Erythroid transcription factor

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• C2H2 zinc finger domain binding Source: MGI
• chromatin binding Source: MGI <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Gata1 regulates dendritic-cell development and survival."
    Gutierrez L., Nikolic T., van Dijk T.B., Hammad H., Vos N., Willart M., Grosveld F., Philipsen S., Lambrecht B.N.
    Blood 110:1933-1941(2007) [PubMed] [Europe PMC] [Abstract]
  • "SCL and associated proteins distinguish active from repressive GATA transcription factor complexes."
    Tripic T., Deng W., Cheng Y., Zhang Y., Vakoc C.R., Gregory G.D., Hardison R.C., Blobel G.A.
    Blood 113:2191-2201(2009) [PubMed] [Europe PMC] [Abstract]
• chromatin DNA binding Source: UniProtKB
• cis-regulatory region sequence-specific DNA binding Source: UniProtKBInferred from direct assayⁱ
  • "Cooperative action of multiple cis-acting elements is required for N-myc expression in branchial arches: specific contribution of GATA3."
    Potvin E., Beuret L., Cadrin-Girard J.F., Carter M., Roy S., Tremblay M., Charron J.
    Mol Cell Biol 30:5348-5363(2010) [PubMed] [Europe PMC] [Abstract]
• DNA binding Source: MGIInferred from direct assayⁱ
  • "Transcriptional regulation of the murine erythroid-specific 5-aminolevulinate synthase gene."
    Kramer M.F., Gunaratne P., Ferreira G.C.
    Gene 247:153-166(2000) [PubMed] [Europe PMC] [Abstract]
  • "GATA factors are essential for transcription of the survival gene E4bp4 and the viability response of interleukin-3 in Ba/F3 hematopoietic cells."
    Yu Y.L., Chiang Y.J., Yen J.J.
    J Biol Chem 277:27144-27153(2002) [PubMed] [Europe PMC] [Abstract]
  • "T to C substitution at -175 or -173 of the gamma-globin promoter affects GATA-1 and Oct-1 binding in vitro differently but can independently reproduce the hereditary persistence of fetal hemoglobin phenotype in transgenic mice."
    Liu L.R., Du Z.W., Zhao H.L., Liu X.L., Huang X.D., Shen J., Ju L.M., Fang F.D., Zhang J.W.
    J Biol Chem 280:7452-7459(2005) [PubMed] [Europe PMC] [Abstract]
  • "Novel roles for KLF1 in erythropoiesis revealed by mRNA-seq."
    Tallack M.R., Magor G.W., Dartigues B., Sun L., Huang S., Fittock J.M., Fry S.V., Glazov E.A., Bailey T.L., Perkins A.C.
    Genome Res 22:2385-2398(2012) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription activator activity, RNA polymerase II-specific Source: MGIInferred from direct assayⁱ
  • "ARR19 (androgen receptor corepressor of 19 kDa), an antisteroidogenic factor, is regulated by GATA-1 in testicular Leydig cells."
    Qamar I., Park E., Gong E.Y., Lee H.J., Lee K.
    J Biol Chem 284:18021-18032(2009) [PubMed] [Europe PMC] [Abstract]
  • "Regulation of the erythroid Kruppel-like factor (EKLF) gene promoter by the erythroid transcription factor GATA-1."
    Crossley M., Tsang A.P., Bieker J.J., Orkin S.H.
    J Biol Chem 269:15440-15444(1994) [PubMed] [Europe PMC] [Abstract]
  • "FOG, a multitype zinc finger protein, acts as a cofactor for transcription factor GATA-1 in erythroid and megakaryocytic differentiation."
    Tsang A.P., Visvader J.E., Turner C.A., Fujiwara Y., Yu C., Weiss M.J., Crossley M., Orkin S.H.
    Cell 90:109-119(1997) [PubMed] [Europe PMC] [Abstract]
  • "Forced GATA-1 expression in the murine myeloid cell line M1: induction of c-Mpl expression and megakaryocytic/erythroid differentiation."
    Yamaguchi Y., Zon L.I., Ackerman S.J., Yamamoto M., Suda T.
    Blood 91:450-457(1998) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription factor activity Source: MGI
• DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• p53 binding Source: MGI <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "GATA-1 associates with and inhibits p53."
    Trainor C.D., Mas C., Archambault P., Di Lello P., Omichinski J.G.
    Blood 114:165-173(2009) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: MGIInferred from direct assayⁱ
  • "Erythropoietin-induced transcription at the murine beta maj-globin promoter. A central role for GATA-1."
    Taxman D.J., Wojchowski D.M.
    J Biol Chem 270:6619-6627(1995) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II-specific DNA-binding transcription factor binding Source: BHF-UCLInferred from physical interactionⁱ
  • "Differential context-dependent effects of friend of GATA-1 (FOG-1) on mast-cell development and differentiation."
    Sugiyama D., Tanaka M., Kitajima K., Zheng J., Yen H., Murotani T., Yamatodani A., Nakano T.
    Blood 111:1924-1932(2008) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: MGI
• sequence-specific DNA binding Source: MGIInferred from direct assayⁱ
  • "Regulation of the erythroid Kruppel-like factor (EKLF) gene promoter by the erythroid transcription factor GATA-1."
    Crossley M., Tsang A.P., Bieker J.J., Orkin S.H.
    J Biol Chem 269:15440-15444(1994) [PubMed] [Europe PMC] [Abstract]
  • "Differential regulation of coproporphyrinogen oxidase gene between erythroid and nonerythroid cells."
    Takahashi S., Taketani S., Akasaka J.E., Kobayashi A., Hayashi N., Yamamoto M., Nagai T.
    Blood 92:3436-3444(1998) [PubMed] [Europe PMC] [Abstract]
• sequence-specific double-stranded DNA binding Source: MGI
• transcription cis-regulatory region binding Source: MGI
• transcription coactivator binding Source: BHF-UCLInferred from physical interactionⁱ
  • "Defects of the heart, eye, and megakaryocytes in peroxisome proliferator activator receptor-binding protein (PBP) null embryos implicate GATA family of transcription factors."
    Crawford S.E., Qi C., Misra P., Stellmach V., Rao M.S., Engel J.D., Zhu Y., Reddy J.K.
    J Biol Chem 277:3585-3592(2002) [PubMed] [Europe PMC] [Abstract]
• transcription coregulator binding Source: BHF-UCLInferred from physical interactionⁱ
  • "hFOG-2, a novel zinc finger protein, binds the co-repressor mCtBP2 and modulates GATA-mediated activation."
    Holmes M., Turner J., Fox A.H., Chisholm O., Crossley M., Chong B.
    J. Biol. Chem. 274:23491-23498(1999) [PubMed] [Europe PMC] [Abstract]
• zinc ion binding Source: InterPro

