TPH1

Functionⁱ

Catalytic activityⁱ

L-tryptophan + tetrahydrobiopterin + O₂ = 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin.

Cofactorⁱ

Pathwayⁱ: serotonin biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes serotonin from L-tryptophan.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:

Tryptophan 5-hydroxylase 1 (TPH1), Tryptophan 5-hydroxylase 2 (TPH2)
no protein annotated in this organism

This subpathway is part of the pathway serotonin biosynthesis, which is itself part of Aromatic compound metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes serotonin from L-tryptophan, the pathway serotonin biosynthesis and in Aromatic compound metabolism.

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	235	TryptophanBy similarity	1
Binding siteⁱ	257	TryptophanBy similarity	1
Binding siteⁱ	265	TryptophanBy similarity	1
Metal bindingⁱ	272	Iron	1
Metal bindingⁱ	277	Iron	1
Metal bindingⁱ	317	Iron	1
Binding siteⁱ	336	TryptophanBy similarity	1
Binding siteⁱ	366	Tryptophan; via carbonyl oxygenBy similarity	1

GO - Molecular functionⁱ

iron ion binding Source: InterPro
tryptophan 5-monooxygenase activity Source: UniProtKB-EC

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

aromatic amino acid family metabolic process Source: InterPro
bone remodeling Source: Ensembl
circadian rhythm Source: Ensembl
mammary gland alveolus development Source: Ensembl
negative regulation of ossification Source: Ensembl
positive regulation of fat cell differentiation Source: Ensembl
response to immobilization stress Source: Ensembl
serotonin biosynthetic process Source: UniProtKB-UniPathway

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Monooxygenase, Oxidoreductase
Biological process	Serotonin biosynthesis
Ligand	Iron, Metal-binding

Enzyme and pathway databases

BioCycⁱ	MetaCyc:HS05250-MONOMER
BRENDAⁱ	1.14.16.4 2681
Reactomeⁱ	R-HSA-209931 Serotonin and melatonin biosynthesis
SABIO-RKⁱ	P17752
SIGNORⁱ	P17752
UniPathwayⁱ	UPA00846;UER00799

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Tryptophan 5-hydroxylase 1 (EC:1.14.16.4) Alternative name(s): Tryptophan 5-monooxygenase 1
Gene namesⁱ	Name:TPH1 Synonyms:TPH, TPRH, TRPH
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 11

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000129167.9
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:12008 TPH1
MIMⁱ	191060 gene
neXtProtⁱ	NX_P17752

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	7166
Open Targets More...OpenTargetsⁱ	ENSG00000129167
PharmGKBⁱ	PA355

Chemistry databases

ChEMBLⁱ	CHEMBL5689
Drug and drug target database More...DrugBankⁱ	DB00150 L-Tryptophan DB05199 LX1031 DB00360 Sapropterin DB12095 Telotristat

Polymorphism and mutation databases

BioMutaⁱ	TPH1
DMDMⁱ	116242823

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000205568	1 – 444	Tryptophan 5-hydroxylase 1Add BLAST		444

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	58	Phosphoserine; by PKASequence analysis		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

PaxDbⁱ	P17752
PeptideAtlas More...PeptideAtlasⁱ	P17752
PRIDEⁱ	P17752
ProteomicsDBⁱ	53513 53514 [P17752-2]

PTM databases

iPTMnetⁱ	P17752
PhosphoSitePlusⁱ	P17752

Expressionⁱ

Tissue specificityⁱ

Isoform 2 seems to be less widely expressed than isoform 1.

