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UniProtKB - P17752 (TPH1_HUMAN)

Entry version 200 (07 Apr 2021)
Sequence version 4 (17 Oct 2006)
Previous versions | rss
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Protein

Tryptophan 5-hydroxylase 1

Gene

TPH1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Oxidizes L-tryptophan to 5-hydroxy-l-tryptophan in the rate-determining step of serotonin biosynthesis.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Fe2+1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: serotonin biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes serotonin from L-tryptophan.By similarity
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Tryptophan 5-hydroxylase 2 (TPH2), Tryptophan 5-monooxygenase (TPH2), Tryptophan 5-hydroxylase 1 (TPH1)
  2. no protein annotated in this organism
This subpathway is part of the pathway serotonin biosynthesis, which is itself part of Aromatic compound metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes serotonin from L-tryptophan, the pathway serotonin biosynthesis and in Aromatic compound metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei235TryptophanBy similarity1
Binding sitei257TryptophanBy similarity1
Binding sitei265TryptophanBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi272IronCombined sources1 Publication1
Metal bindingi277IronCombined sources1 Publication1
Metal bindingi317IronCombined sources1 Publication1
Binding sitei336TryptophanBy similarity1
Binding sitei366Tryptophan; via carbonyl oxygenBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
Biological processSerotonin biosynthesis
LigandIron, Metal-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		MetaCyc:HS05250-MONOMER

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		1.14.16.4, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P17752

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-209931, Serotonin and melatonin biosynthesis
R-HSA-9031628, NGF-stimulated transcription

SABIO-RK: Biochemical Reaction Kinetics Database

More...SABIO-RKi		P17752

SIGNOR Signaling Network Open Resource

More...SIGNORi		P17752

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA00846;UER00799

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tryptophan 5-hydroxylase 1 (EC:1.14.16.4By similarity)
Alternative name(s):
Tryptophan 5-monooxygenase 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TPH1
Synonyms:TPH, TPRH, TRPH
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:12008, TPH1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		191060, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P17752

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000129167.9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		7166

Open Targets

More...OpenTargetsi		ENSG00000129167

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA355

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P17752, Tclin

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL5689

Drug and drug target database

More...DrugBanki		DB05199, LX1031
DB00360, Sapropterin
DB12095, Telotristat ethyl
DB00150, Tryptophan

DrugCentral

More...DrugCentrali		P17752

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		1241

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TPH1

Domain mapping of disease mutations (DMDM)

More...DMDMi		116242823

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002055681 – 444Tryptophan 5-hydroxylase 1Add BLAST444

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei58Phosphoserine; by PKASequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Ubiquitinated, leading to its degradation by the proteasome. Ubiquitinated is triggered by phosphorylation.By similarity
Phosphorylated; triggering degradation by the proteasome.By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P17752

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P17752

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P17752

PeptideAtlas

More...PeptideAtlasi		P17752

PRoteomics IDEntifications database

More...PRIDEi		P17752

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		53513 [P17752-1]
53514 [P17752-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P17752

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P17752

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Seems to be less widely expressed than isoform 1.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000129167, Expressed in buccal mucosa cell and 123 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P17752, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P17752, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000129167, Group enriched (brain, intestine, pituitary gland, stomach)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotetramer.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		113019, 9 interactors

Protein interaction database and analysis system

More...IntActi		P17752, 11 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000250018

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P17752

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P17752, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1444
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P17752

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P17752

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini19 – 94ACTPROSITE-ProRule annotationAdd BLAST76

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3820, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00950000182885

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_023198_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P17752

Identification of Orthologs from Complete Genome Data

More...OMAi		MENWPEL

Database of Orthologous Groups

More...OrthoDBi		614557at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P17752

TreeFam database of animal gene trees

More...TreeFami		TF313327

Family and domain databases

Conserved Domains Database

More...CDDi		cd03346, eu_TrpOH, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.800.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002912, ACT_dom
IPR001273, ArAA_hydroxylase
IPR018301, ArAA_hydroxylase_Fe/CU_BS
IPR036951, ArAA_hydroxylase_sf
IPR036329, Aro-AA_hydroxylase_C_sf
IPR019774, Aromatic-AA_hydroxylase_C
IPR005963, Trp_5_mOase
IPR041904, TrpOH_cat
IPR019773, Tyrosine_3-monooxygenase-like

The PANTHER Classification System

More...PANTHERi		PTHR11473, PTHR11473, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00351, Biopterin_H, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF000336, TH, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00372, FYWHYDRXLASE

