UniProtKB - P17706 (PTN2_HUMAN)
Tyrosine-protein phosphatase non-receptor type 2
PTPN2
Functioni
Catalytic activityi
- EC:3.1.3.48PROSITE-ProRule annotation
Kineticsi
- KM=0.48 mM for p-nitrophenyl phosphate (at pH 6.5 and 25 degrees Celsius)1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 182 | SubstrateBy similarity | 1 | |
Active sitei | 216 | Phosphocysteine intermediatePROSITE-ProRule annotation | 1 | |
Binding sitei | 260 | SubstrateBy similarity | 1 |
GO - Molecular functioni
- integrin binding Source: UniProtKB
- non-membrane spanning protein tyrosine phosphatase activity Source: Ensembl
- protein kinase binding Source: UniProtKB
- protein tyrosine phosphatase activity Source: UniProtKB
- receptor tyrosine kinase binding Source: UniProtKB
- STAT family protein binding Source: Ensembl
- syntaxin binding Source: UniProtKB
GO - Biological processi
- B cell differentiation Source: UniProtKB
- cellular response to cytokine stimulus Source: Reactome
- erythrocyte differentiation Source: UniProtKB
- glucose homeostasis Source: UniProtKB
- insulin receptor signaling pathway Source: UniProtKB
- negative regulation of cell population proliferation Source: UniProtKB
- negative regulation of chemotaxis Source: UniProtKB
- negative regulation of epidermal growth factor receptor signaling pathway Source: UniProtKB
- negative regulation of ERK1 and ERK2 cascade Source: UniProtKB
- negative regulation of inflammatory response Source: UniProtKB
- negative regulation of insulin receptor signaling pathway Source: UniProtKB
- negative regulation of interferon-gamma-mediated signaling pathway Source: UniProtKB
- negative regulation of interleukin-2-mediated signaling pathway Source: UniProtKB
- negative regulation of interleukin-4-mediated signaling pathway Source: UniProtKB
- negative regulation of interleukin-6-mediated signaling pathway Source: UniProtKB
- negative regulation of lipid storage Source: UniProtKB
- negative regulation of macrophage colony-stimulating factor signaling pathway Source: UniProtKB
- negative regulation of macrophage differentiation Source: UniProtKB
- negative regulation of platelet-derived growth factor receptor-beta signaling pathway Source: UniProtKB
- negative regulation of positive thymic T cell selection Source: UniProtKB
- negative regulation of protein tyrosine kinase activity Source: Ensembl
- negative regulation of T cell receptor signaling pathway Source: UniProtKB
- negative regulation of transcription by RNA polymerase II Source: Ensembl
- negative regulation of tumor necrosis factor-mediated signaling pathway Source: UniProtKB
- negative regulation of type I interferon-mediated signaling pathway Source: UniProtKB
- negative regulation of tyrosine phosphorylation of STAT protein Source: UniProtKB
- peptidyl-tyrosine dephosphorylation Source: UniProtKB
- positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway Source: Ensembl
- positive regulation of gluconeogenesis Source: UniProtKB
- positive regulation of PERK-mediated unfolded protein response Source: Ensembl
- regulation of hepatocyte growth factor receptor signaling pathway Source: UniProtKB
- regulation of interferon-gamma-mediated signaling pathway Source: Reactome
- T cell differentiation Source: UniProtKB
Keywordsi
Molecular function | Hydrolase, Protein phosphatase |
Enzyme and pathway databases
BRENDAi | 3.1.3.48, 2681 |
PathwayCommonsi | P17706 |
Reactomei | R-HSA-6807004, Negative regulation of MET activity R-HSA-877312, Regulation of IFNG signaling [P17706-2] R-HSA-9008059, Interleukin-37 signaling |
SignaLinki | P17706 |
SIGNORi | P17706 |
Names & Taxonomyi
Protein namesi | Recommended name: Tyrosine-protein phosphatase non-receptor type 2 (EC:3.1.3.48)Alternative name(s): T-cell protein-tyrosine phosphatase Short name: TCPTP |
Gene namesi | Name:PTPN2 Synonyms:PTPT |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:9650, PTPN2 |
