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Entry version 130 (18 Sep 2019)
Sequence version 2 (21 Jun 2005)
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Protein

Genome polyprotein

Gene
N/A
Organism
Bean yellow mosaic virus
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Capsid protein: involved in aphid transmission, cell-to-cell and systemis movement, encapsidation of the viral RNA and in the regulation of viral RNA amplification.
Nuclear inclusion protein B: an RNA-dependent RNA polymerase that plays an essential role in the virus replication.
Helper component proteinase: required for aphid transmission and also has proteolytic activity. Only cleaves a Gly-Gly dipeptide at its own C-terminus. Interacts with virions and aphid stylets. Acts as a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs. May have RNA-binding activity (By similarity).By similarity
Cytoplasmic inclusion protein: has helicase activity. It may be involved in replication (By similarity).By similarity
Both 6K peptides are indispensable for virus replication.By similarity
Nuclear inclusion protein A: has RNA-binding and proteolytic activities.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Hydrolyzes glutaminyl bonds, and activity is further restricted by preferences for the amino acids in P6 - P1' that vary with the species of potyvirus, e.g. Glu-Xaa-Xaa-Tyr-Xaa-Gln-|-(Ser or Gly) for the enzyme from tobacco etch virus. The natural substrate is the viral polyprotein, but other proteins and oligopeptides containing the appropriate consensus sequence are also cleaved. EC:3.4.22.44
  • Hydrolyzes a Gly-|-Gly bond at its own C-terminus, commonly in the sequence -Tyr-Xaa-Val-Gly-|-Gly, in the processing of the potyviral polyprotein. EC:3.4.22.45

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei192For P1 proteinase activityPROSITE-ProRule annotation1
Active sitei201For P1 proteinase activityPROSITE-ProRule annotation1
Active sitei232For P1 proteinase activityPROSITE-ProRule annotation1
Active sitei627For helper component proteinase activityPROSITE-ProRule annotation1
Active sitei700For helper component proteinase activityPROSITE-ProRule annotation1
Active sitei2067For nuclear inclusion protein A activityPROSITE-ProRule annotation1
Active sitei2102For nuclear inclusion protein A activityPROSITE-ProRule annotation1
Active sitei2172For nuclear inclusion protein A activityPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi1227 – 1234ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHelicase, Hydrolase, Nucleotidyltransferase, Protease, RNA-directed RNA polymerase, Serine protease, Suppressor of RNA silencing, Thiol protease, Transferase
Biological processViral RNA replication
LigandATP-binding, Nucleotide-binding

Protein family/group databases

MEROPS protease database

More...
MEROPSi
C04.008

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Genome polyprotein
Cleaved into the following 10 chains:
P1 proteinase (EC:3.4.-.-)
Alternative name(s):
N-terminal protein
Helper component proteinase (EC:3.4.22.45)
Short name:
HC-pro
6 kDa protein 1
Short name:
6K1
Cytoplasmic inclusion protein (EC:3.6.4.-)
Short name:
CI
6 kDa protein 2
Short name:
6K2
Alternative name(s):
VPg
Nuclear inclusion protein A (EC:3.4.22.44)
Short name:
NI-a
Short name:
NIa
Alternative name(s):
49 kDa proteinase
Short name:
49 kDa-Pro
NIa-pro
Nuclear inclusion protein B (EC:2.7.7.48)
Short name:
NI-b
Short name:
NIb
Alternative name(s):
RNA-directed RNA polymerase
Capsid protein
Short name:
CP
Alternative name(s):
Coat protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBean yellow mosaic virus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri12197 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesRiboviriaPotyviridaePotyvirus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiArachis hypogaea (Peanut) [TaxID: 3818]
Canna [TaxID: 4627]
Crotalaria [TaxID: 3828]
Eustoma [TaxID: 52517]
Freesia [TaxID: 58987]
Gladiolus [TaxID: 49747]
Glycine max (Soybean) (Glycine hispida) [TaxID: 3847]
Lupinus luteus (European yellow lupine) [TaxID: 3873]
Medicago sativa (Alfalfa) [TaxID: 3879]
Papaver somniferum (Opium poppy) [TaxID: 3469]
Phaseolus vulgaris (Kidney bean) (French bean) [TaxID: 3885]
Pisum sativum (Garden pea) [TaxID: 3888]
Robinia pseudoacacia (Black locust) [TaxID: 35938]
Trifolium hybridum (Alsike clover) [TaxID: 74517]
Trifolium incarnatum (Crimson clover) [TaxID: 60916]
Trifolium pratense (Red clover) [TaxID: 57577]
Trifolium repens (Creeping white clover) [TaxID: 3899]
Trifolium subterraneum (Subterranean clover) [TaxID: 3900]
Trifolium vesiculosum [TaxID: 97047]
Trigonella foenum-graecum (Fenugreek) [TaxID: 78534]
Vicia faba (Broad bean) (Faba vulgaris) [TaxID: 3906]
Vicia sativa (Spring vetch) (Tare) [TaxID: 3908]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000007620 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Capsid protein, Helical capsid protein, Virion

