UniProtKB - P17787 (ACHB2_HUMAN)
Neuronal acetylcholine receptor subunit beta-2
CHRNB2
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 84 | Key residue that may interfere with effective access of the conotoxin BuIA to the channel binding siteBy similarity | 1 | |
Sitei | 136 | Key residue for a rapid dissociation (K(off)) from the conotoxin BuIABy similarity | 1 | |
Sitei | 144 | Key residue for a rapid dissociation (K(off)) from the conotoxin BuIABy similarity | 1 |
GO - Molecular functioni
- acetylcholine binding Source: UniProtKB
- acetylcholine-gated cation-selective channel activity Source: UniProtKB
- acetylcholine receptor activity Source: UniProtKB
- drug binding Source: Ensembl
- ligand-gated ion channel activity Source: DFLAT
- neurotransmitter receptor activity Source: GO_Central
- protein-containing complex binding Source: Ensembl
GO - Biological processi
- acetylcholine receptor signaling pathway Source: ARUK-UCL
- action potential Source: Ensembl
- associative learning Source: UniProtKB
- B cell activation Source: UniProtKB
- behavioral response to nicotine Source: UniProtKB
- calcium ion transport Source: UniProtKB
- central nervous system projection neuron axonogenesis Source: UniProtKB
- chemical synaptic transmission Source: GO_Central
- cognition Source: UniProtKB
- conditioned taste aversion Source: Ensembl
- ion transmembrane transport Source: GO_Central
- ion transport Source: UniProtKB
- lateral geniculate nucleus development Source: UniProtKB
- learning Source: UniProtKB
- locomotory behavior Source: UniProtKB
- membrane depolarization Source: UniProtKB
- memory Source: UniProtKB
- negative regulation of action potential Source: UniProtKB
- nervous system process Source: UniProtKB
- optic nerve morphogenesis Source: UniProtKB
- positive regulation of B cell proliferation Source: UniProtKB
- positive regulation of dopamine secretion Source: UniProtKB
- positive regulation of synaptic transmission, dopaminergic Source: Ensembl
- regulation of circadian sleep/wake cycle, non-REM sleep Source: Ensembl
- regulation of circadian sleep/wake cycle, REM sleep Source: UniProtKB
- regulation of dendrite morphogenesis Source: UniProtKB
- regulation of dopamine metabolic process Source: UniProtKB
- regulation of dopamine secretion Source: UniProtKB
- regulation of membrane potential Source: GO_Central
- regulation of synapse assembly Source: UniProtKB
- regulation of synaptic transmission, dopaminergic Source: UniProtKB
- regulation of synaptic vesicle exocytosis Source: Ensembl
- response to acetylcholine Source: ARUK-UCL
- response to cocaine Source: UniProtKB
- response to ethanol Source: UniProtKB
- response to hypoxia Source: UniProtKB
- response to nicotine Source: UniProtKB
- sensory perception of pain Source: UniProtKB
- sensory perception of sound Source: UniProtKB
- signal transduction Source: UniProtKB
- smooth muscle contraction Source: UniProtKB
- social behavior Source: UniProtKB
- synaptic transmission, cholinergic Source: UniProtKB
- synaptic transmission involved in micturition Source: UniProtKB
- vestibulocochlear nerve development Source: UniProtKB
- visual learning Source: UniProtKB
- visual perception Source: UniProtKB
Keywordsi
Molecular function | Ion channel, Ligand-gated ion channel, Receptor |
Biological process | Ion transport, Transport |
Enzyme and pathway databases
PathwayCommonsi | P17787 |
Reactomei | R-HSA-629587, Highly sodium permeable postsynaptic acetylcholine nicotinic receptors R-HSA-629594, Highly calcium permeable postsynaptic nicotinic acetylcholine receptors R-HSA-629597, Highly calcium permeable nicotinic acetylcholine receptors |
Protein family/group databases
TCDBi | 1.A.9.1.6, the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family |
Names & Taxonomyi
Protein namesi | Recommended name: Neuronal acetylcholine receptor subunit beta-2 |
Gene namesi | Name:CHRNB2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000160716.4 |
HGNCi | HGNC:1962, CHRNB2 |
MIMi | 118507, gene |
neXtProti | NX_P17787 |
Subcellular locationi
Plasma Membrane
- acetylcholine-gated channel complex Source: UniProtKB
- external side of plasma membrane Source: UniProtKB
