UniProtKB - P17676 (CEBPB_HUMAN)
CCAAT/enhancer-binding protein beta
CEBPB
Functioni
Important transcription factor regulating the expression of genes involved in immune and inflammatory responses (PubMed:1741402, PubMed:9374525, PubMed:12048245, PubMed:18647749).
Plays also a significant role in adipogenesis, as well as in the gluconeogenic pathway, liver regeneration, and hematopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Its functional capacity is governed by protein interactions and post-translational protein modifications. During early embryogenesis, plays essential and redundant functions with CEBPA. Has a promitotic effect on many cell types such as hepatocytes and adipocytes but has an antiproliferative effect on T-cells by repressing MYC expression, facilitating differentiation along the T-helper 2 lineage. Binds to regulatory regions of several acute-phase and cytokines genes and plays a role in the regulation of acute-phase reaction and inflammation. Plays also a role in intracellular bacteria killing (By similarity).
During adipogenesis, is rapidly expressed and, after activation by phosphorylation, induces CEBPA and PPARG, which turn on the series of adipocyte genes that give rise to the adipocyte phenotype. The delayed transactivation of the CEBPA and PPARG genes by CEBPB appears necessary to allow mitotic clonal expansion and thereby progression of terminal differentiation (PubMed:20829347).
Essential for female reproduction because of a critical role in ovarian follicle development (By similarity).
Restricts osteoclastogenesis: together with NFE2L1; represses expression of DSPP during odontoblast differentiation (By similarity).
1 PublicationBy similarity4 PublicationsEssential for gene expression induction in activated macrophages. Plays a major role in immune responses such as CD4+ T-cell response, granuloma formation and endotoxin shock. Not essential for intracellular bacteria killing.
By similarityActs as a dominant negative through heterodimerization with isoform 2 (PubMed:11741938).
Promotes osteoblast differentiation and osteoclastogenesis (By similarity).
By similarity1 PublicationGO - Molecular functioni
- chromatin binding Source: Ensembl
- DNA binding Source: ProtInc
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: Ensembl
- DNA-binding transcription factor activity Source: ProtInc
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: UniProtKB
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: UniProtKB
- glucocorticoid receptor binding Source: Ensembl
- histone acetyltransferase binding Source: Ensembl
- histone deacetylase binding Source: Ensembl
- kinase binding Source: Ensembl
- protein heterodimerization activity Source: Ensembl
- protein homodimerization activity Source: UniProtKB
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- RNA polymerase II core promoter sequence-specific DNA binding Source: Ensembl
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: MGI
- sequence-specific double-stranded DNA binding Source: ARUK-UCL
- transcription cis-regulatory region binding Source: ARUK-UCL
- ubiquitin-like protein ligase binding Source: Ensembl
GO - Biological processi
- acute-phase response Source: ProtInc
- brown fat cell differentiation Source: Ensembl
- cellular response to amino acid stimulus Source: Ensembl
- cellular response to interleukin-1 Source: Ensembl
- cellular response to lipopolysaccharide Source: Ensembl
- cellular response to organic cyclic compound Source: Ensembl
- defense response to bacterium Source: UniProtKB
- embryonic placenta development Source: Ensembl
- granuloma formation Source: UniProtKB
- hepatocyte proliferation Source: UniProtKB
- immune response Source: ProtInc
- inflammatory response Source: ProtInc
- intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress Source: ParkinsonsUK-UCL
