UniProtKB - P17858 (PFKAL_HUMAN)
ATP-dependent 6-phosphofructokinase, liver type
PFKL
Functioni
Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis (PubMed:22923583).
Negatively regulates the phagocyte oxidative burst in response to bacterial infection by controlling cellular NADPH biosynthesis and NADPH oxidase-derived reactive oxygen species. Upon macrophage activation, drives the metabolic switch toward glycolysis, thus preventing glucose turnover that produces NADPH via pentose phosphate pathway (By similarity).
UniRule annotationBy similarity1 PublicationMiscellaneous
Catalytic activityi
- ATP + β-D-fructose 6-phosphate = ADP + β-D-fructose 1,6-bisphosphate + H+UniRule annotation1 PublicationEC:2.7.1.11UniRule annotation1 Publication
Cofactori
Activity regulationi
: glycolysis Pathwayi
This protein is involved in step 3 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.UniRule annotation This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 25 | ATP; via amide nitrogenUniRule annotation | 1 | |
Metal bindingi | 119 | Magnesium; catalyticUniRule annotation | 1 | |
Active sitei | 166 | Proton acceptorUniRule annotation | 1 | |
Binding sitei | 201 | Substrate; shared with dimeric partnerUniRule annotation | 1 | |
Binding sitei | 264 | SubstrateUniRule annotation | 1 | |
Binding sitei | 292 | Substrate; shared with dimeric partnerUniRule annotation | 1 | |
Binding sitei | 470 | Fructose 2,6-bisphosphate; allosteric activatorUniRule annotation | 1 | |
Binding sitei | 565 | Fructose 2,6-bisphosphate; allosteric activator; shared with dimeric partnerUniRule annotation | 1 | |
Binding sitei | 628 | Fructose 2,6-bisphosphate; allosteric activatorUniRule annotation | 1 | |
Binding sitei | 654 | Fructose 2,6-bisphosphate; allosteric activator; shared with dimeric partnerUniRule annotation | 1 | |
Binding sitei | 734 | Fructose 2,6-bisphosphate; allosteric activatorUniRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 88 – 89 | ATPUniRule annotation | 2 | |
Nucleotide bindingi | 118 – 121 | ATPUniRule annotation | 4 |
GO - Molecular functioni
- 6-phosphofructokinase activity Source: UniProtKB
- AMP binding Source: GO_Central
- ATP binding Source: UniProtKB
- fructose-6-phosphate binding Source: BHF-UCL
- fructose binding Source: BHF-UCL
- identical protein binding Source: IntAct
- kinase binding Source: BHF-UCL
- metal ion binding Source: UniProtKB-KW
- monosaccharide binding Source: GO_Central
GO - Biological processi
- canonical glycolysis Source: GO_Central
- fructose 1,6-bisphosphate metabolic process Source: UniProtKB
- fructose 6-phosphate metabolic process Source: UniProtKB
- glycolytic process Source: UniProtKB
- negative regulation of insulin secretion Source: Ensembl
- response to glucose Source: UniProtKB
Keywordsi
Molecular function | Allosteric enzyme, Kinase, Transferase |
Biological process | Glycolysis |
Ligand | ATP-binding, Magnesium, Metal-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | P17858 |
Reactomei | R-HSA-6798695, Neutrophil degranulation R-HSA-70171, Glycolysis |
SABIO-RKi | P17858 |
SignaLinki | P17858 |
SIGNORi | P17858 |
UniPathwayi | UPA00109;UER00182 |
Names & Taxonomyi
Protein namesi | Recommended name: ATP-dependent 6-phosphofructokinase, liver typeUniRule annotation (EC:2.7.1.11UniRule annotation)Short name: ATP-PFKUniRule annotation Short name: PFK-L Alternative name(s): 6-phosphofructokinase type B Phosphofructo-1-kinase isozyme B Short name: PFK-B PhosphohexokinaseUniRule annotation |
