CHRNB2

Functionⁱ

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodiun ions.1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Length
Siteⁱ	84	Key residue that may interfere with effective access of the conotoxin BuIA to the channel binding siteBy similarity	1
Siteⁱ	136	Key residue for a rapid dissociation (K(off)) from the conotoxin BuIABy similarity	1
Siteⁱ	144	Key residue for a rapid dissociation (K(off)) from the conotoxin BuIABy similarity	1

GO - Molecular functionⁱ

acetylcholine binding
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 15964197
acetylcholine-gated cation-selective channel activity
Source: UniProtKB
Inferred from direct assayⁱ
- 18387948
- 8906617
acetylcholine receptor activity
Source: UniProtKB
Inferred from direct assayⁱ
- 8906617
ligand-gated ion channel activity
Source: DFLAT
Traceable author statementⁱ
- 20438829
protein heterodimerization activity Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

acetylcholine receptor signaling pathway Source: ARUK-UCL
action potential Source: Ensembl
associative learning Source: UniProtKB
B cell activation Source: UniProtKB
behavioral response to nicotine
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 17559419
calcium ion transport Source: UniProtKB
central nervous system projection neuron axonogenesis Source: UniProtKB
chemical synaptic transmission
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
cognition
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 17559419
conditioned taste aversion Source: Ensembl
ion transmembrane transport
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
ion transport
Source: UniProtKB
Non-traceable author statementⁱ
- 8906617
lateral geniculate nucleus development Source: UniProtKB
learning
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 15964197
locomotory behavior Source: UniProtKB
membrane depolarization Source: UniProtKB
memory
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 15964197
negative regulation of action potential Source: UniProtKB
nervous system process
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 17900292
neuromuscular synaptic transmission
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
optic nerve morphogenesis Source: UniProtKB
positive regulation of B cell proliferation Source: UniProtKB
positive regulation of dopamine secretion Source: UniProtKB
positive regulation of synaptic transmission, dopaminergic Source: Ensembl
protein heterooligomerization Source: Ensembl
regulation of circadian sleep/wake cycle, non-REM sleep Source: Ensembl
regulation of circadian sleep/wake cycle, REM sleep Source: UniProtKB
regulation of dendrite morphogenesis Source: UniProtKB
regulation of dopamine metabolic process Source: UniProtKB
regulation of dopamine secretion Source: UniProtKB
regulation of membrane potential
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
regulation of synapse assembly Source: UniProtKB
regulation of synaptic transmission, dopaminergic Source: UniProtKB
regulation of synaptic vesicle exocytosis Source: Ensembl
response to acetylcholine Source: ARUK-UCL
response to cocaine Source: UniProtKB
response to ethanol Source: UniProtKB
response to hypoxia
Source: UniProtKB
Inferred from direct assayⁱ
- 12189247
response to nicotine
Source: UniProtKB
Inferred from direct assayⁱ
- 12189247
sensory perception of pain Source: UniProtKB
sensory perception of sound Source: UniProtKB
signal transduction
Source: UniProtKB
Inferred from direct assayⁱ
- 8906617
smooth muscle contraction Source: UniProtKB
social behavior Source: UniProtKB
synaptic transmission, cholinergic Source: UniProtKB
synaptic transmission involved in micturition Source: UniProtKB
vestibulocochlear nerve development Source: UniProtKB
visual learning
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 15964197
visual perception Source: UniProtKB

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Ion channel, Ligand-gated ion channel, Receptor
Biological process	Ion transport, Transport

Enzyme and pathway databases

Reactomeⁱ	R-HSA-629587 Highly sodium permeable acetylcholine nicotinic receptors R-HSA-629594 Highly calcium permeable postsynaptic nicotinic acetylcholine receptors R-HSA-629597 Highly calcium permeable nicotinic acetylcholine receptors

Reactomeⁱ

R-HSA-629587 Highly sodium permeable acetylcholine nicotinic receptors
R-HSA-629594 Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
R-HSA-629597 Highly calcium permeable nicotinic acetylcholine receptors

Protein family/group databases

TCDBⁱ	1.A.9.1.6 the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family

TCDBⁱ

1.A.9.1.6 the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Neuronal acetylcholine receptor subunit beta-2
Gene namesⁱ	Name:CHRNB2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000160716.4
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:1962 CHRNB2
MIMⁱ	118507 gene
neXtProtⁱ	NX_P17787

