UniProtKB - P17919 (HXB1_MOUSE)
Protein
Homeobox protein Hox-B1
Gene
Hoxb1
Organism
Mus musculus (Mouse)
Status
Functioni
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 199 – 258 | HomeoboxPROSITE-ProRule annotationAdd BLAST | 60 |
GO - Molecular functioni
- DNA binding Source: MGI
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: MGI
- protein domain specific binding Source: MGI
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: MGI
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: MGI
- sequence-specific DNA binding Source: MGI
- sequence-specific double-stranded DNA binding Source: MGI
GO - Biological processi
- anatomical structure formation involved in morphogenesis Source: MGI
- anatomical structure morphogenesis Source: MGI
- anterior/posterior pattern specification Source: MGI
- embryonic skeletal system morphogenesis Source: MGI
- facial nerve structural organization Source: MGI
- facial nucleus development Source: MGI
- positive regulation of transcription by RNA polymerase II Source: MGI
- rhombomere 4 development Source: MGI
- rhombomere 5 development Source: MGI
- rhombomere development Source: MGI
Keywordsi
Molecular function | Developmental protein, DNA-binding |
Biological process | Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Homeobox protein Hox-B1Alternative name(s): Homeobox protein Hox-2.9 |
Gene namesi | Name:Hoxb1 Synonyms:Hox-2.9, Hoxb-1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:96182, Hoxb1 |
Subcellular locationi
Nucleus
Nucleus
- nucleoplasm Source: Reactome
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000200108 | 1 – 297 | Homeobox protein Hox-B1Add BLAST | 297 |
Proteomic databases
PaxDbi | P17919 |
PRIDEi | P17919 |
PTM databases
PhosphoSitePlusi | P17919 |
Expressioni
Developmental stagei
Expressed along the entire length of the primitive streak. In early neurogenesis it is expressed in lateral and paraxial mesoderm, endoderm and superficial ectoderm or in the neural tube. From late neurogenesis to mid-embryogenesis, it presents similar spatial domains in the lateral mesoderm, endoderm and superficial ectoderm but is not detectable in the posterior hindbrain and has increased dramatically in rhombomere 4.
Gene expression databases
Bgeei | ENSMUSG00000018973, Expressed in primitive streak and 94 other tissues |
Genevisiblei | P17919, MM |
Interactioni
GO - Molecular functioni
- protein domain specific binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 200375, 2 interactors |
STRINGi | 10090.ENSMUSP00000019117 |
Miscellaneous databases
RNActi | P17919, protein |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 175 – 180 | Antp-type hexapeptide | 6 |
Sequence similaritiesi
Keywords - Domaini
HomeoboxPhylogenomic databases
eggNOGi | KOG0489, Eukaryota |
GeneTreei | ENSGT00940000159503 |
HOGENOMi | CLU_058839_1_0_1 |
InParanoidi | P17919 |
OMAi | LEYAICN |
OrthoDBi | 1216870at2759 |
PhylomeDBi | P17919 |
TreeFami | TF317730 |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR020479, Homeobox_metazoa |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit |
PRINTSi | PR00024, HOMEOBOX |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P17919-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDYNRMSSFL EYPLCNRGPS AYSAPTSFPP CSAPAVDSYA GESRYGGGLP
60 70 80 90 100
SSALQQNSGY PVQQPPSSLG VSFPSPAPSG YAPAACNPSY GPSQYYSVGQ
110 120 130 140 150
SEGDGSYFHP SSYGAQLGGL PDSYGAGGVG SGPYPPPQPP YGTEQTATFA
160 170 180 190 200
SAYDLLSEDK ESPCSSEPST LTPRTFDWMK VKRNPPKTAK VSELGLGAPG
210 220 230 240 250
GLRTNFTTRQ LTELEKEFHF NKYLSRARRV EIAATLELNE TQVKIWFQNR
260 270 280 290
RMKQKKRERE GGRMPAGPPG CPKEAAGDAS DQSACTSPEA SPSSITS
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 38 | S → T in CAA42078 (PubMed:1673098).Curated | 1 | |
Sequence conflicti | 162 | S → C in CAA42078 (PubMed:1673098).Curated | 1 | |
Sequence conflicti | 198 | A → P (PubMed:1673098).Curated | 1 | |
Sequence conflicti | 200 | G → R (PubMed:1673098).Curated | 1 | |
Sequence conflicti | 217 | E → G in BAB30874 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 234 | A → P in CAA42078 (PubMed:1673098).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X53063 Genomic DNA Translation: CAA37238.1 X59474 mRNA Translation: CAA42078.1 AK017686 mRNA Translation: BAB30874.1 BC103597 mRNA Translation: AAI03598.1 BC103598 mRNA Translation: AAI03599.1 BC103606 mRNA Translation: AAI03607.1 M34005 Genomic DNA Translation: AAA37850.1 |
CCDSi | CCDS25300.1 |
PIRi | A60082, WJMS29 |
RefSeqi | NP_032292.3, NM_008266.5 |
Genome annotation databases
Ensembli | ENSMUST00000019117; ENSMUSP00000019117; ENSMUSG00000018973 |
GeneIDi | 15407 |
KEGGi | mmu:15407 |
UCSCi | uc007lbz.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X53063 Genomic DNA Translation: CAA37238.1 X59474 mRNA Translation: CAA42078.1 AK017686 mRNA Translation: BAB30874.1 BC103597 mRNA Translation: AAI03598.1 BC103598 mRNA Translation: AAI03599.1 BC103606 mRNA Translation: AAI03607.1 M34005 Genomic DNA Translation: AAA37850.1 |
CCDSi | CCDS25300.1 |
PIRi | A60082, WJMS29 |
RefSeqi | NP_032292.3, NM_008266.5 |
3D structure databases
SMRi | P17919 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 200375, 2 interactors |
STRINGi | 10090.ENSMUSP00000019117 |
PTM databases
PhosphoSitePlusi | P17919 |
Proteomic databases
PaxDbi | P17919 |
PRIDEi | P17919 |
Protocols and materials databases
Antibodypediai | 30258, 335 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000019117; ENSMUSP00000019117; ENSMUSG00000018973 |
GeneIDi | 15407 |
KEGGi | mmu:15407 |
UCSCi | uc007lbz.2, mouse |
Organism-specific databases
CTDi | 3211 |
MGIi | MGI:96182, Hoxb1 |
Phylogenomic databases
eggNOGi | KOG0489, Eukaryota |
GeneTreei | ENSGT00940000159503 |
HOGENOMi | CLU_058839_1_0_1 |
InParanoidi | P17919 |
OMAi | LEYAICN |
OrthoDBi | 1216870at2759 |
PhylomeDBi | P17919 |
TreeFami | TF317730 |
Miscellaneous databases
BioGRID-ORCSi | 15407, 1 hit in 17 CRISPR screens |
ChiTaRSi | Hoxb1, mouse |
PROi | PR:P17919 |
RNActi | P17919, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000018973, Expressed in primitive streak and 94 other tissues |
Genevisiblei | P17919, MM |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR020479, Homeobox_metazoa |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit |
PRINTSi | PR00024, HOMEOBOX |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | HXB1_MOUSE | |
Accessioni | P17919Primary (citable) accession number: P17919 Secondary accession number(s): Q3ZAY6, Q9CYH3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1990 |
Last sequence update: | November 1, 1990 | |
Last modified: | December 2, 2020 | |
This is version 161 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Vertebrate homeotic Hox proteins
Nomenclature of vertebrate homeotic Hox proteins and list of entries