CAPN2

Functionⁱ

Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves MYOC at 'Arg-226' (PubMed:17650508). Proteolytically cleaves CPEB3 following neuronal stimulation which abolishes CPEB3 translational repressor activity, leading to translation of CPEB3 target mRNAs (By similarity).By similarity1 Publication

Catalytic activityⁱ

Broad endopeptidase specificity.

Cofactorⁱ

Ca²⁺By similarityNote: Binds 7 Ca²⁺ ions.By similarity

Activity regulationⁱ

Activated by 200-1000 micromolar concentrations of calcium and inhibited by calpastatin.

Sites

Feature key	Position(s)	DescriptionActions	Length
Metal bindingⁱ	89	Calcium 3; via carbonyl oxygenBy similarity	1
Metal bindingⁱ	91	Calcium 3; via carbonyl oxygenBy similarity	1
Metal bindingⁱ	96	Calcium 3By similarity	1
Active siteⁱ	105	By similarity	1
Metal bindingⁱ	175	Calcium 3By similarity	1
Metal bindingⁱ	229	Calcium 2By similarity	1
Metal bindingⁱ	230	Calcium 2By similarity	1
Active siteⁱ	262	By similarity	1
Active siteⁱ	286	By similarity	1
Metal bindingⁱ	292	Calcium 4By similarity	1
Metal bindingⁱ	299	Calcium 4By similarity	1
Metal bindingⁱ	323	Calcium 4; via carbonyl oxygenBy similarity	1
Metal bindingⁱ	542	Calcium 5; via carbonyl oxygenBy similarity	1
Metal bindingⁱ	545	Calcium 5By similarity	1
Metal bindingⁱ	547	Calcium 5; via carbonyl oxygenBy similarity	1
Metal bindingⁱ	552	Calcium 5By similarity	1
Metal bindingⁱ	585	Calcium 6By similarity	1
Metal bindingⁱ	587	Calcium 6By similarity	1
Metal bindingⁱ	589	Calcium 6; via carbonyl oxygenBy similarity	1
Metal bindingⁱ	591	Calcium 6; via carbonyl oxygenBy similarity	1
Metal bindingⁱ	596	Calcium 6By similarity	1
Metal bindingⁱ	615	Calcium 7By similarity	1
Metal bindingⁱ	617	Calcium 7By similarity	1
Metal bindingⁱ	619	Calcium 7; via carbonyl oxygenBy similarity	1
Metal bindingⁱ	621	Calcium 7; via carbonyl oxygenBy similarity	1
Metal bindingⁱ	626	Calcium 7By similarity	1
Metal bindingⁱ	658	Calcium 1By similarity	1
Metal bindingⁱ	661	Calcium 1By similarity	1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Calcium bindingⁱ	585 – 596	1Add BLAST		12
Calcium bindingⁱ	615 – 626	2Add BLAST		12

GO - Molecular functionⁱ

calcium-dependent cysteine-type endopeptidase activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 12150984
calcium ion binding Source: Ensembl
cysteine-type peptidase activity
Source: ProtInc
Traceable author statementⁱ
- 2209092
cytoskeletal protein binding
Source: BHF-UCL
Non-traceable author statementⁱ
- 12150984
enzyme binding Source: Ensembl
protein heterodimerization activity Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

blastocyst development Source: Ensembl
cellular response to amino acid stimulus Source: UniProtKB
myoblast fusion Source: Ensembl
protein autoprocessing Source: Ensembl
proteolysis Source: UniProtKB
proteolysis involved in cellular protein catabolic process
Source: BHF-UCL
Inferred from direct assayⁱ
- 12150984
regulation of cytoskeleton organization
Source: BHF-UCL
Traceable author statementⁱ
- 12150984
response to hypoxia Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hydrolase, Protease, Thiol protease
Ligand	Calcium, Metal-binding

Enzyme and pathway databases

BRENDAⁱ	3.4.22.53 2681
Reactomeⁱ	R-HSA-1474228 Degradation of the extracellular matrix R-HSA-8862803 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
SIGNORⁱ	P17655

