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Entry version 193 (31 Jul 2019)
Sequence version 3 (30 Aug 2005)
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Protein

Synapsin-1

Gene

SYN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-181429 Serotonin Neurotransmitter Release Cycle
R-HSA-212676 Dopamine Neurotransmitter Release Cycle

SIGNOR Signaling Network Open Resource

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SIGNORi
P17600

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Synapsin-1
Alternative name(s):
Brain protein 4.1
Synapsin I
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SYN1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:11494 SYN1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
313440 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P17600

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Golgi apparatus, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Epilepsy X-linked, with variable learning disabilities and behavior disorders (XELBD)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA neurologic disorder characterized by variable combinations of epilepsy, learning difficulties, macrocephaly, and aggressive behavior.
Related information in OMIM

Keywords - Diseasei

Epilepsy

Organism-specific databases

DisGeNET

More...
DisGeNETi
6853

MalaCards human disease database

More...
MalaCardsi
SYN1
MIMi300491 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000008056

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
85294 X-linked epilepsy-learning disabilities-behavior disorders syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA36276

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB01660 Adenosine-5'-Diphosphate Monothiophosphate

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SYN1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
73920800

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001830181 – 705Synapsin-1Add BLAST705

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei9Phosphoserine; by CaMK1 and PKABy similarity1
Modified residuei39PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi55O-linked (GlcNAc) serineBy similarity1
Modified residuei62PhosphoserineBy similarity1
Modified residuei67PhosphoserineBy similarity1
Glycosylationi87O-linked (GlcNAc) threonineBy similarity1
Glycosylationi96O-linked (GlcNAc) serineBy similarity1
Glycosylationi103O-linked (GlcNAc) serineBy similarity1
Glycosylationi261O-linked (GlcNAc) serineBy similarity1
Modified residuei312PhosphotyrosineBy similarity1
Modified residuei427PhosphoserineBy similarity1
Modified residuei430Omega-N-methylarginineBy similarity1
Modified residuei432Phosphoserine; alternateBy similarity1
Glycosylationi432O-linked (GlcNAc) serine; alternateBy similarity1
Modified residuei436PhosphothreonineBy similarity1
Modified residuei438PhosphoserineBy similarity1
Modified residuei476Omega-N-methylarginineBy similarity1
Glycosylationi526O-linked (GlcNAc) threonineBy similarity1
Modified residuei534Omega-N-methylarginineBy similarity1
Modified residuei547Omega-N-methylarginineBy similarity1
Modified residuei551Phosphoserine; by PDPK1Combined sources1
Modified residuei553PhosphoserineCombined sources1
Modified residuei556Omega-N-methylarginineBy similarity1
Glycosylationi564O-linked (GlcNAc) threonineBy similarity1
Modified residuei568Phosphoserine; by CaMK2By similarity1
Glycosylationi578O-linked (GlcNAc) serineBy similarity1
Modified residuei605Phosphoserine; by CaMK2By similarity1
Modified residuei622Omega-N-methylarginineBy similarity1
Modified residuei663PhosphoserineBy similarity1
Modified residuei665PhosphoserineBy similarity1
Modified residuei679Asymmetric dimethylarginineBy similarity1
Modified residuei683PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Substrate of at least four different protein kinases. It is probable that phosphorylation plays a role in the regulation of synapsin-1 in the nerve terminal.
Phosphorylation at Ser-9 dissociates synapsins from synaptic vesicles.By similarity

Keywords - PTMi

Glycoprotein, Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P17600

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P17600

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P17600

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P17600

PeptideAtlas

More...
PeptideAtlasi
P17600

PRoteomics IDEntifications database

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PRIDEi
P17600

ProteomicsDB human proteome resource

More...
ProteomicsDBi
53494 [P17600-1]
53495 [P17600-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P17600

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P17600

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000008056 Expressed in 132 organ(s), highest expression level in anterior cingulate cortex

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P17600 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P17600 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB021929
HPA000397

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

Interacts with CAPON.

Forms a ternary complex with NOS1. Isoform Ib interacts with PRNP (By similarity).

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
SNCAP378402EBI-717274,EBI-985879

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
112719, 36 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P17600

Protein interaction database and analysis system

More...
IntActi
P17600, 16 interactors

Molecular INTeraction database

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MINTi
P17600

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000295987

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P17600

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 28AAdd BLAST28
Regioni29 – 112B; linkerAdd BLAST84
Regioni113 – 420C; actin-binding and synaptic-vesicle bindingAdd BLAST308
Regioni421 – 655D; Pro-rich linkerAdd BLAST235
Regioni656 – 705EAdd BLAST50

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The A region binds phospholipids with a preference for negatively charged species.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the synapsin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3895 Eukaryota
ENOG410XQH5 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000161978

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000231323

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P17600

KEGG Orthology (KO)

