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Entry version 184 (03 Jul 2019)
Sequence version 2 (19 Jul 2005)
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Protein

Ecdysone-induced protein 75B, isoforms C/D

Gene

Eip75B

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Implicated in the regulation of ecdysone-triggered gene hierarchies. Probably plays a key role in mediating the regulation of the larval molt by 20-OH-ecdysone.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi242 – 318Nuclear receptorPROSITE-ProRule annotationAdd BLAST77
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri245 – 265NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri282 – 306NR C4-typePROSITE-ProRule annotationAdd BLAST25

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, DNA-binding, Receptor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ecdysone-induced protein 75B, isoforms C/D
Alternative name(s):
E75-A
Nuclear receptor subfamily 1 group D member 3, isoforms C/D
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Eip75B
Synonyms:NR1D3
ORF Names:CG8127
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0000568 Eip75B

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000535061 – 1199Ecdysone-induced protein 75B, isoforms C/DAdd BLAST1199

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
P17671

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

In mid instar larvae salivary glands, low basal levels are observed in puff stage 1. Levels increase in late larvae from puff stages 3-10, then decrease abruptly at stage 11. In prepupae, isoform C is the predominant form during the transition between puff stages 18-19. At puff stage 1, expression is also present in the gut. By stage 3 it is present in the wing disks, Malpighian tubules and the fat body. At stage 11, expression is only present in the gut and wing disks.1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

The expression of this protein is developmentally regulated and is correlated with the 20-OH-ecdysone induced activity of puff 75B.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0000568 Expressed in 31 organ(s), highest expression level in head

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P17671 differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P17671 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
65284, 10 interactors

Protein interaction database and analysis system

More...
IntActi
P17671, 2 interactors

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P17671

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini352 – 600NR LBDPROSITE-ProRule annotationAdd BLAST249

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi139 – 195Gln/His-richAdd BLAST57
Compositional biasi721 – 756Gln-richAdd BLAST36
Compositional biasi900 – 1103Ser-richAdd BLAST204

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri245 – 265NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri282 – 306NR C4-typePROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3575 Eukaryota
ENOG410XT74 LUCA

Identification of Orthologs from Complete Genome Data

More...
OMAi
NYHNAPV

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.565.10, 1 hit
3.30.50.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR035500 NHR-like_dom_sf
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR001728 ThyrH_rcpt
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00104 Hormone_recep, 1 hit
PF00105 zf-C4, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00398 STRDHORMONER
PR00047 STROIDFINGER
PR00546 THYROIDHORMR

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48508 SSF48508, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform C (identifier: P17671-1) [UniParc]FASTAAdd to basket
Also known as: E75A

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLMSADSSDS AKTSVICSTV SASMLAPPAP EQPSTTAPPI LGVTGRSHLE
60 70 80 90 100
NALKLPPNTS VSAYYQHNSK LGMGQNYNPE FRSLVAPVTD LDTVPPTGVT
110 120 130 140 150
MASSSNSPNS SVKLPHSGVI FVSKSSAVST TDGPTAVLQQ QQPQQQMPQH
160 170 180 190 200
FESLPHHHPQ QEHQPQQQQQ QHHLQHHPHP HVMYPHGYQQ ANLHHSGGIA
210 220 230 240 250
VVPADSRPQT PEYIKSYPVM DTTVASSVKG EPELNIEFDG TTVLCRVCGD
260 270 280 290 300
KASGFHYGVH SCEGCKGFFR RSIQQKIQYR PCTKNQQCSI LRINRNRCQY
310 320 330 340 350
CRLKKCIAVG MSRDAVRFGR VPKREKARIL AAMQQSTQNR GQQRALATEL
360 370 380 390 400
DDQPRLLAAV LRAHLETCEF TKEKVSAMRQ RARDCPSYSM PTLLACPLNP
410 420 430 440 450
APELQSEQEF SQRFAHVIRG VIDFAGMIPG FQLLTQDDKF TLLKAGLFDA
460 470 480 490 500
LFVRLICMFD SSINSIICLN GQVMRRDAIQ NGANARFLVD STFNFAERMN
510 520 530 540 550
SMNLTDAEIG LFCAIVLITP DRPGLRNLEL IEKMYSRLKG CLQYIVAQNR
560 570 580 590 600
PDQPEFLAKL LETMPDLRTL STLHTEKLVV FRTEHKELLR QQMWSMEDGN
610 620 630 640 650
NSDGQQNKSP SGSWADAMDV EAAKSPLGSV SSTESADLDY GSPSSSQPQG
660 670 680 690 700
VSLPSPPQQQ PSALASSAPL LAATLSGGCP LRNRANSGSS GDSGAAEMDI
710 720 730 740 750
VGSHAHLTQN GLTITPIVRH QQQQQQQQQI GILNNAHSRN LNGGHAMCQQ
760 770 780 790 800
QQQHPQLHHH LTAGAARYRK LDSPTDSGIE SGNEKNECKA VSSGGSSSCS
810 820 830 840 850
SPRSSVDDAL DCSDAAANHN QVVQHPQLSV VSVSPVRSPQ PSTSSHLKRQ
860 870 880 890 900
IVEDMPVLKR VLQAPPLYDT NSLMDEAYKP HKKFRALRHR EFETAEADAS
910 920 930 940 950
SSTSGSNSLS AGSPRQSPVP NSVATPPPSA ASAAAGNPAQ SQLHMHLTRS
960 970 980 990 1000
SPKASMASSH SVLAKSLMAE PRMTPEQMKR SDIIQNYLKR ENSTAASSTT
1010 1020 1030 1040 1050
NGVGNRSPSS SSTPPPSAVQ NQQRWGSSSV ITTTCQQRQQ SVSPHSNGSS
1060 1070 1080 1090 1100
SSSSSSSSSS SSSSSTSSNC SSSSASSCQY FQSPHSTSNG TSAPASSSSG
1110 1120 1130 1140 1150
SNSATPLLEL QVDIADSAQP LNLSKKSPTP PPSKLHALVA AANAVQRYPT
1160 1170 1180 1190
LSADVTVTAS NGGPPSAAAS PAPSSSPPAS VGSPNPGLSA AVHKVMLEA
Length:1,199
Mass (Da):128,534
Last modified:July 19, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE29372F5E295F595
GO
Isoform A (identifier: P17672-1) [UniParc]FASTAAdd to basket
Also known as: E75B
The sequence of this isoform can be found in the external entry P17672.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:1,355
Mass (Da):147,171
GO
Isoform B (identifier: P13055-2) [UniParc]FASTAAdd to basket
Also known as: E75C
The sequence of this isoform can be found in the external entry P13055.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:1,412
Mass (Da):151,292
GO
Isoform D (identifier: P17671-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-293: Missing.
     294-315: NRNRCQYCRLKKCIAVGMSRDA → MGEELPILKGILKGNVNYHNAP