Gene namesi | Name:PFKLImported |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:8876, PFKL |
MIMi | 171860, gene |
neXtProti | NX_P17858 |
VEuPathDBi | HostDB:ENSG00000141959 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm UniRule annotation
Cytosol
- 6-phosphofructokinase complex Source: UniProtKB
- cytosol Source: UniProtKB
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
- extracellular region Source: Reactome
Other locations
- ficolin-1-rich granule lumen Source: Reactome
- membrane Source: UniProtKB
- secretory granule lumen Source: Reactome
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 527 | T → A: Does not affect GlcNAcylation. 1 Publication | 1 | |
Mutagenesisi | 529 | S → A: Prevents GlcNAcylation and enhance enzyme activity. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 5211 |
OpenTargetsi | ENSG00000141959 |
PharmGKBi | PA33215 |
Miscellaneous databases
Pharosi | P17858, Tbio |
Chemistry databases
ChEMBLi | CHEMBL2191 |
Genetic variation databases
BioMutai | PFKL |
DMDMi | 134048493 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources1 Publication | |||
ChainiPRO_0000112021 | 2 – 780 | ATP-dependent 6-phosphofructokinase, liver typeAdd BLAST | 779 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources1 Publication | 1 | |
Modified residuei | 377 | PhosphoserineBy similarity | 1 | |
Glycosylationi | 529 | O-linked (GlcNAc) serine1 Publication | 1 | |
Modified residuei | 640 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 775 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, Glycoprotein, PhosphoproteinProteomic databases
CPTACi | CPTAC-425 CPTAC-426 |
EPDi | P17858 |
jPOSTi | P17858 |
MassIVEi | P17858 |
MaxQBi | P17858 |
PaxDbi | P17858 |
PeptideAtlasi | P17858 |
PRIDEi | P17858 |
ProteomicsDBi | 53520 [P17858-1] 53521 [P17858-2] |
TopDownProteomicsi | P17858-1 [P17858-1] |
PTM databases
GlyConnecti | 2022, 1 N-Linked glycan (1 site) |
GlyGeni | P17858, 3 sites, 2 N-linked glycans (1 site), 1 O-linked glycan (1 site) |
iPTMneti | P17858 |
MetOSitei | P17858 |
PhosphoSitePlusi | P17858 |
SwissPalmi | P17858 |
Expressioni
Gene expression databases
Bgeei | ENSG00000141959, Expressed in adult mammalian kidney and 240 other tissues |
ExpressionAtlasi | P17858, baseline and differential |
Genevisiblei | P17858, HS |
Organism-specific databases
HPAi | ENSG00000141959, Low tissue specificity |
Interactioni
Subunit structurei
Homo- and heterotetramers (By similarity). Phosphofructokinase (PFK) enzyme functions as a tetramer composed of different combinations of 3 types of subunits, called PFKM (where M stands for Muscle), PFKL (Liver) and PFKP (Platelet). The composition of the PFK tetramer differs according to the tissue type it is present in. In muscles, it is composed of 4 PFKM subunits (also called M4). In the liver, the predominant form is a tetramer of PFKL subunits (L4). In erythrocytes, both PFKM and PFKL subunits randomly tetramerize to form M4, L4 and other combinations (ML3, M2L2, M3L). The kinetic and regulatory properties of the tetrameric enzyme are dependent on the subunit composition, hence can vary across tissues (Probable).
UniRule annotationCuratedBinary interactionsi
P17858
With | #Exp. | IntAct |
---|---|---|
GTPBP3 [Q969Y2] | 3 | EBI-487243,EBI-740290 |
KRTAP10-7 [P60409] | 3 | EBI-487243,EBI-10172290 |
KRTAP5-9 [P26371] | 3 | EBI-487243,EBI-3958099 |
itself | 3 | EBI-487243,EBI-487243 |
PFKM [P08237] | 6 | EBI-487243,EBI-514788 |