MIMi | 176887, gene |
neXtProti | NX_P17706 |
VEuPathDBi | HostDB:ENSG00000175354.18 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum 1 Publication
Other locations
- Endoplasmic reticulum-Golgi intermediate compartment 1 Publication
Note: Targeted to the endoplasmic reticulum by its C-terminal hydrophobic region.1 Publication
Nucleus
Plasma membrane
Other locations
Note: Predominantly localizes to chromatin (By similarity). Able to shuttle between the nucleus and the cytoplasm and to dephosphorylate plasma membrane receptors (PubMed:9488479). Recruited by activated ITGA1 at the plasma membrane.By similarity1 Publication
Cytosol
- cytosol Source: HPA
Endoplasmic reticulum
- endoplasmic reticulum Source: UniProtKB
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- endoplasmic reticulum-Golgi intermediate compartment Source: UniProtKB
Keywords - Cellular componenti
Cell membrane, Cytoplasm, Endoplasmic reticulum, Membrane, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 182 | D → A: Substrate-trapping mutant; catalytically inactive it forms a stable complex with physiological substrates including INSR and EGFR. Accumulates in the cytoplasm upon stimulation by insulin or EGF; isoform 2. 2 Publications | 1 | |
Mutagenesisi | 222 | R → M: Impairs phosphatase activity. | 1 | |
Mutagenesisi | 304 | S → A: Alters phosphorylation by cyclin-dependent kinases of isoform 2 but has no effect on its phosphatase activity. 1 Publication | 1 | |
Mutagenesisi | 350 – 352 | RKR → QQQ: Alters location to the endoplasmic reticulum; isoform 1. 1 Publication | 3 | |
Mutagenesisi | 380 | K → Q: Prevents location to the nucleus; isoform 2. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 5771 |
MalaCardsi | PTPN2 |
OpenTargetsi | ENSG00000175354 |
Orphaneti | 206, NON RARE IN EUROPE: Crohn disease 771, NON RARE IN EUROPE: Ulcerative colitis 85410, Oligoarticular juvenile idiopathic arthritis 85408, Rheumatoid factor-negative polyarticular juvenile idiopathic arthritis |
PharmGKBi | PA33993 |
Miscellaneous databases
Pharosi | P17706, Tchem |
Chemistry databases
ChEMBLi | CHEMBL3807 |
Genetic variation databases
BioMutai | PTPN2 |
DMDMi | 229462762 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000094752 | 1 – 415 | Tyrosine-protein phosphatase non-receptor type 2Add BLAST | 415 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Modified residuei | 22 | PhosphotyrosineBy similarity | 1 | ||
Modified residuei | 52 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 68 | PhosphotyrosineBy similarity | 1 | ||
Modified residuei | 216 | S-nitrosocysteineBy similarity | 1 | ||
Modified residuei | 293 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 298 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 304 | PhosphoserineCombined sources | 1 | ||
Isoform 2 (identifier: P17706-2) | |||||
Modified residuei | 304 | Phosphoserine1 Publication1 Publication | 1 |
Post-translational modificationi
Keywords - PTMi
Phosphoprotein, S-nitrosylationProteomic databases
EPDi | P17706 |
jPOSTi | P17706 |
MassIVEi | P17706 |
MaxQBi | P17706 |
PaxDbi | P17706 |
PeptideAtlasi | P17706 |
PRIDEi | P17706 |
ProteomicsDBi | 53507 [P17706-1] 53508 [P17706-2] 53509 [P17706-3] |
PTM databases
DEPODi | PTPN2 |
iPTMneti | P17706 |
MetOSitei | P17706 |
PhosphoSitePlusi | P17706 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000175354, Expressed in tendon of biceps brachii and 242 other tissues |
ExpressionAtlasi | P17706, baseline and differential |
Genevisiblei | P17706, HS |
Organism-specific databases
HPAi | ENSG00000175354, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with RMDN3.
Isoform 1 interacts with TMED9.
Isoform 1 interacts with STX17; dephosphorylates STX17.
Interacts with ITGA1 (via cytoplasmic domain); activates the phosphatase activity towards EGFR.
Interacts with TRAF2; probably involved in tumor necrosis factor-mediated signaling.
Interacts with MET.