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF56534, SSF56534, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR01270, Trp_5_monoox, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51671, ACT, 1 hit
PS00367, BH4_AAA_HYDROXYL_1, 1 hit
PS51410, BH4_AAA_HYDROXYL_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P17752-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MIEDNKENKD HSLERGRASL IFSLKNEVGG LIKALKIFQE KHVNLLHIES 
        60         70         80         90        100
RKSKRRNSEF EIFVDCDINR EQLNDIFHLL KSHTNVLSVN LPDNFTLKED 
       110        120        130        140        150
GMETVPWFPK KISDLDHCAN RVLMYGSELD ADHPGFKDNV YRKRRKYFAD 
       160        170        180        190        200
LAMNYKHGDP IPKVEFTEEE IKTWGTVFQE LNKLYPTHAC REYLKNLPLL 
       210        220        230        240        250
SKYCGYREDN IPQLEDVSNF LKERTGFSIR PVAGYLSPRD FLSGLAFRVF 
       260        270        280        290        300
HCTQYVRHSS DPFYTPEPDT CHELLGHVPL LAEPSFAQFS QEIGLASLGA 
       310        320        330        340        350
SEEAVQKLAT CYFFTVEFGL CKQDGQLRVF GAGLLSSISE LKHALSGHAK 
       360        370        380        390        400
VKPFDPKITC KQECLITTFQ DVYFVSESFE DAKEKMREFT KTIKRPFGVK 
       410        420        430        440 
YNPYTRSIQI LKDTKSITSA MNELQHDLDV VSDALAKVSR KPSI
Length:444
Mass (Da):50,985
Last modified:October 17, 2006 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDFAD501446953A91
GO
Isoform 2 (identifier: P17752-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     438-444: VSRKPSI → SLNEDVLQVSVFALLLFLPSLHGECHPDT

Show »
Length:466
Mass (Da):53,394
Checksum:iCAFE34D6173BA604
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PR49E9PR49_HUMAN
Tryptophan 5-hydroxylase 1
TPH1
165Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EMX4E7EMX4_HUMAN
Tryptophan 5-hydroxylase 1
TPH1
206Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti19S → T in AAA67050 (PubMed:7986090).Curated1
Sequence conflicti68I → T in AAA67050 (PubMed:7986090).Curated1
Sequence conflicti90 – 91NL → TP in AAA67050 (PubMed:7986090).Curated2
Sequence conflicti97L → M in AAA67050 (PubMed:7986090).Curated1
Sequence conflicti100D → E in AAA67050 (PubMed:7986090).Curated1
Sequence conflicti104T → S in AAA67050 (PubMed:7986090).Curated1
Sequence conflicti151L → S in AAA67050 (PubMed:7986090).Curated1
Sequence conflicti154N → S in AAA67050 (PubMed:7986090).Curated1
Sequence conflicti157H → Y in AAA67050 (PubMed:7986090).Curated1
Sequence conflicti179Q → R in AAA67050 (PubMed:7986090).Curated1
Sequence conflicti207R → Q in AAA67050 (PubMed:7986090).Curated1
Sequence conflicti217V → I in AAA67050 (PubMed:7986090).Curated1
Sequence conflicti344A → V in AAA67050 (PubMed:7986090).Curated1
Sequence conflicti414T → A in AAA67050 (PubMed:7986090).Curated1
Sequence conflicti419S → N in AAA67050 (PubMed:7986090).Curated1
Sequence conflicti425Q → R in AAA67050 (PubMed:7986090).Curated1
Sequence conflicti436A → G in AAA67050 (PubMed:7986090).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_000546438 – 444VSRKPSI → SLNEDVLQVSVFALLLFLPS LHGECHPDT in isoform 2. Curated7

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X52836 mRNA Translation: CAA37018.1
L29306 mRNA Translation: AAA67050.1
CH471064 Genomic DNA Translation: EAW68421.1
CH471064 Genomic DNA Translation: EAW68422.1
BC106739 mRNA Translation: AAI06740.1
AF057280 Genomic DNA Translation: AAC69458.1
AF057280 Genomic DNA Translation: AAC69459.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS7829.1 [P17752-1]

Protein sequence database of the Protein Information Resource

More...PIRi		S10489

NCBI Reference Sequences

More...RefSeqi		NP_004170.1, NM_004179.2 [P17752-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000250018; ENSP00000250018; ENSG00000129167 [P17752-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		7166