GO - Molecular functioni
- identical protein binding Source: IntAct
- kinase binding Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 111232, 135 interactors |
ComplexPortali | CPX-1998, 6-phosphofructokinase, L4 homotetramer CPX-2000, 6-phosphofructokinase, ML3 heterotetramer CPX-2001, 6-phosphofructokinase, M2L2 heterotetramer CPX-2002, 6-phosphofructokinase, M3L heterotetramer |
CORUMi | P17858 |
IntActi | P17858, 46 interactors |
MINTi | P17858 |
STRINGi | 9606.ENSP00000269848 |
Miscellaneous databases
RNActi | P17858, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 2 – 390 | N-terminal catalytic PFK domain 1Add BLAST | 389 | |
Regioni | 164 – 166 | Substrate bindingUniRule annotation | 3 | |
Regioni | 208 – 210 | Substrate bindingUniRule annotation | 3 | |
Regioni | 298 – 301 | Substrate bindingUniRule annotation | 4 | |
Regioni | 391 – 400 | Interdomain linker | 10 | |
Regioni | 401 – 780 | C-terminal regulatory PFK domain 2Add BLAST | 380 | |
Regioni | 527 – 531 | Fructose 2,6-bisphosphate binding; allosteric activatorUniRule annotation | 5 | |
Regioni | 572 – 574 | Fructose 2,6-bisphosphate binding; allosteric activatorUniRule annotation | 3 | |
Regioni | 660 – 663 | Fructose 2,6-bisphosphate binding; allosteric activatorUniRule annotation | 4 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG2440, Eukaryota |
GeneTreei | ENSGT00940000159292 |
HOGENOMi | CLU_011053_0_0_1 |
InParanoidi | P17858 |
OMAi | WFNLRPM |
OrthoDBi | 172878at2759 |
PhylomeDBi | P17858 |
TreeFami | TF300411 |
Family and domain databases
CDDi | cd00764, Eukaryotic_PFK, 1 hit |
Gene3Di | 3.40.50.460, 2 hits |
HAMAPi | MF_03184, Phosphofructokinase_I_E, 1 hit |
InterProi | View protein in InterPro IPR009161, 6-Pfructokinase_euk IPR022953, ATP_PFK IPR041914, PFK_vert-type IPR015912, Phosphofructokinase_CS IPR000023, Phosphofructokinase_dom IPR035966, PKF_sf |
Pfami | View protein in Pfam PF00365, PFK, 2 hits |
PIRSFi | PIRSF000533, ATP_PFK_euk, 1 hit |
PRINTSi | PR00476, PHFRCTKINASE |
SUPFAMi | SSF53784, SSF53784, 2 hits |
TIGRFAMsi | TIGR02478, 6PF1K_euk, 1 hit |
PROSITEi | View protein in PROSITE PS00433, PHOSPHOFRUCTOKINASE, 2 hits |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAAVDLEKLR ASGAGKAIGV LTSGGDAQGM NAAVRAVTRM GIYVGAKVFL
60 70 80 90 100
IYEGYEGLVE GGENIKQANW LSVSNIIQLG GTIIGSARCK AFTTREGRRA
110 120 130 140 150
AAYNLVQHGI TNLCVIGGDG SLTGANIFRS EWGSLLEELV AEGKISETTA
160 170 180 190 200
RTYSHLNIAG LVGSIDNDFC GTDMTIGTDS ALHRIMEVID AITTTAQSHQ
210 220 230 240 250
RTFVLEVMGR HCGYLALVSA LASGADWLFI PEAPPEDGWE NFMCERLGET
260 270 280 290 300
RSRGSRLNII IIAEGAIDRN GKPISSSYVK DLVVQRLGFD TRVTVLGHVQ
310 320 330 340 350
RGGTPSAFDR ILSSKMGMEA VMALLEATPD TPACVVTLSG NQSVRLPLME
360 370 380 390 400
CVQMTKEVQK AMDDKRFDEA TQLRGGSFEN NWNIYKLLAH QKPPKEKSNF
410 420 430 440 450
SLAILNVGAP AAGMNAAVRS AVRTGISHGH TVYVVHDGFE GLAKGQVQEV
460 470 480 490 500
GWHDVAGWLG RGGSMLGTKR TLPKGQLESI VENIRIYGIH ALLVVGGFEA
510 520 530 540 550
YEGVLQLVEA RGRYEELCIV MCVIPATISN NVPGTDFSLG SDTAVNAAME
560 570 580 590 600
SCDRIKQSAS GTKRRVFIVE TMGGYCGYLA TVTGIAVGAD AAYVFEDPFN
610 620 630 640 650
IHDLKVNVEH MTEKMKTDIQ RGLVLRNEKC HDYYTTEFLY NLYSSEGKGV
660 670 680 690 700
FDCRTNVLGH LQQGGAPTPF DRNYGTKLGV KAMLWLSEKL REVYRKGRVF
710 720 730 740 750
ANAPDSACVI GLKKKAVAFS PVTELKKDTD FEHRMPREQW WLSLRLMLKM
760 770 780
LAQYRISMAA YVSGELEHVT RRTLSMDKGF
