Source: MGI
Inferred from direct assayⁱ
- 7911971
DNA-binding transcription activator activity, RNA polymerase II-specific Source: MGI
protein domain specific binding Source: MGI
proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific Source: MGI
RNA polymerase II proximal promoter sequence-specific DNA binding Source: MGI
RNA polymerase II regulatory region sequence-specific DNA binding Source: MGI
sequence-specific DNA binding
Source: MGI
Inferred from genetic interactionⁱ
- 18787068

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

anatomical structure formation involved in morphogenesis
Source: MGI
Inferred from genetic interactionⁱ
- 10529420
anatomical structure morphogenesis
Source: MGI
Inferred from genetic interactionⁱ
- 10529420
anterior/posterior pattern specification
Source: MGI
Inferred from genetic interactionⁱ
- 10529420
- 10885747
embryonic skeletal system morphogenesis
Source: MGI
Inferred from genetic interactionⁱ
- 10885747
facial nerve structural organization
Source: MGI
Inferred from mutant phenotypeⁱ
- 8898234
facial nucleus development
Source: MGI
Inferred from mutant phenotypeⁱ
- 8898234
positive regulation of transcription by RNA polymerase II
Source: MGI
Inferred from direct assayⁱ
- 18787068
rhombomere 4 development
Source: MGI
Inferred from genetic interactionⁱ
- 10529420
rhombomere 5 development
Source: MGI
Inferred from genetic interactionⁱ
- 10529420
rhombomere development
Source: MGI
Inferred from direct assayⁱ
- 21320481

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental protein, DNA-binding
Biological process	Transcription, Transcription regulation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Homeobox protein Hox-B1 Alternative name(s): Homeobox protein Hox-2.9
Gene namesⁱ	Name:Hoxb1 Synonyms:Hox-2.9, Hoxb-1
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 11

Organism-specific databases

MGIⁱ	MGI:96182 Hoxb1

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000200108	1 – 297	Homeobox protein Hox-B1Add BLAST		297

Proteomic databases

PaxDbⁱ	P17919
PRIDEⁱ	P17919

PTM databases

PhosphoSitePlusⁱ	P17919

PhosphoSitePlusⁱ

P17919

Expressionⁱ

Developmental stageⁱ

Expressed along the entire length of the primitive streak. In early neurogenesis it is expressed in lateral and paraxial mesoderm, endoderm and superficial ectoderm or in the neural tube. From late neurogenesis to mid-embryogenesis, it presents similar spatial domains in the lateral mesoderm, endoderm and superficial ectoderm but is not detectable in the posterior hindbrain and has increased dramatically in rhombomere 4.

Gene expression databases

Bgeeⁱ	ENSMUSG00000018973 Expressed in 83 organ(s), highest expression level in primitive streak
CleanExⁱ	MM_HOXB1
Genevisibleⁱ	P17919 MM

Interactionⁱ

GO - Molecular functionⁱ

protein domain specific binding Source: MGI

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	200375, 2 interactors
STRINGⁱ	10090.ENSMUSP00000019117

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P17919
SMRⁱ	P17919
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	175 – 180	Antp-type hexapeptide		6

Sequence similaritiesⁱ

Belongs to the Antp homeobox family. Labial subfamily.Curated

Keywords - Domainⁱ

Homeobox

Phylogenomic databases

eggNOGⁱ	KOG0489 Eukaryota ENOG410ZTBY LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00910000144005
HOGENOMⁱ	HOG000247020
HOVERGENⁱ	HBG006089
InParanoidⁱ	P17919
KEGG Orthology (KO) More...KOⁱ	K09301
OMAⁱ	YAICNRG
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0LR2
PhylomeDBⁱ	P17919
TreeFamⁱ	TF317730

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00086 homeodomain, 1 hit
InterProⁱ	View protein in InterPro IPR009057 Homeobox-like_sf IPR017970 Homeobox_CS IPR001356 Homeobox_dom IPR020479 Homeobox_metazoa
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00046 Homeobox, 1 hit
PRINTSⁱ	PR00024 HOMEOBOX
SMARTⁱ	View protein in SMART SM00389 HOX, 1 hit
SUPFAMⁱ	SSF46689 SSF46689, 1 hit
PROSITEⁱ	View protein in PROSITE PS00027 HOMEOBOX_1, 1 hit PS50071 HOMEOBOX_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P17919-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MDYNRMSSFL EYPLCNRGPS AYSAPTSFPP CSAPAVDSYA GESRYGGGLP 
        60         70         80         90        100
SSALQQNSGY PVQQPPSSLG VSFPSPAPSG YAPAACNPSY GPSQYYSVGQ 
       110        120        130        140        150
SEGDGSYFHP SSYGAQLGGL PDSYGAGGVG SGPYPPPQPP YGTEQTATFA 
       160        170        180        190        200
SAYDLLSEDK ESPCSSEPST LTPRTFDWMK VKRNPPKTAK VSELGLGAPG 
       210        220        230        240        250
GLRTNFTTRQ LTELEKEFHF NKYLSRARRV EIAATLELNE TQVKIWFQNR 
       260        270        280        290 
RMKQKKRERE GGRMPAGPPG CPKEAAGDAS DQSACTSPEA SPSSITS

