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Entry version 156 (07 Oct 2020)
Sequence version 1 (01 Aug 1990)
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Protein

Genome polyprotein

Gene
N/A
Organism
Plum pox potyvirus (isolate NAT) (PPV)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

involved in aphid transmission, cell-to-cell and systemis movement, encapsidation of the viral RNA and in the regulation of viral RNA amplification.
an RNA-dependent RNA polymerase that plays an essential role in the virus replication.
required for aphid transmission and also has proteolytic activity. Only cleaves a Gly-Gly dipeptide at its own C-terminus. Interacts with virions and aphid stylets. Acts as a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs. May have RNA-binding activity (By similarity).By similarity
has helicase activity. It may be involved in replication.
has RNA-binding and proteolytic activities.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Hydrolyzes glutaminyl bonds, and activity is further restricted by preferences for the amino acids in P6 - P1' that vary with the species of potyvirus, e.g. Glu-Xaa-Xaa-Tyr-Xaa-Gln-|-(Ser or Gly) for the enzyme from tobacco etch virus. The natural substrate is the viral polyprotein, but other proteins and oligopeptides containing the appropriate consensus sequence are also cleaved. EC:3.4.22.44
  • Hydrolyzes a Gly-|-Gly bond at its own C-terminus, commonly in the sequence -Tyr-Xaa-Val-Gly-|-Gly, in the processing of the potyviral polyprotein. EC:3.4.22.45

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei216For P1 proteinase activityPROSITE-ProRule annotation1
Active sitei225For P1 proteinase activityPROSITE-ProRule annotation1
Active sitei259For P1 proteinase activityPROSITE-ProRule annotation1
Active sitei652For helper component proteinase activityPROSITE-ProRule annotation1
Active sitei725For helper component proteinase activityPROSITE-ProRule annotation1
Active sitei2095For nuclear inclusion protein A activityPROSITE-ProRule annotation1
Active sitei2130For nuclear inclusion protein A activityPROSITE-ProRule annotation1
Active sitei2200For nuclear inclusion protein A activityPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi1253 – 1260ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHelicase, Hydrolase, Nucleotidyltransferase, Protease, RNA-directed RNA polymerase, Serine protease, Suppressor of RNA silencing, Thiol protease, Transferase
Biological processViral RNA replication
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.4.22.45, 4919

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Genome polyprotein
Cleaved into the following 10 chains:
P1 proteinase (EC:3.4.-.-)
Alternative name(s):
N-terminal protein
Helper component proteinase (EC:3.4.22.45)
Short name:
HC-pro
6 kDa protein 1
Short name:
6K1
Cytoplasmic inclusion protein (EC:3.6.4.-)
Short name:
CI
6 kDa protein 2
Short name:
6K2
Alternative name(s):
VPg
Nuclear inclusion protein A (EC:3.4.22.44)
Short name:
NI-a
Short name:
NIa
Alternative name(s):
49 kDa proteinase
Short name:
49 kDa-Pro
NIa-pro
Nuclear inclusion protein B (EC:2.7.7.48)
Short name:
NI-b
Short name:
NIb
Alternative name(s):
RNA-directed RNA polymerase
Capsid protein
Short name:
CP
Alternative name(s):
Coat protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPlum pox potyvirus (isolate NAT) (PPV)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri12213 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesRiboviriaOrthornaviraePisuviricotaStelpaviricetesPatataviralesPotyviridaePotyvirus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiPrunus armeniaca (Apricot) (Armeniaca vulgaris) [TaxID: 36596]
Prunus cerasifera (cherry plum) [TaxID: 36595]
Prunus domestica (Garden plum) [TaxID: 3758]
Prunus glandulosa [TaxID: 105665]
Prunus persica (Peach) (Amygdalus persica) [TaxID: 3760]
Prunus salicina [TaxID: 88123]
Prunus spinosa (Blackthorn) (Prunus domestica var. spinosa) [TaxID: 114937]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006685 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Capsid protein, Helical capsid protein, Virion