- liver regeneration Source: UniProtKB
- mammary gland epithelial cell differentiation Source: Ensembl
- mammary gland epithelial cell proliferation Source: Ensembl
- memory Source: Ensembl
- negative regulation of neuron apoptotic process Source: Ensembl
- negative regulation of T cell proliferation Source: UniProtKB
- negative regulation of transcription by RNA polymerase II Source: UniProtKB
- neuron differentiation Source: Ensembl
- ovarian follicle development Source: UniProtKB
- positive regulation of biomineral tissue development Source: MGI
- positive regulation of cold-induced thermogenesis Source: YuBioLab
- positive regulation of fat cell differentiation Source: UniProtKB
- positive regulation of inflammatory response Source: Ensembl
- positive regulation of interleukin-4 production Source: UniProtKB
- positive regulation of osteoblast differentiation Source: Ensembl
- positive regulation of sodium-dependent phosphate transport Source: MGI
- positive regulation of transcription, DNA-templated Source: MGI
- positive regulation of transcription by RNA polymerase II Source: MGI
- positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress Source: ParkinsonsUK-UCL
- regulation of cell differentiation Source: GO_Central
- regulation of dendritic cell differentiation Source: Ensembl
- regulation of interleukin-6 production Source: Ensembl
- regulation of odontoblast differentiation Source: UniProtKB
- regulation of osteoclast differentiation Source: UniProtKB
- regulation of transcription, DNA-templated Source: UniProtKB
- regulation of transcription by RNA polymerase II Source: ComplexPortal
- response to endoplasmic reticulum stress Source: UniProtKB
- T-helper 1 cell activation Source: UniProtKB
Keywordsi
Molecular function | Activator, DNA-binding |
Biological process | Differentiation, Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | P17676 |
Reactomei | R-HSA-2559582, Senescence-Associated Secretory Phenotype (SASP) R-HSA-380994, ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-381340, Transcriptional regulation of white adipocyte differentiation R-HSA-8853884, Transcriptional Regulation by VENTX R-HSA-9616222, Transcriptional regulation of granulopoiesis R-HSA-9633012, Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9648895, Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9725371, Nuclear events stimulated by ALK signaling in cancer |
SignaLinki | P17676 |
SIGNORi | P17676 |
Names & Taxonomyi
Protein namesi | Recommended name: CCAAT/enhancer-binding protein betaImportedShort name: C/EBP betaImported Alternative name(s): Liver activator protein Short name: LAP Liver-enriched inhibitory protein Short name: LIP Nuclear factor NF-IL61 Publication Transcription factor 5 Short name: TCF-5 |
Gene namesi | ORF Names:PP9092 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:1834, CEBPB |
MIMi | 189965, gene |
neXtProti | NX_P17676 |
VEuPathDBi | HostDB:ENSG00000172216 |
Subcellular locationi
Nucleus
- C/EBP complex Source: ComplexPortal
- CHOP-C/EBP complex Source: ComplexPortal
- nuclear matrix Source: Ensembl
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
- RNA polymerase II transcription regulator complex Source: ComplexPortal
Other locations
- chromatin Source: NTNU_SB
- condensed chromosome, centromeric region Source: Ensembl
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 235 | T → S: Loss of transactivation activity in response to IFNG. 1 Publication | 1 | |
Mutagenesisi | 288 | S → A: Loss of nuclear translocation. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 1051 |
OpenTargetsi | ENSG00000172216 |
PharmGKBi | PA26377 |
Miscellaneous databases
Pharosi | P17676, Tbio |
Chemistry databases
DrugBanki | DB04216, Quercetin |
Genetic variation databases
BioMutai | CEBPB |