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketF8WEU2 | F8WEU2_HUMAN | ATP-dependent 6-phosphofructokinase... | PFKL | 42 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 27 | A → R in CAA33597 (PubMed:2533063).Curated | 1 | |
Sequence conflicti | 27 | A → R in CAB46744 (PubMed:2139864).Curated | 1 | |
Sequence conflicti | 86 | S → T in CAB46744 (PubMed:2139864).Curated | 1 | |
Sequence conflicti | 89 | C → S in CAA33597 (PubMed:2533063).Curated | 1 | |
Sequence conflicti | 89 | C → S in CAB46744 (PubMed:2139864).Curated | 1 | |
Sequence conflicti | 103 | Y → N in CAB46744 (PubMed:2139864).Curated | 1 | |
Sequence conflicti | 236 | E → EAPPE in CAB46744 (PubMed:2139864).Curated | 1 | |
Sequence conflicti | 386 | K → R in CAB46744 (PubMed:2139864).Curated | 1 | |
Sequence conflicti | 389 | A → T in CAA33597 (PubMed:2533063).Curated | 1 | |
Sequence conflicti | 389 | A → T in CAB46744 (PubMed:2139864).Curated | 1 | |
Sequence conflicti | 648 | K → N in AAH08964 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 648 | K → N in AAH09919 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 717 | V → A in AAH08964 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 717 | V → A in AAH09919 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_006070 | 81 | G → A1 Publication | 1 | |
Natural variantiVAR_006071 | 151 | R → W1 PublicationCorresponds to variant dbSNP:rs755851304Ensembl. | 1 | |
Natural variantiVAR_030872 | 237 | D → V. Corresponds to variant dbSNP:rs1057037EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_011854 | 1 – 28 | MAAVD…GGDAQ → MCNQGRGRESSRGGLHVQGS CRGLSRSPQQETGFAKAPAG TDCFFHCSPGSRGQGDRKEE VTSEPGGTSIMSRLG in isoform 2. 1 PublicationAdd BLAST | 28 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X15573 mRNA Translation: CAA33597.1 X16911 , X16912, X16913, X16914, X16915, X16916, X16917, X16918, X16919, X16920, X16921, X16922, X16923, X16924, X16925, X16926, X16927, X16928, X16929, X16930 Genomic DNA Translation: CAB46744.1 AP001754 Genomic DNA Translation: BAA95561.1 BC006422 mRNA Translation: AAH06422.1 BC007536 mRNA Translation: AAH07536.1 BC008964 mRNA Translation: AAH08964.1 BC009919 mRNA Translation: AAH09919.1 |
CCDSi | CCDS33582.1 [P17858-1] |
PIRi | A33639 |
RefSeqi | NP_001002021.2, NM_001002021.2 NP_002617.3, NM_002626.5 [P17858-1] |
Genome annotation databases
Ensembli | ENST00000349048.9; ENSP00000269848.6; ENSG00000141959.17 |
GeneIDi | 5211 |
KEGGi | hsa:5211 |
MANE-Selecti | ENST00000349048.9; ENSP00000269848.6; NM_002626.6; NP_002617.3 |
UCSCi | uc002zel.4, human [P17858-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X15573 mRNA Translation: CAA33597.1 X16911 , X16912, X16913, X16914, X16915, X16916, X16917, X16918, X16919, X16920, X16921, X16922, X16923, X16924, X16925, X16926, X16927, X16928, X16929, X16930 Genomic DNA Translation: CAB46744.1 AP001754 Genomic DNA Translation: BAA95561.1 BC006422 mRNA Translation: AAH06422.1 BC007536 mRNA Translation: AAH07536.1 BC008964 mRNA Translation: AAH08964.1 BC009919 mRNA Translation: AAH09919.1 |
CCDSi | CCDS33582.1 [P17858-1] |
PIRi | A33639 |
RefSeqi | NP_001002021.2, NM_001002021.2 NP_002617.3, NM_002626.5 [P17858-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
7LW1 | electron microscopy | 2.90 | A/D/E/F | 1-780 | [»] | |
AlphaFoldDBi | P17858 | |||||
SMRi | P17858 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 111232, 135 interactors |
ComplexPortali | CPX-1998, 6-phosphofructokinase, L4 homotetramer CPX-2000, 6-phosphofructokinase, ML3 heterotetramer CPX-2001, 6-phosphofructokinase, M2L2 heterotetramer CPX-2002, 6-phosphofructokinase, M3L heterotetramer |