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	26 – 233	ExtracellularSequence analysisAdd BLAST	208
Transmembraneⁱ	234 – 258	HelicalSequence analysisAdd BLAST	25
Topological domainⁱ	259 – 265	CytoplasmicSequence analysis	7
Transmembraneⁱ	266 – 284	HelicalSequence analysisAdd BLAST	19
Topological domainⁱ	285 – 299	ExtracellularSequence analysisAdd BLAST	15
Transmembraneⁱ	300 – 321	HelicalSequence analysisAdd BLAST	22
Topological domainⁱ	322 – 458	CytoplasmicSequence analysisAdd BLAST	137
Transmembraneⁱ	459 – 478	HelicalSequence analysisAdd BLAST	20

Keywords - Cellular componentⁱ

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Epilepsy, nocturnal frontal lobe, 3 (ENFL3)2 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionAn autosomal dominant focal epilepsy characterized by nocturnal seizures with hyperkinetic automatisms and poorly organized stereotyped movements.

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	197	F → Y: Increases ligand activation in LS and HS nAChR subtypes. 1 Publication		1

Keywords - Diseaseⁱ

Disease mutation, Epilepsy

Organism-specific databases

DisGeNET More...DisGeNETⁱ	1141
GeneReviewsⁱ	CHRNB2
MalaCards human disease database More...MalaCardsⁱ	CHRNB2
MIMⁱ	605375 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000160716
Orphanetⁱ	98784 Autosomal dominant nocturnal frontal lobe epilepsy
PharmGKBⁱ	PA115

Chemistry databases

ChEMBLⁱ	CHEMBL1883
Drug and drug target database More...DrugBankⁱ	DB05458 ABT-089 DB00514 Dextromethorphan DB00898 Ethanol DB00674 Galantamine DB00184 Nicotine DB05855 Rivanicline DB05740 RPI-78M

Polymorphism and mutation databases

BioMutaⁱ	CHRNB2
DMDMⁱ	113105

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 25	By similarityAdd BLAST		25
ChainⁱPRO_0000000379	26 – 502	Neuronal acetylcholine receptor subunit beta-2Add BLAST		477

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	51	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	155 ↔ 169	By similarity
Glycosylationⁱ	168	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	485	N-linked (GlcNAc...) asparagineSequence analysis	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbⁱ	P17787
PeptideAtlas More...PeptideAtlasⁱ	P17787
PRIDEⁱ	P17787
ProteomicsDBⁱ	53515

PTM databases

PhosphoSitePlusⁱ	P17787

PhosphoSitePlusⁱ

P17787

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000160716 Expressed in 191 organ(s), highest expression level in epithelium of bronchus
CleanExⁱ	HS_CHRNB2
ExpressionAtlasⁱ	P17787 baseline and differential
Genevisibleⁱ	P17787 HS

Interactionⁱ

Subunit structureⁱ

Neuronal AChR is composed of two different types of subunits: alpha and beta. Beta-2 subunit can be combined to alpha-2, alpha-3 or alpha-4 to give rise to functional receptors, complexes with beta-2 may be heteropentamers. Alpha-2/4:beta-2 nAChR complexes are proposed to exist in two subtypes: LS (low agonist sensitivity) with a (alpha-2/4)3:(beta-2)2 and HS (high agonist sensitivity) with a (alpha-2/4)2:(beta-2)3 stoichiometry; the subtypes differ in their subunit binding interfaces which are involved in ligand binding (PubMed:27493220, PubMed:22361591). Interacts with RIC3; which is required for proper folding and assembly (PubMed:16120769). Interacts with LYPD6 (PubMed:27344019). The heteropentamer alpha-3-beta-2 interacts with alpha-conotoxins BuIA, MII, PnIA and GID (By similarity). The heteropentamer alpha-3-beta-2 interacts with the alpha-conotoxins ImI and ImII (PubMed:15609996). The heteropentamer alpha-4-beta-2 interacts with the alpha-conotoxins PnIA, GID and MII (By similarity).By similarity1 Publication4 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
CHRNA4	P43681-1	4	EBI-9008612,EBI-20716158
CHRNA5	P30532	3	EBI-9008612,EBI-6657490