Protein family/group databases

MEROPS protease database More...MEROPSⁱ	C02.002

MEROPSⁱ

C02.002

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Calpain-2 catalytic subunit (EC:3.4.22.53) Alternative name(s): Calcium-activated neutral proteinase 2 Short name: CANP 2 Calpain M-type Calpain large polypeptide L2 Calpain-2 large subunit Millimolar-calpain Short name: M-calpain
Gene namesⁱ	Name:CAPN2 Synonyms:CANPL2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000162909.17
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:1479 CAPN2
MIMⁱ	114230 gene
neXtProtⁱ	NX_P17655

Keywords - Cellular componentⁱ

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	824
Open Targets More...OpenTargetsⁱ	ENSG00000162909
PharmGKBⁱ	PA26060

Chemistry databases

ChEMBLⁱ	CHEMBL2382
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	2337

Polymorphism and mutation databases

BioMutaⁱ	CAPN2
DMDMⁱ	317373596

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
Initiator methionineⁱ		RemovedCombined sources1 Publication
PropeptideⁱPRO_0000026487	2 – 19	Anchors to the small subunitSequence analysisAdd BLAST	18
ChainⁱPRO_0000026488	20 – 700	Calpain-2 catalytic subunitAdd BLAST	681

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	2	N-acetylalanineCombined sources		1

Keywords - PTMⁱ

Acetylation

Proteomic databases

EPDⁱ	P17655
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P17655
PaxDbⁱ	P17655
PeptideAtlas More...PeptideAtlasⁱ	P17655
PRIDEⁱ	P17655
ProteomicsDBⁱ	53499 53500 [P17655-2]

PTM databases

iPTMnetⁱ	P17655
PhosphoSitePlusⁱ	P17655
SwissPalmⁱ	P17655

Expressionⁱ

Tissue specificityⁱ

Ubiquitous.

Gene expression databases

Bgeeⁱ	ENSG00000162909 Expressed in 233 organ(s), highest expression level in nasal cavity epithelium
CleanExⁱ	HS_CAPN2
ExpressionAtlasⁱ	P17655 baseline and differential
Genevisibleⁱ	P17655 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA024470

HPAⁱ

HPA024470

Interactionⁱ

Subunit structureⁱ

Forms a heterodimer with a small (regulatory) subunit (CAPNS1). Interacts with CPEB3; this leads to cleavage of CPEB3.By similarity

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
CAPNS1	P04632	3	EBI-1028956,EBI-711828
ZDHHC17	Q8IUH5	2	EBI-1028956,EBI-524753

GO - Molecular functionⁱ

cytoskeletal protein binding
Source: BHF-UCL
Non-traceable author statementⁱ
- 12150984
enzyme binding Source: Ensembl
protein heterodimerization activity Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	107274, 54 interactors
IntActⁱ	P17655, 13 interactors
Molecular INTeraction database More...MINTⁱ	P17655
STRINGⁱ	9606.ENSP00000295006

