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Protein

Synapsin-1

Gene

SYN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level.

GO - Molecular functioni

  • actin binding Source: UniProtKB-KW
  • ATP binding Source: ParkinsonsUK-UCL
  • calcium-dependent protein binding Source: Ensembl
  • protein kinase binding Source: ParkinsonsUK-UCL
  • transporter activity Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionActin-binding

Enzyme and pathway databases

ReactomeiR-HSA-181429 Serotonin Neurotransmitter Release Cycle
R-HSA-212676 Dopamine Neurotransmitter Release Cycle
SIGNORiP17600

Names & Taxonomyi

Protein namesi
Recommended name:
Synapsin-1
Alternative name(s):
Brain protein 4.1
Synapsin I
Gene namesi
Name:SYN1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000008056.12
HGNCiHGNC:11494 SYN1
MIMi313440 gene
neXtProtiNX_P17600

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Golgi apparatus, Synapse

Pathology & Biotechi

Involvement in diseasei

Epilepsy X-linked, with variable learning disabilities and behavior disorders (XELBD)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA neurologic disorder characterized by variable combinations of epilepsy, learning difficulties, macrocephaly, and aggressive behavior.
See also OMIM:300491

Keywords - Diseasei

Epilepsy

Organism-specific databases

DisGeNETi6853
MalaCardsiSYN1
MIMi300491 phenotype
OpenTargetsiENSG00000008056
Orphaneti85294 X-linked epilepsy-learning disabilities-behavior disorders syndrome
PharmGKBiPA36276

Chemistry databases

DrugBankiDB01660 Adenosine-5'-Diphosphate Monothiophosphate

Polymorphism and mutation databases

BioMutaiSYN1
DMDMi73920800

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001830181 – 705Synapsin-1Add BLAST705

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei9Phosphoserine; by CaMK1 and PKABy similarity1
Modified residuei39PhosphoserineBy similarity1
Glycosylationi55O-linked (GlcNAc) serineBy similarity1
Modified residuei62PhosphoserineBy similarity1
Modified residuei67PhosphoserineBy similarity1
Glycosylationi87O-linked (GlcNAc) threonineBy similarity1
Glycosylationi96O-linked (GlcNAc) serineBy similarity1
Glycosylationi103O-linked (GlcNAc) serineBy similarity1
Glycosylationi261O-linked (GlcNAc) serineBy similarity1
Modified residuei312PhosphotyrosineBy similarity1
Modified residuei427PhosphoserineBy similarity1
Modified residuei430Omega-N-methylarginineBy similarity1
Modified residuei432Phosphoserine; alternateBy similarity1
Glycosylationi432O-linked (GlcNAc) serine; alternateBy similarity1
Modified residuei436PhosphothreonineBy similarity1
Modified residuei438PhosphoserineBy similarity1
Modified residuei476Omega-N-methylarginineBy similarity1
Glycosylationi526O-linked (GlcNAc) threonineBy similarity1
Modified residuei534Omega-N-methylarginineBy similarity1
Modified residuei547Omega-N-methylarginineBy similarity1
Modified residuei551Phosphoserine; by PDPK1Combined sources1
Modified residuei553PhosphoserineCombined sources1
Modified residuei556Omega-N-methylarginineBy similarity1
Glycosylationi564O-linked (GlcNAc) threonineBy similarity1
Modified residuei568Phosphoserine; by CaMK2By similarity1
Glycosylationi578O-linked (GlcNAc) serineBy similarity1
Modified residuei605Phosphoserine; by CaMK2By similarity1
Modified residuei622Omega-N-methylarginineBy similarity1
Modified residuei663PhosphoserineBy similarity1
Modified residuei665PhosphoserineBy similarity1
Modified residuei679Asymmetric dimethylarginineBy similarity1
Modified residuei683PhosphoserineBy similarity1

Post-translational modificationi

Substrate of at least four different protein kinases. It is probable that phosphorylation plays a role in the regulation of synapsin-1 in the nerve terminal.
Phosphorylation at Ser-9 dissociates synapsins from synaptic vesicles.By similarity

