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Protein

Ferritin heavy chain B

Gene

fth1-b

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation (By similarity).By similarity

Miscellaneous

There are three types of ferritin subunits in amphibia: L, M and H chains. M and H chains are fast mineralizing; the L chain is very slow mineralizing (By similarity).By similarity

Catalytic activityi

4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi24Iron 1PROSITE-ProRule annotation1
Metal bindingi59Iron 1PROSITE-ProRule annotation1
Metal bindingi59Iron 2PROSITE-ProRule annotation1
Metal bindingi62Iron 1PROSITE-ProRule annotation1
Metal bindingi104Iron 2PROSITE-ProRule annotation1
Metal bindingi138Iron 2PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processIron storage
LigandIron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ferritin heavy chain B
Short name:
Ferritin H subunit B
Alternative name(s):
Ferritin heavy chain 1 (EC:1.16.3.1)
Gene namesi
Name:fth1-b
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-6256345 fth1

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002010771 – 176Ferritin heavy chain BAdd BLAST176

Proteomic databases

PRIDEiP17663

Interactioni

Subunit structurei

Oligomer of 24 subunits. The functional molecule is roughly spherical and contains a central cavity into which the polymeric mineral iron core is deposited (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliP17663
SMRiP17663
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 156Ferritin-like diironPROSITE-ProRule annotationAdd BLAST150

Sequence similaritiesi

Belongs to the ferritin family.Curated

Phylogenomic databases

HOVERGENiHBG000410
KOiK00522

Family and domain databases

Gene3Di1.20.1260.10, 1 hit
InterProiView protein in InterPro
IPR001519 Ferritin
IPR012347 Ferritin-like
IPR009040 Ferritin-like_diiron
IPR009078 Ferritin-like_SF
IPR014034 Ferritin_CS
IPR008331 Ferritin_DPS_dom
PANTHERiPTHR11431 PTHR11431, 1 hit
PfamiView protein in Pfam
PF00210 Ferritin, 1 hit
SUPFAMiSSF47240 SSF47240, 1 hit
PROSITEiView protein in PROSITE
PS00540 FERRITIN_1, 1 hit
PS00204 FERRITIN_2, 1 hit
PS50905 FERRITIN_LIKE, 1 hit

Sequencei

Sequence statusi: Complete.

P17663-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQSQVRQNFN SDCEAAINRM VNLEMYASYV YLSMSYYFDR DDVALHHVAK
60 70 80 90 100
FFKEQSHEER EHAEKFLKYQ NKRGGRVVLQ DIKKPERDEW SNTLEAMQAA
110 120 130 140 150
LQLEKTVNQA LLDLHKLASD KVDPQLCDFL ESEYLEEQVK AMKELGDYIT
160 170
NLKRLGVPQN GMGEYLFDKH TLGESS
Length:176
Mass (Da):20,563
Last modified:November 1, 1991 - v2
Checksum:iC325E410FB3EC648
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti6R → L in CAA35760 (PubMed:2336402).Curated1
Sequence conflicti15A → I in CAA35760 (PubMed:2336402).Curated1
Sequence conflicti157 – 158VP → A in CAA35760 (PubMed:2336402).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51395 mRNA Translation: CAA35760.1
M55010 mRNA Translation: AAA49708.1
BC044961 mRNA Translation: AAH44961.1
BC170380 mRNA Translation: AAI70380.1
BC170382 mRNA Translation: AAI70382.1
PIRiA37959 FRXL
RefSeqiNP_001079580.1, NM_001086111.1
UniGeneiXl.2168

Genome annotation databases

GeneIDi379267
KEGGixla:379267

Similar proteinsi

Entry informationi

Entry nameiFRIHB_XENLA
AccessioniPrimary (citable) accession number: P17663
Secondary accession number(s): B7ZS33, Q66LL5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: November 1, 1991
Last modified: November 22, 2017
This is version 95 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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