Gene expression databases

Bgeeⁱ	ENSG00000129167 Expressed in 99 organ(s), highest expression level in buccal mucosa cell
CleanExⁱ	HS_TPH1
ExpressionAtlasⁱ	P17752 baseline and differential
Genevisibleⁱ	P17752 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB010767 HPA022483

HPAⁱ

CAB010767
HPA022483

Interactionⁱ

Subunit structureⁱ

Homotetramer.By similarity

Protein-protein interaction databases

BioGridⁱ	113019, 6 interactors
IntActⁱ	P17752, 3 interactors
STRINGⁱ	9606.ENSP00000250018

Chemistry databases

BindingDBⁱ

P17752

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	112 – 117	Combined sources	6
Turnⁱ	118 – 120	Combined sources	3
Turnⁱ	126 – 128	Combined sources	3
Turnⁱ	134 – 137	Combined sources	4
Helixⁱ	140 – 154	Combined sources	15
Helixⁱ	168 – 188	Combined sources	21
Helixⁱ	191 – 204	Combined sources	14
Helixⁱ	214 – 225	Combined sources	12
Beta strandⁱ	228 – 231	Combined sources	4
Beta strandⁱ	233 – 235	Combined sources	3
Helixⁱ	238 – 246	Combined sources	9
Beta strandⁱ	249 – 252	Combined sources	4
Helixⁱ	270 – 276	Combined sources	7
Helixⁱ	278 – 281	Combined sources	4
Helixⁱ	284 – 297	Combined sources	14
Helixⁱ	302 – 313	Combined sources	12
Turnⁱ	314 – 318	Combined sources	5
Beta strandⁱ	320 – 323	Combined sources	4
Beta strandⁱ	326 – 329	Combined sources	4
Helixⁱ	332 – 335	Combined sources	4
Helixⁱ	338 – 344	Combined sources	7
Turnⁱ	345 – 347	Combined sources	3
Beta strandⁱ	349 – 353	Combined sources	5
Helixⁱ	356 – 359	Combined sources	4
Beta strandⁱ	367 – 369	Combined sources	3
Beta strandⁱ	371 – 377	Combined sources	7
Helixⁱ	379 – 392	Combined sources	14

Show more details

3D structure databases

ProteinModelPortalⁱ	P17752
SMRⁱ	P17752
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

P17752

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	19 – 94	ACTPROSITE-ProRule annotationAdd BLAST		76

Sequence similaritiesⁱ

Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.Curated

Phylogenomic databases

eggNOGⁱ	KOG3820 Eukaryota COG3186 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000010268
HOGENOMⁱ	HOG000233373
HOVERGENⁱ	HBG006841
InParanoidⁱ	P17752
KEGG Orthology (KO) More...KOⁱ	K00502
OMAⁱ	VKMREFA
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G05MZ
PhylomeDBⁱ	P17752
TreeFamⁱ	TF313327

Family and domain databases

Gene3Dⁱ	1.10.800.10, 1 hit
InterProⁱ	View protein in InterPro IPR002912 ACT_dom IPR001273 ArAA_hydroxylase IPR018301 ArAA_hydroxylase_Fe/CU_BS IPR036951 ArAA_hydroxylase_sf IPR036329 Aro-AA_hydroxylase_C_sf IPR019774 Aromatic-AA_hydroxylase_C IPR005963 Trp_5_mOase IPR019773 Tyrosine_3-monooxygenase-like
PANTHERⁱ	PTHR11473 PTHR11473, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00351 Biopterin_H, 1 hit
PIRSFⁱ	PIRSF000336 TH, 1 hit
PRINTSⁱ	PR00372 FYWHYDRXLASE
SUPFAMⁱ	SSF56534 SSF56534, 1 hit
TIGRFAMsⁱ	TIGR01270 Trp_5_monoox, 1 hit
PROSITEⁱ	View protein in PROSITE PS51671 ACT, 1 hit PS00367 BH4_AAA_HYDROXYL_1, 1 hit PS51410 BH4_AAA_HYDROXYL_2, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P17752-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MIEDNKENKD HSLERGRASL IFSLKNEVGG LIKALKIFQE KHVNLLHIES 
        60         70         80         90        100
RKSKRRNSEF EIFVDCDINR EQLNDIFHLL KSHTNVLSVN LPDNFTLKED 
       110        120        130        140        150
GMETVPWFPK KISDLDHCAN RVLMYGSELD ADHPGFKDNV YRKRRKYFAD 
       160        170        180        190        200
LAMNYKHGDP IPKVEFTEEE IKTWGTVFQE LNKLYPTHAC REYLKNLPLL 
       210        220        230        240        250
SKYCGYREDN IPQLEDVSNF LKERTGFSIR PVAGYLSPRD FLSGLAFRVF 
       260        270        280        290        300
HCTQYVRHSS DPFYTPEPDT CHELLGHVPL LAEPSFAQFS QEIGLASLGA 
       310        320        330        340        350
SEEAVQKLAT CYFFTVEFGL CKQDGQLRVF GAGLLSSISE LKHALSGHAK 
       360        370        380        390        400
VKPFDPKITC KQECLITTFQ DVYFVSESFE DAKEKMREFT KTIKRPFGVK 
       410        420        430        440 
YNPYTRSIQI LKDTKSITSA MNELQHDLDV VSDALAKVSR KPSI

