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Protein

Interferon gamma

Gene

IFNG

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.

GO - Molecular functioni

  • cytokine activity Source: GO_Central
  • interferon-gamma receptor binding Source: InterPro

GO - Biological processi

Keywordsi

Molecular functionCytokine
Biological processAntiviral defense, Growth regulation

Enzyme and pathway databases

ReactomeiR-SSC-877300 Interferon gamma signaling
R-SSC-877312 Regulation of IFNG signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon gamma
Short name:
IFN-gamma
Gene namesi
Name:IFNG
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23By similarityAdd BLAST23
ChainiPRO_000001645524 – 166Interferon gammaAdd BLAST143

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei24Pyrrolidone carboxylic acidBy similarity1
Glycosylationi39N-linked (GlcNAc...) asparagineBy similarity1
Glycosylationi106N-linked (GlcNAc...) asparagineBy similarity1

Keywords - PTMi

Glycoprotein, Pyrrolidone carboxylic acid

Proteomic databases

PaxDbiP17803
PRIDEiP17803

Expressioni

Tissue specificityi

Released primarily from activated T lymphocytes.

Gene expression databases

BgeeiENSSSCG00000000481 Expressed in 2 organ(s), highest expression level in heart
ExpressionAtlasiP17803 differential
GenevisibleiP17803 SS

Interactioni

Subunit structurei

Homodimer.

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000000511

Structurei

3D structure databases

ProteinModelPortaliP17803
SMRiP17803
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IWSY Eukaryota
ENOG410Z8I5 LUCA
GeneTreeiENSGT00390000007831
HOGENOMiHOG000254784
HOVERGENiHBG056912
InParanoidiP17803
KOiK04687
OMAiWKEESDK
OrthoDBiEOG091G0ZH0
TreeFamiTF336308

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR002069 Interferon_gamma
PANTHERiPTHR11419 PTHR11419, 1 hit
PfamiView protein in Pfam
PF00714 IFN-gamma, 1 hit
PIRSFiPIRSF001936 IFN-gamma, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD002435 Interferon_gamma, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P17803-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSYTTYFLAF QLCVTLCFSG SYCQAPFFKE ITILKDYFNA STSDVPNGGP
60 70 80 90 100
LFLEILKNWK EESDKKIIQS QIVSFYFKFF EIFKDNQAIQ RSMDVIKQDM
110 120 130 140 150
FQRFLNGSSG KLNDFEKLIK IPVDNLQIQR KAISELIKVM NDLSPRSNLR
160
KRKRSQTMFQ GQRASK
Length:166
Mass (Da):19,419
Last modified:August 1, 1990 - v1
Checksum:i19B51CC05D5ED276
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53085 Genomic DNA Translation: CAA37252.1
S63967 Genomic DNA Translation: AAB20280.2
AF493993 mRNA Translation: AAM27193.1
AY188090 mRNA Translation: AAO34390.1
AY293733 mRNA Translation: AAQ24335.1
DQ666352 mRNA Translation: ABG56234.1
PIRiS10513
RefSeqiNP_999113.1, NM_213948.1
UniGeneiSsc.4093

Genome annotation databases

EnsembliENSSSCT00000055560; ENSSSCP00000036242; ENSSSCG00000032963
GeneIDi396991
KEGGissc:396991

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53085 Genomic DNA Translation: CAA37252.1
S63967 Genomic DNA Translation: AAB20280.2
AF493993 mRNA Translation: AAM27193.1
AY188090 mRNA Translation: AAO34390.1
AY293733 mRNA Translation: AAQ24335.1
DQ666352 mRNA Translation: ABG56234.1
PIRiS10513
RefSeqiNP_999113.1, NM_213948.1
UniGeneiSsc.4093

3D structure databases

ProteinModelPortaliP17803
SMRiP17803
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000000511

Proteomic databases

PaxDbiP17803
PRIDEiP17803

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSSSCT00000055560; ENSSSCP00000036242; ENSSSCG00000032963
GeneIDi396991
KEGGissc:396991

Organism-specific databases

CTDi3458

Phylogenomic databases

eggNOGiENOG410IWSY Eukaryota
ENOG410Z8I5 LUCA
GeneTreeiENSGT00390000007831
HOGENOMiHOG000254784
HOVERGENiHBG056912
InParanoidiP17803
KOiK04687
OMAiWKEESDK
OrthoDBiEOG091G0ZH0
TreeFamiTF336308

Enzyme and pathway databases

ReactomeiR-SSC-877300 Interferon gamma signaling
R-SSC-877312 Regulation of IFNG signaling

Gene expression databases

BgeeiENSSSCG00000000481 Expressed in 2 organ(s), highest expression level in heart
ExpressionAtlasiP17803 differential
GenevisibleiP17803 SS

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR002069 Interferon_gamma
PANTHERiPTHR11419 PTHR11419, 1 hit
PfamiView protein in Pfam
PF00714 IFN-gamma, 1 hit
PIRSFiPIRSF001936 IFN-gamma, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD002435 Interferon_gamma, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIFNG_PIG
AccessioniPrimary (citable) accession number: P17803
Secondary accession number(s): Q53ZP3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: September 12, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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