Chemistry databases

BindingDBⁱ

P17655

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	4 – 16	Combined sources	13
Turnⁱ	17 – 19	Combined sources	3
Helixⁱ	27 – 29	Combined sources	3
Helixⁱ	32 – 42	Combined sources	11
Beta strandⁱ	49 – 51	Combined sources	3
Helixⁱ	55 – 58	Combined sources	4
Beta strandⁱ	60 – 68	Combined sources	9
Beta strandⁱ	74 – 76	Combined sources	3
Helixⁱ	78 – 81	Combined sources	4
Beta strandⁱ	82 – 84	Combined sources	3
Helixⁱ	94 – 96	Combined sources	3
Beta strandⁱ	97 – 99	Combined sources	3
Helixⁱ	105 – 115	Combined sources	11
Helixⁱ	118 – 124	Combined sources	7
Beta strandⁱ	131 – 134	Combined sources	4
Beta strandⁱ	136 – 144	Combined sources	9
Beta strandⁱ	146 – 155	Combined sources	10
Beta strandⁱ	158 – 161	Combined sources	4
Beta strandⁱ	164 – 167	Combined sources	4
Beta strandⁱ	169 – 175	Combined sources	7
Helixⁱ	177 – 189	Combined sources	13
Beta strandⁱ	190 – 192	Combined sources	3
Helixⁱ	193 – 195	Combined sources	3
Beta strandⁱ	196 – 199	Combined sources	4
Turnⁱ	204 – 206	Combined sources	3
Helixⁱ	207 – 209	Combined sources	3
Beta strandⁱ	212 – 216	Combined sources	5
Helixⁱ	224 – 233	Combined sources	10
Beta strandⁱ	237 – 241	Combined sources	5
Helixⁱ	247 – 249	Combined sources	3
Beta strandⁱ	259 – 261	Combined sources	3
Beta strandⁱ	264 – 274	Combined sources	11
Beta strandⁱ	277 – 285	Combined sources	9
Beta strandⁱ	294 – 297	Combined sources	4
Beta strandⁱ	299 – 301	Combined sources	3
Helixⁱ	302 – 306	Combined sources	5
Helixⁱ	309 – 315	Combined sources	7
Beta strandⁱ	321 – 327	Combined sources	7
Helixⁱ	328 – 334	Combined sources	7
Beta strandⁱ	336 – 341	Combined sources	6
Helixⁱ	344 – 346	Combined sources	3
Beta strandⁱ	347 – 349	Combined sources	3
Beta strandⁱ	363 – 365	Combined sources	3
Turnⁱ	367 – 370	Combined sources	4
Turnⁱ	378 – 380	Combined sources	3
Helixⁱ	381 – 383	Combined sources	3
Beta strandⁱ	388 – 390	Combined sources	3
Beta strandⁱ	400 – 402	Combined sources	3
Beta strandⁱ	406 – 413	Combined sources	8
Beta strandⁱ	420 – 425	Combined sources	6
Beta strandⁱ	429 – 435	Combined sources	7
Turnⁱ	442 – 444	Combined sources	3
Helixⁱ	450 – 455	Combined sources	6
Beta strandⁱ	459 – 461	Combined sources	3
Beta strandⁱ	466 – 471	Combined sources	6
Beta strandⁱ	474 – 476	Combined sources	3
Beta strandⁱ	479 – 492	Combined sources	14
Beta strandⁱ	495 – 505	Combined sources	11
Beta strandⁱ	507 – 509	Combined sources	3
Beta strandⁱ	527 – 530	Combined sources	4
Helixⁱ	533 – 541	Combined sources	9
Beta strandⁱ	542 – 546	Combined sources	5
Helixⁱ	550 – 560	Combined sources	11
Turnⁱ	561 – 564	Combined sources	4
Helixⁱ	574 – 582	Combined sources	9
Beta strandⁱ	586 – 588	Combined sources	3
Beta strandⁱ	590 – 592	Combined sources	3
Helixⁱ	595 – 612	Combined sources	18
Beta strandⁱ	622 – 624	Combined sources	3
Helixⁱ	627 – 630	Combined sources	4
Turnⁱ	631 – 635	Combined sources	5
Helixⁱ	640 – 650	Combined sources	11
Beta strandⁱ	655 – 657	Combined sources	3
Helixⁱ	659 – 679	Combined sources	21
Beta strandⁱ	687 – 690	Combined sources	4
Helixⁱ	691 – 698	Combined sources	8

Show more details

3D structure databases

ProteinModelPortalⁱ	P17655
SMRⁱ	P17655
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P17655

EvolutionaryTraceⁱ

P17655

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	45 – 344	Calpain catalyticPROSITE-ProRule annotationAdd BLAST	300
Domainⁱ	572 – 605	EF-hand 1PROSITE-ProRule annotationAdd BLAST	34
Domainⁱ	602 – 637	EF-hand 2PROSITE-ProRule annotationAdd BLAST	36
Domainⁱ	667 – 700	EF-hand 3PROSITE-ProRule annotationAdd BLAST	34

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	345 – 514	Domain IIIAdd BLAST	170
Regionⁱ	515 – 529	LinkerAdd BLAST	15
Regionⁱ	530 – 700	Domain IVAdd BLAST	171

