UniProtKB - P17865 (FTSZ_BACSU)
Cell division protein FtsZ
ftsZ
Functioni
Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
UniRule annotation2 PublicationsActivity regulationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 139 | GTPUniRule annotation1 Publication | 1 | |
Binding sitei | 143 | GTPUniRule annotation1 Publication | 1 | |
Binding sitei | 187 | GTPUniRule annotation1 Publication | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 21 – 25 | GTPUniRule annotation1 Publication | 5 | |
Nucleotide bindingi | 108 – 110 | GTPUniRule annotation1 Publication | 3 |
GO - Molecular functioni
- GTPase activity Source: CACAO
- GTP binding Source: GO_Central
- identical protein binding Source: IntAct
GO - Biological processi
- cell division Source: CACAO
- division septum assembly Source: UniProtKB-KW
- FtsZ-dependent cytokinesis Source: UniProtKB-UniRule
- protein polymerization Source: UniProtKB-UniRule
Keywordsi
Biological process | Cell cycle, Cell division, Septation |
Ligand | GTP-binding, Nucleotide-binding |
Enzyme and pathway databases
BioCyci | BSUB:BSU15290-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: Cell division protein FtsZUniRule annotation |
Gene namesi | Name:ftsZUniRule annotation Ordered Locus Names:BSU15290 |
Organismi | Bacillus subtilis (strain 168) |
Taxonomic identifieri | 224308 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus › |
Proteomesi |
|
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm UniRule annotation
Note: Assembles at midcell at the inner surface of the cytoplasmic membrane.UniRule annotation
Other locations
- cell division site Source: GO_Central
- cell septum Source: CACAO
- cytoplasm Source: GO_Central
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 280 | D → R: Disrupts interaction with MciZ. 1 Publication | 1 |
Chemistry databases
ChEMBLi | CHEMBL5690 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000114341 | 1 – 382 | Cell division protein FtsZAdd BLAST | 382 |
Proteomic databases
jPOSTi | P17865 |
PaxDbi | P17865 |
PRIDEi | P17865 |
Interactioni
Subunit structurei
Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner (By similarity).
Interacts directly with several other division proteins (By similarity).
Interacts with FtsA (PubMed:16159787).
Interacts with Phi29 DNA replication protein 1 (PubMed:23836667).
Interacts with the cell division inhibitor MciZ (PubMed:23836667, PubMed:25848052).
UniRule annotation3 PublicationsBinary interactionsi
P17865
GO - Molecular functioni
- identical protein binding Source: IntAct
Protein-protein interaction databases
IntActi | P17865, 9 interactors |
MINTi | P17865 |
STRINGi | 224308.BSU15290 |
Chemistry databases
BindingDBi | P17865 |
Structurei
Secondary structure
3D structure databases
SMRi | P17865 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P17865 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 320 – 382 | DisorderedSequence analysisAdd BLAST | 63 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 325 – 339 | Polar residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 340 – 354 | Basic and acidic residuesSequence analysisAdd BLAST | 15 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | COG0206, Bacteria |
InParanoidi | P17865 |
OMAi | GNPSIGQ |
PhylomeDBi | P17865 |
Family and domain databases
CDDi | cd02201, FtsZ_type1, 1 hit |
DisProti | DP02202 |
Gene3Di | 3.30.1330.20, 1 hit 3.40.50.1440, 1 hit |
HAMAPi | MF_00909, FtsZ, 1 hit |
InterProi | View protein in InterPro IPR000158, Cell_div_FtsZ IPR020805, Cell_div_FtsZ_CS IPR045061, FtsZ/CetZ IPR024757, FtsZ_C IPR008280, Tub_FtsZ_C IPR037103, Tubulin/FtsZ-like_C IPR018316, Tubulin/FtsZ_2-layer-sand-dom IPR036525, Tubulin/FtsZ_GTPase_sf IPR003008, Tubulin_FtsZ_GTPase |
PANTHERi | PTHR30314, PTHR30314, 1 hit |
Pfami | View protein in Pfam PF12327, FtsZ_C, 1 hit PF00091, Tubulin, 1 hit |
PRINTSi | PR00423, CELLDVISFTSZ |
SMARTi | View protein in SMART SM00864, Tubulin, 1 hit SM00865, Tubulin_C, 1 hit |
SUPFAMi | SSF52490, SSF52490, 1 hit SSF55307, SSF55307, 1 hit |