DMDMi | 34223718 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000076617 | 1 – 345 | CCAAT/enhancer-binding protein betaAdd BLAST | 345 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 3 | Asymmetric dimethylarginine; by CARM11 Publication | 1 | |
Modified residuei | 43 | N6-acetyllysine; alternateBy similarity | 1 | |
Modified residuei | 43 | N6-methylated lysine; alternateBy similarity | 1 | |
Modified residuei | 129 | N6-acetyllysine; by KAT2A and KAT2BBy similarity | 1 | |
Modified residuei | 132 | N6-acetyllysine; by KAT2A and KAT2BBy similarity | 1 | |
Modified residuei | 133 | N6-acetyllysine; by KAT2A and KAT2B; alternateBy similarity | 1 | |
Cross-linki | 133 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources | ||
Cross-linki | 174 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO); alternate1 Publication | ||
Cross-linki | 174 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources | ||
Cross-linki | 185 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 187 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 226 | Phosphothreonine; by GSK3-betaBy similarity | 1 | |
Glycosylationi | 227 | O-linked (GlcNAc) serineBy similarity | 1 | |
Glycosylationi | 228 | O-linked (GlcNAc) serineBy similarity | 1 | |
Modified residuei | 231 | Phosphoserine; by GSK3-betaBy similarity | 1 | |
Modified residuei | 235 | Phosphothreonine; by RPS6KA1, CDK2 and MAPK2 Publications | 1 | |
Cross-linki | 260 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 262 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 266 | Phosphothreonine; by RPS6KA1 and PKC/PRKCABy similarity | 1 | |
Modified residuei | 288 | Phosphoserine; by PKC/PRKCA1 Publication | 1 | |
Modified residuei | 325 | Phosphoserine; by CaMK2By similarity | 1 | |
Cross-linki | 332 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Post-translational modificationi
Keywords - PTMi
Acetylation, Glycoprotein, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | P17676 |
jPOSTi | P17676 |
MassIVEi | P17676 |
MaxQBi | P17676 |
PaxDbi | P17676 |
PeptideAtlasi | P17676 |
PRIDEi | P17676 |
ProteomicsDBi | 53503 [P17676-1] |
PTM databases
GlyGeni | P17676, 3 sites, 1 O-linked glycan (1 site) |
iPTMneti | P17676 |
PhosphoSitePlusi | P17676 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000172216, Expressed in layer of synovial tissue and 255 other tissues |
Genevisiblei | P17676, HS |
Organism-specific databases
HPAi | ENSG00000172216, Low tissue specificity |
Interactioni
Subunit structurei
Binds DNA as a homodimer and as a heterodimer (PubMed:11018027, PubMed:11257229, PubMed:11792321).
Interacts with ATF4. Binds DNA as a heterodimer with ATF4 (PubMed:11018027).
Interacts with MYB; within the complex, MYB and CEBPB bind to different promoter regions (PubMed:11792321). Can form stable heterodimers with CEBPD (PubMed:1741402). Can form stable heterodimers with CEBPA and CEBPE (By similarity).
Interacts with SIX1 (PubMed:27923061). Isoform 2 and isoform 3 also form heterodimers.
Interacts with TRIM28 and PTGES2.
Interacts with PRDM16.
Interacts with CCDC85B.
Forms a complex with THOC5.
Interacts with ZNF638; this interaction increases transcriptional activation.
Interacts with CIDEA and CIDEC; these interactions increase transcriptional activation of a subset of CEBPB downstream target genes (By similarity).
Interacts with DDIT3/CHOP (PubMed:20829347).
Interacts with EP300; recruits EP300 to chromatin.
Interacts with RORA; the interaction disrupts interaction with EP300.
Interacts (not methylated) with MED23, MED26, SMARCA2, SMARCB1 and SMARCC1 (PubMed:20111005).
Interacts with KAT2A and KAT2B (By similarity).
Interacts with ATF5; EP300 is required for ATF5 and CEBPB interaction and DNA binding (By similarity).
Interacts with NFE2L1; the heterodimer represses expression of DSPP during odontoblast differentiation (By similarity).
