PTPN2

Functionⁱ

Non-receptor type tyrosine-specific phosphatase that dephosphorylates receptor protein tyrosine kinases including INSR, EGFR, CSF1R, PDGFR. Also dephosphorylates non-receptor protein tyrosine kinases like JAK1, JAK2, JAK3, Src family kinases, STAT1, STAT3 and STAT6 either in the nucleus or the cytoplasm. Negatively regulates numerous signaling pathways and biological processes like hematopoiesis, inflammatory response, cell proliferation and differentiation, and glucose homeostasis. Plays a multifaceted and important role in the development of the immune system. Functions in T-cell receptor signaling through dephosphorylation of FYN and LCK to control T-cells differentiation and activation. Dephosphorylates CSF1R, negatively regulating its downstream signaling and macrophage differentiation. Negatively regulates cytokine (IL2/interleukin-2 and interferon)-mediated signaling through dephosphorylation of the cytoplasmic kinases JAK1, JAK3 and their substrate STAT1, that propagate signaling downstream of the cytokine receptors. Also regulates the IL6/interleukin-6 and IL4/interleukin-4 cytokine signaling through dephosphorylation of STAT3 and STAT6 respectively. In addition to the immune system, it is involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth. Activated by the integrin ITGA1/ITGB1, it dephosphorylates EGFR and negatively regulates EGF signaling. Dephosphorylates PDGFRB and negatively regulates platelet-derived growth factor receptor-beta signaling pathway and therefore cell proliferation. Negatively regulates tumor necrosis factor-mediated signaling downstream via MAPK through SRC dephosphorylation. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of the hepatocyte growth factor receptor MET. Plays also an important role in glucose homeostasis. For instance, negatively regulates the insulin receptor signaling pathway through the dephosphorylation of INSR and control gluconeogenesis and liver glucose production through negative regulation of the IL6 signaling pathways. May also bind DNA.9 Publications

Catalytic activityⁱ

Protein tyrosine phosphate + H₂O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Kineticsⁱ

K_M=
0.48 mM for p-nitrophenyl phosphate (at pH 6.5 and 25 degrees Celsius)
1 Publication
Manual assertion based on experiment inⁱ
- Ref.33
  "Structure determination of T cell protein-tyrosine phosphatase."
  Iversen L.F., Moller K.B., Pedersen A.K., Peters G.H., Petersen A.S., Andersen H.S., Branner S., Mortensen S.B., Moller N.P.
  J. Biol. Chem. 277:19982-19990(2002) [PubMed] [Europe PMC] [Abstract]
  Cited for: X-RAY CRYSTALLOGRAPHY (2.56 ANGSTROMS) OF 1-314, BIOPHYSICOCHEMICAL PROPERTIES.

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	182	SubstrateBy similarity	1
Active siteⁱ	216	Phosphocysteine intermediatePROSITE-ProRule annotation	1
Binding siteⁱ	260	SubstrateBy similarity	1

GO - Molecular functionⁱ

integrin binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 15592458
non-membrane spanning protein tyrosine phosphatase activity Source: Ensembl
protein kinase binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 11909529
- 15696169
protein tyrosine phosphatase activity
Source: UniProtKB
Inferred from direct assayⁱ
receptor tyrosine kinase binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 18819921
STAT family protein binding Source: Ensembl
syntaxin binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 23006999