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004200071 – 3125Genome polyproteinAdd BLAST3125
ChainiPRO_00000403311 – 308P1 proteinaseSequence analysisAdd BLAST308
ChainiPRO_0000040332309 – 766Helper component proteinaseSequence analysisAdd BLAST458
ChainiPRO_0000040333767 – 1116Protein P3By similarityAdd BLAST350
ChainiPRO_00000403341117 – 11686 kDa protein 1By similarityAdd BLAST52
ChainiPRO_00000403351169 – 1803Cytoplasmic inclusion proteinBy similarityAdd BLAST635
ChainiPRO_00000403361804 – 18566 kDa protein 2By similarityAdd BLAST53
ChainiPRO_00000403371857 – 2049Viral genome-linked proteinBy similarityAdd BLAST193
ChainiPRO_00000403382050 – 2292Nuclear inclusion protein ABy similarityAdd BLAST243
ChainiPRO_00000403392293 – 2810Nuclear inclusion protein BBy similarityAdd BLAST518
ChainiPRO_00000403402811 – 3125Capsid proteinBy similarityAdd BLAST315

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1919O-(5'-phospho-RNA)-tyrosineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

VPg is uridylylated by the polymerase and is covalently attached to the 5'-end of the genomic RNA. This uridylylated form acts as a nucleotide-peptide primer for the polymerase (By similarity).By similarity
Potyviral RNA is expressed as two polyproteins which undergo post-translational proteolytic processing. Genome polyprotein is processed by NIa-pro, P1 and HC-pro proteinases resulting in the production of at least ten individual proteins. P3N-PIPO polyprotein is cleaved by P1 and HC-pro proteinases resulting in the production of three individual proteins. The P1 proteinase and the HC-pro cleave only their respective C-termini autocatalytically. 6K1 is essential for proper proteolytic separation of P3 from CI (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei308 – 309Cleavage; by P1 proteinasePROSITE-ProRule annotation2
Sitei766 – 767Cleavage; by autolysisPROSITE-ProRule annotation2
Sitei1116 – 1117Cleavage; by NIa-proBy similarity2
Sitei1168 – 1169Cleavage; by NIa-proBy similarity2
Sitei1803 – 1804Cleavage; by NIa-proBy similarity2
Sitei1856 – 1857Cleavage; by NIa-proBy similarity2
Sitei2049 – 2050Cleavage; by NIa-proBy similarity2
Sitei2292 – 2293Cleavage; by NIa-proBy similarity2
Sitei2810 – 2811Cleavage; by NIa-proBy similarity2

Keywords - PTMi

Covalent protein-RNA linkage, Phosphoprotein

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
P17766

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini165 – 308Peptidase S30PROSITE-ProRule annotationAdd BLAST144
Domaini644 – 766Peptidase C6PROSITE-ProRule annotationAdd BLAST123
Domaini1240 – 1392Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST153
Domaini1411 – 1570Helicase C-terminalPROSITE-ProRule annotationAdd BLAST160
Domaini2050 – 2268Peptidase C4PROSITE-ProRule annotationAdd BLAST219
Domaini2534 – 2658RdRp catalyticPROSITE-ProRule annotationAdd BLAST125

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi360 – 363Involved in interaction with stylet and aphid transmissionBy similarity4
Motifi618 – 620Involved in virions binding and aphid transmissionBy similarity3
Motifi1342 – 1345DECH box4
Motifi1897 – 1904Nuclear localization signalSequence analysis8

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The N-terminus of helper component proteinase is involved in interaction with stylets. The central part is involved in interaction with virions and the C-terminus is involved in cell-to cell movement of the virus.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.40.10.10, 2 hits
3.30.70.270, 1 hit
3.90.70.150, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011492, DEAD_Flavivir
IPR043502, DNA/RNA_pol_sf
IPR001456, HC-pro
IPR031159, HC_PRO_CPD_dom
IPR042308, HC_PRO_CPD_sf
IPR014001, Helicase_ATP-bd
IPR001650, Helicase_C
IPR027417, P-loop_NTPase
IPR002540, Pept_S30_P1_potyvir
IPR009003, Peptidase_S1_PA
IPR043504, Peptidase_S1_PA_chymotrypsin
IPR001592, Poty_coat
IPR001730, Potyv_NIa-pro_dom
IPR039560, Potyvirid-P3
IPR013648, PP_Potyviridae
IPR043128, Rev_trsase/Diguanyl_cyclase
IPR001205, RNA-dir_pol_C
IPR007094, RNA-dir_pol_PSvirus

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07652, Flavi_DEAD, 1 hit
PF00271, Helicase_C, 1 hit
PF00863, Peptidase_C4, 1 hit
PF00851, Peptidase_C6, 1 hit
PF01577, Peptidase_S30, 1 hit
PF00767, Poty_coat, 1 hit
PF08440, Poty_PP, 1 hit
PF13608, Potyvirid-P3, 1 hit
PF00680, RdRP_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00966, NIAPOTYPTASE