GO - Biological processⁱ

• animal organ regeneration Source: MGI
• basophil differentiation Source: Ensembl
• cell-cell signaling Source: MGI <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Megakaryocyte-osteoblast interaction revealed in mice deficient in transcription factors GATA-1 and NF-E2."
    Kacena M.A., Shivdasani R.A., Wilson K., Xi Y., Troiano N., Nazarian A., Gundberg C.M., Bouxsein M.L., Lorenzo J.A., Horowitz M.C.
    J Bone Miner Res 19:652-660(2004) [PubMed] [Europe PMC] [Abstract]
• cell development Source: MGIInferred from mutant phenotypeⁱ
  • "A lineage-selective knockout establishes the critical role of transcription factor GATA-1 in megakaryocyte growth and platelet development."
    Shivdasani R.A., Fujiwara Y., McDevitt M.A., Orkin S.H.
    EMBO J 16:3965-3973(1997) [PubMed] [Europe PMC] [Abstract]
• cell fate commitment Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• cellular response to cAMP Source: Ensembl
• cellular response to follicle-stimulating hormone stimulus Source: Ensembl
• cellular response to lipopolysaccharide Source: MGI
• cellular response to thyroid hormone stimulus Source: MGI
• dendritic cell differentiation Source: MGIInferred from direct assayⁱ
  • "Gata1 regulates dendritic-cell development and survival."
    Gutierrez L., Nikolic T., van Dijk T.B., Hammad H., Vos N., Willart M., Grosveld F., Philipsen S., Lambrecht B.N.
    Blood 110:1933-1941(2007) [PubMed] [Europe PMC] [Abstract]
• embryonic hemopoiesis Source: MGIInferred from mutant phenotypeⁱ
  • "Knock-in mutation of transcription factor GATA-3 into the GATA-1 locus: partial rescue of GATA-1 loss of function in erythroid cells."
    Tsai F.Y., Browne C.P., Orkin S.H.
    Dev Biol 196:218-227(1998) [PubMed] [Europe PMC] [Abstract]
• eosinophil fate commitment Source: MGI
• erythrocyte development Source: MGI
• erythrocyte differentiation Source: MGIInferred from direct assayⁱ
  • "Forced GATA-1 expression in the murine myeloid cell line M1: induction of c-Mpl expression and megakaryocytic/erythroid differentiation."
    Yamaguchi Y., Zon L.I., Ackerman S.J., Yamamoto M., Suda T.
    Blood 91:450-457(1998) [PubMed] [Europe PMC] [Abstract]
• homeostasis of number of cells within a tissue Source: MGI <p>Inferred from Genetic Interaction</p> <p>Used to describe "traditional" genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "Functional overlap of GATA-1 and GATA-2 in primitive hematopoietic development."
    Fujiwara Y., Chang A.N., Williams A.M., Orkin S.H.
    Blood 103:583-585(2004) [PubMed] [Europe PMC] [Abstract]
• in utero embryonic development Source: MGIInferred from mutant phenotypeⁱ
  • "Knock-in mutation of transcription factor GATA-3 into the GATA-1 locus: partial rescue of GATA-1 loss of function in erythroid cells."
    Tsai F.Y., Browne C.P., Orkin S.H.
    Dev Biol 196:218-227(1998) [PubMed] [Europe PMC] [Abstract]
• male gonad development Source: MGI
• megakaryocyte differentiation Source: MGIInferred from direct assayⁱ
  • "Forced GATA-1 expression in the murine myeloid cell line M1: induction of c-Mpl expression and megakaryocytic/erythroid differentiation."
    Yamaguchi Y., Zon L.I., Ackerman S.J., Yamamoto M., Suda T.
    Blood 91:450-457(1998) [PubMed] [Europe PMC] [Abstract]
• myeloid cell differentiation Source: MGIInferred from mutant phenotypeⁱ
  • "Arrested development of embryonic red cell precursors in mouse embryos lacking transcription factor GATA-1."
    Fujiwara Y., Browne C.P., Cunniff K., Goff S.C., Orkin S.H.
    Proc Natl Acad Sci U S A 93:12355-12358(1996) [PubMed] [Europe PMC] [Abstract]
