HLA-G

Functionⁱ

Involved in the presentation of foreign antigens to the immune system. Plays a role in maternal tolerance of the fetus by mediating protection from the deleterious effects of natural killer cells, cytotoxic T-lymphocytes, macrophages and mononuclear cells.

GO - Molecular functionⁱ

identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
peptide antigen binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
protein homodimerization activity
Source: UniProtKB
Inferred from direct assayⁱ
- 22802125
signaling receptor binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 22802125

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

antigen processing and presentation of endogenous peptide antigen via MHC class Ib
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent Source: Reactome
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent Source: Reactome
antigen processing and presentation of peptide antigen via MHC class I Source: Reactome
cellular defense response
Source: ProtInc
Traceable author statementⁱ
- 9539768
immune response
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
immune response-inhibiting cell surface receptor signaling pathway
Source: BHF-UCL
Inferred from direct assayⁱ
- 20702625
interferon-gamma-mediated signaling pathway Source: Reactome
negative regulation of dendritic cell differentiation
Source: BHF-UCL
Inferred from direct assayⁱ
- 20702625
negative regulation of immune response
Source: UniProtKB
Inferred by curatorⁱ
- 22802125
negative regulation of T cell proliferation
Source: BHF-UCL
Inferred from direct assayⁱ
- 20702625
positive regulation of interleukin-12 production
Source: BHF-UCL
Inferred from direct assayⁱ
- 20702625
positive regulation of regulatory T cell differentiation
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 20448110
positive regulation of T cell mediated cytotoxicity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of T cell tolerance induction
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 20448110
positive regulation of tolerance induction
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 22802125
regulation of immune response Source: Reactome
type I interferon signaling pathway Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Immunity

Biological process

Immunity

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1236974 ER-Phagosome pathway R-HSA-1236977 Endosomal/Vacuolar pathway R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-877300 Interferon gamma signaling R-HSA-909733 Interferon alpha/beta signaling R-HSA-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC
SIGNORⁱ	P17693

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: HLA class I histocompatibility antigen, alpha chain G Alternative name(s): HLA G antigen MHC class I antigen G
Gene namesⁱ	Name:HLA-G Synonyms:HLA-6.0, HLAG
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 6

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000204632.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:4964 HLA-G
MIMⁱ	142871 gene
neXtProtⁱ	NX_P17693

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	25 – 308	ExtracellularSequence analysisAdd BLAST	284
Transmembraneⁱ	309 – 332	HelicalSequence analysisAdd BLAST	24
Topological domainⁱ	333 – 338	CytoplasmicSequence analysis	6

Keywords - Cellular componentⁱ

Cell membrane, Membrane, MHC I, Secreted

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	66	C → S: Abolishes homodimerization. Does not affect binding of isoform 2 to LILRB2. 2 Publications		1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	3135
MalaCards human disease database More...MalaCardsⁱ	HLA-G
Open Targets More...OpenTargetsⁱ	ENSG00000204632
PharmGKBⁱ	PA35083

Polymorphism and mutation databases

BioMutaⁱ	HLA-G
DMDMⁱ	122132

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 24	Add BLAST		24
ChainⁱPRO_0000018886	25 – 338	HLA class I histocompatibility antigen, alpha chain GAdd BLAST		314

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	66	InterchainPROSITE-ProRule annotation1 Publication
Glycosylationⁱ	110	N-linked (GlcNAc...) asparagineBy similarity	1
Disulfide bondⁱ	125 ↔ 188	PROSITE-ProRule annotation1 Publication
Disulfide bondⁱ	227 ↔ 283	PROSITE-ProRule annotation1 Publication

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

EPDⁱ	P17693
PaxDbⁱ	P17693
PeptideAtlas More...PeptideAtlasⁱ	P17693
PRIDEⁱ	P17693
ProteomicsDBⁱ	53506

