UniProtKB - P17876 (PTMA_STACT)
Protein
Mannitol-specific phosphotransferase enzyme IIA component
Gene
mtlF
Organism
Staphylococcus carnosus (strain TM300)
Status
Functioni
The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II CmtAB PTS system is involved in D-mannitol transport.1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 63 | Tele-phosphohistidine intermediatePROSITE-ProRule annotation1 Publication | 1 |
GO - Molecular functioni
- kinase activity Source: UniProtKB-KW
GO - Biological processi
- phosphoenolpyruvate-dependent sugar phosphotransferase system Source: UniProtKB-KW
Keywordsi
Molecular function | Kinase, Transferase |
Biological process | Phosphotransferase system, Sugar transport, Transport |
Enzyme and pathway databases
BioCyci | SCAR396513:SCA_RS08420-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: Mannitol-specific phosphotransferase enzyme IIA component1 PublicationAlternative name(s): EIIA1 Publication EIII1 Publication PTS system mannitol-specific EIIA component1 Publication |
Gene namesi | Name:mtlF1 Publication Ordered Locus Names:Sca_1660 |
Organismi | Staphylococcus carnosus (strain TM300) |
Taxonomic identifieri | 396513 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Bacilli › Bacillales › Staphylococcaceae › Staphylococcus › |
Proteomesi |
|
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm Curated
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed1 Publication | |||
ChainiPRO_0000186643 | 2 – 144 | Mannitol-specific phosphotransferase enzyme IIA componentAdd BLAST | 143 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 63 | Phosphohistidine; by HPrBy similarity1 Publication | 1 |
Keywords - PTMi
PhosphoproteinPTM databases
iPTMneti | P17876 |
Interactioni
Subunit structurei
Homodimer or homotrimer. Seems to be a monomer when not phosphorylated.
1 PublicationProtein-protein interaction databases
STRINGi | 396513.SCA_1660 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 3 – 142 | PTS EIIA type-2PROSITE-ProRule annotationAdd BLAST | 140 |
Domaini
The PTS EIIA type-2 domain is phosphorylated by phospho-HPr on a histidyl residue. Then, it transfers the phosphoryl group to the PTS EIIB type-2 domain.PROSITE-ProRule annotation
Phylogenomic databases
eggNOGi | COG4668, Bacteria |
HOGENOMi | CLU_072531_3_0_9 |
OMAi | HGVSEYV |
OrthoDBi | 1810962at2 |
Family and domain databases
CDDi | cd00211, PTS_IIA_fru, 1 hit |
Gene3Di | 3.40.930.10, 1 hit |
InterProi | View protein in InterPro IPR016152, PTrfase/Anion_transptr IPR002178, PTS_EIIA_type-2_dom |
Pfami | View protein in Pfam PF00359, PTS_EIIA_2, 1 hit |
SUPFAMi | SSF55804, SSF55804, 1 hit |
PROSITEi | View protein in PROSITE PS51094, PTS_EIIA_TYPE_2, 1 hit PS00372, PTS_EIIA_TYPE_2_HIS, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P17876-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTELFSNENI FLNQSFEDQN EAIEKAGQAL VDAGAVTEDY IQAMKDREAV
60 70 80 90 100
VSTFMGNGLA IPHGTDEAKS AVLQSGLTLL QIPEGVQWGD DVAKVVVGIA
110 120 130 140
GKDGEHLDLL SKIAITFSEE ENVDRIVNTK SPEEIKAVFE EADV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M30781 Genomic DNA Translation: AAA26656.1 AM295250 Genomic DNA Translation: CAL28566.1 |
PIRi | B31048 JQ0088 |
RefSeqi | WP_015900906.1, NC_012121.1 |
Genome annotation databases
GeneIDi | 60544629 |
KEGGi | sca:SCA_1660 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M30781 Genomic DNA Translation: AAA26656.1 AM295250 Genomic DNA Translation: CAL28566.1 |
PIRi | B31048 JQ0088 |
RefSeqi | WP_015900906.1, NC_012121.1 |
3D structure databases
SMRi | P17876 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 396513.SCA_1660 |
PTM databases
iPTMneti | P17876 |
Genome annotation databases
GeneIDi | 60544629 |
KEGGi | sca:SCA_1660 |
Phylogenomic databases
eggNOGi | COG4668, Bacteria |
HOGENOMi | CLU_072531_3_0_9 |
OMAi | HGVSEYV |
OrthoDBi | 1810962at2 |
Enzyme and pathway databases
BioCyci | SCAR396513:SCA_RS08420-MONOMER |
Family and domain databases
CDDi | cd00211, PTS_IIA_fru, 1 hit |
Gene3Di | 3.40.930.10, 1 hit |
InterProi | View protein in InterPro IPR016152, PTrfase/Anion_transptr IPR002178, PTS_EIIA_type-2_dom |
Pfami | View protein in Pfam PF00359, PTS_EIIA_2, 1 hit |
SUPFAMi | SSF55804, SSF55804, 1 hit |
PROSITEi | View protein in PROSITE PS51094, PTS_EIIA_TYPE_2, 1 hit PS00372, PTS_EIIA_TYPE_2_HIS, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PTMA_STACT | |
Accessioni | P17876Primary (citable) accession number: P17876 Secondary accession number(s): B9DM95 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1990 |
Last sequence update: | January 23, 2007 | |
Last modified: | April 7, 2021 | |
This is version 129 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |