UniProtKB - P17693 (HLAG_HUMAN)
HLA class I histocompatibility antigen, alpha chain G
HLA-G
Functioni
Non-classical major histocompatibility class Ib molecule involved in immune regulatory processes at the maternal-fetal interface (PubMed:23184984, PubMed:29262349, PubMed:19304799).
In complex with B2M/beta-2 microglobulin binds a limited repertoire of nonamer self-peptides derived from intracellular proteins including histones and ribosomal proteins (PubMed:7584149, PubMed:8805247).
Peptide-bound HLA-G-B2M complex acts as a ligand for inhibitory/activating KIR2DL4, LILRB1 and LILRB2 receptors on uterine immune cells to promote fetal development while maintaining maternal-fetal tolerance (PubMed:23184984, PubMed:29262349, PubMed:16366734, PubMed:19304799, PubMed:20448110, PubMed:27859042).
Upon interaction with KIR2DL4 and LILRB1 receptors on decidual NK cells, it triggers NK cell senescence-associated secretory phenotype as a molecular switch to promote vascular remodeling and fetal growth in early pregnancy (PubMed:23184984, PubMed:29262349, PubMed:16366734, PubMed:19304799).
Through interaction with KIR2DL4 receptor on decidual macrophages induces pro-inflammatory cytokine production mainly associated with tissue remodeling (PubMed:19304799).
Through interaction with LILRB2 receptor triggers differentiation of type 1 regulatory T cells and myeloid-derived suppressor cells, both of which actively maintain maternal-fetal tolerance (PubMed:20448110, PubMed:27859042).
May play a role in balancing tolerance and antiviral-immunity at maternal-fetal interface by keeping in check the effector functions of NK, CD8+ T cells and B cells (PubMed:10190900, PubMed:11290782, PubMed:24453251).
Reprograms B cells toward an immune suppressive phenotype via LILRB1 (PubMed:24453251).
May induce immune activation/suppression via intercellular membrane transfer (trogocytosis), likely enabling interaction with KIR2DL4, which resides mostly in endosomes (PubMed:20179272, PubMed:26460007).
Through interaction with the inhibitory receptor CD160 on endothelial cells may control angiogenesis in immune privileged sites (PubMed:16809620).
14 PublicationsLikely does not bind B2M and presents peptides. Negatively regulates NK cell- and CD8+ T cell-mediated cytotoxicity (PubMed:11290782).
Curated1 PublicationLikely does not bind B2M and presents peptides. Negatively regulates NK cell- and CD8+ T cell-mediated cytotoxicity (PubMed:11290782).
Curated1 PublicationLikely does not bind B2M and presents peptides. Negatively regulates NK cell- and CD8+ T cell-mediated cytotoxicity (PubMed:11290782).
Curated1 PublicationNon-classical major histocompatibility class Ib molecule involved in immune regulatory processes at the maternal-fetal interface (PubMed:23184984, PubMed:29262349, PubMed:19304799).
In complex with B2M/beta-2 microglobulin binds a limited repertoire of nonamer self-peptides derived from intracellular proteins including histones and ribosomal proteins (PubMed:7584149, PubMed:8805247).
Peptide-bound HLA-G-B2M complex acts as a ligand for inhibitory/activating KIR2DL4, LILRB1 and LILRB2 receptors on uterine immune cells to promote fetal development while maintaining maternal-fetal tolerance (PubMed:23184984, PubMed:29262349, PubMed:16366734, PubMed:19304799, PubMed:20448110).
Upon interaction with KIR2DL4 and LILRB1 receptors on decidual NK cells, it triggers NK cell senescence-associated secretory phenotype as a molecular switch to promote vascular remodeling and fetal growth in early pregnancy (PubMed:23184984, PubMed:29262349, PubMed:16366734, PubMed:19304799).
Through interaction with KIR2DL4 receptor on decidual macrophages induces pro-inflammatory cytokine production mainly associated with tissue remodeling (PubMed:19304799).
Through interaction with LILRB2 receptor triggers differentiation of type 1 regulatory T cells and myeloid-derived suppressor cells, both of which actively maintain maternal-fetal tolerance (PubMed:20448110).
Reprograms B cells toward an immune suppressive phenotype via LILRB1 (PubMed:24453251).