PTM databases

iPTMnetⁱ	P17693
PhosphoSitePlusⁱ	P17693
SwissPalmⁱ	P17693

Expressionⁱ

Tissue specificityⁱ

Expressed in trophoblasts. Expressed in fetal eye and thymus (PubMed:2336406). Also expressed in adult eye (PubMed:1570318). Isoform 4: Expressed in fetal first trimester trophoblasts (PubMed:7589701). Isoform 7: Expressed in first trimester, second trimester and term placenta, fetal liver, amniotic membrane, skin, cord blood and peripheral blood mononuclear cells (PubMed:11137219).4 Publications

Gene expression databases

Bgeeⁱ	ENSG00000204632 Expressed in 233 organ(s), highest expression level in blood
CleanExⁱ	HS_HLA-G
ExpressionAtlasⁱ	P17693 baseline and differential
Genevisibleⁱ	P17693 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB016158

HPAⁱ

CAB016158

Interactionⁱ

Subunit structureⁱ

Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Homodimer; disulfide-linked (PubMed:12454284, PubMed:16455647). Binds to LILRB1 and LILRB2 (PubMed:16455647). Isoform 2: Forms a non-disulfide-linked homodimer and interacts with LILRB2 (PubMed:28348268).3 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
itself		5	EBI-1043063,EBI-1043063
LILRB1	Q8NHL6	5	EBI-1043063,EBI-2805262
LILRB2	Q8N423	7	EBI-1043063,EBI-2816428

GO - Molecular functionⁱ

identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
protein homodimerization activity
Source: UniProtKB
Inferred from direct assayⁱ
- 22802125
signaling receptor binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 22802125

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	109380, 18 interactors
Database of interacting proteins More...DIPⁱ	DIP-46121N
IntActⁱ	P17693, 7 interactors
Molecular INTeraction database More...MINTⁱ	P17693
STRINGⁱ	9606.ENSP00000353472

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	27 – 36	Combined sources	10
Beta strandⁱ	41 – 43	Combined sources	3
Beta strandⁱ	45 – 52	Combined sources	8
Beta strandⁱ	55 – 61	Combined sources	7
Beta strandⁱ	64 – 66	Combined sources	3
Beta strandⁱ	70 – 73	Combined sources	4
Helixⁱ	74 – 76	Combined sources	3
Helixⁱ	81 – 108	Combined sources	28
Beta strandⁱ	113 – 115	Combined sources	3
Beta strandⁱ	118 – 132	Combined sources	15
Beta strandⁱ	134 – 142	Combined sources	9
Beta strandⁱ	145 – 150	Combined sources	6
Beta strandⁱ	157 – 161	Combined sources	5
Helixⁱ	162 – 173	Combined sources	12
Helixⁱ	176 – 185	Combined sources	10
Helixⁱ	187 – 198	Combined sources	12
Helixⁱ	200 – 203	Combined sources	4
Beta strandⁱ	210 – 218	Combined sources	9
Turnⁱ	219 – 221	Combined sources	3
Beta strandⁱ	222 – 235	Combined sources	14
Beta strandⁱ	238 – 243	Combined sources	6
Beta strandⁱ	246 – 248	Combined sources	3
Helixⁱ	249 – 251	Combined sources	3
Beta strandⁱ	261 – 263	Combined sources	3
Beta strandⁱ	265 – 274	Combined sources	10
Helixⁱ	278 – 280	Combined sources	3
Beta strandⁱ	281 – 286	Combined sources	6
Beta strandⁱ	290 – 292	Combined sources	3
Beta strandⁱ	294 – 296	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	P17693
SMRⁱ	P17693
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P17693

EvolutionaryTraceⁱ

P17693

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	209 – 299	Ig-like C1-typeAdd BLAST		91

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	25 – 114	Alpha-1Add BLAST	90
Regionⁱ	115 – 206	Alpha-2Add BLAST	92
Regionⁱ	207 – 298	Alpha-3Add BLAST	92
Regionⁱ	299 – 308	Connecting peptide	10

Sequence similaritiesⁱ

Belongs to the MHC class I family.Curated

Keywords - Domainⁱ

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410II5V Eukaryota ENOG4111K8F LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118960
HOVERGENⁱ	HBG016709
InParanoidⁱ	P17693
KEGG Orthology (KO) More...KOⁱ	K06751
PhylomeDBⁱ	P17693
TreeFamⁱ	TF336617

