IFNG

Functionⁱ

Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.

GO - Molecular functionⁱ

cytokine activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
interferon-gamma receptor binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

adaptive immune response
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
cell cycle arrest Source: Ensembl
defense response to virus Source: UniProtKB-KW
extrinsic apoptotic signaling pathway Source: Ensembl
humoral immune response
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
interferon-gamma-mediated signaling pathway Source: Ensembl
negative regulation of interleukin-17 production Source: Ensembl
negative regulation of smooth muscle cell proliferation Source: Ensembl
negative regulation of transcription, DNA-templated Source: Ensembl
positive regulation of autophagy Source: UniProtKB
positive regulation of calcidiol 1-monooxygenase activity Source: Ensembl
positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response Source: Ensembl
positive regulation of core promoter binding Source: Ensembl
positive regulation of epithelial cell migration Source: Ensembl
positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity Source: Ensembl
positive regulation of fructose 1,6-bisphosphate metabolic process Source: Ensembl
positive regulation of gene expression Source: Ensembl
positive regulation of interleukin-12 production Source: Ensembl
positive regulation of interleukin-23 production Source: Ensembl
positive regulation of killing of cells of other organism Source: Ensembl
positive regulation of membrane protein ectodomain proteolysis Source: Ensembl
positive regulation of nitric oxide biosynthetic process Source: Ensembl
positive regulation of osteoclast differentiation Source: Ensembl
positive regulation of peptidyl-serine phosphorylation of STAT protein Source: Ensembl
positive regulation of protein complex assembly Source: Ensembl
positive regulation of protein deacetylation Source: Ensembl
positive regulation of protein import into nucleus, translocation Source: Ensembl
positive regulation of protein serine/threonine kinase activity Source: Ensembl
positive regulation of smooth muscle cell apoptotic process Source: Ensembl
positive regulation of tumor necrosis factor (ligand) superfamily member 11 production Source: Ensembl
positive regulation of tyrosine phosphorylation of STAT protein Source: Ensembl
protein import into nucleus, translocation Source: Ensembl
regulation of growth Source: UniProtKB-KW
regulation of insulin secretion Source: Ensembl
regulation of protein ADP-ribosylation Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Cytokine
Biological process	Antiviral defense, Growth regulation

Enzyme and pathway databases

Reactomeⁱ	R-SSC-877300 Interferon gamma signaling R-SSC-877312 Regulation of IFNG signaling

Reactomeⁱ

R-SSC-877300 Interferon gamma signaling
R-SSC-877312 Regulation of IFNG signaling

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Interferon gamma Short name: IFN-gamma
Gene namesⁱ	Name:IFNG
Organismⁱ	Sus scrofa (Pig)
Taxonomic identifierⁱ	9823 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Laurasiatheria › Cetartiodactyla › Suina › Suidae › Sus
Proteomesⁱ	UP000008227 Componentⁱ: Chromosome 5

Keywords - Cellular componentⁱ

Secreted

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 23	By similarityAdd BLAST		23
ChainⁱPRO_0000016455	24 – 166	Interferon gammaAdd BLAST		143

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	24	Pyrrolidone carboxylic acidBy similarity	1
Glycosylationⁱ	39	N-linked (GlcNAc...) asparagineBy similarity	1
Glycosylationⁱ	106	N-linked (GlcNAc...) asparagineBy similarity	1

Keywords - PTMⁱ

Glycoprotein, Pyrrolidone carboxylic acid

Proteomic databases

PaxDbⁱ	P17803
PRIDEⁱ	P17803

Expressionⁱ

Tissue specificityⁱ

Released primarily from activated T lymphocytes.

Gene expression databases

Bgeeⁱ	ENSSSCG00000000481 Expressed in 2 organ(s), highest expression level in heart
ExpressionAtlasⁱ	P17803 differential
Genevisibleⁱ	P17803 SS

Interactionⁱ

Subunit structureⁱ

Homodimer.

GO - Molecular functionⁱ

cytokine activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
interferon-gamma receptor binding Source: InterPro

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	9823.ENSSSCP00000000511

STRINGⁱ

9823.ENSSSCP00000000511

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P17803
SMRⁱ	P17803
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the type II (or gamma) interferon family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	ENOG410IWSY Eukaryota ENOG410Z8I5 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000007831
HOGENOMⁱ	HOG000254784
HOVERGENⁱ	HBG056912
InParanoidⁱ	P17803
KEGG Orthology (KO) More...KOⁱ	K04687
OMAⁱ	WKEESDK
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0ZH0
TreeFamⁱ	TF336308

