UniProtKB - P17655 (CAN2_HUMAN)
Protein
Calpain-2 catalytic subunit
Gene
CAPN2
Organism
Homo sapiens (Human)
Status
Functioni
Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves MYOC at 'Arg-226' (PubMed:17650508). Proteolytically cleaves CPEB3 following neuronal stimulation which abolishes CPEB3 translational repressor activity, leading to translation of CPEB3 target mRNAs (By similarity).By similarity1 Publication
Catalytic activityi
- Broad endopeptidase specificity. EC:3.4.22.53
Cofactori
Ca2+By similarityNote: Binds 7 Ca2+ ions.By similarity
Activity regulationi
Activated by 200-1000 micromolar concentrations of calcium and inhibited by calpastatin.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 89 | Calcium 3; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 91 | Calcium 3; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 96 | Calcium 3By similarity | 1 | |
Active sitei | 105 | By similarity | 1 | |
Metal bindingi | 175 | Calcium 3By similarity | 1 | |
Metal bindingi | 229 | Calcium 2By similarity | 1 | |
Metal bindingi | 230 | Calcium 2By similarity | 1 | |
Active sitei | 262 | By similarity | 1 | |
Active sitei | 286 | By similarity | 1 | |
Metal bindingi | 292 | Calcium 4By similarity | 1 | |
Metal bindingi | 299 | Calcium 4By similarity | 1 | |
Metal bindingi | 323 | Calcium 4; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 542 | Calcium 5; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 545 | Calcium 5By similarity | 1 | |
Metal bindingi | 547 | Calcium 5; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 552 | Calcium 5By similarity | 1 | |
Metal bindingi | 585 | Calcium 6By similarity | 1 | |
Metal bindingi | 587 | Calcium 6By similarity | 1 | |
Metal bindingi | 589 | Calcium 6; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 591 | Calcium 6; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 596 | Calcium 6By similarity | 1 | |
Metal bindingi | 615 | Calcium 7By similarity | 1 | |
Metal bindingi | 617 | Calcium 7By similarity | 1 | |
Metal bindingi | 619 | Calcium 7; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 621 | Calcium 7; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 626 | Calcium 7By similarity | 1 | |
Metal bindingi | 658 | Calcium 1By similarity | 1 | |
Metal bindingi | 661 | Calcium 1By similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Calcium bindingi | 585 – 596 | 1Add BLAST | 12 | |
Calcium bindingi | 615 – 626 | 2Add BLAST | 12 |
GO - Molecular functioni
- calcium-dependent cysteine-type endopeptidase activity Source: BHF-UCL
- calcium ion binding Source: Ensembl
- cysteine-type peptidase activity Source: ProtInc
- cytoskeletal protein binding Source: BHF-UCL
- enzyme binding Source: Ensembl
- protein-containing complex binding Source: Ensembl
GO - Biological processi
- behavioral response to pain Source: Ensembl
- blastocyst development Source: Ensembl
- cellular response to amino acid stimulus Source: UniProtKB
- cellular response to interferon-beta Source: Ensembl
- cellular response to lipopolysaccharide Source: Ensembl
- extracellular matrix disassembly Source: Reactome
- female pregnancy Source: Ensembl
- myoblast fusion Source: Ensembl
- positive regulation of cardiac muscle cell apoptotic process Source: Ensembl
- positive regulation of myoblast fusion Source: Ensembl
- positive regulation of neuron death Source: Ensembl
- positive regulation of phosphatidylcholine biosynthetic process Source: Ensembl
- proteolysis Source: UniProtKB
- proteolysis involved in cellular protein catabolic process Source: BHF-UCL
- regulation of cytoskeleton organization Source: BHF-UCL
- regulation of interleukin-6 production Source: Ensembl
- response to hydrogen peroxide Source: Ensembl
- response to hypoxia Source: Ensembl
Keywordsi
Molecular function | Hydrolase, Protease, Thiol protease |
Ligand | Calcium, Metal-binding |
Enzyme and pathway databases
BRENDAi | 3.4.22.53, 2681 |
PathwayCommonsi | P17655 |
Reactomei | R-HSA-1474228, Degradation of the extracellular matrix R-HSA-8862803, Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models |
SIGNORi | P17655 |
Protein family/group databases
MEROPSi | C02.002 |
Names & Taxonomyi
Protein namesi | Recommended name: Calpain-2 catalytic subunit (EC:3.4.22.53)Alternative name(s): Calcium-activated neutral proteinase 2 Short name: CANP 2 Calpain M-type Calpain large polypeptide L2 Calpain-2 large subunit Millimolar-calpain Short name: M-calpain |
Gene namesi | Name:CAPN2 Synonyms:CANPL2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000162909.17 |
HGNCi | HGNC:1479, CAPN2 |
MIMi | 114230, gene |
neXtProti | NX_P17655 |
Subcellular locationi
Plasma membrane
Other locations
Note: Translocates to the plasma membrane upon Ca2+ binding.