Family and domain databases

Gene3Dⁱ	2.60.40.10, 1 hit 3.30.500.10, 1 hit
InterProⁱ	View protein in InterPro IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR003006 Ig/MHC_CS IPR003597 Ig_C1-set IPR011161 MHC_I-like_Ag-recog IPR037055 MHC_I-like_Ag-recog_sf IPR011162 MHC_I/II-like_Ag-recog IPR001039 MHC_I_a_a1/a2
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07654 C1-set, 1 hit PF00129 MHC_I, 1 hit
PRINTSⁱ	PR01638 MHCCLASSI
SMARTⁱ	View protein in SMART SM00407 IGc1, 1 hit
SUPFAMⁱ	SSF48726 SSF48726, 1 hit SSF54452 SSF54452, 1 hit
PROSITEⁱ	View protein in PROSITE PS50835 IG_LIKE, 1 hit PS00290 IG_MHC, 1 hit

Sequences (7+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 7 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 7 described isoforms and 5 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P17693-1) [UniParc]FASTA Add to basket

Also known as: HLA-G11 Publication

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVVMAPRTLF LLLSGALTLT ETWAGSHSMR YFSAAVSRPG RGEPRFIAMG 
        60         70         80         90        100
YVDDTQFVRF DSDSACPRME PRAPWVEQEG PEYWEEETRN TKAHAQTDRM 
       110        120        130        140        150
NLQTLRGYYN QSEASSHTLQ WMIGCDLGSD GRLLRGYEQY AYDGKDYLAL 
       160        170        180        190        200
NEDLRSWTAA DTAAQISKRK CEAANVAEQR RAYLEGTCVE WLHRYLENGK 
       210        220        230        240        250
EMLQRADPPK THVTHHPVFD YEATLRCWAL GFYPAEIILT WQRDGEDQTQ 
       260        270        280        290        300
DVELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PEPLMLRWKQ 
       310        320        330 
SSLPTIPIMG IVAGLVVLAA VVTGAAVAAV LWRKKSSD

Length:338

Mass (Da):38,224

Last modified:August 1, 1990 - v1

Checksum:ⁱ0678E263BE8962FF

GO

Isoform 2 (identifier: P17693-2) [UniParc]FASTA Add to basket

Also known as: HLA-G21 Publication

The sequence of this isoform differs from the canonical sequence as follows:
115-206: Missing.
207-207: D → K

« Hide

        10         20         30         40         50
MVVMAPRTLF LLLSGALTLT ETWAGSHSMR YFSAAVSRPG RGEPRFIAMG 
        60         70         80         90        100
YVDDTQFVRF DSDSACPRME PRAPWVEQEG PEYWEEETRN TKAHAQTDRM 
       110        120        130        140        150
NLQTLRGYYN QSEAKPPKTH VTHHPVFDYE ATLRCWALGF YPAEIILTWQ 
       160        170        180        190        200
RDGEDQTQDV ELVETRPAGD GTFQKWAAVV VPSGEEQRYT CHVQHEGLPE 
       210        220        230        240 
PLMLRWKQSS LPTIPIMGIV AGLVVLAAVV TGAAVAAVLW RKKSSD

Show »

Length:246

Mass (Da):27,694

Checksum:ⁱC9B5A82501274909

GO

Isoform 3 (identifier: P17693-3) [UniParc]FASTA Add to basket

Also known as: HLA-G31 Publication

The sequence of this isoform differs from the canonical sequence as follows:
115-298: Missing.