  • "Arrest in primitive erythroid cell development caused by promoter-specific disruption of the GATA-1 gene."
    Takahashi S., Onodera K., Motohashi H., Suwabe N., Hayashi N., Yanai N., Nabesima Y., Yamamoto M.
    J Biol Chem 272:12611-12615(1997) [PubMed] [Europe PMC] [Abstract]
• negative regulation of apoptotic process Source: MGIInferred from mutant phenotypeⁱ
  • "Transcription factor GATA-1 permits survival and maturation of erythroid precursors by preventing apoptosis."
    Weiss M.J., Orkin S.H.
    Proc Natl Acad Sci U S A 92:9623-9627(1995) [PubMed] [Europe PMC] [Abstract]
• negative regulation of bone mineralization Source: MGIInferred from mutant phenotypeⁱ
  • "Megakaryocyte-osteoblast interaction revealed in mice deficient in transcription factors GATA-1 and NF-E2."
    Kacena M.A., Shivdasani R.A., Wilson K., Xi Y., Troiano N., Nazarian A., Gundberg C.M., Bouxsein M.L., Lorenzo J.A., Horowitz M.C.
    J Bone Miner Res 19:652-660(2004) [PubMed] [Europe PMC] [Abstract]
• negative regulation of cell population proliferation Source: MGIInferred from mutant phenotypeⁱ
  • "A lineage-selective knockout establishes the critical role of transcription factor GATA-1 in megakaryocyte growth and platelet development."
    Shivdasani R.A., Fujiwara Y., McDevitt M.A., Orkin S.H.
    EMBO J 16:3965-3973(1997) [PubMed] [Europe PMC] [Abstract]
• negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: MGI
• negative regulation of transcription by RNA polymerase II Source: MGIInferred from direct assayⁱ
  • "Gata1 regulates dendritic-cell development and survival."
    Gutierrez L., Nikolic T., van Dijk T.B., Hammad H., Vos N., Willart M., Grosveld F., Philipsen S., Lambrecht B.N.
    Blood 110:1933-1941(2007) [PubMed] [Europe PMC] [Abstract]
• negative regulation of transcription regulatory region DNA binding Source: MGI
• platelet aggregation Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Selective impairment of platelet activation to collagen in the absence of GATA1."
    Hughan S.C., Senis Y., Best D., Thomas A., Frampton J., Vyas P., Watson S.P.
    Blood 105:4369-4376(2005) [PubMed] [Europe PMC] [Abstract]
• platelet formation Source: MGIInferred from mutant phenotypeⁱ
  • "A lineage-selective knockout establishes the critical role of transcription factor GATA-1 in megakaryocyte growth and platelet development."
    Shivdasani R.A., Fujiwara Y., McDevitt M.A., Orkin S.H.
    EMBO J 16:3965-3973(1997) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cytosolic calcium ion concentration Source: MGI
• positive regulation of erythrocyte differentiation Source: MGI
• positive regulation of mast cell degranulation Source: MGI
• positive regulation of osteoblast proliferation Source: MGIInferred from mutant phenotypeⁱ
  • "Megakaryocyte-osteoblast interaction revealed in mice deficient in transcription factors GATA-1 and NF-E2."
    Kacena M.A., Shivdasani R.A., Wilson K., Xi Y., Troiano N., Nazarian A., Gundberg C.M., Bouxsein M.L., Lorenzo J.A., Horowitz M.C.
    J Bone Miner Res 19:652-660(2004) [PubMed] [Europe PMC] [Abstract]
• positive regulation of peptidyl-tyrosine phosphorylation Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Selective impairment of platelet activation to collagen in the absence of GATA1."
    Hughan S.C., Senis Y., Best D., Thomas A., Frampton J., Vyas P., Watson S.P.
    Blood 105:4369-4376(2005) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription, DNA-templated Source: UniProtKBInferred from direct assayⁱ
  • Ref.17