Cytoskeleton
- cortical actin cytoskeleton Source: BHF-UCL
Cytosol
- cytosol Source: BHF-UCL
Endoplasmic reticulum
- endoplasmic reticulum Source: BHF-UCL
- perinuclear endoplasmic reticulum Source: BHF-UCL
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Golgi apparatus
- Golgi apparatus Source: BHF-UCL
Lysosome
- lysosome Source: Ensembl
Mitochondrion
- mitochondrial intermembrane space Source: Ensembl
Nucleus
- nucleus Source: Ensembl
Plasma Membrane
- external side of plasma membrane Source: Ensembl
- plasma membrane Source: BHF-UCL
Other locations
- chromatin Source: Ensembl
- cytoplasm Source: UniProtKB
- dendrite Source: UniProtKB
- focal adhesion Source: UniProtKB
- membrane raft Source: BHF-UCL
- neuronal cell body Source: Ensembl
- pseudopodium Source: BHF-UCL
Keywords - Cellular componenti
Cell membrane, Cytoplasm, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 824 |
OpenTargetsi | ENSG00000162909 |
PharmGKBi | PA26060 |
Miscellaneous databases
Pharosi | P17655, Tchem |
Chemistry databases
ChEMBLi | CHEMBL2382 |
GuidetoPHARMACOLOGYi | 2337 |
Polymorphism and mutation databases
BioMutai | CAPN2 |
DMDMi | 317373596 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources1 Publication | |||
PropeptideiPRO_0000026487 | 2 – 19 | Anchors to the small subunitSequence analysisAdd BLAST | 18 | |
ChainiPRO_0000026488 | 20 – 700 | Calpain-2 catalytic subunitAdd BLAST | 681 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources | 1 |
Keywords - PTMi
AcetylationProteomic databases
CPTACi | CPTAC-468 CPTAC-469 |
EPDi | P17655 |
jPOSTi | P17655 |
MassIVEi | P17655 |
MaxQBi | P17655 |
PaxDbi | P17655 |
PeptideAtlasi | P17655 |
PRIDEi | P17655 |
ProteomicsDBi | 53499 [P17655-1] 53500 [P17655-2] |
PTM databases
iPTMneti | P17655 |
MetOSitei | P17655 |
PhosphoSitePlusi | P17655 |
SwissPalmi | P17655 |
Expressioni
Tissue specificityi
Ubiquitous.
Gene expression databases
Bgeei | ENSG00000162909, Expressed in nasal cavity epithelium and 244 other tissues |
ExpressionAtlasi | P17655, baseline and differential |
Genevisiblei | P17655, HS |
Organism-specific databases
HPAi | ENSG00000162909, Low tissue specificity |
Interactioni
Subunit structurei
Forms a heterodimer with a small (regulatory) subunit (CAPNS1).
Interacts with CPEB3; this leads to cleavage of CPEB3.