« Hide

        10         20         30         40         50
MVVMAPRTLF LLLSGALTLT ETWAGSHSMR YFSAAVSRPG RGEPRFIAMG 
        60         70         80         90        100
YVDDTQFVRF DSDSACPRME PRAPWVEQEG PEYWEEETRN TKAHAQTDRM 
       110        120        130        140        150
NLQTLRGYYN QSEAKQSSLP TIPIMGIVAG LVVLAAVVTG AAVAAVLWRK 

KSSD

Show »

Length:154

Mass (Da):17,070

Checksum:ⁱCECFCC7616238134

GO

Isoform 4 (identifier: P17693-4) [UniParc]FASTA Add to basket

Also known as: HLA-G.3-51 Publication, HLA-G41 Publication

The sequence of this isoform differs from the canonical sequence as follows:
207-298: Missing.

« Hide

        10         20         30         40         50
MVVMAPRTLF LLLSGALTLT ETWAGSHSMR YFSAAVSRPG RGEPRFIAMG 
        60         70         80         90        100
YVDDTQFVRF DSDSACPRME PRAPWVEQEG PEYWEEETRN TKAHAQTDRM 
       110        120        130        140        150
NLQTLRGYYN QSEASSHTLQ WMIGCDLGSD GRLLRGYEQY AYDGKDYLAL 
       160        170        180        190        200
NEDLRSWTAA DTAAQISKRK CEAANVAEQR RAYLEGTCVE WLHRYLENGK 
       210        220        230        240 
EMLQRAKQSS LPTIPIMGIV AGLVVLAAVV TGAAVAAVLW RKKSSD

Show »

Length:246

Mass (Da):27,613

Checksum:ⁱ257B982E358A94D0

GO

Isoform 5 (identifier: P17693-5) [UniParc]FASTA Add to basket

Also known as: HLA-G1sol1 Publication, HLA-G51 Publication

The sequence of this isoform differs from the canonical sequence as follows:
299-338: KQSSLPTIPIMGIVAGLVVLAAVVTGAAVAAVLWRKKSSD → SKEGDGGIMSVRESRSLSEDL

« Hide

        10         20         30         40         50
MVVMAPRTLF LLLSGALTLT ETWAGSHSMR YFSAAVSRPG RGEPRFIAMG 
        60         70         80         90        100
YVDDTQFVRF DSDSACPRME PRAPWVEQEG PEYWEEETRN TKAHAQTDRM 
       110        120        130        140        150
NLQTLRGYYN QSEASSHTLQ WMIGCDLGSD GRLLRGYEQY AYDGKDYLAL 
       160        170        180        190        200
NEDLRSWTAA DTAAQISKRK CEAANVAEQR RAYLEGTCVE WLHRYLENGK 
       210        220        230        240        250
EMLQRADPPK THVTHHPVFD YEATLRCWAL GFYPAEIILT WQRDGEDQTQ 
       260        270        280        290        300
DVELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PEPLMLRWSK 
       310 
EGDGGIMSVR ESRSLSEDL

Show »

Length:319

Mass (Da):36,458

Checksum:ⁱA2010B7518A4230B

GO

Isoform 6 (identifier: P17693-6) [UniParc]FASTA Add to basket

Also known as: HLA-G2sol1 Publication, HLA-G61 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     115-206: Missing.
     207-207: D → K
     299-338: KQSSLPTIPIMGIVAGLVVLAAVVTGAAVAAVLWRKKSSD → SKEGDGGIMSVRESRSLSEDL

« Hide

        10         20         30         40         50
MVVMAPRTLF LLLSGALTLT ETWAGSHSMR YFSAAVSRPG RGEPRFIAMG 
        60         70         80         90        100
YVDDTQFVRF DSDSACPRME PRAPWVEQEG PEYWEEETRN TKAHAQTDRM 
       110        120        130        140        150
NLQTLRGYYN QSEAKPPKTH VTHHPVFDYE ATLRCWALGF YPAEIILTWQ 
       160        170        180        190        200
RDGEDQTQDV ELVETRPAGD GTFQKWAAVV VPSGEEQRYT CHVQHEGLPE 
       210        220 
PLMLRWSKEG DGGIMSVRES RSLSEDL

Show »

Length:227

Mass (Da):25,928

Checksum:ⁱACB75F53EE9D0AA8

GO

Isoform 7 (identifier: P17693-7) [UniParc]FASTA Add to basket

Also known as: HLA-G71 Publication

The sequence of this isoform differs from the canonical sequence as follows:
116-116: S → E
117-338: Missing.

