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Protein

Triosephosphate isomerase

Gene

Tpi1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

It is uncertain if Met-1 or Met-14 is the initiator.Curated

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: gluconeogenesis

This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.
View all proteins of this organism that are known to be involved in the pathway gluconeogenesis and in Carbohydrate biosynthesis.

Pathwayi: glycolysis

This protein is involved in step 1 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate from glycerone phosphate.
Proteins known to be involved in this subpathway in this organism are:
  1. Triosephosphate isomerase (Tpi1), Triosephosphate isomerase (Tpi1)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate from glycerone phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei62SubstrateBy similarity1
Binding sitei64SubstrateBy similarity1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei146ElectrophileBy similarity1
Active sitei216Proton acceptorBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • gluconeogenesis Source: GO_Central
  • glucose metabolic process Source: MGI
  • glyceraldehyde-3-phosphate biosynthetic process Source: GO_Central
  • glyceraldehyde-3-phosphate metabolic process Source: UniProtKB
  • glycerol catabolic process Source: GO_Central
  • glycolytic process Source: GO_Central
  • multicellular organism development Source: MGI

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIsomerase
Biological processGluconeogenesis, Glycolysis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-70171 Glycolysis
R-MMU-70263 Gluconeogenesis

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
P17751

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00109;UER00189

UPA00138

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Triosephosphate isomerase (EC:5.3.1.1)
Short name:
TIM
Alternative name(s):
Triose-phosphate isomerase
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Tpi1
Synonyms:Tpi
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:98797 Tpi1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi213L → Q: 50% reduced activity. 1 Publication1
Mutagenesisi243L → Q: 50% reduced activity. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000901161 – 299Triosephosphate isomeraseAdd BLAST299

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei64N6-acetyllysineBy similarity1
Modified residuei118Nitrated tyrosineCombined sources1
Modified residuei130PhosphoserineBy similarity1
Modified residuei156PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki192Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)By similarity
Modified residuei199N6-succinyllysineCombined sources1
Modified residuei206N6-acetyllysine; alternateCombined sources1
Modified residuei206N6-succinyllysine; alternateCombined sources1
Modified residuei209PhosphoserineCombined sources1
Modified residuei223PhosphothreonineCombined sources1
Modified residuei244N6-acetyllysine; alternateCombined sources1
Modified residuei244N6-methyllysine; alternateBy similarity1
Modified residuei244N6-succinyllysine; alternateCombined sources1
Modified residuei259Nitrated tyrosineCombined sources1
Modified residuei262PhosphoserineCombined sources1
Modified residuei264PhosphothreonineBy similarity1
Modified residuei273PhosphoserineBy similarity1
Modified residuei288N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Nitration, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P17751

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P17751

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P17751

PeptideAtlas

More...
PeptideAtlasi
P17751

PRoteomics IDEntifications database

More...
PRIDEi
P17751

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
P17751

2D gel databases

2-DE database at Universidad Complutense de Madrid

More...
COMPLUYEAST-2DPAGEi
P17751

REPRODUCTION-2DPAGE

More...
REPRODUCTION-2DPAGEi
IPI00467833
P17751

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

More...
SWISS-2DPAGEi
P17751

University College Dublin 2-DE Proteome Database

More...
UCD-2DPAGEi
P17751

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P17751

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P17751

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P17751

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000023456 Expressed in 329 organ(s), highest expression level in muscle of leg

CleanEx database of gene expression profiles

More...
CleanExi
MM_TPI1

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P17751 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P17751 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
204290, 12 interactors

Protein interaction database and analysis system

More...
IntActi
P17751, 16 interactors

Molecular INTeraction database

More...
MINTi
P17751

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000130858

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P17751

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P17751

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the triosephosphate isomerase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1643 Eukaryota
COG0149 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000013354

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG002599

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P17751

KEGG Orthology (KO)

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KOi
K01803

Identification of Orthologs from Complete Genome Data

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OMAi
LCVGEGL

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0LEZ

TreeFam database of animal gene trees

More...
TreeFami
TF300829

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00311 TIM, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.20.20.70, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_00147_B TIM_B, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013785 Aldolase_TIM
IPR035990 TIM_sf
IPR022896 TrioseP_Isoase_bac/euk
IPR000652 Triosephosphate_isomerase
IPR020861 Triosephosphate_isomerase_AS