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

B cell differentiation Source: UniProtKB
cellular response to cytokine stimulus Source: Reactome
erythrocyte differentiation Source: UniProtKB
glucose homeostasis Source: UniProtKB
insulin receptor signaling pathway Source: UniProtKB
negative regulation of cell proliferation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 15592458
negative regulation of chemotaxis Source: UniProtKB
negative regulation of epidermal growth factor receptor signaling pathway
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 15592458
negative regulation of ERK1 and ERK2 cascade Source: UniProtKB
negative regulation of inflammatory response Source: UniProtKB
negative regulation of insulin receptor signaling pathway Source: UniProtKB
negative regulation of interferon-gamma-mediated signaling pathway Source: UniProtKB
negative regulation of interleukin-2-mediated signaling pathway
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 11909529
negative regulation of interleukin-4-mediated signaling pathway
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 17210636
negative regulation of interleukin-6-mediated signaling pathway
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 12359225
negative regulation of lipid storage Source: UniProtKB
negative regulation of macrophage colony-stimulating factor signaling pathway Source: UniProtKB
negative regulation of macrophage differentiation Source: UniProtKB
negative regulation of platelet-derived growth factor receptor-beta signaling pathway Source: UniProtKB
negative regulation of positive thymic T cell selection Source: UniProtKB
negative regulation of protein tyrosine kinase activity Source: Ensembl
negative regulation of T cell receptor signaling pathway Source: UniProtKB
negative regulation of transcription by RNA polymerase II Source: Ensembl
negative regulation of tumor necrosis factor-mediated signaling pathway Source: UniProtKB
negative regulation of type I interferon-mediated signaling pathway
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 11909529
negative regulation of tyrosine phosphorylation of STAT protein
Source: UniProtKB
Inferred from direct assayⁱ
- 12359225
peptidyl-tyrosine dephosphorylation
Source: UniProtKB
Inferred from direct assayⁱ
- 12138178
positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway Source: Ensembl
positive regulation of gluconeogenesis Source: UniProtKB
positive regulation of PERK-mediated unfolded protein response Source: Ensembl
regulation of hepatocyte growth factor receptor signaling pathway
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 18819921
regulation of interferon-gamma-mediated signaling pathway Source: Reactome
T cell differentiation Source: UniProtKB

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hydrolase, Protein phosphatase

Molecular function

Hydrolase, Protein phosphatase

Enzyme and pathway databases

BRENDAⁱ	3.1.3.48 2681
Reactomeⁱ	R-HSA-6807004 Negative regulation of MET activity R-HSA-877312 Regulation of IFNG signaling R-HSA-9008059 Interleukin-37 signaling
SignaLinkⁱ	P17706
SIGNORⁱ	P17706

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Tyrosine-protein phosphatase non-receptor type 2 (EC:3.1.3.48) Alternative name(s): T-cell protein-tyrosine phosphatase Short name: TCPTP
Gene namesⁱ	Name:PTPN2 Synonyms:PTPT
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 18

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000175354.18
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:9650 PTPN2
MIMⁱ	176887 gene
neXtProtⁱ	NX_P17706

Keywords - Cellular componentⁱ

Cell membrane, Cytoplasm, Endoplasmic reticulum, Membrane, Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	182	D → A: Substrate-trapping mutant; catalytically inactive it forms a stable complex with physiological substrates including INSR and EGFR. Accumulates in the cytoplasm upon stimulation by insulin or EGF; isoform 2. 2 Publications	1
Mutagenesisⁱ	222	R → M: Impairs phosphatase activity.	1
Mutagenesisⁱ	304	S → A: Alters phosphorylation by cyclin-dependent kinases of isoform 2 but has no effect on its phosphatase activity. 1 Publication	1
Mutagenesisⁱ	350 – 352	RKR → QQQ: Alters location to the endoplasmic reticulum; isoform 1. 1 Publication	3
Mutagenesisⁱ	380	K → Q: Prevents location to the nucleus; isoform 2. 1 Publication	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	5771
MalaCards human disease database More...MalaCardsⁱ	PTPN2
Open Targets More...OpenTargetsⁱ	ENSG00000175354
Orphanetⁱ	206 Crohn disease 85408 Juvenile rheumatoid factor-negative polyarthritis 85410 Oligoarticular juvenile arthritis 771 Ulcerative colitis
PharmGKBⁱ	PA33993

Chemistry databases

ChEMBLⁱ	CHEMBL3807

ChEMBLⁱ

CHEMBL3807

Polymorphism and mutation databases

BioMutaⁱ	PTPN2
DMDMⁱ	229462762

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000094752	1 – 415	Tyrosine-protein phosphatase non-receptor type 2Add BLAST		415

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	22	PhosphotyrosineBy similarity	1
Modified residueⁱ	52	PhosphoserineBy similarity	1
Modified residueⁱ	68	PhosphotyrosineBy similarity	1
Modified residueⁱ	216	S-nitrosocysteineBy similarity	1
Modified residueⁱ	293	PhosphoserineCombined sources	1
Modified residueⁱ	298	PhosphoserineCombined sources	1
Modified residueⁱ	304	PhosphoserineCombined sources	1
Isoform 2 (identifier: P17706-2)
Modified residueⁱ	304	Phosphoserine1 Publication1 Publication	1