Length:297

Mass (Da):31,672

Last modified:November 1, 1990 - v1

Checksum:ⁱ9798C2B4E897C324

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	38	S → T in CAA42078 (PubMed:1673098).Curated	1
Sequence conflictⁱ	162	S → C in CAA42078 (PubMed:1673098).Curated	1
Sequence conflictⁱ	198	A → P (PubMed:1673098).Curated	1
Sequence conflictⁱ	200	G → R (PubMed:1673098).Curated	1
Sequence conflictⁱ	217	E → G in BAB30874 (PubMed:16141072).Curated	1
Sequence conflictⁱ	234	A → P in CAA42078 (PubMed:1673098).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X53063 Genomic DNA Translation: CAA37238.1 X59474 mRNA Translation: CAA42078.1 AK017686 mRNA Translation: BAB30874.1 BC103597 mRNA Translation: AAI03598.1 BC103598 mRNA Translation: AAI03599.1 BC103606 mRNA Translation: AAI03607.1 M34005 Genomic DNA Translation: AAA37850.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS25300.1
PIRⁱ	A60082 WJMS29
NCBI Reference Sequences More...RefSeqⁱ	NP_032292.3, NM_008266.5
UniGeneⁱ	Mm.890

Genome annotation databases

Ensemblⁱ	ENSMUST00000019117; ENSMUSP00000019117; ENSMUSG00000018973
GeneIDⁱ	15407
KEGGⁱ	mmu:15407
UCSC genome browser More...UCSCⁱ	uc007lbz.2 mouse

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P17919	Homeo box B1		RAT		297	UniRef90_P17919
homeobox protein Hox-B1		MESAU		297
Uncharacterized protein		NEOLE		297
Homeobox protein Hox-B1		CRIGR		297
UPI00042AD6BA		PERMB		300
+6

Protein	Similar proteins		Species	Score	Length	Source
P17919	Homeobox protein Hox-B1	)	HUMAN		301	UniRef50_P14653
Homeobox protein Hox-B1		MACMU		304
Homeobox protein Hox-B1		ATEGE		304
Homeobox protein Hox-B1		MACNE		304
Homeobox protein Hox-B1		PANTR		301
+193

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X53063 Genomic DNA Translation: CAA37238.1 X59474 mRNA Translation: CAA42078.1 AK017686 mRNA Translation: BAB30874.1 BC103597 mRNA Translation: AAI03598.1 BC103598 mRNA Translation: AAI03599.1 BC103606 mRNA Translation: AAI03607.1 M34005 Genomic DNA Translation: AAA37850.1
CCDSⁱ	CCDS25300.1
PIRⁱ	A60082 WJMS29
RefSeqⁱ	NP_032292.3, NM_008266.5
UniGeneⁱ	Mm.890

3D structure databases

ProteinModelPortalⁱ	P17919
SMRⁱ	P17919
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	200375, 2 interactors
STRINGⁱ	10090.ENSMUSP00000019117

PTM databases

PhosphoSitePlusⁱ	P17919

PhosphoSitePlusⁱ

P17919

Proteomic databases

PaxDbⁱ	P17919
PRIDEⁱ	P17919

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000019117; ENSMUSP00000019117; ENSMUSG00000018973
GeneIDⁱ	15407
KEGGⁱ	mmu:15407
UCSCⁱ	uc007lbz.2 mouse

Organism-specific databases

CTDⁱ	3211
MGIⁱ	MGI:96182 Hoxb1

Phylogenomic databases

eggNOGⁱ	KOG0489 Eukaryota ENOG410ZTBY LUCA
GeneTreeⁱ	ENSGT00910000144005
HOGENOMⁱ	HOG000247020
HOVERGENⁱ	HBG006089
InParanoidⁱ	P17919
KOⁱ	K09301
OMAⁱ	YAICNRG
OrthoDBⁱ	EOG091G0LR2
PhylomeDBⁱ	P17919
TreeFamⁱ	TF317730

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P17919
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000018973 Expressed in 83 organ(s), highest expression level in primitive streak
CleanExⁱ	MM_HOXB1
Genevisibleⁱ	P17919 MM

Family and domain databases

CDDⁱ	cd00086 homeodomain, 1 hit
InterProⁱ	View protein in InterPro IPR009057 Homeobox-like_sf IPR017970 Homeobox_CS IPR001356 Homeobox_dom IPR020479 Homeobox_metazoa
Pfamⁱ	View protein in Pfam PF00046 Homeobox, 1 hit
PRINTSⁱ	PR00024 HOMEOBOX
SMARTⁱ	View protein in SMART SM00389 HOX, 1 hit
SUPFAMⁱ	SSF46689 SSF46689, 1 hit
PROSITEⁱ	View protein in PROSITE PS00027 HOMEOBOX_1, 1 hit PS50071 HOMEOBOX_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	HXB1_MOUSE
Accessionⁱ	P17919Primary (citable) accession number: P17919 Secondary accession number(s): Q3ZAY6, Q9CYH3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1990
	Last sequence update:	November 1, 1990
	Last modified:	November 7, 2018
	This is version 149 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Vertebrate homeotic Hox proteins
Nomenclature of vertebrate homeotic Hox proteins and list of entries
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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Supporting data

UniProtKB - P17919 (HXB1_MOUSE)

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Homeobox protein Hox-B1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