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004199961 – 3056Genome polyproteinAdd BLAST3056
ChainiPRO_00000402561 – 284P1 proteinaseSequence analysisAdd BLAST284
ChainiPRO_0000040257285 – 741Helper component proteinaseSequence analysisAdd BLAST457
ChainiPRO_0000040258742 – 1089Protein P3Sequence analysisAdd BLAST348
ChainiPRO_00000402591090 – 11426 kDa protein 1By similarityAdd BLAST53
ChainiPRO_00000402601143 – 1777Cytoplasmic inclusion proteinBy similarityAdd BLAST635
ChainiPRO_00000402611778 – 18306 kDa protein 2By similarityAdd BLAST53
ChainiPRO_00000402621831 – 2021Viral genome-linked proteinBy similarityAdd BLAST191
ChainiPRO_00000402632022 – 2264Nuclear inclusion protein ABy similarityAdd BLAST243
ChainiPRO_00000402642265 – 2783Nuclear inclusion protein BBy similarityAdd BLAST519
ChainiPRO_00000402652784 – 3056Capsid proteinBy similarityAdd BLAST273

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1893O-(5'-phospho-RNA)-tyrosineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

VPg is uridylylated by the polymerase and is covalently attached to the 5'-end of the genomic RNA. This uridylylated form acts as a nucleotide-peptide primer for the polymerase (By similarity).By similarity
Potyviral RNA is expressed as two polyproteins which undergo post-translational proteolytic processing. Genome polyprotein is processed by NIa-pro, P1 and HC-pro proteinases resulting in the production of at least ten individual proteins. P3N-PIPO polyprotein is cleaved by P1 and HC-pro proteinases resulting in the production of three individual proteins. The P1 proteinase and the HC-pro cleave only their respective C-termini autocatalytically. 6K1 is essential for proper proteolytic separation of P3 from CI (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei284 – 285Cleavage; by P1 proteinasePROSITE-ProRule annotation2
Sitei741 – 742Cleavage; by autolysisPROSITE-ProRule annotation2
Sitei1100 – 1101Cleavage; by NIa-proBy similarity2
Sitei1152 – 1153Cleavage; by NIa-proBy similarity2
Sitei1787 – 1788Cleavage; by NIa-proBy similarity2
Sitei1840 – 1841Cleavage; by NIa-proBy similarity2
Sitei2021 – 2022Cleavage; by NIa-proBy similarity2
Sitei2274 – 2275Cleavage; by NIa-proBy similarity2
Sitei2793 – 2794Cleavage; by NIa-proBy similarity2

Keywords - PTMi

Covalent protein-RNA linkage, Phosphoprotein

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
P17765

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini139 – 284Peptidase S30PROSITE-ProRule annotationAdd BLAST146
Domaini619 – 741Peptidase C6PROSITE-ProRule annotationAdd BLAST123
Domaini1214 – 1366Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST153
Domaini1385 – 1544Helicase C-terminalPROSITE-ProRule annotationAdd BLAST160
Domaini2022 – 2240Peptidase C4PROSITE-ProRule annotationAdd BLAST219
Domaini2507 – 2630RdRp catalyticPROSITE-ProRule annotationAdd BLAST124

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi335 – 338Involved in interaction with stylet and aphid transmissionBy similarity4
Motifi593 – 595Involved in virions binding and aphid transmissionBy similarity3
Motifi1316 – 1319DECH box4
Motifi1871 – 1878Nuclear localization signalSequence analysis8

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The N-terminus of helper component proteinase is involved in interaction with stylets. The central part is involved in interaction with virions and the C-terminus is involved in cell-to cell movement of the virus.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.90.70.150, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011545 DEAD/DEAH_box_helicase_dom
IPR001456 HC-pro
IPR031159 HC_PRO_CPD_dom
IPR042308 HC_PRO_CPD_sf
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR002540 Pept_S30_P1_potyvir
IPR009003 Peptidase_S1_PA
IPR001592 Poty_coat
IPR001730 Potyv_NIa-pro_dom
IPR039560 Potyvirid-P3
IPR013648 PP_Potyviridae
IPR001205 RNA-dir_pol_C
IPR007094 RNA-dir_pol_PSvirus