- integral component of plasma membrane Source: GO_Central
- integral component of postsynaptic specialization membrane Source: Ensembl
- plasma membrane Source: Reactome
- plasma membrane raft Source: ARUK-UCL
Other locations
- cholinergic synapse Source: Ensembl
- dopaminergic synapse Source: Ensembl
- integral component of membrane Source: UniProtKB
- neuron projection Source: GO_Central
- synapse Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 26 – 233 | ExtracellularSequence analysisAdd BLAST | 208 | |
Transmembranei | 234 – 258 | HelicalSequence analysisAdd BLAST | 25 | |
Topological domaini | 259 – 265 | CytoplasmicSequence analysis | 7 | |
Transmembranei | 266 – 284 | HelicalSequence analysisAdd BLAST | 19 | |
Topological domaini | 285 – 299 | ExtracellularSequence analysisAdd BLAST | 15 | |
Transmembranei | 300 – 321 | HelicalSequence analysisAdd BLAST | 22 | |
Topological domaini | 322 – 458 | CytoplasmicSequence analysisAdd BLAST | 137 | |
Transmembranei | 459 – 478 | HelicalSequence analysisAdd BLAST | 20 |
Keywords - Cellular componenti
Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, SynapsePathology & Biotechi
Involvement in diseasei
Epilepsy, nocturnal frontal lobe, 3 (ENFL3)2 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_012714 | 287 | V → L in ENFL3. 1 PublicationCorresponds to variant dbSNP:rs74315291EnsemblClinVar. | 1 | |
Natural variantiVAR_012715 | 287 | V → M in ENFL3; approximately 10-fold increase in acetylcholine sensitivity. 1 PublicationCorresponds to variant dbSNP:rs74315291EnsemblClinVar. | 1 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 197 | F → Y: Increases ligand activation in LS and HS nAChR subtypes. 1 Publication | 1 |
Keywords - Diseasei
Disease mutation, EpilepsyOrganism-specific databases
DisGeNETi | 1141 |
GeneReviewsi | CHRNB2 |
MalaCardsi | CHRNB2 |
MIMi | 605375, phenotype |
OpenTargetsi | ENSG00000160716 |
Orphaneti | 98784, Autosomal dominant nocturnal frontal lobe epilepsy |
PharmGKBi | PA115 |
Miscellaneous databases
Pharosi | P17787, Tclin |
Chemistry databases
ChEMBLi | CHEMBL1883 |
DrugBanki | DB00572, Atropine DB00237, Butabarbital DB09028, Cytisine DB01245, Decamethonium DB00514, Dextromethorphan DB07720, Epibatidine DB00898, Ethanol DB00753, Isoflurane DB00657, Mecamylamine DB00333, Methadone DB00184, Nicotine DB00981, Physostigmine DB05458, Pozanicline DB05855, Rivanicline DB05740, RPI-78M DB00747, Scopolamine DB01273, Varenicline |
DrugCentrali | P17787 |
Polymorphism and mutation databases
BioMutai | CHRNB2 |
DMDMi | 113105 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 25 | By similarityAdd BLAST | 25 | |
ChainiPRO_0000000379 | 26 – 502 | Neuronal acetylcholine receptor subunit beta-2Add BLAST | 477 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 51 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 155 ↔ 169 | By similarity | ||
Glycosylationi | 168 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 485 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
MassIVEi | P17787 |
PaxDbi | P17787 |
PeptideAtlasi | P17787 |
PRIDEi | P17787 |
ProteomicsDBi | 53515 |
PTM databases
GlyGeni | P17787, 3 sites |
PhosphoSitePlusi | P17787 |
Expressioni
Gene expression databases
Bgeei | ENSG00000160716, Expressed in epithelium of bronchus and 196 other tissues |
ExpressionAtlasi | P17787, baseline and differential |
Genevisiblei | P17787, HS |
Organism-specific databases
HPAi | ENSG00000160716, Tissue enriched (brain) |
Interactioni
Subunit structurei
Neuronal AChR is composed of two different types of subunits: alpha and beta. Beta-2 subunit can be combined to alpha-2, alpha-3 or alpha-4 to give rise to functional receptors, complexes with beta-2 may be heteropentamers. Alpha-2/4:beta-2 nAChR complexes are proposed to exist in two subtypes: LS (low agonist sensitivity) with a (alpha-2/4)3:(beta-2)2 and HS (high agonist sensitivity) with a (alpha-2/4)2:(beta-2)3 stoichiometry; the subtypes differ in their subunit binding interfaces which are involved in ligand binding (PubMed:27493220, PubMed:22361591).
Interacts with RIC3; which is required for proper folding and assembly (PubMed:16120769).