8 PublicationsLikely does not bind B2M and presents peptides.
CuratedLikely does not bind B2M and presents peptides.
CuratedSites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 31 | Peptide antigen; self-peptide antigen2 Publications | 1 | |
Binding sitei | 94 | Peptide antigen; self-peptide antigen1 Publication | 1 | |
Binding sitei | 101 | Peptide antigen; self-peptide antigen1 Publication | 1 | |
Binding sitei | 108 | Peptide antigen; self-peptide antigen3 Publications | 1 | |
Binding sitei | 167 | Peptide antigen; self-peptide antigen; via carbonyl oxygen3 Publications | 1 | |
Binding sitei | 170 | Peptide antigen; self-peptide antigen2 Publications | 1 | |
Binding sitei | 179 | Peptide antigen; self-peptide antigen; via carbonyl oxygen1 Publication | 1 | |
Binding sitei | 180 | Peptide antigen; self-peptide antigen1 Publication | 1 | |
Binding sitei | 183 | Peptide antigen; self-peptide antigen3 Publications | 1 | |
Binding sitei | 195 | Peptide antigen; self-peptide antigen4 Publications | 1 |
GO - Molecular functioni
- CD8 receptor binding Source: UniProtKB
- identical protein binding Source: IntAct
- peptide antigen binding Source: UniProtKB
- protein homodimerization activity Source: UniProtKB
- signaling receptor binding Source: UniProtKB
GO - Biological processi
- antigen processing and presentation of endogenous peptide antigen via MHC class Ib Source: UniProtKB
- antigen processing and presentation of peptide antigen via MHC class I Source: UniProtKB-KW
- cellular defense response Source: ProtInc
- immune response-inhibiting cell surface receptor signaling pathway Source: BHF-UCL
- negative regulation of angiogenesis Source: UniProtKB
- negative regulation of dendritic cell differentiation Source: BHF-UCL
- negative regulation of G0 to G1 transition Source: UniProtKB
- negative regulation of immune response Source: UniProtKB
- negative regulation of natural killer cell mediated cytotoxicity Source: UniProtKB
- negative regulation of protein kinase B signaling Source: UniProtKB
- negative regulation of T cell mediated cytotoxicity Source: UniProtKB
- negative regulation of T cell proliferation Source: BHF-UCL
- peripheral B cell tolerance induction Source: UniProtKB
- positive regulation of cellular senescence Source: UniProtKB
- positive regulation of endothelial cell apoptotic process Source: UniProtKB
- positive regulation of interleukin-12 production Source: BHF-UCL
- positive regulation of macrophage cytokine production Source: UniProtKB
- positive regulation of natural killer cell cytokine production Source: UniProtKB
- positive regulation of regulatory T cell differentiation Source: BHF-UCL
- positive regulation of T cell tolerance induction Source: BHF-UCL
- positive regulation of tolerance induction Source: UniProtKB
- protection from natural killer cell mediated cytotoxicity Source: UniProtKB
- protein homotrimerization Source: UniProtKB
Keywordsi
Biological process | Immunity |
Enzyme and pathway databases
PathwayCommonsi | P17693 |
Reactomei | R-HSA-1236974, ER-Phagosome pathway R-HSA-1236977, Endosomal/Vacuolar pathway R-HSA-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-877300, Interferon gamma signaling R-HSA-909733, Interferon alpha/beta signaling R-HSA-983170, Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
SignaLinki | P17693 |
SIGNORi | P17693 |
Names & Taxonomyi
Protein namesi | Recommended name: HLA class I histocompatibility antigen, alpha chain GAlternative name(s): HLA G antigen MHC class I antigen G Cleaved into the following chain: |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:4964, HLA-G |
MIMi | 142871, gene |
neXtProti | NX_P17693 |
VEuPathDBi | HostDB:ENSG00000204632 |
Subcellular locationi
Plasma membrane
- Cell membrane 2 Publications; Single-pass type I membrane protein Sequence analysis
Endosome
- Early endosome membrane 1 Publication
Endoplasmic reticulum
- Endoplasmic reticulum membrane 1 Publication
Extracellular region or secreted
- Secreted 1 Publication
Plasma membrane
- Cell membrane 1 Publication; Single-pass type I membrane protein Sequence analysis
Plasma membrane
- Cell membrane 1 Publication; Single-pass type I membrane protein Sequence analysis
Plasma membrane
