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Protein

Mannitol-specific phosphotransferase enzyme IIA component

Gene

mtlF

Organism
Staphylococcus carnosus (strain TM300)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II CmtAB PTS system is involved in D-mannitol transport.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei63Tele-phosphohistidine intermediatePROSITE-ProRule annotation1 Publication1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processPhosphotransferase system, Sugar transport, Transport

Enzyme and pathway databases

BioCyciSCAR396513:SCA_RS08420-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Mannitol-specific phosphotransferase enzyme IIA component1 Publication
Alternative name(s):
EIIA1 Publication
EIII1 Publication
PTS system mannitol-specific EIIA component1 Publication
Gene namesi
Name:mtlF1 Publication
Ordered Locus Names:Sca_1660
OrganismiStaphylococcus carnosus (strain TM300)
Taxonomic identifieri396513 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000000444 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001866432 – 144Mannitol-specific phosphotransferase enzyme IIA componentAdd BLAST143

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei63Phosphohistidine; by HPrBy similarity1 Publication1

Keywords - PTMi

Phosphoprotein

PTM databases

iPTMnetiP17876

Interactioni

Subunit structurei

Homodimer or homotrimer. Seems to be a monomer when not phosphorylated.1 Publication

Protein-protein interaction databases

STRINGi396513.Sca_1660

Structurei

3D structure databases

ProteinModelPortaliP17876
SMRiP17876
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 142PTS EIIA type-2PROSITE-ProRule annotationAdd BLAST140

Domaini

The PTS EIIA type-2 domain is phosphorylated by phospho-HPr on a histidyl residue. Then, it transfers the phosphoryl group to the PTS EIIB type-2 domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105DTZ Bacteria
COG4668 LUCA
HOGENOMiHOG000227563
KOiK02798
OMAiISIVQVP

Family and domain databases

Gene3Di3.40.930.10, 1 hit
InterProiView protein in InterPro
IPR016152 PTrfase/Anion_transptr
IPR002178 PTS_EIIA_type-2_dom
PfamiView protein in Pfam
PF00359 PTS_EIIA_2, 1 hit
SUPFAMiSSF55804 SSF55804, 1 hit
PROSITEiView protein in PROSITE
PS51094 PTS_EIIA_TYPE_2, 1 hit
PS00372 PTS_EIIA_TYPE_2_HIS, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P17876-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTELFSNENI FLNQSFEDQN EAIEKAGQAL VDAGAVTEDY IQAMKDREAV
60 70 80 90 100
VSTFMGNGLA IPHGTDEAKS AVLQSGLTLL QIPEGVQWGD DVAKVVVGIA
110 120 130 140
GKDGEHLDLL SKIAITFSEE ENVDRIVNTK SPEEIKAVFE EADV
Length:144
Mass (Da):15,566
Last modified:January 23, 2007 - v3
Checksum:i77ACE463AFF17957
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M30781 Genomic DNA Translation: AAA26656.1
AM295250 Genomic DNA Translation: CAL28566.1
PIRiB31048
JQ0088
RefSeqiWP_015900906.1, NC_012121.1

Genome annotation databases

KEGGisca:SCA_1660

Similar proteinsi

Entry informationi

Entry nameiPTMA_STACT
AccessioniPrimary (citable) accession number: P17876
Secondary accession number(s): B9DM95
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: January 23, 2007
Last modified: July 18, 2018
This is version 119 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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