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00487, DEXDc, 1 hit
SM00490, HELICc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50494, SSF50494, 1 hit
SSF52540, SSF52540, 2 hits
SSF56672, SSF56672, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51744, HC_PRO_CPD, 1 hit
PS51192, HELICASE_ATP_BIND_1, 1 hit
PS51194, HELICASE_CTER, 1 hit
PS51436, POTYVIRUS_NIA_PRO, 1 hit
PS51871, PV_P1_PRO, 1 hit
PS50507, RDRP_SSRNA_POS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by ribosomal frameshifting. AlignAdd to basket
Isoform Genome polyprotein (identifier: P17766-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSTIVFGSFT CHLDAAIHQD NADRLAKAWT RPENRQVSNA HLLCRRAAES
60 70 80 90 100
LINTYESATA SAWKGLEEKL QPMFAKREFS KTVTKRKGLR CFKESSEKFI
110 120 130 140 150
EKKLRKQYQE ERERLQFLNG PDAIVNQISV DKCEASVRVP SPHIIEKPSF
160 170 180 190 200
VTPSMKKKVV FKKVRMSEAS LQLFMRRVAA NAKANGQKVE IIGRKRVVGN
210 220 230 240 250
YTTKSRLTYF RTHVRHLDGS KPRYDLVLDE ATKKILQLFA NTSGFHHVHK
260 270 280 290 300
KGEVTPGMSG FVVNPMNLSD PMQVYDTDLF IVRGKHNSIL VDSRCKVSKK
310 320 330 340 350
QSNEIIHYSD PGKQFSDGFT NSFMQCKLRE TDHQCTSDLD VKECGYVAAL
360 370 380 390 400
VCQAIIPCGK ITCLQCAQKY SYMSQQEIRD RFSTVIEQHE KTVMDNYPQF
410 420 430 440 450
SHVLAFLKRY RELMRVENQN YEAFKDITHM IGERKEAPFS HLNKINELII
460 470 480 490 500
KGGMMSAQDY IEASDHLREL ARYQKNRTEN IRSGSIKAFR NKISSKAHVN
510 520 530 540 550
MQLMCDNQLD TNGNFVWGQR EYHAKRFFRN YFDVIDVSEG YRRHIVRENP
560 570 580 590 600
RGIRKLAIGN LVMSTNLAAL RKQLLGEECI HFEVSKECTS KRGENFVYQC
610 620 630 640 650
CCVTHEDGTP LESEIISPTK NHLVVGNSGD SKYVDLPTAK GGAMFIAKAG
660 670 680 690 700
YCYINIFLAM LININEDEAK SFTKTVRDTL VPKLGTWPSM MDLATACHFL
710 720 730 740 750
AVLYPETRNA ELPRILVDHE AKIFHVVDSF GSLSTGMHVL KANTINQLIS
760 770 780 790 800
FASDTLDSNM KTYLVGGLEV DKCDEFKNVK LLIRSIYKPQ IMEQVLKEEP
810 820 830 840 850
YLLLMSVLSP GVLMALFNSG SLEKATQYWI TRSHSLAAIT SMLSALAAKV
860 870 880 890 900
SLASTLNAQM SVIDEHAAVL YDSVFVGTQP YASYMMAVKT LERMKARTES
910 920 930 940 950
DHTLNDLGFS VLRQATPHLV EKSYLQELEQ AWKELSWSEK FSAILESQRW
960 970 980 990 1000
RKHIPKPFIP KDGADLGGRY DISVRSLLGN QYKRLRDVVR WKRDDVVCYT
1010 1020 1030 1040 1050
YQSMGKLFCK AIGISPSFLP STLKMLDMLI VFSLLLSIGA TCNSMVNEHK
1060 1070 1080 1090 1100
HLKQLAADRE DKKRFKRLQV LYTRLSEKVG CTPTADEFLE YVGDENPDLL
1110 1120 1130 1140 1150
KHAEDLIGDG QVVVHQSKRD SQANLERVVA FVALVMMLFD SERSDGVYKI
1160 1170 1180 1190 1200
LNKLKGIMGS VDRAVHHQSL DDIEDILDEK KLTVDFVLQS NEVAPTVPFD
1210 1220 1230 1240 1250
STFEKWWMNQ LETGNVIPHY RTEGHFLEFT RENAAHIANE VMHGSHQDIL
1260 1270 1280 1290 1300
IRGAVGSGKS TGLPFHLSKK GHVLLIEPTR PLAENVCKQL RGQPFNVNPT
1310 1320 1330 1340 1350
LRMRGMSTFG STPITVMTSG YALHFLANNP TYLDNYKCII FDECHVHDAS
1360 1370 1380 1390 1400
AMAFRCLLSE YSYPGKILKV SATPPGHEVE FKTQKEVKVI VEESLSFQQF
1410 1420 1430 1440 1450
VSNLGTGCNS DILKHGVNVL VYVASYNEVD TLSKLLTDRS FKVSKVDGRT
1460 1470 1480 1490 1500
MKVGNVEIPT SGTQAKPHFV VATNIIENGV TLDIDVVVDF GLKVVPVLDI
1510 1520 1530 1540 1550
DNRLVRYTKK SISYGERIQR LGRVGRNKPG AALRIGFTEK GLTQIPPIIA