Interacts with LYPD6 (PubMed:27344019). The heteropentamer alpha-3-beta-2 interacts with alpha-conotoxins BuIA, MII, PnIA and GID (By similarity). The heteropentamer alpha-3-beta-2 interacts with the alpha-conotoxins ImI and ImII (PubMed:15609996). The heteropentamer alpha-4-beta-2 interacts with the alpha-conotoxins PnIA, GID and MII (By similarity).
By similarity1 Publication4 PublicationsBinary interactionsi
Hide detailsP17787
With | #Exp. | IntAct |
---|---|---|
CHRNA4 - isoform 1 [P43681-1] | 4 | EBI-9008612,EBI-20716158 |
CHRNA5 [P30532] | 3 | EBI-9008612,EBI-6657490 |
Protein-protein interaction databases
ComplexPortali | CPX-168, Neuronal nicotinic acetylcholine receptor complex, 3xalpha4-2xbeta2 CPX-187, Neuronal nicotinic acetylcholine receptor complex, alpha3-alpha5-beta2 CPX-2170, Neuronal nicotinic acetylcholine receptor complex, alpha2-beta2 CPX-218, Neuronal nicotinic acetylcholine receptor complex, alpha4-alpha5-beta2 CPX-2180, Neuronal nicotinic acetylcholine receptor complex, 2xalpha4-3xbeta2 CPX-2192, Neuronal nicotinic acetylcholine receptor complex, alpha3-alpha6-beta2-beta3 CPX-2193, Neuronal nicotinic acetylcholine receptor complex, alpha3-beta2 CPX-240, Neuronal nicotinic acetylcholine receptor complex, alpha7-beta2 |
CORUMi | P17787 |
IntActi | P17787, 6 interactors |
STRINGi | 9606.ENSP00000357461 |
Chemistry databases
BindingDBi | P17787 |
Miscellaneous databases
RNActi | P17787, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P17787 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P17787 |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3645, Eukaryota |
GeneTreei | ENSGT00940000158417 |
HOGENOMi | CLU_018074_1_3_1 |
InParanoidi | P17787 |
OrthoDBi | 381858at2759 |
PhylomeDBi | P17787 |
TreeFami | TF315605 |
Family and domain databases
Gene3Di | 2.70.170.10, 1 hit |
InterProi | View protein in InterPro IPR032932, CHRNB2 IPR006202, Neur_chan_lig-bd IPR036734, Neur_chan_lig-bd_sf IPR006201, Neur_channel IPR036719, Neuro-gated_channel_TM_sf IPR006029, Neurotrans-gated_channel_TM IPR018000, Neurotransmitter_ion_chnl_CS IPR002394, Nicotinic_acetylcholine_rcpt |
PANTHERi | PTHR18945, PTHR18945, 1 hit PTHR18945:SF80, PTHR18945:SF80, 1 hit |
Pfami | View protein in Pfam PF02931, Neur_chan_LBD, 1 hit PF02932, Neur_chan_memb, 1 hit |
PRINTSi | PR00254, NICOTINICR PR00252, NRIONCHANNEL |
SUPFAMi | SSF63712, SSF63712, 1 hit SSF90112, SSF90112, 1 hit |
TIGRFAMsi | TIGR00860, LIC, 1 hit |
PROSITEi | View protein in PROSITE PS00236, NEUROTR_ION_CHANNEL, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MARRCGPVAL LLGFGLLRLC SGVWGTDTEE RLVEHLLDPS RYNKLIRPAT
60 70 80 90 100
NGSELVTVQL MVSLAQLISV HEREQIMTTN VWLTQEWEDY RLTWKPEEFD
110 120 130 140 150
NMKKVRLPSK HIWLPDVVLY NNADGMYEVS FYSNAVVSYD GSIFWLPPAI
160 170 180 190 200
YKSACKIEVK HFPFDQQNCT MKFRSWTYDR TEIDLVLKSE VASLDDFTPS
210 220 230 240 250
GEWDIVALPG RRNENPDDST YVDITYDFII RRKPLFYTIN LIIPCVLITS
260 270 280 290 300
LAILVFYLPS DCGEKMTLCI SVLLALTVFL LLISKIVPPT SLDVPLVGKY
310 320 330 340 350
LMFTMVLVTF SIVTSVCVLN VHHRSPTTHT MAPWVKVVFL EKLPALLFMQ
360 370 380 390 400
QPRHHCARQR LRLRRRQRER EGAGALFFRE APGADSCTCF VNRASVQGLA
410 420 430 440 450
GAFGAEPAPV AGPGRSGEPC GCGLREAVDG VRFIADHMRS EDDDQSVSED
460 470 480 490 500
WKYVAMVIDR LFLWIFVFVC VFGTIGMFLQ PLFQNYTTTT FLHSDHSAPS
SK
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A1B0GTH5 | A0A1B0GTH5_HUMAN | Neuronal acetylcholine receptor sub... | CHRNB2 | 518 | Annotation score: | ||