Keywords - PTMi

Glycoprotein, Methylation, Phosphoprotein

Proteomic databases

EPDiP17600
MaxQBiP17600
PaxDbiP17600
PeptideAtlasiP17600
PRIDEiP17600
ProteomicsDBi53494
53495 [P17600-2]

PTM databases

iPTMnetiP17600
PhosphoSitePlusiP17600

Expressioni

Gene expression databases

BgeeiENSG00000008056 Expressed in 132 organ(s), highest expression level in anterior cingulate cortex
CleanExiHS_SYN1
ExpressionAtlasiP17600 baseline and differential
GenevisibleiP17600 HS

Organism-specific databases

HPAiCAB021929
HPA000397

Interactioni

Subunit structurei

Homodimer. Interacts with CAPON. Forms a ternary complex with NOS1. Isoform Ib interacts with PRNP (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
SNCAP378402EBI-717274,EBI-985879

GO - Molecular functioni

Protein-protein interaction databases

BioGridi112719, 36 interactors
CORUMiP17600
IntActiP17600, 15 interactors
MINTiP17600
STRINGi9606.ENSP00000295987

Structurei

3D structure databases

ProteinModelPortaliP17600
SMRiP17600
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 28AAdd BLAST28
Regioni29 – 112B; linkerAdd BLAST84
Regioni113 – 420C; actin-binding and synaptic-vesicle bindingAdd BLAST308
Regioni421 – 655D; Pro-rich linkerAdd BLAST235
Regioni656 – 705EAdd BLAST50

Domaini

The A region binds phospholipids with a preference for negatively charged species.By similarity

Sequence similaritiesi

Belongs to the synapsin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3895 Eukaryota
ENOG410XQH5 LUCA
GeneTreeiENSGT00530000063319
HOGENOMiHOG000231323
HOVERGENiHBG016354
InParanoidiP17600
KOiK19941
OMAiNGDHRNI
OrthoDBiEOG091G0BZ1
PhylomeDBiP17600
TreeFamiTF319919

Family and domain databases

Gene3Di3.30.1490.20, 1 hit
InterProiView protein in InterPro
IPR013815 ATP_grasp_subdomain_1
IPR016185 PreATP-grasp_dom_sf
IPR028713 SYN1
IPR001359 Synapsin
IPR020898 Synapsin_ATP-bd_dom
IPR019735 Synapsin_CS
IPR019736 Synapsin_P_site
IPR020897 Synapsin_pre-ATP-grasp_dom
PANTHERiPTHR10841 PTHR10841, 1 hit
PTHR10841:SF22 PTHR10841:SF22, 1 hit
PfamiView protein in Pfam
PF02078 Synapsin, 1 hit
PF02750 Synapsin_C, 1 hit
PF10581 Synapsin_N, 1 hit
PRINTSiPR01368 SYNAPSIN
SUPFAMiSSF52440 SSF52440, 1 hit
PROSITEiView protein in PROSITE
PS00415 SYNAPSIN_1, 1 hit
PS00416 SYNAPSIN_2, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform IA (identifier: P17600-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNYLRRRLSD SNFMANLPNG YMTDLQRPQP PPPPPGAHSP GATPGPGTAT
60 70 80 90 100
AERSSGVAPA ASPAAPSPGS SGGGGFFSSL SNAVKQTTAA AAATFSEQVG
110 120 130 140 150
GGSGGAGRGG AASRVLLVID EPHTDWAKYF KGKKIHGEID IKVEQAEFSD
160 170 180 190 200
LNLVAHANGG FSVDMEVLRN GVKVVRSLKP DFVLIRQHAF SMARNGDYRS
210 220 230 240 250
LVIGLQYAGI PSVNSLHSVY NFCDKPWVFA QMVRLHKKLG TEEFPLIDQT
260 270 280 290 300
FYPNHKEMLS STTYPVVVKM GHAHSGMGKV KVDNQHDFQD IASVVALTKT
310 320 330 340 350
YATAEPFIDA KYDVRVQKIG QNYKAYMRTS VSGNWKTNTG SAMLEQIAMS
360 370 380 390 400
DRYKLWVDTC SEIFGGLDIC AVEALHGKDG RDHIIEVVGS SMPLIGDHQD
410 420 430 440 450
EDKQLIVELV VNKMAQALPR QRQRDASPGR GSHGQTPSPG ALPLGRQTSQ
460 470 480 490 500
QPAGPPAQQR PPPQGGPPQP GPGPQRQGPP LQQRPPPQGQ QHLSGLGPPA
510 520 530 540 550
GSPLPQRLPS PTSAPQQPAS QAAPPTQGQG RQSRPVAGGP GAPPAARPPA
560 570 580 590 600
SPSPQRQAGP PQATRQTSVS GPAPPKASGA PPGGQQRQGP PQKPPGPAGP
610 620 630 640 650
TRQASQAGPV PRTGPPTTQQ PRPSGPGPAG RPKPQLAQKP SQDVPPPATA
660 670 680 690 700
AAGGPPHPQL NKSQSLTNAF NLPEPAPPRP SLSQDEVKAE TIRSLRKSFA