    "CCAR1/CoCoA pair-mediated recruitment of the Mediator defines a novel pathway for GATA1 function."
    Mizuta S., Minami T., Fujita H., Kaminaga C., Matsui K., Ishino R., Fujita A., Oda K., Kawai A., Hasegawa N., Urahama N., Roeder R.G., Ito M.
    Genes Cells 19:28-51(2014) [PubMed] [Europe PMC] [Abstract]

    Cited for: INTERACTION WITH MED1; CCAR1 AND CALCOCO1.
• positive regulation of transcription by RNA polymerase II Source: BHF-UCLInferred from direct assayⁱ
  • "X-linked thrombocytopenia with thalassemia from a mutation in the amino finger of GATA-1 affecting DNA binding rather than FOG-1 interaction."
    Yu C., Niakan K.K., Matsushita M., Stamatoyannopoulos G., Orkin S.H., Raskind W.H.
    Blood 100:2040-2045(2002) [PubMed] [Europe PMC] [Abstract]
• regulation of definitive erythrocyte differentiation Source: BHF-UCLInferred from direct assayⁱ
  • "X-linked thrombocytopenia with thalassemia from a mutation in the amino finger of GATA-1 affecting DNA binding rather than FOG-1 interaction."
    Yu C., Niakan K.K., Matsushita M., Stamatoyannopoulos G., Orkin S.H., Raskind W.H.
    Blood 100:2040-2045(2002) [PubMed] [Europe PMC] [Abstract]
• regulation of glycoprotein biosynthetic process Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Selective impairment of platelet activation to collagen in the absence of GATA1."
    Hughan S.C., Senis Y., Best D., Thomas A., Frampton J., Vyas P., Watson S.P.
    Blood 105:4369-4376(2005) [PubMed] [Europe PMC] [Abstract]
• regulation of primitive erythrocyte differentiation Source: MGIInferred from genetic interactionⁱ
  • "Functional overlap of GATA-1 and GATA-2 in primitive hematopoietic development."
    Fujiwara Y., Chang A.N., Williams A.M., Orkin S.H.
    Blood 103:583-585(2004) [PubMed] [Europe PMC] [Abstract]
• Sertoli cell development Source: Ensembl