Sequence similaritiesⁱ

Belongs to the peptidase C2 family.Curated

Keywords - Domainⁱ

Repeat

Phylogenomic databases

eggNOGⁱ	KOG0045 Eukaryota ENOG410XP0B LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118971
HOVERGENⁱ	HBG012645
InParanoidⁱ	P17655
KEGG Orthology (KO) More...KOⁱ	K03853
OMAⁱ	TNIHLGK
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G049E
PhylomeDBⁱ	P17655
TreeFamⁱ	TF314748

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00214 Calpain_III, 1 hit cd00044 CysPc, 1 hit
InterProⁱ	View protein in InterPro IPR033883 C2_III IPR022684 Calpain_cysteine_protease IPR022682 Calpain_domain_III IPR022683 Calpain_III IPR036213 Calpain_III_sf IPR029539 CAPN2 IPR011992 EF-hand-dom_pair IPR018247 EF_Hand_1_Ca_BS IPR002048 EF_hand_dom IPR038765 Papain_like_cys_pep_sf IPR000169 Pept_cys_AS IPR001300 Peptidase_C2_calpain_cat
PANTHERⁱ	PTHR10183:SF268 PTHR10183:SF268, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01067 Calpain_III, 1 hit PF13833 EF-hand_8, 1 hit PF00648 Peptidase_C2, 1 hit
PRINTSⁱ	PR00704 CALPAIN
SMARTⁱ	View protein in SMART SM00720 calpain_III, 1 hit SM00230 CysPc, 1 hit
SUPFAMⁱ	SSF47473 SSF47473, 1 hit SSF49758 SSF49758, 1 hit SSF54001 SSF54001, 1 hit
PROSITEⁱ	View protein in PROSITE PS50203 CALPAIN_CAT, 1 hit PS00018 EF_HAND_1, 2 hits PS50222 EF_HAND_2, 3 hits PS00139 THIOL_PROTEASE_CYS, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: P17655-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGIAAKLAK DREAAEGLGS HDRAIKYLNQ DYEALRNECL EAGTLFQDPS 
        60         70         80         90        100
FPAIPSALGF KELGPYSSKT RGIEWKRPTE ICADPQFIIG GATRTDICQG 
       110        120        130        140        150
ALGDCWLLAA IASLTLNEEI LARVVPLNQS FQENYAGIFH FQFWQYGEWV 
       160        170        180        190        200
EVVVDDRLPT KDGELLFVHS AEGSEFWSAL LEKAYAKING CYEALSGGAT 
       210        220        230        240        250
TEGFEDFTGG IAEWYELKKP PPNLFKIIQK ALQKGSLLGC SIDITSAADS 
       260        270        280        290        300
EAITFQKLVK GHAYSVTGAE EVESNGSLQK LIRIRNPWGE VEWTGRWNDN 
       310        320        330        340        350
CPSWNTIDPE ERERLTRRHE DGEFWMSFSD FLRHYSRLEI CNLTPDTLTS 
       360        370        380        390        400
DTYKKWKLTK MDGNWRRGST AGGCRNYPNT FWMNPQYLIK LEEEDEDEED 
       410        420        430        440        450
GESGCTFLVG LIQKHRRRQR KMGEDMHTIG FGIYEVPEEL SGQTNIHLSK 
       460        470        480        490        500
NFFLTNRARE RSDTFINLRE VLNRFKLPPG EYILVPSTFE PNKDGDFCIR 
       510        520        530        540        550
VFSEKKADYQ AVDDEIEANL EEFDISEDDI DDGFRRLFAQ LAGEDAEISA 
       560        570        580        590        600
FELQTILRRV LAKRQDIKSD GFSIETCKIM VDMLDSDGSG KLGLKEFYIL 
       610        620        630        640        650
WTKIQKYQKI YREIDVDRSG TMNSYEMRKA LEEAGFKMPC QLHQVIVARF 
       660        670        680        690        700
ADDQLIIDFD NFVRCLVRLE TLFKIFKQLD PENTGTIELD LISWLCFSVL

Length:700

Mass (Da):79,995

Last modified:January 11, 2011 - v6

Checksum:ⁱ8CF8294351A024E3

GO

Isoform 2 (identifier: P17655-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-78: Missing.
79-79: T → M