- Cell membrane 1 Publication; Single-pass type I membrane protein Sequence analysis
Endosome
- Early endosome 1 Publication
Extracellular region or secreted
- Secreted 4 Publications
Extracellular region or secreted
- Secreted 1 Publication
Extracellular region or secreted
- Secreted 1 Publication
Plasma membrane
- filopodium membrane 1 Publication
Note: HLA-G trogocytosis from extravillous trophoblast's filopodia occurs in the majority of decidual NK cells.1 Publication
Endoplasmic reticulum
- integral component of lumenal side of endoplasmic reticulum membrane Source: Reactome
Endosome
- early endosome Source: UniProtKB
- early endosome membrane Source: Reactome
- recycling endosome membrane Source: Reactome
Extracellular region or secreted
- extracellular space Source: GO_Central
Golgi apparatus
- cis-Golgi network membrane Source: UniProtKB
- Golgi membrane Source: Reactome
Plasma Membrane
- external side of plasma membrane Source: GO_Central
- filopodium membrane Source: UniProtKB-SubCell
- MHC class I protein complex Source: UniProtKB-KW
- plasma membrane Source: UniProtKB
Other locations
- ER to Golgi transport vesicle membrane Source: Reactome
- membrane Source: UniProtKB
- phagocytic vesicle membrane Source: Reactome
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 25 – 308 | ExtracellularSequence analysisAdd BLAST | 284 | |
Transmembranei | 309 – 332 | HelicalSequence analysisAdd BLAST | 24 | |
Topological domaini | 333 – 338 | CytoplasmicSequence analysis | 6 |
Keywords - Cellular componenti
Cell membrane, Cell projection, Endoplasmic reticulum, Endosome, Membrane, MHC I, SecretedPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 66 | C → S: Abolishes homodimerization and homotrimerization. Decreases functional interaction with LILRB1. Does not affect homodimerization of isoform 2 and its binding to LILRB2. 3 Publications | 1 | |
Mutagenesisi | 138 | E → H: Enables TAPBP-independent transport to the cell surface. 1 Publication | 1 | |
Mutagenesisi | 138 | E → Q: Decreases TAPBP-dependent transport to the cell surface. 1 Publication | 1 | |
Mutagenesisi | 171 | C → S: Abolishes homodimerization. Decreases functional interaction with LILRB1. 1 Publication | 1 | |
Mutagenesisi | 334 – 335 | KK → AA: Abolishes binding to COPB1 and Golgi-to-ER retrograde transport. 1 Publication | 2 |
Organism-specific databases
DisGeNETi | 3135 |
MalaCardsi | HLA-G |
OpenTargetsi | ENSG00000204632 |
PharmGKBi | PA35083 |
Miscellaneous databases
Pharosi | P17693, Tbio |
Genetic variation databases
BioMutai | HLA-G |
DMDMi | 122132 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 24 | Add BLAST | 24 | |
ChainiPRO_0000018886 | 25 – 338 | HLA class I histocompatibility antigen, alpha chain GAdd BLAST | 314 | |
ChainiPRO_0000445908 | ? – 338 | Soluble HLA class I histocompatibility antigen, alpha chain G1 Publication |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 66 | InterchainPROSITE-ProRule annotation2 Publications | ||
Glycosylationi | 110 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 125 ↔ 188 | PROSITE-ProRule annotation4 Publications | ||
Disulfide bondi | 171 | Interchain1 Publication | ||
Disulfide bondi | 227 ↔ 283 | PROSITE-ProRule annotation4 Publications |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
EPDi | P17693 |
jPOSTi | P17693 |
MassIVEi | P17693 |
PaxDbi | P17693 |
PeptideAtlasi | P17693 |
PRIDEi | P17693 |
ProteomicsDBi | 53506 |
PTM databases
GlyGeni | P17693, 1 site |
iPTMneti | P17693 |
PhosphoSitePlusi | P17693 |
SwissPalmi | P17693 |
Expressioni
Tissue specificityi
Developmental stagei
Inductioni
Gene expression databases
Bgeei | ENSG00000204632, Expressed in blood and 241 other tissues |
ExpressionAtlasi | P17693, baseline and differential |
Genevisiblei | P17693, HS |
Organism-specific databases
HPAi | ENSG00000204632, Group enriched (pituitary gland, placenta) |
Interactioni
Subunit structurei
Forms a heterotrimer with B2M and a self-peptide (peptide-bound HLA-G-B2M) (PubMed:7584149, PubMed:8805247). HLA-G-B2M complex interacts with components of the antigen processing machinery TAPBP and TAP1-TAP2 complex; this interaction is required for loading of high affinity peptides and heterotrimer translocation to the cell surface (PubMed:7584149).