By similarityBinary interactionsi
Hide detailsGO - Molecular functioni
- cytoskeletal protein binding Source: BHF-UCL
- enzyme binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 107274, 70 interactors |
ComplexPortali | CPX-2674, M-Calpain complex |
IntActi | P17655, 25 interactors |
MINTi | P17655 |
STRINGi | 9606.ENSP00000295006 |
Chemistry databases
BindingDBi | P17655 |
Miscellaneous databases
RNActi | P17655, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P17655 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P17655 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 45 – 344 | Calpain catalyticPROSITE-ProRule annotationAdd BLAST | 300 | |
Domaini | 572 – 605 | EF-hand 1PROSITE-ProRule annotationAdd BLAST | 34 | |
Domaini | 602 – 637 | EF-hand 2PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 667 – 700 | EF-hand 3PROSITE-ProRule annotationAdd BLAST | 34 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 345 – 514 | Domain IIIAdd BLAST | 170 | |
Regioni | 515 – 529 | LinkerAdd BLAST | 15 | |
Regioni | 530 – 700 | Domain IVAdd BLAST | 171 |
Sequence similaritiesi
Belongs to the peptidase C2 family.Curated
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG0045, Eukaryota |
GeneTreei | ENSGT00940000154784 |
HOGENOMi | CLU_010982_0_0_1 |
InParanoidi | P17655 |
OMAi | MQKLIRI |
OrthoDBi | 704215at2759 |
PhylomeDBi | P17655 |
TreeFami | TF314748 |
Family and domain databases
CDDi | cd00214, Calpain_III, 1 hit cd00044, CysPc, 1 hit cd16199, EFh_PEF_CAPN2, 1 hit |
InterProi | View protein in InterPro IPR033883, C2_III IPR022684, Calpain_cysteine_protease IPR022682, Calpain_domain_III IPR022683, Calpain_III IPR036213, Calpain_III_sf IPR029539, CAPN2 IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom IPR042736, EFh_PEF_CAPN2 IPR038765, Papain-like_cys_pep_sf IPR000169, Pept_cys_AS IPR001300, Peptidase_C2_calpain_cat |
PANTHERi | PTHR10183:SF268, PTHR10183:SF268, 1 hit |
Pfami | View protein in Pfam PF01067, Calpain_III, 1 hit PF13833, EF-hand_8, 1 hit PF00648, Peptidase_C2, 1 hit |
PRINTSi | PR00704, CALPAIN |
SMARTi | View protein in SMART SM00720, calpain_III, 1 hit SM00230, CysPc, 1 hit |
SUPFAMi | SSF47473, SSF47473, 1 hit SSF49758, SSF49758, 1 hit SSF54001, SSF54001, 1 hit |
PROSITEi | View protein in PROSITE PS50203, CALPAIN_CAT, 1 hit PS00018, EF_HAND_1, 2 hits PS50222, EF_HAND_2, 3 hits PS00139, THIOL_PROTEASE_CYS, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: P17655-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAGIAAKLAK DREAAEGLGS HDRAIKYLNQ DYEALRNECL EAGTLFQDPS
60 70 80 90 100
FPAIPSALGF KELGPYSSKT RGIEWKRPTE ICADPQFIIG GATRTDICQG
110 120 130 140 150
ALGDCWLLAA IASLTLNEEI LARVVPLNQS FQENYAGIFH FQFWQYGEWV
160 170 180 190 200
EVVVDDRLPT KDGELLFVHS AEGSEFWSAL LEKAYAKING CYEALSGGAT
210 220 230 240 250
TEGFEDFTGG IAEWYELKKP PPNLFKIIQK ALQKGSLLGC SIDITSAADS
260 270 280 290 300
EAITFQKLVK GHAYSVTGAE EVESNGSLQK LIRIRNPWGE VEWTGRWNDN
310 320 330 340 350
CPSWNTIDPE ERERLTRRHE DGEFWMSFSD FLRHYSRLEI CNLTPDTLTS
360 370 380 390 400
DTYKKWKLTK MDGNWRRGST AGGCRNYPNT FWMNPQYLIK LEEEDEDEED
410 420 430 440 450
GESGCTFLVG LIQKHRRRQR KMGEDMHTIG FGIYEVPEEL SGQTNIHLSK
460 470 480 490 500
NFFLTNRARE RSDTFINLRE VLNRFKLPPG EYILVPSTFE PNKDGDFCIR
510 520 530 540 550
VFSEKKADYQ AVDDEIEANL EEFDISEDDI DDGFRRLFAQ LAGEDAEISA
560 570 580 590 600
FELQTILRRV LAKRQDIKSD GFSIETCKIM VDMLDSDGSG KLGLKEFYIL
610 620 630 640 650
WTKIQKYQKI YREIDVDRSG TMNSYEMRKA LEEAGFKMPC QLHQVIVARF
660 670 680 690 700
ADDQLIIDFD NFVRCLVRLE TLFKIFKQLD PENTGTIELD LISWLCFSVL