« Hide

        10         20         30         40         50
MEICADPQFI IGGATRTDIC QGALGDCWLL AAIASLTLNE EILARVVPLN 
        60         70         80         90        100
QSFQENYAGI FHFQFWQYGE WVEVVVDDRL PTKDGELLFV HSAEGSEFWS 
       110        120        130        140        150
ALLEKAYAKI NGCYEALSGG ATTEGFEDFT GGIAEWYELK KPPPNLFKII 
       160        170        180        190        200
QKALQKGSLL GCSIDITSAA DSEAITFQKL VKGHAYSVTG AEEVESNGSL 
       210        220        230        240        250
QKLIRIRNPW GEVEWTGRWN DNCPSWNTID PEERERLTRR HEDGEFWMSF 
       260        270        280        290        300
SDFLRHYSRL EICNLTPDTL TSDTYKKWKL TKMDGNWRRG STAGGCRNYP 
       310        320        330        340        350
NTFWMNPQYL IKLEEEDEDE EDGESGCTFL VGLIQKHRRR QRKMGEDMHT 
       360        370        380        390        400
IGFGIYEVPE ELSGQTNIHL SKNFFLTNRA RERSDTFINL REVLNRFKLP 
       410        420        430        440        450
PGEYILVPST FEPNKDGDFC IRVFSEKKAD YQAVDDEIEA NLEEFDISED 
       460        470        480        490        500
DIDDGFRRLF AQLAGEDAEI SAFELQTILR RVLAKRQDIK SDGFSIETCK 
       510        520        530        540        550
IMVDMLDSDG SGKLGLKEFY ILWTKIQKYQ KIYREIDVDR SGTMNSYEMR 
       560        570        580        590        600
KALEEAGFKM PCQLHQVIVA RFADDQLIID FDNFVRCLVR LETLFKIFKQ 
       610        620 
LDPENTGTIE LDLISWLCFS VL

Note: No experimental confirmation available.

Show »

Length:622

Mass (Da):71,476

Checksum:ⁱ60ED3A3498F6DD5D

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	C9JWY7	C9JWY7_HUMAN		Calpain-2 catalytic subunit Calpain-2 catalytic subunit	CAPN2	131	Annotation score:

Sequence cautionⁱ

The sequence AAH07686 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

The sequence AAH11828 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	73 – 74	IE → MR in AAA35645 (PubMed:2852952).Curated	2
Sequence conflictⁱ	256	Q → K in AAF99682 (PubMed:10944468).Curated	1
Sequence conflictⁱ	300	N → S in AAF99682 (PubMed:10944468).Curated	1
Sequence conflictⁱ	534	F → V in AAA35645 (PubMed:2852952).Curated	1
Sequence conflictⁱ	534	F → V in AAF99682 (PubMed:10944468).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_014435	22	D → ECombined sources5 PublicationsCorresponds to variant dbSNP:rs25655Ensembl.	1
Natural variantⁱVAR_021404	68	S → G2 PublicationsCorresponds to variant dbSNP:rs2230083Ensembl.	1
Natural variantⁱVAR_021405	476	K → R1 PublicationCorresponds to variant dbSNP:rs9804140Ensembl.	1
Natural variantⁱVAR_021406	521	E → Q1 PublicationCorresponds to variant dbSNP:rs28370127Ensembl.	1
Natural variantⁱVAR_014436	568	K → Q1 PublicationCorresponds to variant dbSNP:rs17599Ensembl.	1
Natural variantⁱVAR_021407	677	K → Q1 PublicationCorresponds to variant dbSNP:rs2230082Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_043027	1 – 78	Missing in isoform 2. 1 PublicationAdd BLAST		78
Alternative sequenceⁱVSP_043028	79	T → M in isoform 2. 1 Publication		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M23254 mRNA Translation: AAA35645.1 AF261089 mRNA Translation: AAF99682.1 AK316211 mRNA Translation: BAH14582.1 AY835586 Genomic DNA Translation: AAV80421.1 AC096542 Genomic DNA No translation available. AC099065 Genomic DNA No translation available. BC007686 mRNA Translation: AAH07686.1 Sequence problems. BC011828 mRNA Translation: AAH11828.1 Sequence problems. BC021303 mRNA Translation: AAH21303.1 J04700 Genomic DNA Translation: AAA52760.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS31035.1 [P17655-1] CCDS53478.1 [P17655-2]
PIRⁱ	S10590 CIHUH2
NCBI Reference Sequences More...RefSeqⁱ	NP_001139540.1, NM_001146068.1 [P17655-2] NP_001739.2, NM_001748.4
UniGeneⁱ	Hs.350899