7 PublicationsBinary interactionsi
Hide detailsP17706
With | #Exp. | IntAct |
---|---|---|
GHR [P10912] | 8 | EBI-984930,EBI-286316 |
Isoform 1 [P17706-1]
With | #Exp. | IntAct |
---|---|---|
TMED10 [P49755] | 5 | EBI-4409481,EBI-998422 |
TMED9 [Q9BVK6] | 5 | EBI-4409481,EBI-1056827 |
GO - Molecular functioni
- integrin binding Source: UniProtKB
- protein kinase binding Source: UniProtKB
- receptor tyrosine kinase binding Source: UniProtKB
- STAT family protein binding Source: Ensembl
- syntaxin binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 111737, 144 interactors |
CORUMi | P17706 |
IntActi | P17706, 36 interactors |
MINTi | P17706 |
STRINGi | 9606.ENSP00000311857 |
Chemistry databases
BindingDBi | P17706 |
Miscellaneous databases
RNActi | P17706, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P17706 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P17706 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 5 – 275 | Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd BLAST | 271 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 216 – 222 | Substrate bindingBy similarity | 7 | |
Regioni | 346 – 415 | Endoplasmic reticulum locationAdd BLAST | 70 | |
Regioni | 376 – 415 | Mediates interaction with STX171 PublicationAdd BLAST | 40 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0789, Eukaryota |
GeneTreei | ENSGT00940000154686 |
HOGENOMi | CLU_001645_9_0_1 |
InParanoidi | P17706 |
OMAi | RMISHFH |
OrthoDBi | 411281at2759 |
PhylomeDBi | P17706 |
TreeFami | TF315897 |
Family and domain databases
Gene3Di | 3.90.190.10, 1 hit |
InterProi | View protein in InterPro IPR029021, Prot-tyrosine_phosphatase-like IPR000242, PTPase_domain IPR012265, Ptpn1/Ptpn2 IPR016130, Tyr_Pase_AS IPR003595, Tyr_Pase_cat IPR000387, TYR_PHOSPHATASE_dom |
Pfami | View protein in Pfam PF00102, Y_phosphatase, 1 hit |
PIRSFi | PIRSF000926, Tyr-Ptase_nr1, 1 hit |
PRINTSi | PR00700, PRTYPHPHTASE |
SMARTi | View protein in SMART SM00194, PTPc, 1 hit SM00404, PTPc_motif, 1 hit |
SUPFAMi | SSF52799, SSF52799, 1 hit |
PROSITEi | View protein in PROSITE PS00383, TYR_PHOSPHATASE_1, 1 hit PS50056, TYR_PHOSPHATASE_2, 1 hit PS50055, TYR_PHOSPHATASE_PTP, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MPTTIEREFE ELDTQRRWQP LYLEIRNESH DYPHRVAKFP ENRNRNRYRD
60 70 80 90 100
VSPYDHSRVK LQNAENDYIN ASLVDIEEAQ RSYILTQGPL PNTCCHFWLM
110 120 130 140 150
VWQQKTKAVV MLNRIVEKES VKCAQYWPTD DQEMLFKETG FSVKLLSEDV
160 170 180 190 200
KSYYTVHLLQ LENINSGETR TISHFHYTTW PDFGVPESPA SFLNFLFKVR
210 220 230 240 250
ESGSLNPDHG PAVIHCSAGI GRSGTFSLVD TCLVLMEKGD DINIKQVLLN
260 270 280 290 300
MRKYRMGLIQ TPDQLRFSYM AIIEGAKCIK GDSSIQKRWK ELSKEDLSPA
310 320 330 340 350
FDHSPNKIMT EKYNGNRIGL EEEKLTGDRC TGLSSKMQDT MEENSESALR
360 370 380 390 400
KRIREDRKAT TAQKVQQMKQ RLNENERKRK RWLYWQPILT KMGFMSVILV
410
GAFVGWTLFF QQNAL
The sequence of this isoform differs from the canonical sequence as follows:
382-415: WLYWQPILTKMGFMSVILVGAFVGWTLFFQQNAL → PRLTDT
Computationally mapped potential isoform sequencesi
There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketK7EQG9 | K7EQG9_HUMAN | Tyrosine-protein phosphatase non-re... | PTPN2 | 386 | Annotation score: | ||
D3DUJ3 | D3DUJ3_HUMAN | Protein tyrosine phosphatase, non-r... | PTPN2 hCG_1999834 | 316 | Annotation score: | ||
K7ENP9 | K7ENP9_HUMAN | Tyrosine-protein phosphatase non-re... | PTPN2 | 146 | Annotation score: | ||
K7EIY0 | K7EIY0_HUMAN | Tyrosine-protein phosphatase non-re... | PTPN2 | 112 | Annotation score: | ||