Family and domain databases

InterProⁱ	View protein in InterPro IPR009079 4_helix_cytokine-like_core IPR002069 Interferon_gamma
PANTHERⁱ	PTHR11419 PTHR11419, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00714 IFN-gamma, 1 hit
PIRSFⁱ	PIRSF001936 IFN-gamma, 1 hit
ProDomⁱ	View protein in ProDom or Entries sharing at least one domain PD002435 Interferon_gamma, 1 hit
SUPFAMⁱ	SSF47266 SSF47266, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P17803-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSYTTYFLAF QLCVTLCFSG SYCQAPFFKE ITILKDYFNA STSDVPNGGP 
        60         70         80         90        100
LFLEILKNWK EESDKKIIQS QIVSFYFKFF EIFKDNQAIQ RSMDVIKQDM 
       110        120        130        140        150
FQRFLNGSSG KLNDFEKLIK IPVDNLQIQR KAISELIKVM NDLSPRSNLR 
       160 
KRKRSQTMFQ GQRASK

Length:166

Mass (Da):19,419

Last modified:August 1, 1990 - v1

Checksum:ⁱ19B51CC05D5ED276

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X53085 Genomic DNA Translation: CAA37252.1 S63967 Genomic DNA Translation: AAB20280.2 AF493993 mRNA Translation: AAM27193.1 AY188090 mRNA Translation: AAO34390.1 AY293733 mRNA Translation: AAQ24335.1 DQ666352 mRNA Translation: ABG56234.1
PIRⁱ	S10513
NCBI Reference Sequences More...RefSeqⁱ	NP_999113.1, NM_213948.1
UniGeneⁱ	Ssc.4093

Genome annotation databases

Ensemblⁱ	ENSSSCT00000055560; ENSSSCP00000036242; ENSSSCG00000032963
GeneIDⁱ	396991
KEGGⁱ	ssc:396991

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P17803	Interferon gamma		PIG		166	UniRef100_P17803
Interferon gamma (Fragment)		PIG		55

Protein	Similar proteins		Species	Score	Length	Source
P17803	Interferon gamma		PIG		166	UniRef90_P17803
Interferon gamma (Fragment)		PIG		55
Interferon gamma		PIG		166
Interferon gamma		PIG		166
Interferon gamma		PIG		166
+3

Protein	Similar proteins		Species	Score	Length	Source
P17803	Interferon gamma		MOUSE		155	UniRef50_P01580
Interferon gamma		SAISC		166
Interferon gamma		CALJA		166
Interferon gamma		SIGHI		170
Interferon gamma		PHOSU		174
+211

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X53085 Genomic DNA Translation: CAA37252.1 S63967 Genomic DNA Translation: AAB20280.2 AF493993 mRNA Translation: AAM27193.1 AY188090 mRNA Translation: AAO34390.1 AY293733 mRNA Translation: AAQ24335.1 DQ666352 mRNA Translation: ABG56234.1
PIRⁱ	S10513
RefSeqⁱ	NP_999113.1, NM_213948.1
UniGeneⁱ	Ssc.4093

3D structure databases

ProteinModelPortalⁱ	P17803
SMRⁱ	P17803
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	9823.ENSSSCP00000000511

STRINGⁱ

9823.ENSSSCP00000000511

Proteomic databases

PaxDbⁱ	P17803
PRIDEⁱ	P17803

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSSSCT00000055560; ENSSSCP00000036242; ENSSSCG00000032963
GeneIDⁱ	396991
KEGGⁱ	ssc:396991

Organism-specific databases

CTDⁱ	3458

CTDⁱ

3458

Phylogenomic databases

eggNOGⁱ	ENOG410IWSY Eukaryota ENOG410Z8I5 LUCA
GeneTreeⁱ	ENSGT00390000007831
HOGENOMⁱ	HOG000254784
HOVERGENⁱ	HBG056912
InParanoidⁱ	P17803
KOⁱ	K04687
OMAⁱ	WKEESDK
OrthoDBⁱ	EOG091G0ZH0
TreeFamⁱ	TF336308

Enzyme and pathway databases

Reactomeⁱ	R-SSC-877300 Interferon gamma signaling R-SSC-877312 Regulation of IFNG signaling

Reactomeⁱ

R-SSC-877300 Interferon gamma signaling
R-SSC-877312 Regulation of IFNG signaling

Gene expression databases

Bgeeⁱ	ENSSSCG00000000481 Expressed in 2 organ(s), highest expression level in heart
ExpressionAtlasⁱ	P17803 differential
Genevisibleⁱ	P17803 SS

Family and domain databases

InterProⁱ	View protein in InterPro IPR009079 4_helix_cytokine-like_core IPR002069 Interferon_gamma
PANTHERⁱ	PTHR11419 PTHR11419, 1 hit
Pfamⁱ	View protein in Pfam PF00714 IFN-gamma, 1 hit
PIRSFⁱ	PIRSF001936 IFN-gamma, 1 hit
ProDomⁱ	View protein in ProDom or Entries sharing at least one domain PD002435 Interferon_gamma, 1 hit
SUPFAMⁱ	SSF47266 SSF47266, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	IFNG_PIG
Accessionⁱ	P17803Primary (citable) accession number: P17803 Secondary accession number(s): Q53ZP3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 1, 1990
	Last sequence update:	August 1, 1990
	Last modified:	September 12, 2018
	This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P17803 (IFNG_PIG)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Interferon gamma

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