Genome annotation databases

Ensemblⁱ	ENST00000295006; ENSP00000295006; ENSG00000162909 [P17655-1] ENST00000433674; ENSP00000413158; ENSG00000162909 [P17655-2]
GeneIDⁱ	824
KEGGⁱ	hsa:824
UCSC genome browser More...UCSCⁱ	uc001hob.5 human [P17655-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P17655	Calpain-2 catalytic subunit	)	RAT		700	UniRef90_Q07009
Calpain-2 catalytic subunit		MOUSE		700
Calpain-2 catalytic subunit		BOVIN		700
Calpain-2 catalytic subunit		MACFA		700
Calpain 2		MUSPF		830
+106
P17655-2	Calpain 2		LOXAF		623	UniRef90_G3UKD2
Calpain-2 catalytic subunit		FUKDA		651
Calpain 2		CANLF		636
Uncharacterized protein		PANPA		622
Uncharacterized protein		MANLE		622
+32

Protein	Similar proteins		Species	Score	Length	Source
P17655	Calpain-2 catalytic subunit	)	RAT		700	UniRef50_Q07009
Calpain-2 catalytic subunit		MACFA		700
Calpain-2 catalytic subunit		MOUSE		700
Calpain-2 catalytic subunit		BOVIN		700
Calpain 2		MUSPF		830
+171
P17655-2	Calpain-1 catalytic subunit	)	HUMAN		714	UniRef50_P07384
Calpain-1 catalytic subunit		BOVIN		716
Calpain-1 catalytic subunit		PONAB		714
Calpain-1 catalytic subunit		PIG		714
Calpain-1 catalytic subunit		CHICK		705
+897

Cross-referencesⁱ

Web resourcesⁱ

NIEHS-SNPs

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M23254 mRNA Translation: AAA35645.1 AF261089 mRNA Translation: AAF99682.1 AK316211 mRNA Translation: BAH14582.1 AY835586 Genomic DNA Translation: AAV80421.1 AC096542 Genomic DNA No translation available. AC099065 Genomic DNA No translation available. BC007686 mRNA Translation: AAH07686.1 Sequence problems. BC011828 mRNA Translation: AAH11828.1 Sequence problems. BC021303 mRNA Translation: AAH21303.1 J04700 Genomic DNA Translation: AAA52760.1
CCDSⁱ	CCDS31035.1 [P17655-1] CCDS53478.1 [P17655-2]
PIRⁱ	S10590 CIHUH2
RefSeqⁱ	NP_001139540.1, NM_001146068.1 [P17655-2] NP_001739.2, NM_001748.4
UniGeneⁱ	Hs.350899

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1KFU	X-ray	2.50	L	2-700	[»]
	1KFX	X-ray	3.15	L	2-700	[»]
	2NQA	X-ray	2.20	A/B	48-346	[»]
ProteinModelPortalⁱ	P17655
SMRⁱ	P17655
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	107274, 54 interactors
IntActⁱ	P17655, 13 interactors
MINTⁱ	P17655
STRINGⁱ	9606.ENSP00000295006

Chemistry databases

BindingDBⁱ	P17655
ChEMBLⁱ	CHEMBL2382
GuidetoPHARMACOLOGYⁱ	2337

Protein family/group databases

MEROPSⁱ	C02.002

MEROPSⁱ

C02.002

PTM databases

iPTMnetⁱ	P17655
PhosphoSitePlusⁱ	P17655
SwissPalmⁱ	P17655

Polymorphism and mutation databases

BioMutaⁱ	CAPN2
DMDMⁱ	317373596

Proteomic databases

EPDⁱ	P17655
MaxQBⁱ	P17655
PaxDbⁱ	P17655
PeptideAtlasⁱ	P17655
PRIDEⁱ	P17655
ProteomicsDBⁱ	53499 53500 [P17655-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	824
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000295006; ENSP00000295006; ENSG00000162909 [P17655-1] ENST00000433674; ENSP00000413158; ENSG00000162909 [P17655-2]
GeneIDⁱ	824
KEGGⁱ	hsa:824
UCSCⁱ	uc001hob.5 human [P17655-1]