K7EIE9 | K7EIE9_HUMAN | Tyrosine-protein phosphatase non-re... | PTPN2 | 151 | Annotation score: | ||
K7ERU1 | K7ERU1_HUMAN | Tyrosine-protein phosphatase non-re... | PTPN2 | 42 | Annotation score: | ||
K7ELS9 | K7ELS9_HUMAN | Tyrosine-protein phosphatase non-re... | PTPN2 | 68 | Annotation score: | ||
K7ER87 | K7ER87_HUMAN | Tyrosine-protein phosphatase non-re... | PTPN2 | 165 | Annotation score: | ||
A0A2R8YD79 | A0A2R8YD79_HUMAN | Tyrosine-protein phosphatase non-re... | PTPN2 | 166 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 407 | T → R in AAA65997 (PubMed:2546150).Curated | 1 | |
Sequence conflicti | 407 | T → R in M81478 (PubMed:1731319).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_054821 | 165 | N → NYIENLWITLYLKLLMLDVK RSLK in isoform 4. Curated | 1 | |
Alternative sequenceiVSP_043383 | 347 – 380 | Missing in isoform 3. 1 PublicationAdd BLAST | 34 | |
Alternative sequenceiVSP_005125 | 382 – 415 | WLYWQ…QQNAL → PRLTDT in isoform 2, isoform 3 and isoform 4. 2 PublicationsAdd BLAST | 34 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M25393 mRNA Translation: AAA65997.1 AK292570 mRNA Translation: BAF85259.1 EF445017 Genomic DNA Translation: ACA06062.1 EF445017 Genomic DNA Translation: ACA06064.1 AP001077 Genomic DNA No translation available. AP002449 Genomic DNA No translation available. AP005482 Genomic DNA No translation available. CH471113 Genomic DNA Translation: EAX01532.1 CH471113 Genomic DNA Translation: EAX01539.1 BC008244 mRNA Translation: AAH08244.1 BC016727 mRNA Translation: AAH16727.1 M81478 mRNA No translation available. |
CCDSi | CCDS11863.1 [P17706-2] CCDS11864.1 [P17706-3] CCDS11865.1 [P17706-1] CCDS59306.1 [P17706-4] |
PIRi | A33899 |
RefSeqi | NP_001193942.1, NM_001207013.1 [P17706-4] NP_002819.2, NM_002828.3 [P17706-1] NP_536347.1, NM_080422.2 [P17706-2] NP_536348.1, NM_080423.2 [P17706-3] |
Genome annotation databases
Ensembli | ENST00000309660; ENSP00000311857; ENSG00000175354 [P17706-1] ENST00000327283; ENSP00000320298; ENSG00000175354 [P17706-2] ENST00000353319; ENSP00000320546; ENSG00000175354 [P17706-3] ENST00000591115; ENSP00000466936; ENSG00000175354 [P17706-4] |
GeneIDi | 5771 |
KEGGi | hsa:5771 |
UCSCi | uc002krl.4, human [P17706-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M25393 mRNA Translation: AAA65997.1 AK292570 mRNA Translation: BAF85259.1 EF445017 Genomic DNA Translation: ACA06062.1 EF445017 Genomic DNA Translation: ACA06064.1 AP001077 Genomic DNA No translation available. AP002449 Genomic DNA No translation available. AP005482 Genomic DNA No translation available. CH471113 Genomic DNA Translation: EAX01532.1 CH471113 Genomic DNA Translation: EAX01539.1 BC008244 mRNA Translation: AAH08244.1 BC016727 mRNA Translation: AAH16727.1 M81478 mRNA No translation available. |
CCDSi | CCDS11863.1 [P17706-2] CCDS11864.1 [P17706-3] CCDS11865.1 [P17706-1] CCDS59306.1 [P17706-4] |
PIRi | A33899 |
RefSeqi | NP_001193942.1, NM_001207013.1 [P17706-4] NP_002819.2, NM_002828.3 [P17706-1] NP_536347.1, NM_080422.2 [P17706-2] NP_536348.1, NM_080423.2 [P17706-3] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1L8K | X-ray | 2.56 | A | 1-314 | [»] | |
SMRi | P17706 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 111737, 144 interactors |
CORUMi | P17706 |
IntActi | P17706, 36 interactors |
MINTi | P17706 |
STRINGi | 9606.ENSP00000311857 |
Chemistry databases
BindingDBi | P17706 |
ChEMBLi | CHEMBL3807 |
PTM databases
DEPODi | PTPN2 |