By similarity6 PublicationsBinary interactionsi
P17676
Isoform 1 [P17676-1]
With | #Exp. | IntAct |
---|---|---|
SUMO1 [P63165] | 5 | EBI-9997012,EBI-80140 |
GO - Molecular functioni
- glucocorticoid receptor binding Source: Ensembl
- histone acetyltransferase binding Source: Ensembl
- histone deacetylase binding Source: Ensembl
- kinase binding Source: Ensembl
- protein heterodimerization activity Source: Ensembl
- protein homodimerization activity Source: UniProtKB
- ubiquitin-like protein ligase binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 107480, 87 interactors |
ComplexPortali | CPX-3361, bZIP transcription factor complex, CEBPB-CEBPB CPX-504, c-Myb-C/EBPbeta complex CPX-509, bZIP transcription factor complex, CEBPA-CEBPB CPX-6470, bZIP transcription factor complex, ATF3-CEBPB CPX-6471, bZIP transcription factor complex, ATF3-CEBPG CPX-6526, bZIP transcription factor complex, ATF4-CEBPB CPX-70, bZIP transcription factor complex, CEBPB-DDIT3 CPX-7007, bZIP transcription factor complex, BATF-CEBPB CPX-7096, bZIP transcription factor complex, BATF3-CEBPB |
CORUMi | P17676 |
DIPi | DIP-35345N |
ELMi | P17676 |
IntActi | P17676, 28 interactors |
MINTi | P17676 |
STRINGi | 9606.ENSP00000305422 |
Miscellaneous databases
RNActi | P17676, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P17676 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P17676 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 271 – 334 | bZIPPROSITE-ProRule annotationAdd BLAST | 64 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 24 | Required for Lys-174 sumoylationAdd BLAST | 24 | |
Regioni | 24 – 135 | Required for MYC transcriptional repressionBy similarityAdd BLAST | 112 | |
Regioni | 46 – 67 | DisorderedSequence analysisAdd BLAST | 22 | |
Regioni | 79 – 116 | DisorderedSequence analysisAdd BLAST | 38 | |
Regioni | 157 – 178 | DisorderedSequence analysisAdd BLAST | 22 | |
Regioni | 218 – 271 | DisorderedSequence analysisAdd BLAST | 54 | |
Regioni | 275 – 295 | Basic motifPROSITE-ProRule annotationAdd BLAST | 21 | |
Regioni | 297 – 304 | Leucine-zipperPROSITE-ProRule annotation | 8 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 116 – 124 | 9aaTAD | 9 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 157 – 175 | Pro residuesSequence analysisAdd BLAST | 19 | |
Compositional biasi | 218 – 236 | Polar residuesSequence analysisAdd BLAST | 19 |
Domaini
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG3119, Eukaryota |
GeneTreei | ENSGT00940000162137 |
HOGENOMi | CLU_043327_1_0_1 |
InParanoidi | P17676 |
OMAi | KNCKKAA |
OrthoDBi | 1284308at2759 |
PhylomeDBi | P17676 |
TreeFami | TF105008 |
Family and domain databases
InterProi | View protein in InterPro IPR004827, bZIP IPR016468, C/EBP_chordates |
Pfami | View protein in Pfam PF07716, bZIP_2, 1 hit |
PIRSFi | PIRSF005879, CCAAT/enhancer-binding, 1 hit |
SMARTi | View protein in SMART SM00338, BRLZ, 1 hit |
PROSITEi | View protein in PROSITE PS50217, BZIP, 1 hit |
s (3)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative initiation. AlignAdd to basketThis isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MQRLVAWDPA CLPLPPPPPA FKSMEVANFY YEADCLAAAY GGKAAPAAPP
60 70 80 90 100
AARPGPRPPA GELGSIGDHE RAIDFSPYLE PLGAPQAPAP ATATDTFEAA
110 120 130 140 150
PPAPAPAPAS SGQHHDFLSD LFSDDYGGKN CKKPAEYGYV SLGRLGAAKG
160 170 180 190 200