« Hide

        10         20         30         40         50
MVVMAPRTLF LLLSGALTLT ETWAGSHSMR YFSAAVSRPG RGEPRFIAMG 
        60         70         80         90        100
YVDDTQFVRF DSDSACPRME PRAPWVEQEG PEYWEEETRN TKAHAQTDRM 
       110 
NLQTLRGYYN QSEASE

Show »

Length:116

Mass (Da):13,286

Checksum:ⁱFE98D2D0E1628C31

GO

Computationally mapped potential isoform sequencesⁱ

There are 5 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

Q5RJ85	Q5RJ85_HUMAN	HLA class I histocompatibility anti... HLA class I histocompatibility antigen, alpha chain G (HLA-G histocompatibility antigen, class I, G, isoform CRA_b)	HLA-G hCG_1999524	343	Annotation score:
Q8MH48	Q8MH48_HUMAN	HLA class I histocompatibility anti... HLA class I histocompatibility antigen, alpha chain G (MHC class I antigen) (MHC class Ib antigen)	HLA-G	338	Annotation score:
Q31611	Q31611_HUMAN	B2 microglobulin B2 microglobulin (HLA class I histocompatibility antigen, alpha chain G)	HLA-G HLA-G2.2	246	Annotation score:
A0A0G2JPQ3	A0A0G2JPQ3_HUMAN	HLA class I histocompatibility anti... HLA class I histocompatibility antigen, alpha chain G	HLA-G	343	Annotation score:
A0A0G2JNX1	A0A0G2JNX1_HUMAN	HLA class I histocompatibility anti... HLA class I histocompatibility antigen, alpha chain G	HLA-G	246	Annotation score:

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_059191	115 – 298	Missing in isoform 3. 1 PublicationAdd BLAST	184
Alternative sequenceⁱVSP_059192	115 – 206	Missing in isoform 2 and isoform 6. 1 PublicationAdd BLAST	92
Alternative sequenceⁱVSP_059193	116	S → E in isoform 7. 1 Publication	1
Alternative sequenceⁱVSP_059194	117 – 338	Missing in isoform 7. 1 PublicationAdd BLAST	222
Alternative sequenceⁱVSP_059196	207 – 298	Missing in isoform 4. 2 PublicationsAdd BLAST	92
Alternative sequenceⁱVSP_059195	207	D → K in isoform 2 and isoform 6. 1 Publication	1
Alternative sequenceⁱVSP_059197	299 – 338	KQSSL…KKSSD → SKEGDGGIMSVRESRSLSED L in isoform 5 and isoform 6. 1 PublicationAdd BLAST	40

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X17273 mRNA Translation: CAA35174.1 J03027 Genomic DNA Translation: AAA98745.1 M90683 mRNA Translation: AAA52673.1 AF055066 Genomic DNA Translation: AAC24826.1 BA000025 Genomic DNA Translation: BAB63336.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS4668.1 [P17693-1]
PIRⁱ	A39953
NCBI Reference Sequences More...RefSeqⁱ	NP_002118.1, NM_002127.5 [P17693-1]
UniGeneⁱ	Hs.512152