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KOi
K19941

Identification of Orthologs from Complete Genome Data

More...
OMAi
AFSMAKN

Database of Orthologous Groups

More...
OrthoDBi
799740at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P17600

TreeFam database of animal gene trees

More...
TreeFami
TF319919

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.30.1490.20, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR013815 ATP_grasp_subdomain_1
IPR016185 PreATP-grasp_dom_sf
IPR028713 SYN1
IPR001359 Synapsin
IPR020898 Synapsin_ATP-bd_dom
IPR019735 Synapsin_CS
IPR019736 Synapsin_P_site
IPR020897 Synapsin_pre-ATP-grasp_dom

The PANTHER Classification System

More...
PANTHERi
PTHR10841:SF24 PTHR10841:SF24, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02078 Synapsin, 1 hit
PF02750 Synapsin_C, 1 hit
PF10581 Synapsin_N, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01368 SYNAPSIN

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52440 SSF52440, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00415 SYNAPSIN_1, 1 hit
PS00416 SYNAPSIN_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform IA (identifier: P17600-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNYLRRRLSD SNFMANLPNG YMTDLQRPQP PPPPPGAHSP GATPGPGTAT
60 70 80 90 100
AERSSGVAPA ASPAAPSPGS SGGGGFFSSL SNAVKQTTAA AAATFSEQVG
110 120 130 140 150
GGSGGAGRGG AASRVLLVID EPHTDWAKYF KGKKIHGEID IKVEQAEFSD
160 170 180 190 200
LNLVAHANGG FSVDMEVLRN GVKVVRSLKP DFVLIRQHAF SMARNGDYRS
210 220 230 240 250
LVIGLQYAGI PSVNSLHSVY NFCDKPWVFA QMVRLHKKLG TEEFPLIDQT
260 270 280 290 300
FYPNHKEMLS STTYPVVVKM GHAHSGMGKV KVDNQHDFQD IASVVALTKT
310 320 330 340 350
YATAEPFIDA KYDVRVQKIG QNYKAYMRTS VSGNWKTNTG SAMLEQIAMS
360 370 380 390 400
DRYKLWVDTC SEIFGGLDIC AVEALHGKDG RDHIIEVVGS SMPLIGDHQD
410 420 430 440 450
EDKQLIVELV VNKMAQALPR QRQRDASPGR GSHGQTPSPG ALPLGRQTSQ
460 470 480 490 500
QPAGPPAQQR PPPQGGPPQP GPGPQRQGPP LQQRPPPQGQ QHLSGLGPPA
510 520 530 540 550
GSPLPQRLPS PTSAPQQPAS QAAPPTQGQG RQSRPVAGGP GAPPAARPPA
560 570 580 590 600
SPSPQRQAGP PQATRQTSVS GPAPPKASGA PPGGQQRQGP PQKPPGPAGP
610 620 630 640 650
TRQASQAGPV PRTGPPTTQQ PRPSGPGPAG RPKPQLAQKP SQDVPPPATA
660 670 680 690 700
AAGGPPHPQL NKSQSLTNAF NLPEPAPPRP SLSQDEVKAE TIRSLRKSFA

SLFSD
Length:705
Mass (Da):74,111
Last modified:August 30, 2005 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBE4CE46C942300B0
GO
Isoform IB (identifier: P17600-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     661-669: NKSQSLTNA → KASPAQAQP
     670-705: Missing.

Show »
Length:669
Mass (Da):70,033
Checksum:i5E400115415D3E32
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1W2PSE9A0A1W2PSE9_HUMAN
Synapsin-1
SYN1
55Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2PS00A0A1W2PS00_HUMAN
Synapsin-1
SYN1
148Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti138E → G in AAC41930 (PubMed:2110562).Curated1
Sequence conflicti138E → G in AAC41931 (PubMed:2110562).Curated1
Sequence conflicti631R → A in AAC41930 (PubMed:2110562).Curated1
Sequence conflicti631R → A in AAC41931 (PubMed:2110562).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_006316661 – 669NKSQSLTNA → KASPAQAQP in isoform IB. Curated9
Alternative sequenceiVSP_006317670 – 705Missing in isoform IB. CuratedAdd BLAST36

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M58378
, M58321, M58341, M58351, M58353, M58359, M58371, M58372, M58373, M58374, M58375, M58376, M58377 Genomic DNA Translation: AAC41930.1
M58378
, M58321, M58341, M58351, M58353, M58359, M58371, M58372, M58373, M58374, M58375, M58376, M58377 Genomic DNA Translation: AAC41931.1 Sequence problems.
AL009172 Genomic DNA No translation available.
Z84466 Genomic DNA No translation available.
CH471164 Genomic DNA Translation: EAW59313.1
M55301 Genomic DNA Translation: AAA60608.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS14280.1 [P17600-1]
CCDS35233.1 [P17600-2]