iPTMneti | P17706 |
MetOSitei | P17706 |
PhosphoSitePlusi | P17706 |
Genetic variation databases
BioMutai | PTPN2 |
DMDMi | 229462762 |
Proteomic databases
EPDi | P17706 |
jPOSTi | P17706 |
MassIVEi | P17706 |
MaxQBi | P17706 |
PaxDbi | P17706 |
PeptideAtlasi | P17706 |
PRIDEi | P17706 |
ProteomicsDBi | 53507 [P17706-1] 53508 [P17706-2] 53509 [P17706-3] |
Protocols and materials databases
Antibodypediai | 6936, 290 antibodies |
CPTCi | P17706, 1 antibody |
DNASUi | 5771 |
Genome annotation databases
Ensembli | ENST00000309660; ENSP00000311857; ENSG00000175354 [P17706-1] ENST00000327283; ENSP00000320298; ENSG00000175354 [P17706-2] ENST00000353319; ENSP00000320546; ENSG00000175354 [P17706-3] ENST00000591115; ENSP00000466936; ENSG00000175354 [P17706-4] |
GeneIDi | 5771 |
KEGGi | hsa:5771 |
UCSCi | uc002krl.4, human [P17706-1] |
Organism-specific databases
CTDi | 5771 |
DisGeNETi | 5771 |
GeneCardsi | PTPN2 |
HGNCi | HGNC:9650, PTPN2 |
HPAi | ENSG00000175354, Low tissue specificity |
MalaCardsi | PTPN2 |
MIMi | 176887, gene |
neXtProti | NX_P17706 |
OpenTargetsi | ENSG00000175354 |
Orphaneti | 206, NON RARE IN EUROPE: Crohn disease 771, NON RARE IN EUROPE: Ulcerative colitis 85410, Oligoarticular juvenile idiopathic arthritis 85408, Rheumatoid factor-negative polyarticular juvenile idiopathic arthritis |
PharmGKBi | PA33993 |
VEuPathDBi | HostDB:ENSG00000175354.18 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0789, Eukaryota |
GeneTreei | ENSGT00940000154686 |
HOGENOMi | CLU_001645_9_0_1 |
InParanoidi | P17706 |
OMAi | RMISHFH |
OrthoDBi | 411281at2759 |
PhylomeDBi | P17706 |
TreeFami | TF315897 |
Enzyme and pathway databases
BRENDAi | 3.1.3.48, 2681 |
PathwayCommonsi | P17706 |
Reactomei | R-HSA-6807004, Negative regulation of MET activity R-HSA-877312, Regulation of IFNG signaling [P17706-2] R-HSA-9008059, Interleukin-37 signaling |
SignaLinki | P17706 |
SIGNORi | P17706 |
Miscellaneous databases
BioGRID-ORCSi | 5771, 19 hits in 883 CRISPR screens |
ChiTaRSi | PTPN2, human |
EvolutionaryTracei | P17706 |
GeneWikii | PTPN2 |
GenomeRNAii | 5771 |
Pharosi | P17706, Tchem |
PROi | PR:P17706 |
RNActi | P17706, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000175354, Expressed in tendon of biceps brachii and 242 other tissues |
ExpressionAtlasi | P17706, baseline and differential |
Genevisiblei | P17706, HS |
Family and domain databases
Gene3Di | 3.90.190.10, 1 hit |
InterProi | View protein in InterPro IPR029021, Prot-tyrosine_phosphatase-like IPR000242, PTPase_domain IPR012265, Ptpn1/Ptpn2 IPR016130, Tyr_Pase_AS IPR003595, Tyr_Pase_cat IPR000387, TYR_PHOSPHATASE_dom |
Pfami | View protein in Pfam PF00102, Y_phosphatase, 1 hit |
PIRSFi | PIRSF000926, Tyr-Ptase_nr1, 1 hit |
PRINTSi | PR00700, PRTYPHPHTASE |
SMARTi | View protein in SMART SM00194, PTPc, 1 hit SM00404, PTPc_motif, 1 hit |
SUPFAMi | SSF52799, SSF52799, 1 hit |
PROSITEi | View protein in PROSITE PS00383, TYR_PHOSPHATASE_1, 1 hit PS50056, TYR_PHOSPHATASE_2, 1 hit PS50055, TYR_PHOSPHATASE_PTP, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PTN2_HUMAN | |
Accessioni | P17706Primary (citable) accession number: P17706 Secondary accession number(s): A8K955 Q96HR2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1990 |
Last sequence update: | May 5, 2009 | |
Last modified: | February 10, 2021 | |
This is version 213 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 18
Human chromosome 18: entries, gene names and cross-references to MIM