GO - Molecular functionⁱ

protein heterodimerization activity Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

ComplexPortalⁱ	CPX-168 Neuronal nicotinic acetylcholine receptor complex, 3xalpha4-2xbeta2 CPX-187 Neuronal nicotinic acetylcholine receptor complex, alpha3-alpha5-beta2 CPX-2170 Neuronal nicotinic acetylcholine receptor complex, alpha2-beta2 CPX-218 Neuronal nicotinic acetylcholine receptor complex, alpha4-alpha5-beta2 CPX-2180 Neuronal nicotinic acetylcholine receptor complex, 2xalpha4-3xbeta2 CPX-2192 Neuronal nicotinic acetylcholine receptor complex, alpha3-alpha6-beta2-beta3 CPX-2193 Neuronal nicotinic acetylcholine receptor complex, alpha3-beta2 CPX-240 Neuronal nicotinic acetylcholine receptor complex, alpha7-beta2
CORUMⁱ	P17787
IntActⁱ	P17787, 4 interactors
STRINGⁱ	9606.ENSP00000357461

Chemistry databases

BindingDBⁱ

P17787

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	28 – 36	Combined sources	9
Turnⁱ	39 – 41	Combined sources	3
Beta strandⁱ	44 – 46	Combined sources	3
Turnⁱ	51 – 53	Combined sources	3
Beta strandⁱ	56 – 71	Combined sources	16
Turnⁱ	72 – 75	Combined sources	4
Beta strandⁱ	76 – 88	Combined sources	13
Turnⁱ	96 – 101	Combined sources	6
Beta strandⁱ	104 – 107	Combined sources	4
Turnⁱ	109 – 111	Combined sources	3
Beta strandⁱ	118 – 122	Combined sources	5
Beta strandⁱ	135 – 138	Combined sources	4
Beta strandⁱ	141 – 145	Combined sources	5
Beta strandⁱ	148 – 153	Combined sources	6
Beta strandⁱ	166 – 174	Combined sources	9
Beta strandⁱ	182 – 186	Combined sources	5
Beta strandⁱ	201 – 207	Combined sources	7
Beta strandⁱ	209 – 214	Combined sources	6
Turnⁱ	216 – 218	Combined sources	3
Beta strandⁱ	222 – 232	Combined sources	11
Helixⁱ	235 – 249	Combined sources	15
Helixⁱ	250 – 254	Combined sources	5
Turnⁱ	255 – 257	Combined sources	3
Helixⁱ	260 – 262	Combined sources	3
Helixⁱ	265 – 286	Combined sources	22
Helixⁱ	289 – 291	Combined sources	3
Helixⁱ	296 – 322	Combined sources	27
Turnⁱ	326 – 328	Combined sources	3
Helixⁱ	333 – 342	Combined sources	10
Helixⁱ	344 – 346	Combined sources	3
Helixⁱ	447 – 475	Combined sources	29
Beta strandⁱ	480 – 484	Combined sources	5

Show more details

3D structure databases

ProteinModelPortalⁱ	P17787
SMRⁱ	P17787
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P17787

EvolutionaryTraceⁱ

P17787

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Beta-2/CHRNB2 sub-subfamily. [View classification]Curated

Keywords - Domainⁱ

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3645 Eukaryota ENOG410XQGR LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118930
HOGENOMⁱ	HOG000006757
HOVERGENⁱ	HBG003756
InParanoidⁱ	P17787
KEGG Orthology (KO) More...KOⁱ	K04813
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0R20
PhylomeDBⁱ	P17787
TreeFamⁱ	TF315605

Family and domain databases

Gene3Dⁱ	2.70.170.10, 1 hit
InterProⁱ	View protein in InterPro IPR032932 CHRNB2 IPR006202 Neur_chan_lig-bd IPR036734 Neur_chan_lig-bd_sf IPR006201 Neur_channel IPR036719 Neuro-gated_channel_TM_sf IPR006029 Neurotrans-gated_channel_TM IPR018000 Neurotransmitter_ion_chnl_CS IPR002394 Nicotinic_acetylcholine_rcpt
PANTHERⁱ	PTHR18945 PTHR18945, 1 hit PTHR18945:SF80 PTHR18945:SF80, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02931 Neur_chan_LBD, 1 hit PF02932 Neur_chan_memb, 1 hit
PRINTSⁱ	PR00254 NICOTINICR PR00252 NRIONCHANNEL
SUPFAMⁱ	SSF63712 SSF63712, 1 hit SSF90112 SSF90112, 1 hit
TIGRFAMsⁱ	TIGR00860 LIC, 1 hit
PROSITEⁱ	View protein in PROSITE PS00236 NEUROTR_ION_CHANNEL, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show all Align All