Post-translational modificationⁱ

Isoform 2: Specifically phosphorylated in a cell cycle-dependent manner by cyclin-dependent kinases CDK1 and CDK2. Probably activated through phosphorylation by PKR.2 Publications

Keywords - PTMⁱ

Phosphoprotein, S-nitrosylation

Proteomic databases

EPDⁱ	P17706
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P17706
PaxDbⁱ	P17706
PeptideAtlas More...PeptideAtlasⁱ	P17706
PRIDEⁱ	P17706
ProteomicsDBⁱ	53507 53508 [P17706-2] 53509 [P17706-3]

PTM databases

DEPODⁱ	P17706
iPTMnetⁱ	P17706
PhosphoSitePlusⁱ	P17706

Expressionⁱ

Tissue specificityⁱ

Ubiquitously expressed. Isoform 2 is probably the major isoform. Isoform 1 is expressed in T-cells and in placenta.2 Publications

Inductionⁱ

Up-regulated by IL4/interleukin-4 (at protein level).1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000175354 Expressed in 231 organ(s), highest expression level in tendon of biceps brachii
CleanExⁱ	HS_PTPN2
ExpressionAtlasⁱ	P17706 baseline and differential
Genevisibleⁱ	P17706 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA015004 HPA046176

HPAⁱ

HPA015004
HPA046176

Interactionⁱ

Subunit structureⁱ

Interacts with RMDN3. Isoform 1 interacts with TMED9. Isoform 1 interacts with STX17; dephosphorylates STX17. Interacts with ITGA1 (via cytoplasmic domain); activates the phosphatase activity towards EGFR. Interacts with TRAF2; probably involved in tumor necrosis factor-mediated signaling. Interacts with MET.7 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
GHR	P10912	8	EBI-984930,EBI-286316
TMED10	P49755	5	EBI-4409481,EBI-998422
TMED9	Q9BVK6	5	EBI-4409481,EBI-1056827

GO - Molecular functionⁱ

integrin binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 15592458
protein kinase binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 11909529
- 15696169
receptor tyrosine kinase binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 18819921
STAT family protein binding Source: Ensembl
syntaxin binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 23006999

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	111737, 90 interactors
CORUMⁱ	P17706
IntActⁱ	P17706, 26 interactors
Molecular INTeraction database More...MINTⁱ	P17706
STRINGⁱ	9606.ENSP00000311857

Chemistry databases

BindingDBⁱ	P17706

BindingDBⁱ

P17706

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	7 – 14	Combined sources	8
Helixⁱ	19 – 28	Combined sources	10
Helixⁱ	35 – 38	Combined sources	4
Helixⁱ	40 – 45	Combined sources	6
Turnⁱ	55 – 57	Combined sources	3
Beta strandⁱ	58 – 60	Combined sources	3
Beta strandⁱ	68 – 76	Combined sources	9
Helixⁱ	77 – 79	Combined sources	3
Beta strandⁱ	81 – 87	Combined sources	7
Turnⁱ	91 – 93	Combined sources	3
Helixⁱ	94 – 103	Combined sources	10
Beta strandⁱ	108 – 111	Combined sources	4
Beta strandⁱ	129 – 132	Combined sources	4
Beta strandⁱ	134 – 136	Combined sources	3
Turnⁱ	137 – 140	Combined sources	4
Beta strandⁱ	141 – 150	Combined sources	10
Beta strandⁱ	152 – 163	Combined sources	12
Turnⁱ	164 – 166	Combined sources	3
Beta strandⁱ	169 – 177	Combined sources	9
Beta strandⁱ	182 – 184	Combined sources	3
Helixⁱ	190 – 201	Combined sources	12
Turnⁱ	202 – 205	Combined sources	4
Beta strandⁱ	212 – 221	Combined sources	10
Helixⁱ	222 – 235	Combined sources	14
Beta strandⁱ	236 – 239	Combined sources	4
Helixⁱ	244 – 251	Combined sources	8
Turnⁱ	252 – 254	Combined sources	3
Helixⁱ	262 – 275	Combined sources	14

Show more details

3D structure databases

ProteinModelPortalⁱ	P17706
SMRⁱ	P17706
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P17706

EvolutionaryTraceⁱ

P17706

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	5 – 275	Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd BLAST		271