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00270 DEAD, 1 hit
PF00271 Helicase_C, 1 hit
PF00863 Peptidase_C4, 1 hit
PF00851 Peptidase_C6, 1 hit
PF01577 Peptidase_S30, 1 hit
PF00767 Poty_coat, 1 hit
PF08440 Poty_PP, 1 hit
PF13608 Potyvirid-P3, 1 hit
PF00680 RdRP_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00966 NIAPOTYPTASE

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50494 SSF50494, 1 hit
SSF52540 SSF52540, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51744 HC_PRO_CPD, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS51436 POTYVIRUS_NIA_PRO, 1 hit
PS51871 PV_P1_PRO, 1 hit
PS50507 RDRP_SSRNA_POS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by ribosomal frameshifting. AlignAdd to basket
Isoform Genome polyprotein (identifier: P17765-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTTINIGTIP VVINQNADTQ MGEGTKNIFP IVKDFVDPFA DLEMRCAERV
60 70 80 90 100
KRMGELCFSK KGRYITMIPK PDYIKAREKE QREEELNFQN SEHVLNSLDT
110 120 130 140 150
TCTPEHHSSR NNGMQVSFKT QHYKRTFRKP RIQAKKRDLK GQHTIHYVAK
160 170 180 190 200
ELLSIVKKRD MVLEVVDKRK HANFATFRRY GKTYGMHITL NHMVRKRRRV
210 220 230 240 250
DVTLNKLMTE IAMHCAIPFE CLNTLTLRKG HSGLVLQTET VPNVHKIKSK
260 270 280 290 300
ITIVRGVVNE GNIPVLIDAR KKLSGRDMST IREFSAGDLF WKGYNQTFID
310 320 330 340 350
NRPTDLNHQC TSDLNVTQCG SVMALLTLAL FPCGRITCKK CVENFLNQNN
360 370 380 390 400
KERFNNASVF INQVIQLLEK GFSEFKHSKE ILLMFKERLQ MENPATDQCM
410 420 430 440 450
EIAKATAALP EAPFSHIKEI NNVLLKYGSL SNEEVGGASK HLLEVVRYIR
460 470 480 490 500
NRTDSIQRND LSKFRNKISS KTHINLDLMC DNQLDKNANF VWGQRAYHAK
510 520 530 540 550
RFLSNYFNEI NPSEGYDKFI FRKLPNGARE LAIGRLIMPT NFEAFREQMK
560 570 580 590 600
GKMIDNGPIG KDCVSRMRGS FCYPCCCTTD DVGTAVISDF KMPTKYHLVL
610 620 630 640 650
GGNDLAKYIK LPTDTTGNMY IAKDGFCHIN IFFAMLVNVS EEKSKDFTKM
660 670 680 690 700
VRDQIMPKLG EWPTMMDVAT ACWQLTVWFP DTLSAELPRI LVDHKLGIMH
710 720 730 740 750
VLDSYGSISA GYHVLKANIV SQLIKFASDD LESELKYYRV GGDCNFGSRV
760 770 780 790 800
RIDTKFLLKS IYRPDLLERI IEHEPFVLVL AMQSPAVLLA LFNSASLEKA
810 820 830 840 850
VQYWMHREMQ VSHIMTLLAV LASNVSASKL LTTQFEIIEA SAPQILAEMD
860 870 880 890 900
KVHLPMHSIH SANVFLMNMS ESRETDKTID ELGFYSFKKS SRILMEKTLM
910 920 930 940 950
ADLEEQWQGL GLLERLSLIK RSWRVRAKYS SFAIQREEPG IRDKFTTSLK
960 970 980 990 1000
LSGAQIKQQL LAQKDQAVHF VERRIEGTKK FVANQSISLI KMCLPRLADI
1010 1020 1030 1040 1050
VNILTVIALL NAILAFMLDH IKRFNEARRI AQEKKEKQHL KELNTLYNKY
1060 1070 1080 1090 1100
WDNEKPTYLE FKSDVIEKLP HTLATFEKYY FEDDKYTFQA KPNDMVALEK
1110 1120 1130 1140 1150
IIAVTALVLM IFDAERSDCV YKVLNKLKGI LSTTTQDAYR FQSLDTSKTL
1160 1170 1180 1190 1200
LEEKEMTIDF EINEGEVKAF SGTQTTFSEW WDNQLQNGNV ITHYRTEGQF
1210 1220 1230 1240 1250
MEFTRANAQP VANEIAHNDA HDILVRGAVG SGKSTGLPFY LSNKGKVLMI
1260 1270 1280 1290 1300
ESTRPLAENV FKQLKSEPFY ASPTLRMRGT TSYGASPITI MTSGYALHYY