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketC9JWY7 | C9JWY7_HUMAN | Calpain-2 catalytic subunit | CAPN2 | 131 | Annotation score: |
Sequence cautioni
The sequence AAH07686 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH11828 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 73 – 74 | IE → MR in AAA35645 (PubMed:2852952).Curated | 2 | |
Sequence conflicti | 256 | Q → K in AAF99682 (PubMed:10944468).Curated | 1 | |
Sequence conflicti | 300 | N → S in AAF99682 (PubMed:10944468).Curated | 1 | |
Sequence conflicti | 534 | F → V in AAA35645 (PubMed:2852952).Curated | 1 | |
Sequence conflicti | 534 | F → V in AAF99682 (PubMed:10944468).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_014435 | 22 | D → ECombined sources5 PublicationsCorresponds to variant dbSNP:rs25655Ensembl. | 1 | |
Natural variantiVAR_021404 | 68 | S → G2 PublicationsCorresponds to variant dbSNP:rs2230083Ensembl. | 1 | |
Natural variantiVAR_021405 | 476 | K → R1 PublicationCorresponds to variant dbSNP:rs9804140Ensembl. | 1 | |
Natural variantiVAR_021406 | 521 | E → Q1 PublicationCorresponds to variant dbSNP:rs28370127Ensembl. | 1 | |
Natural variantiVAR_014436 | 568 | K → Q1 PublicationCorresponds to variant dbSNP:rs17599Ensembl. | 1 | |
Natural variantiVAR_021407 | 677 | K → Q1 PublicationCorresponds to variant dbSNP:rs2230082EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_043027 | 1 – 78 | Missing in isoform 2. 1 PublicationAdd BLAST | 78 | |
Alternative sequenceiVSP_043028 | 79 | T → M in isoform 2. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M23254 mRNA Translation: AAA35645.1 AF261089 mRNA Translation: AAF99682.1 AK316211 mRNA Translation: BAH14582.1 AY835586 Genomic DNA Translation: AAV80421.1 AC096542 Genomic DNA No translation available. AC099065 Genomic DNA No translation available. BC007686 mRNA Translation: AAH07686.1 Sequence problems. BC011828 mRNA Translation: AAH11828.1 Sequence problems. BC021303 mRNA Translation: AAH21303.1 J04700 Genomic DNA Translation: AAA52760.1 |
CCDSi | CCDS31035.1 [P17655-1] CCDS53478.1 [P17655-2] |
PIRi | S10590, CIHUH2 |
RefSeqi | NP_001139540.1, NM_001146068.1 [P17655-2] NP_001739.2, NM_001748.4 [P17655-1] |
Genome annotation databases
Ensembli | ENST00000295006; ENSP00000295006; ENSG00000162909 [P17655-1] ENST00000433674; ENSP00000413158; ENSG00000162909 [P17655-2] |
GeneIDi | 824 |
KEGGi | hsa:824 |
UCSCi | uc001hob.5, human [P17655-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
NIEHS-SNPs |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M23254 mRNA Translation: AAA35645.1 AF261089 mRNA Translation: AAF99682.1 AK316211 mRNA Translation: BAH14582.1 AY835586 Genomic DNA Translation: AAV80421.1 AC096542 Genomic DNA No translation available. AC099065 Genomic DNA No translation available. BC007686 mRNA Translation: AAH07686.1 Sequence problems. BC011828 mRNA Translation: AAH11828.1 Sequence problems. BC021303 mRNA Translation: AAH21303.1 J04700 Genomic DNA Translation: AAA52760.1 |
CCDSi | CCDS31035.1 [P17655-1] CCDS53478.1 [P17655-2] |
PIRi | S10590, CIHUH2 |
RefSeqi | NP_001139540.1, NM_001146068.1 [P17655-2] NP_001739.2, NM_001748.4 [P17655-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1KFU | X-ray | 2.50 | L | 2-700 | [»] | |
1KFX | X-ray | 3.15 | L | 2-700 | [»] | |
2NQA | X-ray | 2.20 | A/B | 48-346 | [»] | |
SMRi | P17655 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 107274, 70 interactors |
ComplexPortali | CPX-2674, M-Calpain complex |
IntActi | P17655, 25 interactors |
MINTi | P17655 |
STRINGi | 9606.ENSP00000295006 |
Chemistry databases
BindingDBi | P17655 |