Interacts with CALCR; this interaction is required for appropriate folding (PubMed:9640257).
Interacts with COPB1; this interaction mediates the endoplasmic reticulum (ER) retrieval of HLA-G-B2M complexes that bind low affinity peptides (PubMed:11520457, PubMed:12582157). On the cell surface, peptide-bound HLA-G-B2M molecules (referred to as monomers) can form disulfide-linked homomultimers, homodimers and homotrimers (PubMed:12454284, PubMed:12874224, PubMed:16455647).
Interacts with KIR2DL4; this interaction is direct (PubMed:10190900, PubMed:16366734).
Interacts with LILRB1 and LILRB2 receptors; this interaction is direct (PubMed:16455647, PubMed:16366734, PubMed:17056715, PubMed:12853576).
Interacts with CD160; this interactions is direct (PubMed:16809620).
Interacts with CD8A homodimer; this interaction is direct and might down-regulate T cell receptor signaling (PubMed:12853576). Isoform 2:
Forms a non-disulfide-linked homodimer and interacts with LILRB2 (PubMed:28348268).
14 PublicationsBinary interactionsi
P17693
With | #Exp. | IntAct |
---|---|---|
itself | 5 | EBI-1043063,EBI-1043063 |
LILRB1 [Q8NHL6] | 5 | EBI-1043063,EBI-2805262 |
LILRB2 [Q8N423] | 7 | EBI-1043063,EBI-2816428 |
HLA-G - isoform 2 [P17693-2]
With | #Exp. | IntAct |
---|---|---|
itself | 3 | EBI-16586375,EBI-16586375 |
LILRB2 [Q8N423] | 4 | EBI-16586375,EBI-2816428 |
Isoform 5 [P17693-5]
With | #Exp. | IntAct |
---|---|---|
LILRB2 [Q8N423] | 2 | EBI-16586455,EBI-2816428 |
Isoform 6 [P17693-6]
With | #Exp. | IntAct |
---|---|---|
LILRB2 [Q8N423] | 3 | EBI-16586550,EBI-2816428 |
GO - Molecular functioni
- CD8 receptor binding Source: UniProtKB
- identical protein binding Source: IntAct
- protein homodimerization activity Source: UniProtKB
- signaling receptor binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 109380, 130 interactors |
DIPi | DIP-46121N |
IntActi | P17693, 15 interactors |
MINTi | P17693 |
STRINGi | 9606.ENSP00000412927 |
Miscellaneous databases
RNActi | P17693, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | P17693 |
SMRi | P17693 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P17693 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 209 – 299 | Ig-like C1-typeAdd BLAST | 91 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 25 – 114 | Alpha-1Add BLAST | 90 | |
Regioni | 115 – 206 | Alpha-2Add BLAST | 92 | |
Regioni | 207 – 298 | Alpha-3Add BLAST | 92 | |
Regioni | 299 – 308 | Connecting peptide | 10 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 334 – 336 | ER-retrieval signal1 Publication | 3 |
Sequence similaritiesi
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502RQEK, Eukaryota |
GeneTreei | ENSGT00980000198488 |
HOGENOMi | CLU_047501_1_1_1 |
InParanoidi | P17693 |
OMAi | HILQGMF |
PhylomeDBi | P17693 |
TreeFami | TF336617 |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit 3.30.500.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003006, Ig/MHC_CS IPR003597, Ig_C1-set IPR011161, MHC_I-like_Ag-recog IPR037055, MHC_I-like_Ag-recog_sf IPR011162, MHC_I/II-like_Ag-recog IPR001039, MHC_I_a_a1/a2 |
Pfami | View protein in Pfam PF07654, C1-set, 1 hit PF00129, MHC_I, 1 hit |
PRINTSi | PR01638, MHCCLASSI |