Length:444

Mass (Da):50,985

Last modified:October 17, 2006 - v4

Checksum:ⁱDFAD501446953A91

GO

Isoform 2 (identifier: P17752-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
438-444: VSRKPSI → SLNEDVLQVSVFALLLFLPSLHGECHPDT

« Hide

        10         20         30         40         50
MIEDNKENKD HSLERGRASL IFSLKNEVGG LIKALKIFQE KHVNLLHIES 
        60         70         80         90        100
RKSKRRNSEF EIFVDCDINR EQLNDIFHLL KSHTNVLSVN LPDNFTLKED 
       110        120        130        140        150
GMETVPWFPK KISDLDHCAN RVLMYGSELD ADHPGFKDNV YRKRRKYFAD 
       160        170        180        190        200
LAMNYKHGDP IPKVEFTEEE IKTWGTVFQE LNKLYPTHAC REYLKNLPLL 
       210        220        230        240        250
SKYCGYREDN IPQLEDVSNF LKERTGFSIR PVAGYLSPRD FLSGLAFRVF 
       260        270        280        290        300
HCTQYVRHSS DPFYTPEPDT CHELLGHVPL LAEPSFAQFS QEIGLASLGA 
       310        320        330        340        350
SEEAVQKLAT CYFFTVEFGL CKQDGQLRVF GAGLLSSISE LKHALSGHAK 
       360        370        380        390        400
VKPFDPKITC KQECLITTFQ DVYFVSESFE DAKEKMREFT KTIKRPFGVK 
       410        420        430        440        450
YNPYTRSIQI LKDTKSITSA MNELQHDLDV VSDALAKSLN EDVLQVSVFA 
       460 
LLLFLPSLHG ECHPDT

Show »

Length:466

Mass (Da):53,394

Checksum:ⁱCAFE34D6173BA604

GO

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

E7EMX4	E7EMX4_HUMAN	Tryptophan 5-hydroxylase 1 Tryptophan 5-hydroxylase 1	TPH1	206	Annotation score:
E9PR49	E9PR49_HUMAN	Tryptophan 5-hydroxylase 1 Tryptophan 5-hydroxylase 1	TPH1	165	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	19	S → T in AAA67050 (PubMed:7986090).Curated	1
Sequence conflictⁱ	68	I → T in AAA67050 (PubMed:7986090).Curated	1
Sequence conflictⁱ	90 – 91	NL → TP in AAA67050 (PubMed:7986090).Curated	2
Sequence conflictⁱ	97	L → M in AAA67050 (PubMed:7986090).Curated	1
Sequence conflictⁱ	100	D → E in AAA67050 (PubMed:7986090).Curated	1
Sequence conflictⁱ	104	T → S in AAA67050 (PubMed:7986090).Curated	1
Sequence conflictⁱ	151	L → S in AAA67050 (PubMed:7986090).Curated	1
Sequence conflictⁱ	154	N → S in AAA67050 (PubMed:7986090).Curated	1
Sequence conflictⁱ	157	H → Y in AAA67050 (PubMed:7986090).Curated	1
Sequence conflictⁱ	179	Q → R in AAA67050 (PubMed:7986090).Curated	1
Sequence conflictⁱ	207	R → Q in AAA67050 (PubMed:7986090).Curated	1
Sequence conflictⁱ	217	V → I in AAA67050 (PubMed:7986090).Curated	1
Sequence conflictⁱ	344	A → V in AAA67050 (PubMed:7986090).Curated	1
Sequence conflictⁱ	414	T → A in AAA67050 (PubMed:7986090).Curated	1
Sequence conflictⁱ	419	S → N in AAA67050 (PubMed:7986090).Curated	1
Sequence conflictⁱ	425	Q → R in AAA67050 (PubMed:7986090).Curated	1
Sequence conflictⁱ	436	A → G in AAA67050 (PubMed:7986090).Curated	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_000546	438 – 444	VSRKPSI → SLNEDVLQVSVFALLLFLPS LHGECHPDT in isoform 2. Curated		7