1310 1320 1330 1340 1350
ANNPAMMKEY KFVIIDECHV HDANAIAFVS LLKEYSFDGK LIKVSATPPG
1360 1370 1380 1390 1400
REVEFTTQYP VTLVTEESLS FEQFVSQQGT GANCDMLDVC DNILVYVASY
1410 1420 1430 1440 1450
NEVDQLSKML LDRGHIVTKV DGRTMKNGKT EIESKGSRSK RHFIVATNII
1460 1470 1480 1490 1500
ENGVTLDIEG VVDFGLKVVP ELDVDNRLMR YTKQNVSYGE RIQRLGRVGR
1510 1520 1530 1540 1550
HKAGKALRIG VTEKGLVKPP SVITTEAAFY CFAYGLPVMA EGVTPSLLSK
1560 1570 1580 1590 1600
CTVQQARSMM SFELPIMYTV NLVRFDGTMH PSVHNLLKPY KLRDSNVVLN
1610 1620 1630 1640 1650
KMAIPHGNVR NWPTVRDFKC MGVRIDAPED TRVPFHARDI PDKLHKEIFE
1660 1670 1680 1690 1700
VCCKYKGDAG FSKLNVVNAC KIAYTLQTDP SSIQRTIKIL DELIAREQQK
1710 1720 1730 1740 1750
REYFQNVANT SCAGSSYSLS NIINAIRARS TSDYTQENLS VLHSARAQLL
1760 1770 1780 1790 1800
EFKNINSDFS NLSTLSEFGA LECLQFESLQ EISKHLQLKG HWNKPVLIQD
1810 1820 1830 1840 1850
FLIAAGVLGG GCWMLYQYFK QETSKAFVFQ GKNRRTKQKL RFRDARDMKG
1860 1870 1880 1890 1900
RMEVYADEGT IVENFGSKYT KKGKVRGTTT GMGTKTRRFT NMYGFDPTEY
1910 1920 1930 1940 1950
SFARYLDPIT GETLDEQPIT NLNLVSEHFQ EMRRKYRENE IMESQQFAAN
1960 1970 1980 1990 2000
PRIEAYFVKD AGQKVLKVDL TPHKPLLYSD KFGNIMGYPE REGELRQTGA
2010 2020 2030 2040 2050
AEFIDPKELP EPKESTDFDF ESLSKIGGLR DYNPIAANVC LLENESAEYC
2060 2070 2080 2090 2100
DEIYGIGYGN VIITNQHLFR HNNGELTIKS KHGTFKCKNT CALKLLPIEG
2110 2120 2130 2140 2150
HDLLLIQMPK DFPVFPQKLR FREPTHEDKI VLVSTNFQEK SFSSVVSESS
2160 2170 2180 2190 2200
NISRVKQANF FKHWISTVAG QCGNPMVSTK DGFIVGIHSL TAVSGDLNVF
2210 2220 2230 2240 2250
TSIPPNFEDE VLKQMSKKSW CCGWKLNMSQ IGWDGIKIVD DQPKDPFPVS
2260 2270 2280 2290 2300
KMVGLLNDLQ LSFQSAKNTK WLLERAHGNI KAVAQASSAL VTKHVVKGKC
2310 2320 2330 2340 2350
RLFEVYLTTD EEAEKFFRPL MGAYQKSRLN KEAYVKDLMK YATPIEVGLV
2360 2370 2380 2390 2400
DTRCFERSFE KVQNMLELKG FSKCNYVTYG PDILSALNMK AAMGALYSGK
2410 2420 2430 2440 2450
KKDHFSEISE EKFDNILQAS CERLYSGRMG VWNGSLKAEL RPQEKVLANK
2460 2470 2480 2490 2500
TRSFTAAPID TLLAGKVCVD DFNNKFYSLH LKIPSTVGIT KFYGGWDRLL
2510 2520 2530 2540 2550
DSLPDGWVYC DADGSQFDSS LTPYLLNAVL EMRLRLMEEW DLGEQMLKNL
2560 2570 2580 2590 2600
YTEIVYTPIL TPDGTIVKKF KGNNSGQPST VVDNTLMVIM AVYYAAEKLG
2610 2620 2630 2640 2650
IKGNLEDTLV FFANGDDLLI AIKPECESYL DKFEGLFSEL GLKYDFSSRT
2660 2670 2680 2690 2700
KNKGDLWFMS HRGIQIDGMW IPKLEEERIV SILEWDRAIQ PEHRLEAICA
2710 2720 2730 2740 2750
AMIEAWGYPT LLNHIRKFYL WVLGQAPYSQ LSAEGKAPYI SEVALKHLYT
2760 2770 2780 2790 2800
EEKVTPTELE RYNIALIDCF ESESDEVLTC RFQSDQEQLN AGEEKKDKRK
2810 2820 2830 2840 2850
KNEGDPNKDS EGQSVRQIVP DRDVNAGTVG TFSVPRLKKI AGKLNIPKIG
2860 2870 2880 2890 2900
GKIVLNLDHL LEYNPPQDDI SNVIATQAQF EAWYNGVKQA YEVEDSQMGI
2910 2920 2930 2940 2950
ILNGLMVWCI ENGTSGDLQG EWTMMDGEEQ VTYPLKPILD NAKPTFRQIM
2960 2970 2980 2990 3000
SHFSEVAEAY IEKRNATERY MPRYGLQRNL TDYGLARYAF DFYKLTSRTP
3010 3020 3030 3040 3050
VRAREAHMQM KAAAVRGKST RLFGLDGNVG TDEENTERHT AGDVNRDMHT