1560 1570 1580 1590 1600
TEAAFLCFTY GLPVMTNGVS TSLLAMCTVK QARTMQQFEL SPFYTVALVR
1610 1620 1630 1640 1650
FDGTMHQEIF RLLKSYRLRD SEVILNKLAI PNSNVCGWMS VRDYKRQGCN
1660 1670 1680 1690 1700
LDLDENIRVP FYVKDIPETL HERIWQAVET HKSDAGFGRI CSSSACKIAY
1710 1720 1730 1740 1750
TLQTDIHSIP RTIKIIDALL EQERTKQAHF RAMTSQSCSS SNFSLSSITS
1760 1770 1780 1790 1800
AIRSKYAKDH TEENIGVLQM AKSQLLEFKN LNIDPSYPEL IRNFGALECV
1810 1820 1830 1840 1850
HHQTKEGVSK ALQLKGHWNK RLITRDATLM LGVLGGGAWM IFSYLRDSFK
1860 1870 1880 1890 1900
EEVIHQGFNR RQRQKLKFRQ ARDNRMAREV YGDDSTMEAY FGSAYSKKGK
1910 1920 1930 1940 1950
SKGKTRGMGT KTRKFVNMYG YDPTDYNFVR FVDPLTGHTL DESPLMDINL
1960 1970 1980 1990 2000
VQEHFSQIRN DYIGDDKITM QHIMSNPGIV AYYIKDATQK ALKVDLTPHN
2010 2020 2030 2040 2050
PLRVCDKTAT IAGFPEREFE LRQTGHPVFV EPNAIPKINE EGDEEVDHES
2060 2070 2080 2090 2100
KSLFRGLRDY NPIASSICQL NNSSGARQSE MFGLGFGGLI VTNQHLFKRN
2110 2120 2130 2140 2150
DGELTIRSHH GEFVVKDTKT LKLLPCKGRD IVIIRLPKDF PPFPRRLQFR
2160 2170 2180 2190 2200
TPTTEDRVCL IGSNFQTKSI SSTMSETSAT YPVDNSHFWK HWISTKDGHC
2210 2220 2230 2240 2250
GLPIVSTRDG SILGLHSLAN STNTQNFYAA FPDNFETTYL SNQDNDNWIK
2260 2270 2280 2290 2300
QWRYNPDEVC WGSLQLKRDI PQSPFTICKL LTDLDGEFVY TQSKTTHWLR
2310 2320 2330 2340 2350
DRLEGNLKAV GACPGQLVTK HVVKGKCTLF ETYLLTHPEE HEFFRPLMGA
2360 2370 2380 2390 2400
YQKSALNKDA YVKDLMKYSK PIVVGAVDCD QFERAVDVVI SMLISKGFEE
2410 2420 2430 2440 2450
CNYVTDPDDI FSALNMKAAV GALYSGKKRD YFENVSDQDK ESFVRASCKR
2460 2470 2480 2490 2500
LFMGKKGVWN GSLKAELRPK EKVEANKTRS FTAAPIDTLL GGKVCVDDFN
2510 2520 2530 2540 2550
NQFYSLNLHC PWSVGMTKFR GGWDKLLKAL PEGWIYCDAD GSQFDSSLSP
2560 2570 2580 2590 2600
YLINAVLNIR LAFMEEWDIG EQMLSNLYTE IVYTPIATPD GTIVKKFKGN
2610 2620 2630 2640 2650
NSGQPSTVVD NTLMVILAMT YSLLKLGHHP DTHDCICRYF VNGDDLVLAV
2660 2670 2680 2690 2700
HPAYESIYDE LQEHFSQLGL NYTFTTKTEN KEELWFMSHK GVLYDDMYIP
2710 2720 2730 2740 2750
KLEPERIVSI LEWDRSNEPI HRLEAICASM VEAWGYKELL REIRKFYSWV
2760 2770 2780 2790 2800
LEQAPYNALS KDGKAPYIAE TALKKLYTDT EASETEIERY LEAFYDNIND
2810 2820 2830 2840 2850
DGESNVVVHQ ADEREDEEEV DALQPPPVIQ PAPRTTAPML NPIFTPATTQ
2860 2870 2880 2890 2900
PATKPVSQVS GPQLQTFGTY SHEDASPSNS NALVNTNRDR DVDAGSTGTF
2910 2920 2930 2940 2950
TVPRLKAMTS KLSLPKVKGK AIMNLNHLAH YSPAQVDLSN TRAPQSCFQT
2960 2970 2980 2990 3000
WYEGVKRDYD VTDDEMSIIL NGLMVWCIEN GTSPNINGMW VMMDGETQVE
3010 3020 3030 3040 3050
YPIKPLLDHA KPTFRQIMAH FSNVAEAYIE KRNYEKAYMP RYGIQRNLTD
3060 3070 3080 3090 3100
YSLARYAFDF YEMTSTTPVR AREAHIQMKA AALRNVQNRL FGLDGNVGTQ
3110 3120
EEDTERHTAG DVNRNMHNLL GMRGV
Note: Produced by conventional translation.
Length:3,125
Mass (Da):354,266
Last modified:August 1, 1990 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iED0DD33C439CB712
GO
Isoform P3N-PIPO polyprotein (identifier: P0CK02-1) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry P0CK02.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:1,020
Mass (Da):116,033
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
D13751 Genomic RNA Translation: BAA02898.1