ChEMBLi | CHEMBL2382 |
GuidetoPHARMACOLOGYi | 2337 |
Protein family/group databases
MEROPSi | C02.002 |
PTM databases
iPTMneti | P17655 |
MetOSitei | P17655 |
PhosphoSitePlusi | P17655 |
SwissPalmi | P17655 |
Polymorphism and mutation databases
BioMutai | CAPN2 |
DMDMi | 317373596 |
Proteomic databases
CPTACi | CPTAC-468 CPTAC-469 |
EPDi | P17655 |
jPOSTi | P17655 |
MassIVEi | P17655 |
MaxQBi | P17655 |
PaxDbi | P17655 |
PeptideAtlasi | P17655 |
PRIDEi | P17655 |
ProteomicsDBi | 53499 [P17655-1] 53500 [P17655-2] |
Protocols and materials databases
Antibodypediai | 20748, 424 antibodies |
DNASUi | 824 |
Genome annotation databases
Ensembli | ENST00000295006; ENSP00000295006; ENSG00000162909 [P17655-1] ENST00000433674; ENSP00000413158; ENSG00000162909 [P17655-2] |
GeneIDi | 824 |
KEGGi | hsa:824 |
UCSCi | uc001hob.5, human [P17655-1] |
Organism-specific databases
CTDi | 824 |
DisGeNETi | 824 |
EuPathDBi | HostDB:ENSG00000162909.17 |
GeneCardsi | CAPN2 |
HGNCi | HGNC:1479, CAPN2 |
HPAi | ENSG00000162909, Low tissue specificity |
MIMi | 114230, gene |
neXtProti | NX_P17655 |
OpenTargetsi | ENSG00000162909 |
PharmGKBi | PA26060 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0045, Eukaryota |
GeneTreei | ENSGT00940000154784 |
HOGENOMi | CLU_010982_0_0_1 |
InParanoidi | P17655 |
OMAi | MQKLIRI |
OrthoDBi | 704215at2759 |
PhylomeDBi | P17655 |
TreeFami | TF314748 |
Enzyme and pathway databases
BRENDAi | 3.4.22.53, 2681 |
PathwayCommonsi | P17655 |
Reactomei | R-HSA-1474228, Degradation of the extracellular matrix R-HSA-8862803, Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models |
SIGNORi | P17655 |
Miscellaneous databases
BioGRID-ORCSi | 824, 5 hits in 842 CRISPR screens |
ChiTaRSi | CAPN2, human |
EvolutionaryTracei | P17655 |
GeneWikii | CAPN2 |
GenomeRNAii | 824 |
Pharosi | P17655, Tchem |
PROi | PR:P17655 |
RNActi | P17655, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000162909, Expressed in nasal cavity epithelium and 244 other tissues |
ExpressionAtlasi | P17655, baseline and differential |
Genevisiblei | P17655, HS |
Family and domain databases
CDDi | cd00214, Calpain_III, 1 hit cd00044, CysPc, 1 hit cd16199, EFh_PEF_CAPN2, 1 hit |
InterProi | View protein in InterPro IPR033883, C2_III IPR022684, Calpain_cysteine_protease IPR022682, Calpain_domain_III IPR022683, Calpain_III IPR036213, Calpain_III_sf IPR029539, CAPN2 IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom IPR042736, EFh_PEF_CAPN2 IPR038765, Papain-like_cys_pep_sf IPR000169, Pept_cys_AS IPR001300, Peptidase_C2_calpain_cat |
PANTHERi | PTHR10183:SF268, PTHR10183:SF268, 1 hit |
Pfami | View protein in Pfam PF01067, Calpain_III, 1 hit PF13833, EF-hand_8, 1 hit PF00648, Peptidase_C2, 1 hit |
PRINTSi | PR00704, CALPAIN |
SMARTi | View protein in SMART SM00720, calpain_III, 1 hit SM00230, CysPc, 1 hit |
SUPFAMi | SSF47473, SSF47473, 1 hit SSF49758, SSF49758, 1 hit SSF54001, SSF54001, 1 hit |
PROSITEi | View protein in PROSITE PS50203, CALPAIN_CAT, 1 hit PS00018, EF_HAND_1, 2 hits PS50222, EF_HAND_2, 3 hits PS00139, THIOL_PROTEASE_CYS, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CAN2_HUMAN | |
Accessioni | P17655Primary (citable) accession number: P17655 Secondary accession number(s): A6NDG7 Q9HBB1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1990 |
Last sequence update: | January 11, 2011 | |
Last modified: | December 2, 2020 | |
This is version 234 of the entry and version 6 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - Peptidase families
Classification of peptidase families and list of entries