P17787-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MARRCGPVAL LLGFGLLRLC SGVWGTDTEE RLVEHLLDPS RYNKLIRPAT 
        60         70         80         90        100
NGSELVTVQL MVSLAQLISV HEREQIMTTN VWLTQEWEDY RLTWKPEEFD 
       110        120        130        140        150
NMKKVRLPSK HIWLPDVVLY NNADGMYEVS FYSNAVVSYD GSIFWLPPAI 
       160        170        180        190        200
YKSACKIEVK HFPFDQQNCT MKFRSWTYDR TEIDLVLKSE VASLDDFTPS 
       210        220        230        240        250
GEWDIVALPG RRNENPDDST YVDITYDFII RRKPLFYTIN LIIPCVLITS 
       260        270        280        290        300
LAILVFYLPS DCGEKMTLCI SVLLALTVFL LLISKIVPPT SLDVPLVGKY 
       310        320        330        340        350
LMFTMVLVTF SIVTSVCVLN VHHRSPTTHT MAPWVKVVFL EKLPALLFMQ 
       360        370        380        390        400
QPRHHCARQR LRLRRRQRER EGAGALFFRE APGADSCTCF VNRASVQGLA 
       410        420        430        440        450
GAFGAEPAPV AGPGRSGEPC GCGLREAVDG VRFIADHMRS EDDDQSVSED 
       460        470        480        490        500
WKYVAMVIDR LFLWIFVFVC VFGTIGMFLQ PLFQNYTTTT FLHSDHSAPS 

SK

Length:502

Mass (Da):57,019

Last modified:August 1, 1990 - v1

Checksum:ⁱ7EEDEF6ADFDC9F23

GO

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A1B0GTH5	A0A1B0GTH5_HUMAN	Neuronal acetylcholine receptor sub... Neuronal acetylcholine receptor subunit beta-2	CHRNB2	518	Annotation score:
A0A1B0GVD7	A0A1B0GVD7_HUMAN	Neuronal acetylcholine receptor sub... Neuronal acetylcholine receptor subunit beta-2	CHRNB2	504	Annotation score:
A0A1B0GUQ6	A0A1B0GUQ6_HUMAN	Neuronal acetylcholine receptor sub... Neuronal acetylcholine receptor subunit beta-2	CHRNB2	34	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	26	T → A in CAA05108 (PubMed:9921897).Curated	1
Sequence conflictⁱ	426	E → A in CAA05108 (PubMed:9921897).Curated	1
Sequence conflictⁱ	446	S → SVR in CAA05108 (PubMed:9921897).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_012714	287	V → L in ENFL3. 1 PublicationCorresponds to variant dbSNP:rs74315291EnsemblClinVar.	1
Natural variantⁱVAR_012715	287	V → M in ENFL3; approximately 10-fold increase in acetylcholine sensitivity. 1 PublicationCorresponds to variant dbSNP:rs74315291EnsemblClinVar.	1
Natural variantⁱVAR_021564	397	Q → H1 PublicationCorresponds to variant dbSNP:rs55685423EnsemblClinVar.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X53179 mRNA Translation: CAA37320.1 U62437 mRNA Translation: AAB40115.1 Y08415 mRNA Translation: CAA69692.1 AJ001935 AJ001939 Genomic DNA Translation: CAA05108.1 AF077186 Genomic DNA Translation: AAD45422.1 BC075040 mRNA Translation: AAH75040.1 BC075041 mRNA Translation: AAH75041.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS1070.1
PIRⁱ	S10505
NCBI Reference Sequences More...RefSeqⁱ	NP_000739.1, NM_000748.2
UniGeneⁱ	Hs.2306

Genome annotation databases

Ensemblⁱ	ENST00000368476; ENSP00000357461; ENSG00000160716
GeneIDⁱ	1141
KEGGⁱ	hsa:1141