SLFSD
Length:705
Mass (Da):74,111
Last modified:August 30, 2005 - v3
Checksum:iBE4CE46C942300B0
GO
Isoform IB (identifier: P17600-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     661-669: NKSQSLTNA → KASPAQAQP
     670-705: Missing.

Show »
Length:669
Mass (Da):70,033
Checksum:i5E400115415D3E32
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1W2PS00A0A1W2PS00_HUMAN
Synapsin-1
SYN1
148Annotation score:
A0A1W2PSE9A0A1W2PSE9_HUMAN
Synapsin-1
SYN1
55Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti138E → G in AAC41930 (PubMed:2110562).Curated1
Sequence conflicti138E → G in AAC41931 (PubMed:2110562).Curated1
Sequence conflicti631R → A in AAC41930 (PubMed:2110562).Curated1
Sequence conflicti631R → A in AAC41931 (PubMed:2110562).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_006316661 – 669NKSQSLTNA → KASPAQAQP in isoform IB. Curated9
Alternative sequenceiVSP_006317670 – 705Missing in isoform IB. CuratedAdd BLAST36

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M58378
, M58321, M58341, M58351, M58353, M58359, M58371, M58372, M58373, M58374, M58375, M58376, M58377 Genomic DNA Translation: AAC41930.1
M58378
, M58321, M58341, M58351, M58353, M58359, M58371, M58372, M58373, M58374, M58375, M58376, M58377 Genomic DNA Translation: AAC41931.1 Sequence problems.
AL009172 Genomic DNA No translation available.
Z84466 Genomic DNA No translation available.
CH471164 Genomic DNA Translation: EAW59313.1
M55301 Genomic DNA Translation: AAA60608.1
CCDSiCCDS14280.1 [P17600-1]
CCDS35233.1 [P17600-2]
PIRiA35363
RefSeqiNP_008881.2, NM_006950.3 [P17600-1]
NP_598006.1, NM_133499.2 [P17600-2]
UniGeneiHs.225936

Genome annotation databases

EnsembliENST00000295987; ENSP00000295987; ENSG00000008056 [P17600-1]
ENST00000340666; ENSP00000343206; ENSG00000008056 [P17600-2]
GeneIDi6853
KEGGihsa:6853
UCSCiuc004did.4 human [P17600-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M58378
, M58321, M58341, M58351, M58353, M58359, M58371, M58372, M58373, M58374, M58375, M58376, M58377 Genomic DNA Translation: AAC41930.1
M58378
, M58321, M58341, M58351, M58353, M58359, M58371, M58372, M58373, M58374, M58375, M58376, M58377 Genomic DNA Translation: AAC41931.1 Sequence problems.
AL009172 Genomic DNA No translation available.
Z84466 Genomic DNA No translation available.
CH471164 Genomic DNA Translation: EAW59313.1
M55301 Genomic DNA Translation: AAA60608.1
CCDSiCCDS14280.1 [P17600-1]
CCDS35233.1 [P17600-2]
PIRiA35363
RefSeqiNP_008881.2, NM_006950.3 [P17600-1]
NP_598006.1, NM_133499.2 [P17600-2]
UniGeneiHs.225936