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	216 – 222	Substrate bindingBy similarity	7
Regionⁱ	346 – 415	Endoplasmic reticulum locationAdd BLAST	70
Regionⁱ	376 – 415	Mediates interaction with STX171 PublicationAdd BLAST	40

Sequence similaritiesⁱ

Belongs to the protein-tyrosine phosphatase family. Non-receptor class 1 subfamily.Curated

Phylogenomic databases

eggNOGⁱ	KOG0789 Eukaryota COG5599 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00900000140785
HOGENOMⁱ	HOG000273908
HOVERGENⁱ	HBG008321
InParanoidⁱ	P17706
KEGG Orthology (KO) More...KOⁱ	K18026
OMAⁱ	WQQLYLE
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G082B
PhylomeDBⁱ	P17706
TreeFamⁱ	TF315897

Family and domain databases

Gene3Dⁱ	3.90.190.10, 1 hit
InterProⁱ	View protein in InterPro IPR029021 Prot-tyrosine_phosphatase-like IPR000242 PTPase_domain IPR012265 Ptpn1/Ptpn2 IPR016130 Tyr_Pase_AS IPR003595 Tyr_Pase_cat IPR000387 TYR_PHOSPHATASE_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00102 Y_phosphatase, 1 hit
PIRSFⁱ	PIRSF000926 Tyr-Ptase_nr1, 1 hit
PRINTSⁱ	PR00700 PRTYPHPHTASE
SMARTⁱ	View protein in SMART SM00194 PTPc, 1 hit SM00404 PTPc_motif, 1 hit
SUPFAMⁱ	SSF52799 SSF52799, 1 hit
PROSITEⁱ	View protein in PROSITE PS00383 TYR_PHOSPHATASE_1, 1 hit PS50056 TYR_PHOSPHATASE_2, 1 hit PS50055 TYR_PHOSPHATASE_PTP, 1 hit

Sequences (4+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 4 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 4 described isoforms and 9 potential isoforms that are computationally mapped.ⁱShow all

Isoform 1 (identifier: P17706-1) [UniParc]FASTA Add to basket

Also known as: PTPB, p48TC, TC48, TC-PTPb

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPTTIEREFE ELDTQRRWQP LYLEIRNESH DYPHRVAKFP ENRNRNRYRD 
        60         70         80         90        100
VSPYDHSRVK LQNAENDYIN ASLVDIEEAQ RSYILTQGPL PNTCCHFWLM 
       110        120        130        140        150
VWQQKTKAVV MLNRIVEKES VKCAQYWPTD DQEMLFKETG FSVKLLSEDV 
       160        170        180        190        200
KSYYTVHLLQ LENINSGETR TISHFHYTTW PDFGVPESPA SFLNFLFKVR 
       210        220        230        240        250
ESGSLNPDHG PAVIHCSAGI GRSGTFSLVD TCLVLMEKGD DINIKQVLLN 
       260        270        280        290        300
MRKYRMGLIQ TPDQLRFSYM AIIEGAKCIK GDSSIQKRWK ELSKEDLSPA 
       310        320        330        340        350
FDHSPNKIMT EKYNGNRIGL EEEKLTGDRC TGLSSKMQDT MEENSESALR 
       360        370        380        390        400
KRIREDRKAT TAQKVQQMKQ RLNENERKRK RWLYWQPILT KMGFMSVILV 
       410 
GAFVGWTLFF QQNAL

Note: Minor isoform.

Length:415

Mass (Da):48,473

Last modified:May 5, 2009 - v2

Checksum:ⁱ0207694A4F058E68

GO

Isoform 2 (identifier: P17706-2) [UniParc]FASTA Add to basket

Also known as: PTPA, p45TC, TC45, TC-PTPa

The sequence of this isoform differs from the canonical sequence as follows:
382-415: WLYWQPILTKMGFMSVILVGAFVGWTLFFQQNAL → PRLTDT