MLGVRI
Note: Produced by conventional translation.
Length:3,056
Mass (Da):347,722
Last modified:June 21, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBA4D2F2D2D4624B3
GO
Isoform P3N-PIPO polyprotein (identifier: P0CJ95-1) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry P0CJ95.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: Produced by -1 ribosomal frameshifting in P3 ORF.
Length:975
Mass (Da):111,115
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti2775D → G. 1
Natural varianti2805D → N. 1
Natural varianti2855L → F. 1
Natural varianti2862E → K. 1
Natural varianti2897Q → R. 1
Natural varianti2975G → E. 1
Natural varianti2994K → E. 1
Natural varianti3017G → A. 1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AY192568 Genomic RNA Translation: AAP30002.1
D00490 Genomic RNA Translation: BAA00378.1

Protein sequence database of the Protein Information Resource

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PIRi
JU0115

Keywords - Coding sequence diversityi

Ribosomal frameshifting

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY192568 Genomic RNA Translation: AAP30002.1
D00490 Genomic RNA Translation: BAA00378.1
PIRiJU0115

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein family/group databases

MEROPSiC04.008

Proteomic databases

PRIDEiP17765

Family and domain databases

Gene3Di3.90.70.150, 1 hit
InterProiView protein in InterPro
IPR011545 DEAD/DEAH_box_helicase_dom
IPR001456 HC-pro
IPR031159 HC_PRO_CPD_dom
IPR042308 HC_PRO_CPD_sf
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR002540 Pept_S30_P1_potyvir
IPR009003 Peptidase_S1_PA
IPR001592 Poty_coat
IPR001730 Potyv_NIa-pro_dom
IPR039560 Potyvirid-P3
IPR013648 PP_Potyviridae
IPR001205 RNA-dir_pol_C
IPR007094 RNA-dir_pol_PSvirus
PfamiView protein in Pfam
PF00270 DEAD, 1 hit
PF00271 Helicase_C, 1 hit
PF00863 Peptidase_C4, 1 hit
PF00851 Peptidase_C6, 1 hit
PF01577 Peptidase_S30, 1 hit
PF00767 Poty_coat, 1 hit
PF08440 Poty_PP, 1 hit
PF13608 Potyvirid-P3, 1 hit
PF00680 RdRP_1, 1 hit
PRINTSiPR00966 NIAPOTYPTASE
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
SSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS51744 HC_PRO_CPD, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS51436 POTYVIRUS_NIA_PRO, 1 hit
PS51871 PV_P1_PRO, 1 hit
PS50507 RDRP_SSRNA_POS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPOLG_BYMV
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P17765
Secondary accession number(s): Q65887, Q6Y1D8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: June 21, 2005
Last modified: September 18, 2019
This is version 130 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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