3D structure databases

ProteinModelPortaliP17600
SMRiP17600
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112719, 36 interactors
CORUMiP17600
IntActiP17600, 15 interactors
MINTiP17600
STRINGi9606.ENSP00000295987

Chemistry databases

DrugBankiDB01660 Adenosine-5'-Diphosphate Monothiophosphate

PTM databases

iPTMnetiP17600
PhosphoSitePlusiP17600

Polymorphism and mutation databases

BioMutaiSYN1
DMDMi73920800

Proteomic databases

EPDiP17600
MaxQBiP17600
PaxDbiP17600
PeptideAtlasiP17600
PRIDEiP17600
ProteomicsDBi53494
53495 [P17600-2]

Protocols and materials databases

DNASUi6853
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000295987; ENSP00000295987; ENSG00000008056 [P17600-1]
ENST00000340666; ENSP00000343206; ENSG00000008056 [P17600-2]
GeneIDi6853
KEGGihsa:6853
UCSCiuc004did.4 human [P17600-1]

Organism-specific databases

CTDi6853
DisGeNETi6853
EuPathDBiHostDB:ENSG00000008056.12
GeneCardsiSYN1
HGNCiHGNC:11494 SYN1
HPAiCAB021929
HPA000397
MalaCardsiSYN1
MIMi300491 phenotype
313440 gene
neXtProtiNX_P17600
OpenTargetsiENSG00000008056
Orphaneti85294 X-linked epilepsy-learning disabilities-behavior disorders syndrome
PharmGKBiPA36276
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3895 Eukaryota
ENOG410XQH5 LUCA
GeneTreeiENSGT00530000063319
HOGENOMiHOG000231323
HOVERGENiHBG016354
InParanoidiP17600
KOiK19941
OMAiNGDHRNI
OrthoDBiEOG091G0BZ1
PhylomeDBiP17600
TreeFamiTF319919

Enzyme and pathway databases

ReactomeiR-HSA-181429 Serotonin Neurotransmitter Release Cycle
R-HSA-212676 Dopamine Neurotransmitter Release Cycle
SIGNORiP17600

Miscellaneous databases

ChiTaRSiSYN1 human
GeneWikiiSynapsin_I
GenomeRNAii6853
PROiPR:P17600
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000008056 Expressed in 132 organ(s), highest expression level in anterior cingulate cortex
CleanExiHS_SYN1
ExpressionAtlasiP17600 baseline and differential
GenevisibleiP17600 HS

Family and domain databases

Gene3Di3.30.1490.20, 1 hit
InterProiView protein in InterPro
IPR013815 ATP_grasp_subdomain_1
IPR016185 PreATP-grasp_dom_sf
IPR028713 SYN1
IPR001359 Synapsin
IPR020898 Synapsin_ATP-bd_dom
IPR019735 Synapsin_CS
IPR019736 Synapsin_P_site
IPR020897 Synapsin_pre-ATP-grasp_dom
PANTHERiPTHR10841 PTHR10841, 1 hit
PTHR10841:SF22 PTHR10841:SF22, 1 hit
PfamiView protein in Pfam
PF02078 Synapsin, 1 hit
PF02750 Synapsin_C, 1 hit
PF10581 Synapsin_N, 1 hit
PRINTSiPR01368 SYNAPSIN
SUPFAMiSSF52440 SSF52440, 1 hit
PROSITEiView protein in PROSITE
PS00415 SYNAPSIN_1, 1 hit
PS00416 SYNAPSIN_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSYN1_HUMAN
AccessioniPrimary (citable) accession number: P17600
Secondary accession number(s): B1AJQ1, O75825, Q5H9A9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 30, 2005
Last modified: November 7, 2018
This is version 187 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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