SMARTi | View protein in SMART SM00407, IGc1, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit SSF54452, SSF54452, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit PS00290, IG_MHC, 1 hit |
s (7+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 7 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 7 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MVVMAPRTLF LLLSGALTLT ETWAGSHSMR YFSAAVSRPG RGEPRFIAMG
60 70 80 90 100
YVDDTQFVRF DSDSACPRME PRAPWVEQEG PEYWEEETRN TKAHAQTDRM
110 120 130 140 150
NLQTLRGYYN QSEASSHTLQ WMIGCDLGSD GRLLRGYEQY AYDGKDYLAL
160 170 180 190 200
NEDLRSWTAA DTAAQISKRK CEAANVAEQR RAYLEGTCVE WLHRYLENGK
210 220 230 240 250
EMLQRADPPK THVTHHPVFD YEATLRCWAL GFYPAEIILT WQRDGEDQTQ
260 270 280 290 300
DVELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PEPLMLRWKQ
310 320 330
SSLPTIPIMG IVAGLVVLAA VVTGAAVAAV LWRKKSSD
The sequence of this isoform differs from the canonical sequence as follows:
115-206: Missing.
207-207: D → K
299-338: KQSSLPTIPIMGIVAGLVVLAAVVTGAAVAAVLWRKKSSD → SKEGDGGIMSVRESRSLSEDL
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ5RJ85 | Q5RJ85_HUMAN | HLA class I histocompatibility anti... | HLA-G hCG_1999524 | 343 | Annotation score: | ||
Q31611 | Q31611_HUMAN | B2 microglobulin | HLA-G HLA-G2.2 | 246 | Annotation score: | ||
A0A0G2JPQ3 | A0A0G2JPQ3_HUMAN | HLA class I histocompatibility anti... | HLA-G | 343 | Annotation score: | ||
Q8MH48 | Q8MH48_HUMAN | HLA class I histocompatibility anti... | HLA-G | 338 | Annotation score: | ||
A0A0G2JNX1 | A0A0G2JNX1_HUMAN | HLA class I histocompatibility anti... | HLA-G | 246 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_059191 | 115 – 298 | Missing in isoform 3. 1 PublicationAdd BLAST | 184 | |
Alternative sequenceiVSP_059192 | 115 – 206 | Missing in isoform 2 and isoform 6. 1 PublicationAdd BLAST | 92 | |
Alternative sequenceiVSP_059193 | 116 | S → E in isoform 7. 1 Publication | 1 | |
Alternative sequenceiVSP_059194 | 117 – 338 | Missing in isoform 7. 1 PublicationAdd BLAST | 222 | |
Alternative sequenceiVSP_059196 | 207 – 298 | Missing in isoform 4. 2 PublicationsAdd BLAST | 92 | |
Alternative sequenceiVSP_059195 | 207 | D → K in isoform 2 and isoform 6. 1 Publication | 1 | |
Alternative sequenceiVSP_059197 | 299 – 338 | KQSSL…KKSSD → SKEGDGGIMSVRESRSLSED L in isoform 5 and isoform 6. 1 PublicationAdd BLAST | 40 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X17273 mRNA Translation: CAA35174.1 J03027 Genomic DNA Translation: AAA98745.1 M90683 mRNA Translation: AAA52673.1 AF055066 Genomic DNA Translation: AAC24826.1 BA000025 Genomic DNA Translation: BAB63336.1 |
CCDSi | CCDS4668.1 [P17693-1] |
PIRi | A39953 |
RefSeqi | NP_002118.1, NM_002127.5 [P17693-1] |
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X17273 mRNA Translation: CAA35174.1 J03027 Genomic DNA Translation: AAA98745.1 M90683 mRNA Translation: AAA52673.1 AF055066 Genomic DNA Translation: AAC24826.1 BA000025 Genomic DNA Translation: BAB63336.1 |
CCDSi | CCDS4668.1 [P17693-1] |
PIRi | A39953 |
RefSeqi | NP_002118.1, NM_002127.5 [P17693-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1YDP | X-ray | 1.90 | A | 26-300 | [»] | |
2D31 | X-ray | 3.20 | A/D | 25-300 | [»] | |
2DYP | X-ray | 2.50 | A | 25-300 | [»] | |
3BZE | X-ray | 2.50 | P/Q/R/S | 3-11 | [»] | |
3CDG | X-ray | 3.40 | P/Q | 3-11 | [»] | |