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P17787	Neuronal acetylcholine receptor subunit beta-2		HUMAN		518	UniRef100_P17787
CHRNB2 isoform 2		PANTR		518
Uncharacterized protein		PANPA		502
Cholinergic receptor nicotinic beta 2 subunit		GORGO		502
Cholinergic receptor, nicotinic, beta 2 (Neuronal)		HUMAN		502
+2

Protein	Similar proteins		Species	Score	Length	Source
P17787	Neuronal acetylcholine receptor subunit beta-2		MOUSE		501	UniRef90_Q9ERK7
Neuronal acetylcholine receptor subunit beta-2	)	RAT		500
Cholinergic receptor nicotinic beta 2 subunit		PONAB		518
Uncharacterized protein		RHIBE		518
neuronal acetylcholine receptor subunit beta-2 isoform X1		DIPOR		504
+84

Protein	Similar proteins		Species	Score	Length	Source
P17787	Neuronal acetylcholine receptor subunit beta-2		MOUSE		501	UniRef50_Q9ERK7
Neuronal acetylcholine receptor subunit beta-2	)	RAT		500
Neuronal acetylcholine receptor subunit beta-2		CHICK		491
Uncharacterized protein		RHIBE		518
CHRNB2 isoform 2		PONAB		518
+165

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X53179 mRNA Translation: CAA37320.1 U62437 mRNA Translation: AAB40115.1 Y08415 mRNA Translation: CAA69692.1 AJ001935 AJ001939 Genomic DNA Translation: CAA05108.1 AF077186 Genomic DNA Translation: AAD45422.1 BC075040 mRNA Translation: AAH75040.1 BC075041 mRNA Translation: AAH75041.1
CCDSⁱ	CCDS1070.1
PIRⁱ	S10505
RefSeqⁱ	NP_000739.1, NM_000748.2
UniGeneⁱ	Hs.2306

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2GVT	model	-	B/D/E	30-233	[»]
	2K58	NMR	-	B	231-265	[»]
	2K59	NMR	-	B	264-291	[»]
	2KSR	NMR	-	A	231-330	[»]
				A	453-486	[»]
	2LM2	NMR	-	A	231-330	[»]
				A	458-485	[»]
	5KXI	X-ray	3.94	B/C/E	26-355	[»]
				B/C/E	446-502	[»]
	6CNJ	electron microscopy	3.40	B/C/E	26-353	[»]
				B/C/E	446-502	[»]
	6CNK	electron microscopy	3.70	C/E	26-353	[»]
				C/E	446-502	[»]
ProteinModelPortalⁱ	P17787
SMRⁱ	P17787
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

ComplexPortalⁱ	CPX-168 Neuronal nicotinic acetylcholine receptor complex, 3xalpha4-2xbeta2 CPX-187 Neuronal nicotinic acetylcholine receptor complex, alpha3-alpha5-beta2 CPX-2170 Neuronal nicotinic acetylcholine receptor complex, alpha2-beta2 CPX-218 Neuronal nicotinic acetylcholine receptor complex, alpha4-alpha5-beta2 CPX-2180 Neuronal nicotinic acetylcholine receptor complex, 2xalpha4-3xbeta2 CPX-2192 Neuronal nicotinic acetylcholine receptor complex, alpha3-alpha6-beta2-beta3 CPX-2193 Neuronal nicotinic acetylcholine receptor complex, alpha3-beta2 CPX-240 Neuronal nicotinic acetylcholine receptor complex, alpha7-beta2
CORUMⁱ	P17787
IntActⁱ	P17787, 4 interactors
STRINGⁱ	9606.ENSP00000357461

Chemistry databases

BindingDBⁱ	P17787
ChEMBLⁱ	CHEMBL1883
DrugBankⁱ	DB05458 ABT-089 DB00514 Dextromethorphan DB00898 Ethanol DB00674 Galantamine DB00184 Nicotine DB05855 Rivanicline DB05740 RPI-78M