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:7166

UCSC genome browser

More...UCSCi		uc001mnp.3, human [P17752-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52836 mRNA Translation: CAA37018.1
L29306 mRNA Translation: AAA67050.1
CH471064 Genomic DNA Translation: EAW68421.1
CH471064 Genomic DNA Translation: EAW68422.1
BC106739 mRNA Translation: AAI06740.1
AF057280 Genomic DNA Translation: AAC69458.1
AF057280 Genomic DNA Translation: AAC69459.1
CCDSiCCDS7829.1 [P17752-1]
PIRiS10489
RefSeqiNP_004170.1, NM_004179.2 [P17752-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1IN9model-A2-444[»]
1MLWX-ray1.71A102-402[»]
3HF6X-ray1.80A105-393[»]
3HF8X-ray1.85A105-393[»]
3HFBX-ray1.92A104-393[»]
5J6DX-ray1.90A/B102-402[»]
5L01X-ray1.90A1-444[»]
5TPGX-ray1.50A104-402[»]
SMRiP17752
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi113019, 9 interactors
IntActiP17752, 11 interactors
STRINGi9606.ENSP00000250018

Chemistry databases

BindingDBiP17752
ChEMBLiCHEMBL5689
DrugBankiDB05199, LX1031
DB00360, Sapropterin
DB12095, Telotristat ethyl
DB00150, Tryptophan
DrugCentraliP17752
GuidetoPHARMACOLOGYi1241

PTM databases

iPTMnetiP17752
PhosphoSitePlusiP17752

Genetic variation databases

BioMutaiTPH1
DMDMi116242823

Proteomic databases

jPOSTiP17752
MassIVEiP17752
PaxDbiP17752
PeptideAtlasiP17752
PRIDEiP17752
ProteomicsDBi53513 [P17752-1]
53514 [P17752-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		4386, 601 antibodies

Genome annotation databases

EnsembliENST00000250018; ENSP00000250018; ENSG00000129167 [P17752-1]
GeneIDi7166
KEGGihsa:7166
UCSCiuc001mnp.3, human [P17752-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		7166
DisGeNETi7166

GeneCards: human genes, protein and diseases

More...GeneCardsi		TPH1
HGNCiHGNC:12008, TPH1
HPAiENSG00000129167, Group enriched (brain, intestine, pituitary gland, stomach)
MIMi191060, gene
neXtProtiNX_P17752
OpenTargetsiENSG00000129167
PharmGKBiPA355
VEuPathDBiHostDB:ENSG00000129167.9

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3820, Eukaryota
GeneTreeiENSGT00950000182885
HOGENOMiCLU_023198_0_0_1
InParanoidiP17752
OMAiMENWPEL
OrthoDBi614557at2759
PhylomeDBiP17752
TreeFamiTF313327

Enzyme and pathway databases

UniPathwayiUPA00846;UER00799
BioCyciMetaCyc:HS05250-MONOMER
BRENDAi1.14.16.4, 2681
PathwayCommonsiP17752
ReactomeiR-HSA-209931, Serotonin and melatonin biosynthesis
R-HSA-9031628, NGF-stimulated transcription
SABIO-RKiP17752
SIGNORiP17752

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		7166, 9 hits in 986 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		TPH1, human
EvolutionaryTraceiP17752

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		TPH1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		7166
PharosiP17752, Tclin

Protein Ontology

More...PROi		PR:P17752
RNActiP17752, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000129167, Expressed in buccal mucosa cell and 123 other tissues
ExpressionAtlasiP17752, baseline and differential
GenevisibleiP17752, HS

Family and domain databases

CDDicd03346, eu_TrpOH, 1 hit
Gene3Di1.10.800.10, 1 hit
InterProiView protein in InterPro
IPR002912, ACT_dom
IPR001273, ArAA_hydroxylase
IPR018301, ArAA_hydroxylase_Fe/CU_BS
IPR036951, ArAA_hydroxylase_sf
IPR036329, Aro-AA_hydroxylase_C_sf
IPR019774, Aromatic-AA_hydroxylase_C
IPR005963, Trp_5_mOase
IPR041904, TrpOH_cat
IPR019773, Tyrosine_3-monooxygenase-like
PANTHERiPTHR11473, PTHR11473, 1 hit
PfamiView protein in Pfam
PF00351, Biopterin_H, 1 hit
PIRSFiPIRSF000336, TH, 1 hit
PRINTSiPR00372, FYWHYDRXLASE
SUPFAMiSSF56534, SSF56534, 1 hit
TIGRFAMsiTIGR01270, Trp_5_monoox, 1 hit
PROSITEiView protein in PROSITE
PS51671, ACT, 1 hit
PS00367, BH4_AAA_HYDROXYL_1, 1 hit
PS51410, BH4_AAA_HYDROXYL_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTPH1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P17752
Secondary accession number(s): D3DQX6
, O95188, O95189, Q16736, Q3KPG8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: October 17, 2006
Last modified: April 7, 2021
This is version 200 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families
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