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Mutagenesis

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stageⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• C2H2 zinc finger domain binding Source: MGI
• p53 binding Source: MGIInferred from physical interactionⁱ
  • "GATA-1 associates with and inhibits p53."
    Trainor C.D., Mas C., Archambault P., Di Lello P., Omichinski J.G.
    Blood 114:165-173(2009) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II-specific DNA-binding transcription factor binding Source: BHF-UCLInferred from physical interactionⁱ
  • "Differential context-dependent effects of friend of GATA-1 (FOG-1) on mast-cell development and differentiation."
    Sugiyama D., Tanaka M., Kitajima K., Zheng J., Yen H., Murotani T., Yamatodani A., Nakano T.
    Blood 111:1924-1932(2008) [PubMed] [Europe PMC] [Abstract]
• transcription coactivator binding Source: BHF-UCLInferred from physical interactionⁱ
  • "Defects of the heart, eye, and megakaryocytes in peroxisome proliferator activator receptor-binding protein (PBP) null embryos implicate GATA family of transcription factors."
    Crawford S.E., Qi C., Misra P., Stellmach V., Rao M.S., Engel J.D., Zhu Y., Reddy J.K.
    J Biol Chem 277:3585-3592(2002) [PubMed] [Europe PMC] [Abstract]
• transcription coregulator binding Source: BHF-UCLInferred from physical interactionⁱ
  • "hFOG-2, a novel zinc finger protein, binds the co-repressor mCtBP2 and modulates GATA-mediated activation."
    Holmes M., Turner J., Fox A.H., Chisholm O., Crossley M., Chong B.
    J. Biol. Chem. 274:23491-23498(1999) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Region

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domainⁱ

Zinc finger

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MDFPGLGALG TSEPLPQFVD SALVSSPSDS TGFFSSGPEG LDAASSSTSP 
        60         70         80         90        100
NAATAAASAL AYYREAEAYR HSPVFQVYPL LNSMEGIPGG SPYASWAYGK 
       110        120        130        140        150
TALYPASTVC PSHEDAPSQA LEDQEGKSNN TFLDTLKTER LSPDLLTLGT 
       160        170        180        190        200
ALPASLPVTG SAYGGADFPS PFFSPTGSPL SSAAYSSPKF HGSLPLAPCE 
       210        220        230        240        250
ARECVNCGAT ATPLWRRDRT GHYLCNACGL YHKMNGQNRP LIRPKKRMIV 
       260        270        280        290        300
SKRAGTQCTN CQTTTTTLWR RNASGDPVCN ACGLYFKLHQ VNRPLTMRKD 
       310        320        330        340        350
GIQTRNRKAS GKGKKKRGSN LAGAGAAEGP AGGFMVVAGS SSSGNCGEVA 
       360        370        380        390        400
SGLALGTAGT AHLYQGLGPV VLSGPVSHLM PFPGPLLGSP TTSFPTGPAP 
       410 
TTSSTSVIAP LSS                                         

        10         20         30         40         50
MEGIPGGSPY ASWAYGKTAL YPASTVCPSH EDAPSQALED QEGKSNNTFL 
        60         70         80         90        100
DTLKTERLSP DLLTLGTALP ASLPVTGSAY GGADFPSPFF SPTGSPLSSA 
       110        120        130        140        150
AYSSPKFHGS LPLAPCEARE CVNCGATATP LWRRDRTGHY LCNACGLYHK 
       160        170        180        190        200
MNGQNRPLIR PKKRMIVSKR AGTQCTNCQT TTTTLWRRNA SGDPVCNACG 
       210        220        230        240        250
LYFKLHQVNR PLTMRKDGIQ TRNRKASGKG KKKRGSNLAG AGAAEGPAGG 
       260        270        280        290        300
FMVVAGSSSS GNCGEVASGL ALGTAGTAHL YQGLGPVVLS GPVSHLMPFP 
       310        320        330
GPLLGSPTTS FPTGPAPTTS STSVIAPLSS                       

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
2. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references