Protein family/group databases

TCDBⁱ	1.A.9.1.6 the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family

TCDBⁱ

1.A.9.1.6 the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family

PTM databases

PhosphoSitePlusⁱ	P17787

PhosphoSitePlusⁱ

P17787

Polymorphism and mutation databases

BioMutaⁱ	CHRNB2
DMDMⁱ	113105

Proteomic databases

PaxDbⁱ	P17787
PeptideAtlasⁱ	P17787
PRIDEⁱ	P17787
ProteomicsDBⁱ	53515

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000368476; ENSP00000357461; ENSG00000160716
GeneIDⁱ	1141
KEGGⁱ	hsa:1141

Organism-specific databases

CTDⁱ	1141
DisGeNETⁱ	1141
EuPathDBⁱ	HostDB:ENSG00000160716.4
GeneCardsⁱ	CHRNB2
GeneReviewsⁱ	CHRNB2
HGNCⁱ	HGNC:1962 CHRNB2
MalaCardsⁱ	CHRNB2
MIMⁱ	118507 gene 605375 phenotype
neXtProtⁱ	NX_P17787
OpenTargetsⁱ	ENSG00000160716
Orphanetⁱ	98784 Autosomal dominant nocturnal frontal lobe epilepsy
PharmGKBⁱ	PA115
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3645 Eukaryota ENOG410XQGR LUCA
GeneTreeⁱ	ENSGT00760000118930
HOGENOMⁱ	HOG000006757
HOVERGENⁱ	HBG003756
InParanoidⁱ	P17787
KOⁱ	K04813
OrthoDBⁱ	EOG091G0R20
PhylomeDBⁱ	P17787
TreeFamⁱ	TF315605

Enzyme and pathway databases

Reactomeⁱ	R-HSA-629587 Highly sodium permeable acetylcholine nicotinic receptors R-HSA-629594 Highly calcium permeable postsynaptic nicotinic acetylcholine receptors R-HSA-629597 Highly calcium permeable nicotinic acetylcholine receptors

Reactomeⁱ

R-HSA-629587 Highly sodium permeable acetylcholine nicotinic receptors
R-HSA-629594 Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
R-HSA-629597 Highly calcium permeable nicotinic acetylcholine receptors

Miscellaneous databases

ChiTaRSⁱ	CHRNB2 human
EvolutionaryTraceⁱ	P17787
GeneWikiⁱ	CHRNB2
GenomeRNAiⁱ	1141
Protein Ontology More...PROⁱ	PR:P17787
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000160716 Expressed in 191 organ(s), highest expression level in epithelium of bronchus
CleanExⁱ	HS_CHRNB2
ExpressionAtlasⁱ	P17787 baseline and differential
Genevisibleⁱ	P17787 HS

Family and domain databases

Gene3Dⁱ	2.70.170.10, 1 hit
InterProⁱ	View protein in InterPro IPR032932 CHRNB2 IPR006202 Neur_chan_lig-bd IPR036734 Neur_chan_lig-bd_sf IPR006201 Neur_channel IPR036719 Neuro-gated_channel_TM_sf IPR006029 Neurotrans-gated_channel_TM IPR018000 Neurotransmitter_ion_chnl_CS IPR002394 Nicotinic_acetylcholine_rcpt
PANTHERⁱ	PTHR18945 PTHR18945, 1 hit PTHR18945:SF80 PTHR18945:SF80, 1 hit
Pfamⁱ	View protein in Pfam PF02931 Neur_chan_LBD, 1 hit PF02932 Neur_chan_memb, 1 hit
PRINTSⁱ	PR00254 NICOTINICR PR00252 NRIONCHANNEL
SUPFAMⁱ	SSF63712 SSF63712, 1 hit SSF90112 SSF90112, 1 hit
TIGRFAMsⁱ	TIGR00860 LIC, 1 hit
PROSITEⁱ	View protein in PROSITE PS00236 NEUROTR_ION_CHANNEL, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ACHB2_HUMAN
Accessionⁱ	P17787Primary (citable) accession number: P17787 Secondary accession number(s): Q9UEH9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 1, 1990
	Last sequence update:	August 1, 1990
	Last modified:	November 7, 2018
	This is version 194 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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UniProtKB - P17787 (ACHB2_HUMAN)

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Neuronal acetylcholine receptor subunit beta-2

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

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GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

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Organism-specific databases

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Gene expression databases

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Protein-protein interaction databases

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Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

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Sequence databases

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Protein family/group databases

PTM databases

Polymorphism and mutation databases

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Gene expression databases

Family and domain databases

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<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