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Protein

Cytochrome c oxidase subunit 7C, mitochondrial

Gene

Cox7c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

BRENDAi1.9.3.1 3474

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 7C, mitochondrial
Alternative name(s):
Cytochrome c oxidase polypeptide VIIc
Gene namesi
Name:Cox7c
Synonyms:Cox7c1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:103226 Cox7c

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini17 – 33Mitochondrial matrixBy similarityAdd BLAST17
Transmembranei34 – 60HelicalBy similarityAdd BLAST27
Topological domaini61 – 63Mitochondrial intermembraneBy similarity3

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 16MitochondrionBy similarityAdd BLAST16
ChainiPRO_000000616617 – 63Cytochrome c oxidase subunit 7C, mitochondrialAdd BLAST47

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei25N6-acetyllysine; alternateCombined sources1
Modified residuei25N6-succinyllysine; alternateCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP17665
MaxQBiP17665
PaxDbiP17665
PeptideAtlasiP17665
PRIDEiP17665
TopDownProteomicsiP17665

PTM databases

iPTMnetiP17665
PhosphoSitePlusiP17665

Expressioni

Gene expression databases

BgeeiENSMUSG00000017778
CleanExiMM_COX7C
ExpressionAtlasiP17665 baseline and differential
GenevisibleiP17665 MM

Interactioni

Protein-protein interaction databases

CORUMiP17665
STRINGi10090.ENSMUSP00000115419

Structurei

3D structure databases

ProteinModelPortaliP17665
SMRiP17665
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c oxidase VIIc family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4527 Eukaryota
ENOG4112B97 LUCA
GeneTreeiENSGT00390000018086
HOVERGENiHBG051093
InParanoidiP17665
KOiK02272
OMAiVRHQILK
OrthoDBiEOG091G16OJ
PhylomeDBiP17665
TreeFamiTF105069

Family and domain databases

CDDicd00929 Cyt_c_Oxidase_VIIc, 1 hit
Gene3Di4.10.49.10, 1 hit
InterProiView protein in InterPro
IPR004202 COX7C/Cox8
IPR036636 COX7C/Cox8_sf
PANTHERiPTHR13313 PTHR13313, 1 hit
PfamiView protein in Pfam
PF02935 COX7C, 1 hit
SUPFAMiSSF81427 SSF81427, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P17665-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGQSIRRFT TSVVRRSHYE EGPGKNLPFS VENKWRLLAM MTVYFGSGFA
60
APFFIVRHQL LKK
Length:63
Mass (Da):7,333
Last modified:August 1, 1990 - v1
Checksum:iC6A2AD4ABFEB2C7B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52940 mRNA Translation: CAA37115.1
AK002494 mRNA Translation: BAB22142.1
AK027989 mRNA Translation: BAC25693.1
AK131871 mRNA Translation: BAE20843.1
AK153444 mRNA Translation: BAE31999.1
AK168077 mRNA Translation: BAE40050.1
BC010772 mRNA Translation: AAH10772.1
BC086792 mRNA Translation: AAH86792.1
CCDSiCCDS26668.1
PIRiS10303
RefSeqiNP_031775.1, NM_007749.3
UniGeneiMm.378898
Mm.439961

Genome annotation databases

EnsembliENSMUST00000131011; ENSMUSP00000115419; ENSMUSG00000017778
GeneIDi12867
KEGGimmu:12867
UCSCiuc007riy.1 mouse

Similar proteinsi

Entry informationi

Entry nameiCOX7C_MOUSE
AccessioniPrimary (citable) accession number: P17665
Secondary accession number(s): Q3U5S7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: May 23, 2018
This is version 151 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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