A0A1B0GVD7 | A0A1B0GVD7_HUMAN | Neuronal acetylcholine receptor sub... | CHRNB2 | 504 | Annotation score: | ||
A0A1B0GUQ6 | A0A1B0GUQ6_HUMAN | Neuronal acetylcholine receptor sub... | CHRNB2 | 34 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 26 | T → A in CAA05108 (PubMed:9921897).Curated | 1 | |
Sequence conflicti | 426 | E → A in CAA05108 (PubMed:9921897).Curated | 1 | |
Sequence conflicti | 446 | S → SVR in CAA05108 (PubMed:9921897).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_012714 | 287 | V → L in ENFL3. 1 PublicationCorresponds to variant dbSNP:rs74315291EnsemblClinVar. | 1 | |
Natural variantiVAR_012715 | 287 | V → M in ENFL3; approximately 10-fold increase in acetylcholine sensitivity. 1 PublicationCorresponds to variant dbSNP:rs74315291EnsemblClinVar. | 1 | |
Natural variantiVAR_021564 | 397 | Q → H1 PublicationCorresponds to variant dbSNP:rs55685423EnsemblClinVar. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X53179 mRNA Translation: CAA37320.1 U62437 mRNA Translation: AAB40115.1 Y08415 mRNA Translation: CAA69692.1 AJ001935 , AJ001936, AJ001937, AJ001938, AJ001939 Genomic DNA Translation: CAA05108.1 AF077186 Genomic DNA Translation: AAD45422.1 BC075040 mRNA Translation: AAH75040.1 BC075041 mRNA Translation: AAH75041.1 |
CCDSi | CCDS1070.1 |
PIRi | S10505 |
RefSeqi | NP_000739.1, NM_000748.2 |
Genome annotation databases
Ensembli | ENST00000368476; ENSP00000357461; ENSG00000160716 |
GeneIDi | 1141 |
KEGGi | hsa:1141 |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X53179 mRNA Translation: CAA37320.1 U62437 mRNA Translation: AAB40115.1 Y08415 mRNA Translation: CAA69692.1 AJ001935 , AJ001936, AJ001937, AJ001938, AJ001939 Genomic DNA Translation: CAA05108.1 AF077186 Genomic DNA Translation: AAD45422.1 BC075040 mRNA Translation: AAH75040.1 BC075041 mRNA Translation: AAH75041.1 |
CCDSi | CCDS1070.1 |
PIRi | S10505 |
RefSeqi | NP_000739.1, NM_000748.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2GVT | model | - | B/D/E | 30-233 | [»] | |
2K58 | NMR | - | B | 231-265 | [»] | |
2K59 | NMR | - | B | 264-291 | [»] | |
2KSR | NMR | - | A | 231-330 | [»] | |
A | 453-486 | [»] | ||||
2LM2 | NMR | - | A | 231-330 | [»] | |
A | 458-485 | [»] | ||||
5KXI | X-ray | 3.94 | B/C/E | 26-355 | [»] | |
B/C/E | 446-502 | [»] | ||||
6CNJ | electron microscopy | 3.40 | B/C/E | 26-353 | [»] | |
B/C/E | 446-502 | [»] | ||||
6CNK | electron microscopy | 3.70 | C/E | 26-353 | [»] | |
C/E | 446-502 | [»] | ||||
6UR8 | electron microscopy | 3.71 | B/C/E | 26-502 | [»] | |
6USF | electron microscopy | 3.87 | B/C/E | 26-502 | [»] | |
SMRi | P17787 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
ComplexPortali | CPX-168, Neuronal nicotinic acetylcholine receptor complex, 3xalpha4-2xbeta2 CPX-187, Neuronal nicotinic acetylcholine receptor complex, alpha3-alpha5-beta2 CPX-2170, Neuronal nicotinic acetylcholine receptor complex, alpha2-beta2 CPX-218, Neuronal nicotinic acetylcholine receptor complex, alpha4-alpha5-beta2 CPX-2180, Neuronal nicotinic acetylcholine receptor complex, 2xalpha4-3xbeta2 CPX-2192, Neuronal nicotinic acetylcholine receptor complex, alpha3-alpha6-beta2-beta3 CPX-2193, Neuronal nicotinic acetylcholine receptor complex, alpha3-beta2 CPX-240, Neuronal nicotinic acetylcholine receptor complex, alpha7-beta2 |
CORUMi | P17787 |
IntActi | P17787, 6 interactors |
STRINGi | 9606.ENSP00000357461 |
Chemistry databases
BindingDBi | P17787 |
ChEMBLi | CHEMBL1883 |