ALHPGCFAPL HPPPPPPPPP AELKAEPGFE PADCKRKEEA GAPGGGAGMA
210 220 230 240 250
AGFPYALRAY LGYQAVPSGS SGSLSTSSSS SPPGTPSPAD AKAPPTACYA
260 270 280 290 300
GAAPAPSQVK SKAKKTVDKH SDEYKIRRER NNIAVRKSRD KAKMRNLETQ
310 320 330 340
HKVLELTAEN ERLQKKVEQL SRELSTLRNL FKQLPEPLLA SSGHC
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 241 | A → P no nucleotide entry (PubMed:7635140).Curated | 1 | |
Sequence conflicti | 253 | A → G in CAA36794 (PubMed:2112087).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_016300 | 195 | G → S1 PublicationCorresponds to variant dbSNP:rs4253440Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_053313 | 1 – 198 | Missing in isoform 3. CuratedAdd BLAST | 198 | |
Alternative sequenceiVSP_053314 | 1 – 23 | Missing in isoform 2. CuratedAdd BLAST | 23 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X52560 Genomic DNA Translation: CAA36794.1 AF289608 mRNA Translation: AAL55792.1 AY193834 Genomic DNA Translation: AAN86350.1 AK291536 mRNA Translation: BAF84225.1 AL161937 Genomic DNA No translation available. CH471077 Genomic DNA Translation: EAW75629.1 BC007538 mRNA Translation: AAH07538.1 BC021931 mRNA Translation: AAH21931.1 |
CCDSi | CCDS13429.1 [P17676-1] |
PIRi | S12788 S66246 |
RefSeqi | NP_001272807.1, NM_001285878.1 [P17676-2] NP_001272808.1, NM_001285879.1 [P17676-3] NP_005185.2, NM_005194.3 [P17676-1] |
Genome annotation databases
Ensembli | ENST00000303004; ENSP00000305422; ENSG00000172216 |
GeneIDi | 1051 |
KEGGi | hsa:1051 |
MANE-Selecti | ENST00000303004.5; ENSP00000305422.3; NM_005194.4; NP_005185.2 |
UCSCi | uc002xvi.4, human [P17676-1] |
Keywords - Coding sequence diversityi
Alternative initiationSimilar proteinsi
Cross-referencesi
Web resourcesi
SeattleSNPs |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X52560 Genomic DNA Translation: CAA36794.1 AF289608 mRNA Translation: AAL55792.1 AY193834 Genomic DNA Translation: AAN86350.1 AK291536 mRNA Translation: BAF84225.1 AL161937 Genomic DNA No translation available. CH471077 Genomic DNA Translation: EAW75629.1 BC007538 mRNA Translation: AAH07538.1 BC021931 mRNA Translation: AAH21931.1 |
CCDSi | CCDS13429.1 [P17676-1] |
PIRi | S12788 S66246 |
RefSeqi | NP_001272807.1, NM_001285878.1 [P17676-2] NP_001272808.1, NM_001285879.1 [P17676-3] NP_005185.2, NM_005194.3 [P17676-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1GTW | X-ray | 1.85 | A/B | 259-336 | [»] | |
1GU4 | X-ray | 1.80 | A/B | 259-336 | [»] | |
1GU5 | X-ray | 2.10 | A/B | 259-336 | [»] | |
1H88 | X-ray | 2.80 | A/B | 259-336 | [»] | |
1H89 | X-ray | 2.45 | A/B | 273-336 | [»] | |
1H8A | X-ray | 2.23 | A/B | 259-336 | [»] | |
1HJB | X-ray | 3.00 | A/B/D/E | 259-345 | [»] | |
1IO4 | X-ray | 3.00 | A/B | 259-336 | [»] | |
2E42 | X-ray | 1.80 | A/B | 259-336 | [»] | |
2E43 | X-ray | 2.10 | A/B | 259-336 | [»] | |
6MG1 | X-ray | 1.75 | A/B | 269-344 | [»] | |
6MG2 | X-ray | 1.93 | A/B | 269-344 | [»] | |
6MG3 | X-ray | 2.05 | A/B | 269-344 | [»] | |
SMRi | P17676 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 107480, 87 interactors |
ComplexPortali | CPX-3361, bZIP transcription factor complex, CEBPB-CEBPB CPX-504, c-Myb-C/EBPbeta complex CPX-509, bZIP transcription factor complex, CEBPA-CEBPB CPX-6470, bZIP transcription factor complex, ATF3-CEBPB CPX-6471, bZIP transcription factor complex, ATF3-CEBPG CPX-6526, bZIP transcription factor complex, ATF4-CEBPB CPX-70, bZIP transcription factor complex, CEBPB-DDIT3 CPX-7007, bZIP transcription factor complex, BATF-CEBPB CPX-7096, bZIP transcription factor complex, BATF3-CEBPB |