3CII | X-ray | 4.41 | C/F | 3-11 | [»] | |
3KYN | X-ray | 2.40 | A | 26-299 | [»] | |
3KYO | X-ray | 1.70 | A/C | 26-298 | [»] | |
6AEE | X-ray | 3.30 | A/D | 25-300 | [»] | |
6K60 | X-ray | 3.15 | A/E | 25-300 | [»] | |
AlphaFoldDBi | P17693 | |||||
SMRi | P17693 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 109380, 130 interactors |
DIPi | DIP-46121N |
IntActi | P17693, 15 interactors |
MINTi | P17693 |
STRINGi | 9606.ENSP00000412927 |
PTM databases
GlyGeni | P17693, 1 site |
iPTMneti | P17693 |
PhosphoSitePlusi | P17693 |
SwissPalmi | P17693 |
Genetic variation databases
BioMutai | HLA-G |
DMDMi | 122132 |
Proteomic databases
EPDi | P17693 |
jPOSTi | P17693 |
MassIVEi | P17693 |
PaxDbi | P17693 |
PeptideAtlasi | P17693 |
PRIDEi | P17693 |
ProteomicsDBi | 53506 |
Protocols and materials databases
ABCDi | P17693, 49 sequenced antibodies |
Antibodypediai | 4253, 1477 antibodies from 40 providers |
DNASUi | 3135 |
Genome annotation databases
Organism-specific databases
CTDi | 3135 |
DisGeNETi | 3135 |
GeneCardsi | HLA-G |
HGNCi | HGNC:4964, HLA-G |
HPAi | ENSG00000204632, Group enriched (pituitary gland, placenta) |
MalaCardsi | HLA-G |
MIMi | 142871, gene |
neXtProti | NX_P17693 |
OpenTargetsi | ENSG00000204632 |
PharmGKBi | PA35083 |
VEuPathDBi | HostDB:ENSG00000204632 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502RQEK, Eukaryota |
GeneTreei | ENSGT00980000198488 |
HOGENOMi | CLU_047501_1_1_1 |
InParanoidi | P17693 |
OMAi | HILQGMF |
PhylomeDBi | P17693 |
TreeFami | TF336617 |
Enzyme and pathway databases
PathwayCommonsi | P17693 |
Reactomei | R-HSA-1236974, ER-Phagosome pathway R-HSA-1236977, Endosomal/Vacuolar pathway R-HSA-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-877300, Interferon gamma signaling R-HSA-909733, Interferon alpha/beta signaling R-HSA-983170, Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
SignaLinki | P17693 |
SIGNORi | P17693 |
Miscellaneous databases
BioGRID-ORCSi | 3135, 6 hits in 1068 CRISPR screens |
ChiTaRSi | HLA-G, human |
EvolutionaryTracei | P17693 |
GeneWikii | HLA-G |
GenomeRNAii | 3135 |
Pharosi | P17693, Tbio |
PROi | PR:P17693 |
RNActi | P17693, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000204632, Expressed in blood and 241 other tissues |
ExpressionAtlasi | P17693, baseline and differential |
Genevisiblei | P17693, HS |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit 3.30.500.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003006, Ig/MHC_CS IPR003597, Ig_C1-set IPR011161, MHC_I-like_Ag-recog IPR037055, MHC_I-like_Ag-recog_sf IPR011162, MHC_I/II-like_Ag-recog IPR001039, MHC_I_a_a1/a2 |
Pfami | View protein in Pfam PF07654, C1-set, 1 hit PF00129, MHC_I, 1 hit |
PRINTSi | PR01638, MHCCLASSI |
SMARTi | View protein in SMART SM00407, IGc1, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit SSF54452, SSF54452, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit PS00290, IG_MHC, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | HLAG_HUMAN | |
Accessioni | P17693Primary (citable) accession number: P17693 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1990 |
Last sequence update: | August 1, 1990 | |
Last modified: | May 25, 2022 | |
This is version 206 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families