« Hide

        10         20         30         40         50
MPTTIEREFE ELDTQRRWQP LYLEIRNESH DYPHRVAKFP ENRNRNRYRD 
        60         70         80         90        100
VSPYDHSRVK LQNAENDYIN ASLVDIEEAQ RSYILTQGPL PNTCCHFWLM 
       110        120        130        140        150
VWQQKTKAVV MLNRIVEKES VKCAQYWPTD DQEMLFKETG FSVKLLSEDV 
       160        170        180        190        200
KSYYTVHLLQ LENINSGETR TISHFHYTTW PDFGVPESPA SFLNFLFKVR 
       210        220        230        240        250
ESGSLNPDHG PAVIHCSAGI GRSGTFSLVD TCLVLMEKGD DINIKQVLLN 
       260        270        280        290        300
MRKYRMGLIQ TPDQLRFSYM AIIEGAKCIK GDSSIQKRWK ELSKEDLSPA 
       310        320        330        340        350
FDHSPNKIMT EKYNGNRIGL EEEKLTGDRC TGLSSKMQDT MEENSESALR 
       360        370        380 
KRIREDRKAT TAQKVQQMKQ RLNENERKRK RPRLTDT

Note: Major isoform.1 Publication1 Publication Contains a nuclear location signal at positions 377-381 (PubMed:7593185) and an autoinhibitory region acting through intramolecular interactions is found at positions 353-387.1 Publication1 Publication

Show »

Length:387

Mass (Da):45,168

Checksum:ⁱ0F3E622EBA5A92CB

GO

Isoform 3 (identifier: P17706-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
347-380: Missing.
382-415: WLYWQPILTKMGFMSVILVGAFVGWTLFFQQNAL → PRLTDT

« Hide

        10         20         30         40         50
MPTTIEREFE ELDTQRRWQP LYLEIRNESH DYPHRVAKFP ENRNRNRYRD 
        60         70         80         90        100
VSPYDHSRVK LQNAENDYIN ASLVDIEEAQ RSYILTQGPL PNTCCHFWLM 
       110        120        130        140        150
VWQQKTKAVV MLNRIVEKES VKCAQYWPTD DQEMLFKETG FSVKLLSEDV 
       160        170        180        190        200
KSYYTVHLLQ LENINSGETR TISHFHYTTW PDFGVPESPA SFLNFLFKVR 
       210        220        230        240        250
ESGSLNPDHG PAVIHCSAGI GRSGTFSLVD TCLVLMEKGD DINIKQVLLN 
       260        270        280        290        300
MRKYRMGLIQ TPDQLRFSYM AIIEGAKCIK GDSSIQKRWK ELSKEDLSPA 
       310        320        330        340        350
FDHSPNKIMT EKYNGNRIGL EEEKLTGDRC TGLSSKMQDT MEENSERPRL 

TDT

Note: No experimental confirmation available.

Show »

Length:353

Mass (Da):40,990

Checksum:ⁱ5AE668EB7D76CB93

GO

Isoform 4 (identifier: P17706-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
165-165: N → NYIENLWITLYLKLLMLDVKRSLK
382-415: WLYWQPILTKMGFMSVILVGAFVGWTLFFQQNAL → PRLTDT

« Hide

        10         20         30         40         50
MPTTIEREFE ELDTQRRWQP LYLEIRNESH DYPHRVAKFP ENRNRNRYRD 
        60         70         80         90        100
VSPYDHSRVK LQNAENDYIN ASLVDIEEAQ RSYILTQGPL PNTCCHFWLM 
       110        120        130        140        150
VWQQKTKAVV MLNRIVEKES VKCAQYWPTD DQEMLFKETG FSVKLLSEDV 
       160        170        180        190        200
KSYYTVHLLQ LENINYIENL WITLYLKLLM LDVKRSLKSG ETRTISHFHY 
       210        220        230        240        250
TTWPDFGVPE SPASFLNFLF KVRESGSLNP DHGPAVIHCS AGIGRSGTFS 
       260        270        280        290        300
LVDTCLVLME KGDDINIKQV LLNMRKYRMG LIQTPDQLRF SYMAIIEGAK 
       310        320        330        340        350
CIKGDSSIQK RWKELSKEDL SPAFDHSPNK IMTEKYNGNR IGLEEEKLTG 
       360        370        380        390        400
DRCTGLSSKM QDTMEENSES ALRKRIREDR KATTAQKVQQ MKQRLNENER 
       410
KRKRPRLTDT

Note: No experimental confirmation available. Gene prediction based on cDNA data.