CORUMi | P17676 |
DIPi | DIP-35345N |
ELMi | P17676 |
IntActi | P17676, 28 interactors |
MINTi | P17676 |
STRINGi | 9606.ENSP00000305422 |
Chemistry databases
DrugBanki | DB04216, Quercetin |
PTM databases
GlyGeni | P17676, 3 sites, 1 O-linked glycan (1 site) |
iPTMneti | P17676 |
PhosphoSitePlusi | P17676 |
Genetic variation databases
BioMutai | CEBPB |
DMDMi | 34223718 |
Proteomic databases
EPDi | P17676 |
jPOSTi | P17676 |
MassIVEi | P17676 |
MaxQBi | P17676 |
PaxDbi | P17676 |
PeptideAtlasi | P17676 |
PRIDEi | P17676 |
ProteomicsDBi | 53503 [P17676-1] |
Protocols and materials databases
Antibodypediai | 3782, 682 antibodies from 42 providers |
DNASUi | 1051 |
Genome annotation databases
Ensembli | ENST00000303004; ENSP00000305422; ENSG00000172216 |
GeneIDi | 1051 |
KEGGi | hsa:1051 |
MANE-Selecti | ENST00000303004.5; ENSP00000305422.3; NM_005194.4; NP_005185.2 |
UCSCi | uc002xvi.4, human [P17676-1] |
Organism-specific databases
CTDi | 1051 |
DisGeNETi | 1051 |
GeneCardsi | CEBPB |
HGNCi | HGNC:1834, CEBPB |
HPAi | ENSG00000172216, Low tissue specificity |
MIMi | 189965, gene |
neXtProti | NX_P17676 |
OpenTargetsi | ENSG00000172216 |
PharmGKBi | PA26377 |
VEuPathDBi | HostDB:ENSG00000172216 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3119, Eukaryota |
GeneTreei | ENSGT00940000162137 |
HOGENOMi | CLU_043327_1_0_1 |
InParanoidi | P17676 |
OMAi | KNCKKAA |
OrthoDBi | 1284308at2759 |
PhylomeDBi | P17676 |
TreeFami | TF105008 |
Enzyme and pathway databases
PathwayCommonsi | P17676 |
Reactomei | R-HSA-2559582, Senescence-Associated Secretory Phenotype (SASP) R-HSA-380994, ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-381340, Transcriptional regulation of white adipocyte differentiation R-HSA-8853884, Transcriptional Regulation by VENTX R-HSA-9616222, Transcriptional regulation of granulopoiesis R-HSA-9633012, Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-9648895, Response of EIF2AK1 (HRI) to heme deficiency R-HSA-9725371, Nuclear events stimulated by ALK signaling in cancer |
SignaLinki | P17676 |
SIGNORi | P17676 |
Miscellaneous databases
BioGRID-ORCSi | 1051, 50 hits in 1068 CRISPR screens |
ChiTaRSi | CEBPB, human |
EvolutionaryTracei | P17676 |
GeneWikii | CEBPB |
GenomeRNAii | 1051 |
Pharosi | P17676, Tbio |
PROi | PR:P17676 |
RNActi | P17676, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000172216, Expressed in layer of synovial tissue and 255 other tissues |
Genevisiblei | P17676, HS |
Family and domain databases
InterProi | View protein in InterPro IPR004827, bZIP IPR016468, C/EBP_chordates |
Pfami | View protein in Pfam PF07716, bZIP_2, 1 hit |
PIRSFi | PIRSF005879, CCAAT/enhancer-binding, 1 hit |
SMARTi | View protein in SMART SM00338, BRLZ, 1 hit |
PROSITEi | View protein in PROSITE PS50217, BZIP, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CEBPB_HUMAN | |
Accessioni | P17676Primary (citable) accession number: P17676 Secondary accession number(s): A8K671, Q96IH2, Q9H4Z5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1990 |
Last sequence update: | August 22, 2003 | |
Last modified: | February 23, 2022 | |
This is version 224 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families