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X52836 mRNA Translation: CAA37018.1 L29306 mRNA Translation: AAA67050.1 CH471064 Genomic DNA Translation: EAW68421.1 CH471064 Genomic DNA Translation: EAW68422.1 BC106739 mRNA Translation: AAI06740.1 AF057280 Genomic DNA Translation: AAC69458.1 AF057280 Genomic DNA Translation: AAC69459.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS7829.1 [P17752-1]
PIRⁱ	S10489
NCBI Reference Sequences More...RefSeqⁱ	NP_004170.1, NM_004179.2 [P17752-1]
UniGeneⁱ	Hs.591999

Genome annotation databases

Ensemblⁱ	ENST00000250018; ENSP00000250018; ENSG00000129167 [P17752-1]
GeneIDⁱ	7166
KEGGⁱ	hsa:7166
UCSC genome browser More...UCSCⁱ	uc001mnp.3 human [P17752-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Protein	Similar proteins		Species	Score	Length	Source
P17752	Tryptophan 5-hydroxylase 1		RABIT		444	UniRef90_P17752
Uncharacterized protein		PAPAN		491
Tryptophan hydroxylase 1 (Fragment)		HUMAN		57
Tryptophan hydroxylase 1 (Fragment)		PANTR		57
Tryptophan hydroxylase 1 (Fragment)		PONPY		57
+146

Protein	Similar proteins		Species	Score	Length	Source
P17752	Phenylalanine-4-hydroxylase	)	HUMAN		452	UniRef50_P00439
Phenylalanine-4-hydroxylase	)	RAT		453
Phenylalanine-4-hydroxylase		MOUSE		453
Phenylalanine-4-hydroxylase		BOVIN		451
Tryptophan 5-hydroxylase 1		RABIT		444
+356

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X52836 mRNA Translation: CAA37018.1 L29306 mRNA Translation: AAA67050.1 CH471064 Genomic DNA Translation: EAW68421.1 CH471064 Genomic DNA Translation: EAW68422.1 BC106739 mRNA Translation: AAI06740.1 AF057280 Genomic DNA Translation: AAC69458.1 AF057280 Genomic DNA Translation: AAC69459.1
CCDSⁱ	CCDS7829.1 [P17752-1]
PIRⁱ	S10489
RefSeqⁱ	NP_004170.1, NM_004179.2 [P17752-1]
UniGeneⁱ	Hs.591999

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1IN9	model	-	A	2-444	[»]
	1MLW	X-ray	1.71	A	102-402	[»]
	3HF6	X-ray	1.80	A	105-393	[»]
	3HF8	X-ray	1.85	A	105-393	[»]
	3HFB	X-ray	1.92	A	104-393	[»]
	5J6D	X-ray	1.90	A/B	102-402	[»]
	5L01	X-ray	1.90	A	1-444	[»]
	5TPG	X-ray	1.50	A	104-402	[»]
ProteinModelPortalⁱ	P17752
SMRⁱ	P17752
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	113019, 6 interactors
IntActⁱ	P17752, 3 interactors
STRINGⁱ	9606.ENSP00000250018

Chemistry databases

BindingDBⁱ	P17752
ChEMBLⁱ	CHEMBL5689
DrugBankⁱ	DB00150 L-Tryptophan DB05199 LX1031 DB00360 Sapropterin DB12095 Telotristat