Organism-specific databases

CTDⁱ	824
DisGeNETⁱ	824
EuPathDBⁱ	HostDB:ENSG00000162909.17
GeneCardsⁱ	CAPN2
HGNCⁱ	HGNC:1479 CAPN2
HPAⁱ	HPA024470
MIMⁱ	114230 gene
neXtProtⁱ	NX_P17655
OpenTargetsⁱ	ENSG00000162909
PharmGKBⁱ	PA26060
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0045 Eukaryota ENOG410XP0B LUCA
GeneTreeⁱ	ENSGT00760000118971
HOVERGENⁱ	HBG012645
InParanoidⁱ	P17655
KOⁱ	K03853
OMAⁱ	TNIHLGK
OrthoDBⁱ	EOG091G049E
PhylomeDBⁱ	P17655
TreeFamⁱ	TF314748

Enzyme and pathway databases

BRENDAⁱ	3.4.22.53 2681
Reactomeⁱ	R-HSA-1474228 Degradation of the extracellular matrix R-HSA-8862803 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
SIGNORⁱ	P17655

Miscellaneous databases

ChiTaRSⁱ	CAPN2 human
EvolutionaryTraceⁱ	P17655
GeneWikiⁱ	CAPN2
GenomeRNAiⁱ	824
Protein Ontology More...PROⁱ	PR:P17655
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000162909 Expressed in 233 organ(s), highest expression level in nasal cavity epithelium
CleanExⁱ	HS_CAPN2
ExpressionAtlasⁱ	P17655 baseline and differential
Genevisibleⁱ	P17655 HS

Family and domain databases

CDDⁱ	cd00214 Calpain_III, 1 hit cd00044 CysPc, 1 hit
InterProⁱ	View protein in InterPro IPR033883 C2_III IPR022684 Calpain_cysteine_protease IPR022682 Calpain_domain_III IPR022683 Calpain_III IPR036213 Calpain_III_sf IPR029539 CAPN2 IPR011992 EF-hand-dom_pair IPR018247 EF_Hand_1_Ca_BS IPR002048 EF_hand_dom IPR038765 Papain_like_cys_pep_sf IPR000169 Pept_cys_AS IPR001300 Peptidase_C2_calpain_cat
PANTHERⁱ	PTHR10183:SF268 PTHR10183:SF268, 1 hit
Pfamⁱ	View protein in Pfam PF01067 Calpain_III, 1 hit PF13833 EF-hand_8, 1 hit PF00648 Peptidase_C2, 1 hit
PRINTSⁱ	PR00704 CALPAIN
SMARTⁱ	View protein in SMART SM00720 calpain_III, 1 hit SM00230 CysPc, 1 hit
SUPFAMⁱ	SSF47473 SSF47473, 1 hit SSF49758 SSF49758, 1 hit SSF54001 SSF54001, 1 hit
PROSITEⁱ	View protein in PROSITE PS50203 CALPAIN_CAT, 1 hit PS00018 EF_HAND_1, 2 hits PS50222 EF_HAND_2, 3 hits PS00139 THIOL_PROTEASE_CYS, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CAN2_HUMAN
Accessionⁱ	P17655Primary (citable) accession number: P17655 Secondary accession number(s): A6NDG7 Q9HBB1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 1, 1990
	Last sequence update:	January 11, 2011
	Last modified:	November 7, 2018
	This is version 219 of the entry and version 6 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Peptidase families
Classification of peptidase families and list of entries
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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UniProtKB - P17655 (CAN2_HUMAN)

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Calpain-2 catalytic subunit

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

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Keywords - PTMi

Proteomic databases

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<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

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Keywords - Coding sequence diversityi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