Genome annotation databases

Ensemblⁱ	ENST00000360323; ENSP00000353472; ENSG00000204632 [P17693-1] ENST00000376815; ENSP00000366011; ENSG00000204632 [P17693-3] ENST00000383621; ENSP00000373116; ENSG00000206506 [P17693-1] ENST00000383622; ENSP00000373117; ENSG00000206506 [P17693-3] ENST00000415687; ENSP00000389969; ENSG00000237216 [P17693-3] ENST00000423011; ENSP00000389522; ENSG00000233095 [P17693-1] ENST00000423373; ENSP00000405238; ENSG00000235346 [P17693-1] ENST00000428701; ENSP00000412927; ENSG00000204632 [P17693-1] ENST00000428952; ENSP00000388176; ENSG00000235680 [P17693-1] ENST00000429890; ENSP00000401326; ENSG00000235680 [P17693-3] ENST00000444098; ENSP00000398200; ENSG00000230413 [P17693-1] ENST00000445373; ENSP00000416408; ENSG00000230413 [P17693-3] ENST00000448306; ENSP00000413926; ENSG00000233095 [P17693-3] ENST00000449127; ENSP00000408773; ENSG00000237216 [P17693-1] ENST00000457132; ENSP00000410247; ENSG00000235346 [P17693-3] ENST00000546545; ENSP00000447762; ENSG00000230413 [P17693-1] ENST00000546634; ENSP00000447780; ENSG00000235346 [P17693-1] ENST00000547241; ENSP00000448085; ENSG00000233095 [P17693-1] ENST00000547931; ENSP00000448363; ENSG00000237216 [P17693-1] ENST00000550897; ENSP00000449903; ENSG00000235680 [P17693-1] ENST00000553052; ENSP00000449291; ENSG00000206506 [P17693-1] ENST00000622601; ENSP00000479399; ENSG00000276051 [P17693-3]
GeneIDⁱ	3135
KEGGⁱ	hsa:3135

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P17693	HLA class I histocompatibility antigen, alpha chain G		HUMAN		343	UniRef100_P17693
HLA-G histocompatibility antigen, class I, G, isoform CRA_a		HUMAN		338
HLA-G (Fragment)		HUMAN		337
HLA-G histocompatibility antigen, class I, G		HUMAN		335
HLA-G protein (Fragment)		HUMAN		80
+180
P17693-3	B2 microglobulin		HUMAN		154	UniRef100_Q29897

Protein	Similar proteins		Species	Score	Length	Source
P17693	Patr class I histocompatibility antigen, alpha chain G		PANTR		338	UniRef90_P17693
HLA class I histocompatibility antigen, alpha chain G		HUMAN		343
Uncharacterized protein		PANPA		355
Major histocompatibility complex, class I, G		GORGO		350
MHC-G (Fragment)		western gorilla		304
+294
P17693-2	Uncharacterized protein		PANTR		254	UniRef90_P17693-2
Uncharacterized protein		PANPA		254
B2 microglobulin		HUMAN		246
MHC-G (Fragment)		PONPY		212
MHC-G (Fragment)		western gorilla		212
+4
P17693-3	Uncharacterized protein		PANTR		162	UniRef90_A0A2I3RMX1
Uncharacterized protein		PANPA		162
B2 microglobulin		HUMAN		154
HLA-G isoform 7		PANTR		154
MHC-G (Fragment)		PANTR		120
P17693-6	Isoform 2 of HLA class I histocompatibility antigen, alpha chain G		HUMAN		246	UniRef90_P17693-2
Uncharacterized protein		PANTR		254
Uncharacterized protein		PANPA		254
MHC-G (Fragment)		PONPY		212
MHC-G (Fragment)		western gorilla		212
+4

Protein	Similar proteins		Species	Score	Length	Source
P17693	HLA class I histocompatibility antigen, alpha chain E	)	HUMAN		358	UniRef50_P13747
Patr class I histocompatibility antigen, alpha chain G		PANTR		338
DLA class I histocompatibility antigen, A9/A9 alpha chain		CANLF		362
H-2 class I histocompatibility antigen, K-D alpha chain	)	MOUSE		368
Popy class I histocompatibility antigen, alpha chain E (Fragment)		PONPY		359
+8953
P17693-2	Uncharacterized protein		PANTR		254	UniRef50_P17693-2
Uncharacterized protein		PANPA		254
B2 microglobulin		HUMAN		246
MHC-G (Fragment)		PONPY		212
MHC-G (Fragment)		western gorilla		212
+38
P17693-3	Uncharacterized protein		PANTR		162	UniRef50_A0A2I3RMX1
Uncharacterized protein		PANPA		162
B2 microglobulin		HUMAN		154
Uncharacterized protein		MACNE		162
Uncharacterized protein		COLAP		164
+5
P17693-4	MHC class I antigen (Fragment)		MACFA		240	UniRef50_P17693-4
HLA class I histocompatibility antigen, Cw-6 alpha chain		HUMAN		224
H-2 class I histocompatibility antigen, Q9 alpha chain-like		MESAU		205
Uncharacterized protein		PIG		244
Putative Major histocompatibility complex class I-related protein		Daphnia magna		206
+25
P17693-6	Isoform 2 of HLA class I histocompatibility antigen, alpha chain G		HUMAN		246	UniRef50_P17693-2
Uncharacterized protein		PANTR		254
Uncharacterized protein		PANPA		254
MHC-G (Fragment)		PONPY		212
MHC-G (Fragment)		western gorilla		212
+38
P17693-7	Uncharacterized protein		MACMU		113	UniRef50_P17693-7
MHC-G (Fragment)		MACFA		113
Class I histocompatibility antigen, Gogo-C*0203 alpha chain		FUKDA		115
Truncated MHC class I antigen (Fragment)		HUMAN		124
Truncated MHC class I antigen (Fragment)		CHLAE		112
+44

