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Protein

Pancreatic lipase-related protein 2

Gene

Pnliprp2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Lipase with broad substrate specificity. Can hydrolyze both phospholipids and galactolipids. Acts preferentially on monoglycerides, phospholipids and galactolipids. Contributes to milk fat hydrolysis (By similarity).By similarity2 Publications

Caution

It is uncertain whether Met-1 or Met-15 is the initiator.Curated

Catalytic activityi

Triacylglycerol + H2O = diacylglycerol + a carboxylate.
1,2-diacyl-3-beta-D-galactosyl-sn-glycerol + 2 H2O = 3-beta-D-galactosyl-sn-glycerol + 2 carboxylates.

Activity regulationi

CLPS stimulates triacylglycerol lipase activity (PubMed:21382969, PubMed:2302735). Triacylglycerol lipase activity is not inhibited by increasing bile salt concentration (PubMed:21382969).2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei184NucleophileBy similarity1
Active sitei208Charge relay systemBy similarity1
Metal bindingi219Calcium; via carbonyl oxygenBy similarity1
Metal bindingi222Calcium; via carbonyl oxygenBy similarity1
Metal bindingi224CalciumBy similarity1
Metal bindingi227CalciumBy similarity1
Active sitei295Charge relay systemBy similarity1

GO - Molecular functioni

GO - Biological processi

  • cellular defense response Source: MGI
  • galactolipid catabolic process Source: UniProtKB
  • intestinal lipid catabolic process Source: MGI
  • phospholipid catabolic process Source: UniProtKB
  • response to bacterium Source: MGI

Keywordsi

Molecular functionHydrolase
Biological processLipid degradation, Lipid metabolism
LigandCalcium, Metal-binding

Protein family/group databases

ESTHERimouse-LIPR2 Pancreatic_lipase

Chemistry databases

SwissLipidsiSLP:000001480

Names & Taxonomyi

Protein namesi
Recommended name:
Pancreatic lipase-related protein 2By similarity (EC:3.1.1.26, EC:3.1.1.3)
Short name:
PL-RP2By similarity
Alternative name(s):
Cytotoxic T-lymphocyte lipase1 Publication
Galactolipase
Gene namesi
Name:Pnliprp2Imported
Synonyms:Plrp2By similarity
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1336202 Pnliprp2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
ChainiPRO_000001779431 – 482Pancreatic lipase-related protein 2Add BLAST452

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi34 ↔ 40PROSITE-ProRule annotation
Glycosylationi92N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi122 ↔ 133PROSITE-ProRule annotation
Disulfide bondi269 ↔ 293PROSITE-ProRule annotation
Disulfide bondi317 ↔ 328PROSITE-ProRule annotation
Glycosylationi366N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi466 ↔ 482PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP17892
PeptideAtlasiP17892
PRIDEiP17892

PTM databases

PhosphoSitePlusiP17892

Expressioni

Inductioni

By interleukin-4.

Gene expression databases

BgeeiENSMUSG00000025091 Expressed in 89 organ(s), highest expression level in islet of Langerhans
CleanExiMM_PNLIPRP2

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000026081

Structurei

3D structure databases

ProteinModelPortaliP17892
SMRiP17892
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini370 – 482PLATPROSITE-ProRule annotationAdd BLAST113

Sequence similaritiesi

Belongs to the AB hydrolase superfamily. Lipase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IHRX Eukaryota
ENOG410Y92X LUCA
GeneTreeiENSGT00760000119069
HOGENOMiHOG000038552
HOVERGENiHBG003243
InParanoidiP17892
KOiK14075
OMAiPWDPKDI
OrthoDBiEOG091G0DJ5
TreeFamiTF324997