Show »

Length:410

Mass (Da):48,017

Checksum:ⁱD6463B9A0F952068

GO

Computationally mapped potential isoform sequencesⁱ

There are 9 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation
K7EQG9	K7EQG9_HUMAN	Tyrosine-protein phosphatase non-re... Tyrosine-protein phosphatase non-receptor type, EC 3.1.3.48	PTPN2	386	Annotation score:
K7ENP9	K7ENP9_HUMAN	Tyrosine-protein phosphatase Tyrosine-protein phosphatase, EC 3.1.3.48	PTPN2	146	Annotation score:
K7EIE9	K7EIE9_HUMAN	Tyrosine-protein phosphatase Tyrosine-protein phosphatase, EC 3.1.3.48	PTPN2	151	Annotation score:
K7EIY0	K7EIY0_HUMAN	Tyrosine-protein phosphatase Tyrosine-protein phosphatase, EC 3.1.3.48	PTPN2	112	Annotation score:
D3DUJ3	D3DUJ3_HUMAN	Tyrosine-protein phosphatase Tyrosine-protein phosphatase, EC 3.1.3.48	PTPN2 hCG_1999834	316	Annotation score:
K7ERU1	K7ERU1_HUMAN	Tyrosine-protein phosphatase Tyrosine-protein phosphatase, EC 3.1.3.48	PTPN2	42	Annotation score:
K7ER87	K7ER87_HUMAN	Tyrosine-protein phosphatase Tyrosine-protein phosphatase, EC 3.1.3.48	PTPN2	165	Annotation score:
K7ELS9	K7ELS9_HUMAN	Tyrosine-protein phosphatase Tyrosine-protein phosphatase, EC 3.1.3.48	PTPN2	68	Annotation score:
A0A2R8YD79	A0A2R8YD79_HUMAN	Tyrosine-protein phosphatase Tyrosine-protein phosphatase, EC 3.1.3.48	PTPN2	166	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	407	T → R in AAA65997 (PubMed:2546150).Curated		1
Sequence conflictⁱ	407	T → R in M81478 (PubMed:1731319).Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_054821	165	N → NYIENLWITLYLKLLMLDVK RSLK in isoform 4. Curated	1
Alternative sequenceⁱVSP_043383	347 – 380	Missing in isoform 3. 1 PublicationAdd BLAST	34
Alternative sequenceⁱVSP_005125	382 – 415	WLYWQ…QQNAL → PRLTDT in isoform 2, isoform 3 and isoform 4. 2 PublicationsAdd BLAST	34

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M25393 mRNA Translation: AAA65997.1 AK292570 mRNA Translation: BAF85259.1 EF445017 Genomic DNA Translation: ACA06062.1 EF445017 Genomic DNA Translation: ACA06064.1 AP001077 Genomic DNA No translation available. AP002449 Genomic DNA No translation available. AP005482 Genomic DNA No translation available. CH471113 Genomic DNA Translation: EAX01532.1 CH471113 Genomic DNA Translation: EAX01539.1 BC008244 mRNA Translation: AAH08244.1 BC016727 mRNA Translation: AAH16727.1 M81478 mRNA No translation available.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS11863.1 [P17706-2] CCDS11864.1 [P17706-3] CCDS11865.1 [P17706-1] CCDS59306.1 [P17706-4]
PIRⁱ	A33899
NCBI Reference Sequences More...RefSeqⁱ	NP_001193942.1, NM_001207013.1 [P17706-4] NP_002819.2, NM_002828.3 [P17706-1] NP_536347.1, NM_080422.2 [P17706-2] NP_536348.1, NM_080423.2 [P17706-3]
UniGeneⁱ	Hs.654527 Hs.663373

Genome annotation databases

Ensemblⁱ	ENST00000309660; ENSP00000311857; ENSG00000175354 [P17706-1] ENST00000327283; ENSP00000320298; ENSG00000175354 [P17706-2] ENST00000353319; ENSP00000320546; ENSG00000175354 [P17706-3] ENST00000591115; ENSP00000466936; ENSG00000175354 [P17706-4]
GeneIDⁱ	5771
KEGGⁱ	hsa:5771
UCSC genome browser More...UCSCⁱ	uc002krl.4 human [P17706-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P17706	Tyrosine-protein phosphatase non-receptor type		GORGO		415	UniRef100_P17706
Tyrosine-protein phosphatase		HUMAN		316
UPI0000112381		HUMAN		314
P17706-2	Tyrosine-protein phosphatase non-receptor type		HUMAN		387	UniRef100_A8K3N4
UPI0000141B6D		HUMAN		288