PTM databases

iPTMnetⁱ	P17752
PhosphoSitePlusⁱ	P17752

Polymorphism and mutation databases

BioMutaⁱ	TPH1
DMDMⁱ	116242823

Proteomic databases

PaxDbⁱ	P17752
PeptideAtlasⁱ	P17752
PRIDEⁱ	P17752
ProteomicsDBⁱ	53513 53514 [P17752-2]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000250018; ENSP00000250018; ENSG00000129167 [P17752-1]
GeneIDⁱ	7166
KEGGⁱ	hsa:7166
UCSCⁱ	uc001mnp.3 human [P17752-1]

Organism-specific databases

CTDⁱ	7166
DisGeNETⁱ	7166
EuPathDBⁱ	HostDB:ENSG00000129167.9
GeneCardsⁱ	TPH1
HGNCⁱ	HGNC:12008 TPH1
HPAⁱ	CAB010767 HPA022483
MIMⁱ	191060 gene
neXtProtⁱ	NX_P17752
OpenTargetsⁱ	ENSG00000129167
PharmGKBⁱ	PA355
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3820 Eukaryota COG3186 LUCA
GeneTreeⁱ	ENSGT00390000010268
HOGENOMⁱ	HOG000233373
HOVERGENⁱ	HBG006841
InParanoidⁱ	P17752
KOⁱ	K00502
OMAⁱ	VKMREFA
OrthoDBⁱ	EOG091G05MZ
PhylomeDBⁱ	P17752
TreeFamⁱ	TF313327

Enzyme and pathway databases

UniPathwayⁱ	UPA00846;UER00799
BioCycⁱ	MetaCyc:HS05250-MONOMER
BRENDAⁱ	1.14.16.4 2681
Reactomeⁱ	R-HSA-209931 Serotonin and melatonin biosynthesis
SABIO-RKⁱ	P17752
SIGNORⁱ	P17752

Miscellaneous databases

EvolutionaryTraceⁱ	P17752
GeneWikiⁱ	TPH1
GenomeRNAiⁱ	7166
Protein Ontology More...PROⁱ	PR:P17752
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000129167 Expressed in 99 organ(s), highest expression level in buccal mucosa cell
CleanExⁱ	HS_TPH1
ExpressionAtlasⁱ	P17752 baseline and differential
Genevisibleⁱ	P17752 HS

Family and domain databases

Gene3Dⁱ	1.10.800.10, 1 hit
InterProⁱ	View protein in InterPro IPR002912 ACT_dom IPR001273 ArAA_hydroxylase IPR018301 ArAA_hydroxylase_Fe/CU_BS IPR036951 ArAA_hydroxylase_sf IPR036329 Aro-AA_hydroxylase_C_sf IPR019774 Aromatic-AA_hydroxylase_C IPR005963 Trp_5_mOase IPR019773 Tyrosine_3-monooxygenase-like
PANTHERⁱ	PTHR11473 PTHR11473, 1 hit
Pfamⁱ	View protein in Pfam PF00351 Biopterin_H, 1 hit
PIRSFⁱ	PIRSF000336 TH, 1 hit
PRINTSⁱ	PR00372 FYWHYDRXLASE
SUPFAMⁱ	SSF56534 SSF56534, 1 hit
TIGRFAMsⁱ	TIGR01270 Trp_5_monoox, 1 hit
PROSITEⁱ	View protein in PROSITE PS51671 ACT, 1 hit PS00367 BH4_AAA_HYDROXYL_1, 1 hit PS51410 BH4_AAA_HYDROXYL_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TPH1_HUMAN
Accessionⁱ	P17752Primary (citable) accession number: P17752 Secondary accession number(s): D3DQX6 , O95188, O95189, Q16736, Q3KPG8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 1, 1990
	Last sequence update:	October 17, 2006
	Last modified:	November 7, 2018
	This is version 183 of the entry and version 4 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PATHWAY comments
Index of metabolic and biosynthesis pathways
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P17752 (TPH1_HUMAN)

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Tryptophan 5-hydroxylase 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: serotonin biosynthesis

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytosol

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

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Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

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<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

Pathwayⁱ: serotonin biosynthesis

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