Family and domain databases

CDDicd00707 Pancreat_lipase_like, 1 hit
Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR013818 Lipase/vitellogenin
IPR016272 Lipase_LIPH
IPR033906 Lipase_N
IPR002331 Lipase_panc
IPR001024 PLAT/LH2_dom
IPR036392 PLAT/LH2_dom_sf
IPR000734 TAG_lipase
PANTHERiPTHR11610 PTHR11610, 1 hit
PfamiView protein in Pfam
PF00151 Lipase, 1 hit
PF01477 PLAT, 1 hit
PIRSFiPIRSF000865 Lipoprotein_lipase_LIPH, 1 hit
PRINTSiPR00823 PANCLIPASE
PR00821 TAGLIPASE
SMARTiView protein in SMART
SM00308 LH2, 1 hit
SUPFAMiSSF49723 SSF49723, 1 hit
SSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS50095 PLAT, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P17892-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPMDVRGCLF PSVQMLLCWL VSLLLATVGG KEVCYGHLGC FSNDKPWAGM
60 70 80 90 100
IQRPSKIFPW SPEDIDTRFL LYTNENPNNY QIISATDPAT INASNFQLDR
110 120 130 140 150
KTRFIIHGFI DKGEEGWLLD MCKKMFQVEK VNCICVDWKR GSRTEYTQAS
160 170 180 190 200
YNTRVVGAEI AFLVQVLSTE MGYSPENVHL IGHSLGSHVA GEAGRRLEGH
210 220 230 240 250
VGRITGLDPA EPCFQGLPEE VRLDPSDAMF VDVIHTDSAP IIPYLGFGMS
260 270 280 290 300
QKVGHLDFFP NGGKEMPGCQ KNILSTIVDI NGIWEGTRNF AACNHLRSYK
310 320 330 340 350
YYASSILNPD GFLGYPCSSY EKFQHNDCFP CPEQGCPKMG HYADQFEGKT
360 370 380 390 400
ATVEQTFFLN TGDSGNFTRW RYKVSVTLSG AKKLSGYILV ALYGCNGNSK
410 420 430 440 450
QYEVFKGSLQ PEARYIRDID VDVNVGEIQK VKFLWNNKVI NLFRPTMGAS
460 470 480
QITVQRGKDG KEFNFCSSNT VHEDVLQSLY PC
Length:482
Mass (Da):54,017
Last modified:February 17, 2016 - v2
Checksum:i616E5F972362BE3C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti156V → L in AAA37491 (PubMed:2302735).Curated1
Sequence conflicti182G → P in AAA37491 (PubMed:2302735).Curated1
Sequence conflicti266M → I in AAA37491 (PubMed:2302735).Curated1
Sequence conflicti331C → S in AAA37491 (PubMed:2302735).Curated1
Sequence conflicti362 – 364GDS → ADT in AAA37491 (PubMed:2302735).Curated3
Sequence conflicti381A → P in AAA37491 (PubMed:2302735).Curated1
Sequence conflicti397G → A in AAA37491 (PubMed:2302735).Curated1
Sequence conflicti454 – 457VQRG → LQRA in AAA37491 (PubMed:2302735).Curated4
Sequence conflicti467S → T in AAA37491 (PubMed:2302735).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M30687 mRNA Translation: AAA37491.1
AK131882 mRNA Translation: BAE20849.1
AC102548 Genomic DNA No translation available.
AC127545 Genomic DNA No translation available.
BC094923 mRNA Translation: AAH94923.1
CCDSiCCDS38030.1
PIRiA34671
RefSeqiNP_035258.2, NM_011128.2
UniGeneiMm.212333

Genome annotation databases

EnsembliENSMUST00000026081; ENSMUSP00000026081; ENSMUSG00000025091
GeneIDi18947
KEGGimmu:18947
UCSCiuc008iau.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M30687 mRNA Translation: AAA37491.1
AK131882 mRNA Translation: BAE20849.1
AC102548 Genomic DNA No translation available.
AC127545 Genomic DNA No translation available.
BC094923 mRNA Translation: AAH94923.1
CCDSiCCDS38030.1
PIRiA34671
RefSeqiNP_035258.2, NM_011128.2
UniGeneiMm.212333

3D structure databases

ProteinModelPortaliP17892
SMRiP17892
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000026081

Chemistry databases

SwissLipidsiSLP:000001480

Protein family/group databases

ESTHERimouse-LIPR2 Pancreatic_lipase

PTM databases

PhosphoSitePlusiP17892

Proteomic databases

PaxDbiP17892
PeptideAtlasiP17892
PRIDEiP17892

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000026081; ENSMUSP00000026081; ENSMUSG00000025091
GeneIDi18947
KEGGimmu:18947
UCSCiuc008iau.2 mouse

Organism-specific databases

CTDi5408
MGIiMGI:1336202 Pnliprp2

Phylogenomic databases

eggNOGiENOG410IHRX Eukaryota
ENOG410Y92X LUCA
GeneTreeiENSGT00760000119069
HOGENOMiHOG000038552
HOVERGENiHBG003243
InParanoidiP17892
KOiK14075
OMAiPWDPKDI
OrthoDBiEOG091G0DJ5
TreeFamiTF324997

Miscellaneous databases

PROiPR:P17892
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000025091 Expressed in 89 organ(s), highest expression level in islet of Langerhans
CleanExiMM_PNLIPRP2

Family and domain databases

CDDicd00707 Pancreat_lipase_like, 1 hit
Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR013818 Lipase/vitellogenin
IPR016272 Lipase_LIPH
IPR033906 Lipase_N
IPR002331 Lipase_panc
IPR001024 PLAT/LH2_dom
IPR036392 PLAT/LH2_dom_sf
IPR000734 TAG_lipase
PANTHERiPTHR11610 PTHR11610, 1 hit
PfamiView protein in Pfam
PF00151 Lipase, 1 hit
PF01477 PLAT, 1 hit
PIRSFiPIRSF000865 Lipoprotein_lipase_LIPH, 1 hit
PRINTSiPR00823 PANCLIPASE
PR00821 TAGLIPASE
SMARTiView protein in SMART
SM00308 LH2, 1 hit
SUPFAMiSSF49723 SSF49723, 1 hit
SSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS50095 PLAT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLIPR2_MOUSE
AccessioniPrimary (citable) accession number: P17892
Secondary accession number(s): Q4VBW7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: February 17, 2016
Last modified: October 10, 2018
This is version 144 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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