Protein sequence database of the Protein Information Resource

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PIRi
JQ0003, GNVSPP

NCBI Reference Sequences

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RefSeqi
NP_040807.1, NC_001445.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
1494049

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
vg:1494049

Keywords - Coding sequence diversityi

Ribosomal frameshifting

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13751 Genomic RNA Translation: BAA02898.1
PIRiJQ0003, GNVSPP
RefSeqiNP_040807.1, NC_001445.1

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PRIDEiP17766

Genome annotation databases

GeneIDi1494049
KEGGivg:1494049

Enzyme and pathway databases

BRENDAi3.4.22.45, 4919

Family and domain databases

Gene3Di2.40.10.10, 2 hits
3.30.70.270, 1 hit
3.90.70.150, 1 hit
InterProiView protein in InterPro
IPR011492, DEAD_Flavivir
IPR043502, DNA/RNA_pol_sf
IPR001456, HC-pro
IPR031159, HC_PRO_CPD_dom
IPR042308, HC_PRO_CPD_sf
IPR014001, Helicase_ATP-bd
IPR001650, Helicase_C
IPR027417, P-loop_NTPase
IPR002540, Pept_S30_P1_potyvir
IPR009003, Peptidase_S1_PA
IPR043504, Peptidase_S1_PA_chymotrypsin
IPR001592, Poty_coat
IPR001730, Potyv_NIa-pro_dom
IPR039560, Potyvirid-P3
IPR013648, PP_Potyviridae
IPR043128, Rev_trsase/Diguanyl_cyclase
IPR001205, RNA-dir_pol_C
IPR007094, RNA-dir_pol_PSvirus
PfamiView protein in Pfam
PF07652, Flavi_DEAD, 1 hit
PF00271, Helicase_C, 1 hit
PF00863, Peptidase_C4, 1 hit
PF00851, Peptidase_C6, 1 hit
PF01577, Peptidase_S30, 1 hit
PF00767, Poty_coat, 1 hit
PF08440, Poty_PP, 1 hit
PF13608, Potyvirid-P3, 1 hit
PF00680, RdRP_1, 1 hit
PRINTSiPR00966, NIAPOTYPTASE
SMARTiView protein in SMART
SM00487, DEXDc, 1 hit
SM00490, HELICc, 1 hit
SUPFAMiSSF50494, SSF50494, 1 hit
SSF52540, SSF52540, 2 hits
SSF56672, SSF56672, 1 hit
PROSITEiView protein in PROSITE
PS51744, HC_PRO_CPD, 1 hit
PS51192, HELICASE_ATP_BIND_1, 1 hit
PS51194, HELICASE_CTER, 1 hit
PS51436, POTYVIRUS_NIA_PRO, 1 hit
PS51871, PV_P1_PRO, 1 hit
PS50507, RDRP_SSRNA_POS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPOLG_PPVNA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P17766
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: October 7, 2020
This is version 156 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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