Protein sequence database of the Protein Information Resource

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PIRi
A35363

NCBI Reference Sequences

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RefSeqi
NP_008881.2, NM_006950.3 [P17600-1]
NP_598006.1, NM_133499.2 [P17600-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000295987; ENSP00000295987; ENSG00000008056 [P17600-1]
ENST00000340666; ENSP00000343206; ENSG00000008056 [P17600-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
6853

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:6853

UCSC genome browser

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UCSCi
uc004did.4 human [P17600-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M58378
, M58321, M58341, M58351, M58353, M58359, M58371, M58372, M58373, M58374, M58375, M58376, M58377 Genomic DNA Translation: AAC41930.1
M58378
, M58321, M58341, M58351, M58353, M58359, M58371, M58372, M58373, M58374, M58375, M58376, M58377 Genomic DNA Translation: AAC41931.1 Sequence problems.
AL009172 Genomic DNA No translation available.
Z84466 Genomic DNA No translation available.
CH471164 Genomic DNA Translation: EAW59313.1
M55301 Genomic DNA Translation: AAA60608.1
CCDSiCCDS14280.1 [P17600-1]
CCDS35233.1 [P17600-2]
PIRiA35363
RefSeqiNP_008881.2, NM_006950.3 [P17600-1]
NP_598006.1, NM_133499.2 [P17600-2]

3D structure databases

SMRiP17600
ModBaseiSearch...

Protein-protein interaction databases

BioGridi112719, 36 interactors
CORUMiP17600
IntActiP17600, 16 interactors
MINTiP17600
STRINGi9606.ENSP00000295987

Chemistry databases

DrugBankiDB01660 Adenosine-5'-Diphosphate Monothiophosphate

PTM databases

iPTMnetiP17600
PhosphoSitePlusiP17600

Polymorphism and mutation databases

BioMutaiSYN1
DMDMi73920800

Proteomic databases

EPDiP17600
jPOSTiP17600
MaxQBiP17600
PaxDbiP17600
PeptideAtlasiP17600
PRIDEiP17600
ProteomicsDBi53494 [P17600-1]
53495 [P17600-2]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
6853
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000295987; ENSP00000295987; ENSG00000008056 [P17600-1]
ENST00000340666; ENSP00000343206; ENSG00000008056 [P17600-2]
GeneIDi6853
KEGGihsa:6853
UCSCiuc004did.4 human [P17600-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
6853
DisGeNETi6853

GeneCards: human genes, protein and diseases

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GeneCardsi
SYN1
HGNCiHGNC:11494 SYN1
HPAiCAB021929
HPA000397
MalaCardsiSYN1
MIMi300491 phenotype
313440 gene
neXtProtiNX_P17600
OpenTargetsiENSG00000008056
Orphaneti85294 X-linked epilepsy-learning disabilities-behavior disorders syndrome
PharmGKBiPA36276

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3895 Eukaryota
ENOG410XQH5 LUCA
GeneTreeiENSGT00940000161978
HOGENOMiHOG000231323
InParanoidiP17600
KOiK19941
OMAiAFSMAKN
OrthoDBi799740at2759
PhylomeDBiP17600
TreeFamiTF319919

Enzyme and pathway databases

ReactomeiR-HSA-181429 Serotonin Neurotransmitter Release Cycle
R-HSA-212676 Dopamine Neurotransmitter Release Cycle
SIGNORiP17600

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SYN1 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Synapsin_I

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
6853

Protein Ontology

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PROi
PR:P17600

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000008056 Expressed in 132 organ(s), highest expression level in anterior cingulate cortex
ExpressionAtlasiP17600 baseline and differential
GenevisibleiP17600 HS

Family and domain databases

Gene3Di3.30.1490.20, 1 hit
InterProiView protein in InterPro
IPR013815 ATP_grasp_subdomain_1
IPR016185 PreATP-grasp_dom_sf
IPR028713 SYN1
IPR001359 Synapsin
IPR020898 Synapsin_ATP-bd_dom
IPR019735 Synapsin_CS
IPR019736 Synapsin_P_site
IPR020897 Synapsin_pre-ATP-grasp_dom
PANTHERiPTHR10841:SF24 PTHR10841:SF24, 1 hit
PfamiView protein in Pfam
PF02078 Synapsin, 1 hit
PF02750 Synapsin_C, 1 hit
PF10581 Synapsin_N, 1 hit
PRINTSiPR01368 SYNAPSIN
SUPFAMiSSF52440 SSF52440, 1 hit
PROSITEiView protein in PROSITE
PS00415 SYNAPSIN_1, 1 hit
PS00416 SYNAPSIN_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSYN1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P17600
Secondary accession number(s): B1AJQ1, O75825, Q5H9A9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 30, 2005
Last modified: July 31, 2019
This is version 193 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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