DrugBanki | DB00572, Atropine DB00237, Butabarbital DB09028, Cytisine DB01245, Decamethonium DB00514, Dextromethorphan DB07720, Epibatidine DB00898, Ethanol DB00753, Isoflurane DB00657, Mecamylamine DB00333, Methadone DB00184, Nicotine DB00981, Physostigmine DB05458, Pozanicline DB05855, Rivanicline DB05740, RPI-78M DB00747, Scopolamine DB01273, Varenicline |
DrugCentrali | P17787 |
Protein family/group databases
TCDBi | 1.A.9.1.6, the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family |
PTM databases
GlyGeni | P17787, 3 sites |
PhosphoSitePlusi | P17787 |
Polymorphism and mutation databases
BioMutai | CHRNB2 |
DMDMi | 113105 |
Proteomic databases
MassIVEi | P17787 |
PaxDbi | P17787 |
PeptideAtlasi | P17787 |
PRIDEi | P17787 |
ProteomicsDBi | 53515 |
Protocols and materials databases
Antibodypediai | 20401, 257 antibodies |
Genome annotation databases
Ensembli | ENST00000368476; ENSP00000357461; ENSG00000160716 |
GeneIDi | 1141 |
KEGGi | hsa:1141 |
Organism-specific databases
CTDi | 1141 |
DisGeNETi | 1141 |
EuPathDBi | HostDB:ENSG00000160716.4 |
GeneCardsi | CHRNB2 |
GeneReviewsi | CHRNB2 |
HGNCi | HGNC:1962, CHRNB2 |
HPAi | ENSG00000160716, Tissue enriched (brain) |
MalaCardsi | CHRNB2 |
MIMi | 118507, gene 605375, phenotype |
neXtProti | NX_P17787 |
OpenTargetsi | ENSG00000160716 |
Orphaneti | 98784, Autosomal dominant nocturnal frontal lobe epilepsy |
PharmGKBi | PA115 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3645, Eukaryota |
GeneTreei | ENSGT00940000158417 |
HOGENOMi | CLU_018074_1_3_1 |
InParanoidi | P17787 |
OrthoDBi | 381858at2759 |
PhylomeDBi | P17787 |
TreeFami | TF315605 |
Enzyme and pathway databases
PathwayCommonsi | P17787 |
Reactomei | R-HSA-629587, Highly sodium permeable postsynaptic acetylcholine nicotinic receptors R-HSA-629594, Highly calcium permeable postsynaptic nicotinic acetylcholine receptors R-HSA-629597, Highly calcium permeable nicotinic acetylcholine receptors |
Miscellaneous databases
BioGRID-ORCSi | 1141, 4 hits in 845 CRISPR screens |
ChiTaRSi | CHRNB2, human |
EvolutionaryTracei | P17787 |
GeneWikii | CHRNB2 |
GenomeRNAii | 1141 |
Pharosi | P17787, Tclin |
PROi | PR:P17787 |
RNActi | P17787, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000160716, Expressed in epithelium of bronchus and 196 other tissues |
ExpressionAtlasi | P17787, baseline and differential |
Genevisiblei | P17787, HS |
Family and domain databases
Gene3Di | 2.70.170.10, 1 hit |
InterProi | View protein in InterPro IPR032932, CHRNB2 IPR006202, Neur_chan_lig-bd IPR036734, Neur_chan_lig-bd_sf IPR006201, Neur_channel IPR036719, Neuro-gated_channel_TM_sf IPR006029, Neurotrans-gated_channel_TM IPR018000, Neurotransmitter_ion_chnl_CS IPR002394, Nicotinic_acetylcholine_rcpt |
PANTHERi | PTHR18945, PTHR18945, 1 hit PTHR18945:SF80, PTHR18945:SF80, 1 hit |
Pfami | View protein in Pfam PF02931, Neur_chan_LBD, 1 hit PF02932, Neur_chan_memb, 1 hit |
PRINTSi | PR00254, NICOTINICR PR00252, NRIONCHANNEL |
SUPFAMi | SSF63712, SSF63712, 1 hit SSF90112, SSF90112, 1 hit |
TIGRFAMsi | TIGR00860, LIC, 1 hit |
PROSITEi | View protein in PROSITE PS00236, NEUROTR_ION_CHANNEL, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ACHB2_HUMAN | |
Accessioni | P17787Primary (citable) accession number: P17787 Secondary accession number(s): Q9UEH9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1990 |
Last sequence update: | August 1, 1990 | |
Last modified: | December 2, 2020 | |
This is version 210 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations