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Protein

Alcohol dehydrogenase

Gene

ADH

Organism
Fragaria ananassa (Strawberry) (Fragaria chiloensis x Fragaria virginiana)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

This protein is responsible for the conversion of alcohols to aldehydes in plants and is important for NAD metabolism during anaerobic respiration.

Catalytic activityi

A primary alcohol + NAD+ = an aldehyde + NADH.By similarity
A secondary alcohol + NAD+ = a ketone + NADH.By similarity

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi48Zinc 1; catalyticBy similarity1
Metal bindingi50Zinc 1By similarity1
Binding sitei50NADBy similarity1
Binding sitei50SubstrateBy similarity1
Metal bindingi70Zinc 1; catalyticBy similarity1
Binding sitei70SubstrateBy similarity1
Metal bindingi100Zinc 2By similarity1
Metal bindingi103Zinc 2By similarity1
Metal bindingi106Zinc 2By similarity1
Metal bindingi114Zinc 2By similarity1
Metal bindingi178Zinc 1; catalyticBy similarity1
Binding sitei227NADBy similarity1
Binding sitei232NADBy similarity1
Binding sitei273NAD; via carbonyl oxygenBy similarity1
Binding sitei296NAD; via carbonyl oxygenBy similarity1
Binding sitei323NAD; via amide nitrogenBy similarity1
Binding sitei373NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi203 – 208NADBy similarity6
Nucleotide bindingi296 – 298NADBy similarity3

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase (EC:1.1.1.1By similarity)
Gene namesi
Name:ADH
OrganismiFragaria ananassa (Strawberry) (Fragaria chiloensis x Fragaria virginiana)
Taxonomic identifieri3747 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsRosalesRosaceaeRosoideaePotentilleaeFragariinaeFragaria

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001606981 – 380Alcohol dehydrogenaseAdd BLAST380

Proteomic databases

PRIDEiP17648

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP17648
SMRiP17648
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiView protein in InterPro
IPR013149 ADH_C
IPR013154 ADH_N
IPR002328 ADH_Zn_CS
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SUPFAMiSSF50129 SSF50129, 2 hits
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit

Sequencei

Sequence statusi: Complete.

P17648-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSTEGKVIC CRAAVAWEAG KPLVIEEVEV APPQANVVRV KILYTSLCHT
60 70 80 90 100
DVYFWEAKGQ NPLFPRIYGH EAGGIVESVG EGVTDLKAGD HVLPVFTGEC
110 120 130 140 150
KECDHCKSEE SNMCDLLRIN TDRGVMLNDG KSRFSIKGKP IYHFVGTSTF
160 170 180 190 200
SVYTVTHVGC LAKINPQSPL DKVCILSCGI STGLGATLNV RKPKKGSTVA
210 220 230 240 250
VFGLGAVGLA AAEGARMAGA SRIIGVDLNS NRFEEAKKFG ITEFVNPKDH
260 270 280 290 300
KKPVQEVIAE LTNGGVDRSI ECTGNIQAMI PAFECVHDGW GVAVLVGVPH
310 320 330 340 350
KDAVFTTHPM NFLNERTLKG TFFGNYKPRT DIPSVVEKYM NKELEVDKFI
360 370 380
THQLPFSQIN KAFDYMLKGE GIRCIITMEE
Length:380
Mass (Da):41,459
Last modified:November 1, 1990 - v2
Checksum:i250DB0044299C7F4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15588 Genomic DNA Translation: CAA33613.1
PIRiA58722

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15588 Genomic DNA Translation: CAA33613.1
PIRiA58722

3D structure databases

ProteinModelPortaliP17648
SMRiP17648
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP17648

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiView protein in InterPro
IPR013149 ADH_C
IPR013154 ADH_N
IPR002328 ADH_Zn_CS
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SUPFAMiSSF50129 SSF50129, 2 hits
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiADH_FRAAN
AccessioniPrimary (citable) accession number: P17648
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: November 1, 1990
Last modified: November 22, 2017
This is version 105 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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