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X17273 mRNA Translation: CAA35174.1 J03027 Genomic DNA Translation: AAA98745.1 M90683 mRNA Translation: AAA52673.1 AF055066 Genomic DNA Translation: AAC24826.1 BA000025 Genomic DNA Translation: BAB63336.1
CCDSⁱ	CCDS4668.1 [P17693-1]
PIRⁱ	A39953
RefSeqⁱ	NP_002118.1, NM_002127.5 [P17693-1]
UniGeneⁱ	Hs.512152

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1YDP	X-ray	1.90	A	26-300	[»]
	2D31	X-ray	3.20	A/D	25-300	[»]
	2DYP	X-ray	2.50	A	25-300	[»]
	3BZE	X-ray	2.50	P/Q/R/S	3-11	[»]
	3CDG	X-ray	3.40	P/Q	3-11	[»]
	3CII	X-ray	4.41	C/F	3-11	[»]
	3KYN	X-ray	2.40	A	26-299	[»]
	3KYO	X-ray	1.70	A/C	26-298	[»]
ProteinModelPortalⁱ	P17693
SMRⁱ	P17693
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	109380, 18 interactors
DIPⁱ	DIP-46121N
IntActⁱ	P17693, 7 interactors
MINTⁱ	P17693
STRINGⁱ	9606.ENSP00000353472

PTM databases

iPTMnetⁱ	P17693
PhosphoSitePlusⁱ	P17693
SwissPalmⁱ	P17693

Polymorphism and mutation databases

BioMutaⁱ	HLA-G
DMDMⁱ	122132

Proteomic databases

EPDⁱ	P17693
PaxDbⁱ	P17693
PeptideAtlasⁱ	P17693
PRIDEⁱ	P17693
ProteomicsDBⁱ	53506

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	3135
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000360323; ENSP00000353472; ENSG00000204632 [P17693-1] ENST00000376815; ENSP00000366011; ENSG00000204632 [P17693-3] ENST00000383621; ENSP00000373116; ENSG00000206506 [P17693-1] ENST00000383622; ENSP00000373117; ENSG00000206506 [P17693-3] ENST00000415687; ENSP00000389969; ENSG00000237216 [P17693-3] ENST00000423011; ENSP00000389522; ENSG00000233095 [P17693-1] ENST00000423373; ENSP00000405238; ENSG00000235346 [P17693-1] ENST00000428701; ENSP00000412927; ENSG00000204632 [P17693-1] ENST00000428952; ENSP00000388176; ENSG00000235680 [P17693-1] ENST00000429890; ENSP00000401326; ENSG00000235680 [P17693-3] ENST00000444098; ENSP00000398200; ENSG00000230413 [P17693-1] ENST00000445373; ENSP00000416408; ENSG00000230413 [P17693-3] ENST00000448306; ENSP00000413926; ENSG00000233095 [P17693-3] ENST00000449127; ENSP00000408773; ENSG00000237216 [P17693-1] ENST00000457132; ENSP00000410247; ENSG00000235346 [P17693-3] ENST00000546545; ENSP00000447762; ENSG00000230413 [P17693-1] ENST00000546634; ENSP00000447780; ENSG00000235346 [P17693-1] ENST00000547241; ENSP00000448085; ENSG00000233095 [P17693-1] ENST00000547931; ENSP00000448363; ENSG00000237216 [P17693-1] ENST00000550897; ENSP00000449903; ENSG00000235680 [P17693-1] ENST00000553052; ENSP00000449291; ENSG00000206506 [P17693-1] ENST00000622601; ENSP00000479399; ENSG00000276051 [P17693-3]
GeneIDⁱ	3135
KEGGⁱ	hsa:3135