Note: No experimental confirmation available.
Show »
Length:906
Mass (Da):96,437
Checksum:iBD692B3171F48A44
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P13055E75BB_DROME
Ecdysone-induced protein 75B, isofo...
Eip75B NR1D3, CG8127
1,412Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
P17672E75BA_DROME
Ecdysone-induced protein 75B, isofo...
Eip75B NR1D3, CG8127
1,355Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0S0WIG6A0A0S0WIG6_DROME
Ecdysone-induced protein 75B, isofo...
Eip75B 57B, 75B, anon-WO0172774.31, anon-WO0172774.32, BcDNA:GM02640
991Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M9NED3M9NED3_DROME
Ecdysone-induced protein 75B, isofo...
Eip75B 57B, 75B, anon-WO0172774.31, anon-WO0172774.32, BcDNA:GM02640
1,412Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAA35923 differs from that shown. Reason: Frameshift at position 1164.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti239D → G in ACD81870 (Ref. 4) Curated1
Sequence conflicti572T → N in ACD81870 (Ref. 4) Curated1
Sequence conflicti578L → P in ACD81870 (Ref. 4) Curated1
Sequence conflicti889H → R in ACD81870 (Ref. 4) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0149151 – 293Missing in isoform D. 1 PublicationAdd BLAST293
Alternative sequenceiVSP_014916294 – 315NRNRC…MSRDA → MGEELPILKGILKGNVNYHN AP in isoform D. 1 PublicationAdd BLAST22

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X51548 mRNA Translation: CAA35923.1 Frameshift.
AE014296 Genomic DNA Translation: AAN11687.1
AE014296 Genomic DNA Translation: AAN11689.1
BT032856 mRNA Translation: ACD81870.1
BT032857 mRNA Translation: ACD81871.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A34598

NCBI Reference Sequences

More...
RefSeqi
NP_730322.1, NM_168756.2 [P17671-1]
NP_730323.1, NM_168757.1 [P17671-2]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0075149; FBpp0074915; FBgn0000568 [P17671-1]
FBtr0075151; FBpp0074917; FBgn0000568 [P17671-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
39999

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51548 mRNA Translation: CAA35923.1 Frameshift.
AE014296 Genomic DNA Translation: AAN11687.1
AE014296 Genomic DNA Translation: AAN11689.1
BT032856 mRNA Translation: ACD81870.1
BT032857 mRNA Translation: ACD81871.1
PIRiA34598
RefSeqiNP_730322.1, NM_168756.2 [P17671-1]
NP_730323.1, NM_168757.1 [P17671-2]

3D structure databases

SMRiP17671
ModBaseiSearch...

Protein-protein interaction databases

BioGridi65284, 10 interactors
IntActiP17671, 2 interactors

Proteomic databases

PRIDEiP17671

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0075149; FBpp0074915; FBgn0000568 [P17671-1]
FBtr0075151; FBpp0074917; FBgn0000568 [P17671-2]
GeneIDi39999

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
39999
FlyBaseiFBgn0000568 Eip75B

Phylogenomic databases

eggNOGiKOG3575 Eukaryota
ENOG410XT74 LUCA
OMAiNYHNAPV

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Eip75B fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
39999

Gene expression databases

BgeeiFBgn0000568 Expressed in 31 organ(s), highest expression level in head
ExpressionAtlasiP17671 differential
GenevisibleiP17671 DM

Family and domain databases

Gene3Di1.10.565.10, 1 hit
3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR035500 NHR-like_dom_sf
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR001728 ThyrH_rcpt
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA
PfamiView protein in Pfam
PF00104 Hormone_recep, 1 hit
PF00105 zf-C4, 1 hit
PRINTSiPR00398 STRDHORMONER
PR00047 STROIDFINGER
PR00546 THYROIDHORMR
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit
SUPFAMiSSF48508 SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE75BC_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P17671
Secondary accession number(s): B3DN68
, B3DN69, Q8IQS1, Q8IQS3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: July 19, 2005
Last modified: July 3, 2019
This is version 184 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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