Protein	Similar proteins		Species	Score	Length	Source
P17706	Tyrosine-protein phosphatase non-receptor type		GORGO		415	UniRef90_P17706
Tyrosine-protein phosphatase		HUMAN		316
Tyrosine-protein phosphatase non-receptor type		PIG		447
Tyrosine-protein phosphatase non-receptor type		PANPA		424
Tyrosine-protein phosphatase non-receptor type		CANLF		416
+84
P17706-2	Tyrosine-protein phosphatase non-receptor type		BOVIN		388	UniRef90_A5D982
tyrosine-protein phosphatase non-receptor type 2 isoform X3		DELLE		474
tyrosine-protein phosphatase non-receptor type 2 isoform X5		PHYCD		474
tyrosine-protein phosphatase non-receptor type 2 isoform X1		TURTR		474
Tyrosine-protein phosphatase non-receptor type		ODORO		388
+64
P17706-3	Tyrosine-protein phosphatase non-receptor type		NOMLE		353	UniRef90_A0A2I3GXA4
Tyrosine-protein phosphatase non-receptor type		ODORO		354
Tyrosine-protein phosphatase non-receptor type		PANTR		353
Tyrosine-protein phosphatase non-receptor type		PANPA		353
Tyrosine-protein phosphatase non-receptor type		GORGO		353
+10
P17706-4	Tyrosine-protein phosphatase non-receptor type		CALJA		409	UniRef90_F7GM40
Tyrosine-protein phosphatase non-receptor type		SAIBB		411
Tyrosine-protein phosphatase non-receptor type		Cebus capucinus imitator		410
Tyrosine-protein phosphatase non-receptor type		AOTNA		410
Tyrosine-protein phosphatase non-receptor type		PANTR		410
+33

Protein	Similar proteins		Species	Score	Length	Source
P17706	Tyrosine-protein phosphatase non-receptor type 1	)	HUMAN		435	UniRef50_P18031
Tyrosine-protein phosphatase non-receptor type 1		MOUSE		432
Tyrosine-protein phosphatase non-receptor type 1		RAT		432
Tyrosine-protein phosphatase non-receptor type 1		CHICK		434
Tyrosine-protein phosphatase non-receptor type		PANTR		435
+590
P17706-2	Tyrosine-protein phosphatase non-receptor type		MELGA		431	UniRef50_G1N965
Tyrosine-protein phosphatase non-receptor type		SAIBB		419
Tyrosine-protein phosphatase non-receptor type		ODORO		354
Tyrosine-protein phosphatase non-receptor type		MACFA		353
Tyrosine-protein phosphatase non-receptor type		CERAT		353
+202
P17706-3	Tyrosine-protein phosphatase non-receptor type		MELGA		431	UniRef50_G1N965
Tyrosine-protein phosphatase non-receptor type		SAIBB		419
Tyrosine-protein phosphatase non-receptor type		ODORO		354
Tyrosine-protein phosphatase non-receptor type		MACFA		353
Tyrosine-protein phosphatase non-receptor type		CERAT		353
+202
P17706-4	Tyrosine-protein phosphatase non-receptor type		MELGA		431	UniRef50_G1N965
Tyrosine-protein phosphatase non-receptor type		SAIBB		419
Tyrosine-protein phosphatase non-receptor type		ODORO		354
Tyrosine-protein phosphatase non-receptor type		MACFA		353
Tyrosine-protein phosphatase non-receptor type		CERAT		353
+202

Entry informationⁱ

Entry nameⁱ	PTN2_HUMAN
Accessionⁱ	P17706Primary (citable) accession number: P17706 Secondary accession number(s): A8K955 , A8MXU3, K7ENG3, Q96AU5, Q96HR2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 1, 1990
	Last sequence update:	May 5, 2009
	Last modified:	September 12, 2018
	This is version 195 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

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UniProtKB - P17706 (PTN2_HUMAN)

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Tyrosine-protein phosphatase non-receptor type 2

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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Functionⁱ

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GO - Molecular functionⁱ

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Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Computationally mapped potential isoform sequencesⁱ

Keywords - Coding sequence diversityⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