Organism-specific databases

CTDⁱ	3135
DisGeNETⁱ	3135
EuPathDBⁱ	HostDB:ENSG00000204632.11
GeneCardsⁱ	HLA-G
H-InvDBⁱ	HIX0166674 HIX0167370
HGNCⁱ	HGNC:4964 HLA-G
HPAⁱ	CAB016158
MalaCardsⁱ	HLA-G
MIMⁱ	142871 gene
neXtProtⁱ	NX_P17693
OpenTargetsⁱ	ENSG00000204632
PharmGKBⁱ	PA35083
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410II5V Eukaryota ENOG4111K8F LUCA
GeneTreeⁱ	ENSGT00760000118960
HOVERGENⁱ	HBG016709
InParanoidⁱ	P17693
KOⁱ	K06751
PhylomeDBⁱ	P17693
TreeFamⁱ	TF336617

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1236974 ER-Phagosome pathway R-HSA-1236977 Endosomal/Vacuolar pathway R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-877300 Interferon gamma signaling R-HSA-909733 Interferon alpha/beta signaling R-HSA-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC
SIGNORⁱ	P17693

Miscellaneous databases

ChiTaRSⁱ	HLA-G human
EvolutionaryTraceⁱ	P17693
GeneWikiⁱ	HLA-G
GenomeRNAiⁱ	3135
Protein Ontology More...PROⁱ	PR:P17693
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000204632 Expressed in 233 organ(s), highest expression level in blood
CleanExⁱ	HS_HLA-G
ExpressionAtlasⁱ	P17693 baseline and differential
Genevisibleⁱ	P17693 HS

Family and domain databases

Gene3Dⁱ	2.60.40.10, 1 hit 3.30.500.10, 1 hit
InterProⁱ	View protein in InterPro IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR003006 Ig/MHC_CS IPR003597 Ig_C1-set IPR011161 MHC_I-like_Ag-recog IPR037055 MHC_I-like_Ag-recog_sf IPR011162 MHC_I/II-like_Ag-recog IPR001039 MHC_I_a_a1/a2
Pfamⁱ	View protein in Pfam PF07654 C1-set, 1 hit PF00129 MHC_I, 1 hit
PRINTSⁱ	PR01638 MHCCLASSI
SMARTⁱ	View protein in SMART SM00407 IGc1, 1 hit
SUPFAMⁱ	SSF48726 SSF48726, 1 hit SSF54452 SSF54452, 1 hit
PROSITEⁱ	View protein in PROSITE PS50835 IG_LIKE, 1 hit PS00290 IG_MHC, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	HLAG_HUMAN
Accessionⁱ	P17693Primary (citable) accession number: P17693
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 1, 1990
	Last sequence update:	August 1, 1990
	Last modified:	November 7, 2018
	This is version 184 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM

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UniProtKB - P17693 (HLAG_HUMAN)

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HLA class I histocompatibility antigen, alpha chain G

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

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Plasma membrane

Plasma membrane

Plasma membrane

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Extracellular region or secreted

Extracellular region or secreted

Endoplasmic reticulum

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Extracellular region or secreted

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Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

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Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

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<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

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Family and domain databases

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

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<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

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Protein-protein interaction databases

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Proteomic databases

Protocols and materials databases

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Organism-specific databases

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Miscellaneous databases

Gene expression databases

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