CORUMi | P17858 |
IntActi | P17858, 46 interactors |
MINTi | P17858 |
STRINGi | 9606.ENSP00000269848 |
Chemistry databases
ChEMBLi | CHEMBL2191 |
PTM databases
GlyConnecti | 2022, 1 N-Linked glycan (1 site) |
GlyGeni | P17858, 3 sites, 2 N-linked glycans (1 site), 1 O-linked glycan (1 site) |
iPTMneti | P17858 |
MetOSitei | P17858 |
PhosphoSitePlusi | P17858 |
SwissPalmi | P17858 |
Genetic variation databases
BioMutai | PFKL |
DMDMi | 134048493 |
Proteomic databases
CPTACi | CPTAC-425 CPTAC-426 |
EPDi | P17858 |
jPOSTi | P17858 |
MassIVEi | P17858 |
MaxQBi | P17858 |
PaxDbi | P17858 |
PeptideAtlasi | P17858 |
PRIDEi | P17858 |
ProteomicsDBi | 53520 [P17858-1] 53521 [P17858-2] |
TopDownProteomicsi | P17858-1 [P17858-1] |
Protocols and materials databases
Antibodypediai | 24185, 323 antibodies from 34 providers |
DNASUi | 5211 |
Genome annotation databases
Ensembli | ENST00000349048.9; ENSP00000269848.6; ENSG00000141959.17 |
GeneIDi | 5211 |
KEGGi | hsa:5211 |
MANE-Selecti | ENST00000349048.9; ENSP00000269848.6; NM_002626.6; NP_002617.3 |
UCSCi | uc002zel.4, human [P17858-1] |
Organism-specific databases
CTDi | 5211 |
DisGeNETi | 5211 |
GeneCardsi | PFKL |
HGNCi | HGNC:8876, PFKL |
HPAi | ENSG00000141959, Low tissue specificity |
MIMi | 171860, gene |
neXtProti | NX_P17858 |
OpenTargetsi | ENSG00000141959 |
PharmGKBi | PA33215 |
VEuPathDBi | HostDB:ENSG00000141959 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2440, Eukaryota |
GeneTreei | ENSGT00940000159292 |
HOGENOMi | CLU_011053_0_0_1 |
InParanoidi | P17858 |
OMAi | WFNLRPM |
OrthoDBi | 172878at2759 |
PhylomeDBi | P17858 |
TreeFami | TF300411 |
Enzyme and pathway databases
UniPathwayi | UPA00109;UER00182 |
PathwayCommonsi | P17858 |
Reactomei | R-HSA-6798695, Neutrophil degranulation R-HSA-70171, Glycolysis |
SABIO-RKi | P17858 |
SignaLinki | P17858 |
SIGNORi | P17858 |
Miscellaneous databases
BioGRID-ORCSi | 5211, 16 hits in 1076 CRISPR screens |
ChiTaRSi | PFKL, human |
GeneWikii | PFKL |
GenomeRNAii | 5211 |
Pharosi | P17858, Tbio |
PROi | PR:P17858 |
RNActi | P17858, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000141959, Expressed in adult mammalian kidney and 240 other tissues |
ExpressionAtlasi | P17858, baseline and differential |
Genevisiblei | P17858, HS |
Family and domain databases
CDDi | cd00764, Eukaryotic_PFK, 1 hit |
Gene3Di | 3.40.50.460, 2 hits |
HAMAPi | MF_03184, Phosphofructokinase_I_E, 1 hit |
InterProi | View protein in InterPro IPR009161, 6-Pfructokinase_euk IPR022953, ATP_PFK IPR041914, PFK_vert-type IPR015912, Phosphofructokinase_CS IPR000023, Phosphofructokinase_dom IPR035966, PKF_sf |
Pfami | View protein in Pfam PF00365, PFK, 2 hits |
PIRSFi | PIRSF000533, ATP_PFK_euk, 1 hit |
PRINTSi | PR00476, PHFRCTKINASE |
SUPFAMi | SSF53784, SSF53784, 2 hits |
TIGRFAMsi | TIGR02478, 6PF1K_euk, 1 hit |
PROSITEi | View protein in PROSITE PS00433, PHOSPHOFRUCTOKINASE, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | PFKAL_HUMAN | |
Accessioni | P17858Primary (citable) accession number: P17858 Secondary accession number(s): Q96A64, Q96IH4, Q9BR91 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1990 |
Last sequence update: | March 6, 2007 | |
Last modified: | May 25, 2022 | |
This is version 240 of the entry and version 6 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 21
Human chromosome 21: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families