The PANTHER Classification System

More...
PANTHERi
PTHR21139 PTHR21139, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00121 TIM, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51351 SSF51351, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00419 tim, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00171 TIM_1, 1 hit
PS51440 TIM_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P17751-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEGKAEQQGA GLTMAEGGEK EEFCFTAIYI SGQWREPCVC TDLQRLEPGT
60 70 80 90 100
MAPTRKFFVG GNWKMNGRKK CLGELICTLN AANVPAGTEV VCAPPTAYID
110 120 130 140 150
FARQKLDPKI AVAAQNCYKV TNGAFTGEIS PGMIKDLGAT WVVLGHSERR
160 170 180 190 200
HVFGESDELI GQKVSHALAE GLGVIACIGE KLDEREAGIT EKVVFEQTKV
210 220 230 240 250
IADNVKDWSK VVLAYEPVWA IGTGKTATPQ QAQEVHEKLR GWLKSNVNDG
260 270 280 290
VAQSTRIIYG GSVTGATCKE LASQPDVDGF LVGGASLKPE FVDIINAKQ
Length:299
Mass (Da):32,192
Last modified:October 19, 2011 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD465FD57108A3BD4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7BXC3H7BXC3_MOUSE
Triosephosphate isomerase
Tpi1
167Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC36016 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH46761 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB27194 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAE26832 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAE29073 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAE29810 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAE35334 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAE39523 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAE40350 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAE40594 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAA37420 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti124A → P in CAA37420 (PubMed:2377473).Curated1
Sequence conflicti157D → G in BAE39523 (PubMed:16141072).Curated1
Sequence conflicti244K → R in BAB27194 (PubMed:16141072).Curated1
Sequence conflicti245S → P in BAE26832 (PubMed:16141072).Curated1
Sequence conflicti266A → G in BAB27194 (PubMed:16141072).Curated1
Sequence conflicti272A → Q in BAB27194 (PubMed:16141072).Curated1
Sequence conflicti273 – 275SQP → TPA in CAA37420 (PubMed:2377473).Curated3
Sequence conflicti277V → M in BAB25634 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC002397 Genomic DNA Translation: AAC36016.1 Different initiation.
AC142254 Genomic DNA No translation available.
AK008373 mRNA Translation: BAB25634.1
AK010808 mRNA Translation: BAB27194.1 Different initiation.
AK146013 mRNA Translation: BAE26832.1 Different initiation.
AK149768 mRNA Translation: BAE29073.1 Different initiation.
AK150735 mRNA Translation: BAE29810.1 Different initiation.
AK159741 mRNA Translation: BAE35334.1 Different initiation.
AK167437 mRNA Translation: BAE39523.1 Different initiation.
AK168446 mRNA Translation: BAE40350.1 Different initiation.
AK168756 mRNA Translation: BAE40594.1 Different initiation.
X53333 mRNA Translation: CAA37420.1 Different initiation.
BC046761 mRNA Translation: AAH46761.1 Different initiation.
L31777 Genomic DNA Translation: AAB48543.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS20530.2

Protein sequence database of the Protein Information Resource

More...
PIRi
S10490 ISMST

NCBI Reference Sequences

More...
RefSeqi
NP_033441.2, NM_009415.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.4222
Mm.439915

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000172132; ENSMUSP00000130858; ENSMUSG00000023456

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
21991

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:21991

UCSC genome browser

More...
UCSCi
uc012esp.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC002397 Genomic DNA Translation: AAC36016.1 Different initiation.
AC142254 Genomic DNA No translation available.
AK008373 mRNA Translation: BAB25634.1
AK010808 mRNA Translation: BAB27194.1 Different initiation.
AK146013 mRNA Translation: BAE26832.1 Different initiation.
AK149768 mRNA Translation: BAE29073.1 Different initiation.
AK150735 mRNA Translation: BAE29810.1 Different initiation.
AK159741 mRNA Translation: BAE35334.1 Different initiation.
AK167437 mRNA Translation: BAE39523.1 Different initiation.
AK168446 mRNA Translation: BAE40350.1 Different initiation.
AK168756 mRNA Translation: BAE40594.1 Different initiation.
X53333 mRNA Translation: CAA37420.1 Different initiation.
BC046761 mRNA Translation: AAH46761.1 Different initiation.
L31777 Genomic DNA Translation: AAB48543.1
CCDSiCCDS20530.2
PIRiS10490 ISMST
RefSeqiNP_033441.2, NM_009415.2
UniGeneiMm.4222
Mm.439915

3D structure databases

ProteinModelPortaliP17751
SMRiP17751
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204290, 12 interactors
IntActiP17751, 16 interactors
MINTiP17751
STRINGi10090.ENSMUSP00000130858

PTM databases

iPTMnetiP17751
PhosphoSitePlusiP17751
SwissPalmiP17751

2D gel databases

COMPLUYEAST-2DPAGEiP17751
REPRODUCTION-2DPAGEiIPI00467833
P17751
SWISS-2DPAGEiP17751
UCD-2DPAGEiP17751

Proteomic databases

EPDiP17751
MaxQBiP17751
PaxDbiP17751
PeptideAtlasiP17751
PRIDEiP17751
TopDownProteomicsiP17751

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000172132; ENSMUSP00000130858; ENSMUSG00000023456
GeneIDi21991
KEGGimmu:21991
UCSCiuc012esp.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
7167
MGIiMGI:98797 Tpi1

Phylogenomic databases

eggNOGiKOG1643 Eukaryota
COG0149 LUCA
GeneTreeiENSGT00390000013354
HOVERGENiHBG002599
InParanoidiP17751
KOiK01803
OMAiLCVGEGL
OrthoDBiEOG091G0LEZ
TreeFamiTF300829

Enzyme and pathway databases

UniPathwayi
UPA00109;UER00189

UPA00138

ReactomeiR-MMU-70171 Glycolysis
R-MMU-70263 Gluconeogenesis
SABIO-RKiP17751

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Tpi1 mouse

Protein Ontology

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PROi
PR:P17751

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000023456 Expressed in 329 organ(s), highest expression level in muscle of leg
CleanExiMM_TPI1
ExpressionAtlasiP17751 baseline and differential
GenevisibleiP17751 MM

Family and domain databases

CDDicd00311 TIM, 1 hit
Gene3Di3.20.20.70, 1 hit
HAMAPiMF_00147_B TIM_B, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR035990 TIM_sf
IPR022896 TrioseP_Isoase_bac/euk
IPR000652 Triosephosphate_isomerase
IPR020861 Triosephosphate_isomerase_AS
PANTHERiPTHR21139 PTHR21139, 1 hit
PfamiView protein in Pfam
PF00121 TIM, 1 hit
SUPFAMiSSF51351 SSF51351, 1 hit
TIGRFAMsiTIGR00419 tim, 1 hit
PROSITEiView protein in PROSITE
PS00171 TIM_1, 1 hit
PS51440 TIM_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTPIS_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P17751
Secondary accession number(s): Q3TJH2
, Q3UC04, Q3UKG9, Q64513, Q9CVF9, Q9CWE7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: October 19, 2011
Last modified: December 5, 2018
This is version 170 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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