TIGRFAMsi | TIGR00065, ftsZ, 1 hit |
PROSITEi | View protein in PROSITE PS01134, FTSZ_1, 1 hit PS01135, FTSZ_2, 1 hit |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MLEFETNIDG LASIKVIGVG GGGNNAVNRM IENEVQGVEY IAVNTDAQAL
60 70 80 90 100
NLSKAEVKMQ IGAKLTRGLG AGANPEVGKK AAEESKEQIE EALKGADMVF
110 120 130 140 150
VTAGMGGGTG TGAAPVIAQI AKDLGALTVG VVTRPFTFEG RKRQLQAAGG
160 170 180 190 200
ISAMKEAVDT LIVIPNDRIL EIVDKNTPML EAFREADNVL RQGVQGISDL
210 220 230 240 250
IATPGLINLD FADVKTIMSN KGSALMGIGI ATGENRAAEA AKKAISSPLL
260 270 280 290 300
EAAIDGAQGV LMNITGGTNL SLYEVQEAAD IVASASDQDV NMIFGSVINE
310 320 330 340 350
NLKDEIVVTV IATGFIEQEK DVTKPQRPSL NQSIKTHNQS VPKREPKREE
360 370 380
PQQQNTVSRH TSQPADDTLD IPTFLRNRNK RG
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 345 – 346 | EP → DA in AAA22457 (PubMed:3139638).Curated | 2 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M22630 Genomic DNA Translation: AAA22457.1 AL009126 Genomic DNA Translation: CAB13402.2 J05400 Genomic DNA Translation: AAA83361.1 |
PIRi | I39848 |
RefSeqi | NP_389412.2, NC_000964.3 WP_003232167.1, NZ_JNCM01000035.1 |
Genome annotation databases
EnsemblBacteriai | CAB13402; CAB13402; BSU_15290 |
GeneIDi | 935971 |
KEGGi | bsu:BSU15290 |
PATRICi | fig|224308.179.peg.1667 |
Similar proteinsi
Cross-referencesi
Web resourcesi
Protein Spotlight Becoming two - Issue 171 of July 2015 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M22630 Genomic DNA Translation: AAA22457.1 AL009126 Genomic DNA Translation: CAB13402.2 J05400 Genomic DNA Translation: AAA83361.1 |
PIRi | I39848 |
RefSeqi | NP_389412.2, NC_000964.3 WP_003232167.1, NZ_JNCM01000035.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2RHH | X-ray | 2.00 | A | 12-315 | [»] | |
2RHJ | X-ray | 1.76 | A | 12-315 | [»] | |
2RHL | X-ray | 2.45 | A/B | 12-315 | [»] | |
2RHO | X-ray | 2.45 | A/B | 12-315 | [»] | |
2VAM | X-ray | 2.50 | A | 1-382 | [»] | |
2VXY | X-ray | 1.70 | A | 1-382 | [»] | |
4U39 | X-ray | 3.19 | A/B/C/D/E/F/G/H/I | 12-315 | [»] | |
SMRi | P17865 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
IntActi | P17865, 9 interactors |
MINTi | P17865 |
STRINGi | 224308.BSU15290 |
Chemistry databases
BindingDBi | P17865 |
ChEMBLi | CHEMBL5690 |
Proteomic databases
jPOSTi | P17865 |
PaxDbi | P17865 |
PRIDEi | P17865 |
Genome annotation databases
EnsemblBacteriai | CAB13402; CAB13402; BSU_15290 |
GeneIDi | 935971 |
KEGGi | bsu:BSU15290 |
PATRICi | fig|224308.179.peg.1667 |
Phylogenomic databases
eggNOGi | COG0206, Bacteria |
InParanoidi | P17865 |
OMAi | GNPSIGQ |
PhylomeDBi | P17865 |
Enzyme and pathway databases
BioCyci | BSUB:BSU15290-MONOMER |
Miscellaneous databases
EvolutionaryTracei | P17865 |
PROi | PR:P17865 |
Family and domain databases
CDDi | cd02201, FtsZ_type1, 1 hit |
DisProti | DP02202 |
Gene3Di | 3.30.1330.20, 1 hit 3.40.50.1440, 1 hit |
HAMAPi | MF_00909, FtsZ, 1 hit |
InterProi | View protein in InterPro IPR000158, Cell_div_FtsZ IPR020805, Cell_div_FtsZ_CS IPR045061, FtsZ/CetZ IPR024757, FtsZ_C IPR008280, Tub_FtsZ_C IPR037103, Tubulin/FtsZ-like_C IPR018316, Tubulin/FtsZ_2-layer-sand-dom IPR036525, Tubulin/FtsZ_GTPase_sf IPR003008, Tubulin_FtsZ_GTPase |
PANTHERi | PTHR30314, PTHR30314, 1 hit |
Pfami | View protein in Pfam PF12327, FtsZ_C, 1 hit PF00091, Tubulin, 1 hit |
PRINTSi | PR00423, CELLDVISFTSZ |
SMARTi | View protein in SMART SM00864, Tubulin, 1 hit SM00865, Tubulin_C, 1 hit |
SUPFAMi | SSF52490, SSF52490, 1 hit SSF55307, SSF55307, 1 hit |
TIGRFAMsi | TIGR00065, ftsZ, 1 hit |
PROSITEi | View protein in PROSITE PS01134, FTSZ_1, 1 hit PS01135, FTSZ_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | FTSZ_BACSU | |
Accessioni | P17865Primary (citable) accession number: P17865 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1990 |
Last sequence update: | June 16, 2009 | |
Last modified: | February 23, 2022 | |
This is version 166 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Protein Spotlight
Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries