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Protein

Antifungal protein

Gene

afp

Organism
Aspergillus giganteus
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This protein inhibits the growth of a variety of fungal species.

GO - Biological processi

Keywordsi

Molecular functionAntimicrobial, Fungicide

Names & Taxonomyi

Protein namesi
Recommended name:
Antifungal protein
Gene namesi
Name:afp
OrganismiAspergillus giganteus
Taxonomic identifieri5060 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
PropeptideiPRO_000002063922 – 43Sequence analysisAdd BLAST22
ChainiPRO_000002064044 – 94Antifungal protein1 PublicationAdd BLAST51

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi50 ↔ 761 Publication
Disulfide bondi57 ↔ 831 Publication
Disulfide bondi69 ↔ 711 Publication
Disulfide bondi92 ↔ 941 Publication

Keywords - PTMi

Disulfide bond

Structurei

Secondary structure

194
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi48 – 51Combined sources4
Turni52 – 55Combined sources4
Beta strandi56 – 59Combined sources4
Beta strandi81 – 84Combined sources4
Turni87 – 89Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AFPNMR-A44-94[»]
ProteinModelPortaliP17737
SMRiP17737
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP17737

Family & Domainsi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di2.40.50.60, 1 hit
InterProiView protein in InterPro
IPR023112 Antifungal-protein_dom_sf
IPR022706 Antifungal_prot
PfamiView protein in Pfam
PF11402 Antifungal_prot, 1 hit
SUPFAMiSSF57598 SSF57598, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P17737-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFVSLASLG FALVAALGAV ATPVEADSLT AGGLDARDES AVLATYNGKC
60 70 80 90
YKKDNICKYK AQSGKTAICK CYVKKCPRDG AKCEFDSYKG KCYC
Length:94
Mass (Da):9,994
Last modified:November 1, 1995 - v2
Checksum:i0084E4F9047A8E1F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti35 – 41DARDESA → MQEMRAR (PubMed:2374718).Curated7

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X60771 Genomic DNA Translation: CAA43181.1
X53432 mRNA Translation: CAA37523.1
PIRiS44064

Similar proteinsi

Entry informationi

Entry nameiAFP_ASPGI
AccessioniPrimary (citable) accession number: P17737
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: November 1, 1995
Last modified: May 23, 2018
This is version 80 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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