UniProtKB - P17599 (SYN1_BOVIN)
Synapsin-1
SYN1
Functioni
Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level (By similarity).
By similarityGO - Molecular functioni
- actin binding Source: UniProtKB-KW
- ATP binding Source: InterPro
GO - Biological processi
- neurotransmitter secretion Source: GO_Central
Keywordsi
Molecular function | Actin-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Synapsin-1Alternative name(s): Synapsin I |
Gene namesi | Name:SYN1 |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Subcellular locationi
Golgi apparatus
- Golgi apparatus By similarity
Other locations
Golgi apparatus
- Golgi apparatus Source: UniProtKB-SubCell
Other locations
- synaptic vesicle Source: AgBase
- synaptic vesicle membrane Source: GO_Central
Keywords - Cellular componenti
Cell junction, Golgi apparatus, SynapsePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000183016 | 1 – 706 | Synapsin-1Add BLAST | 706 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 9 | Phosphoserine; by CaMK1 and PKABy similarity | 1 | |
Modified residuei | 39 | PhosphoserineBy similarity | 1 | |
Glycosylationi | 55 | O-linked (GlcNAc) serineBy similarity | 1 | |
Modified residuei | 62 | PhosphoserineBy similarity | 1 | |
Modified residuei | 67 | PhosphoserineBy similarity | 1 | |
Glycosylationi | 87 | O-linked (GlcNAc) threonineBy similarity | 1 | |
Glycosylationi | 96 | O-linked (GlcNAc) serineBy similarity | 1 | |
Glycosylationi | 103 | O-linked (GlcNAc) serineBy similarity | 1 | |
Glycosylationi | 261 | O-linked (GlcNAc) serineBy similarity | 1 | |
Modified residuei | 312 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 427 | PhosphoserineBy similarity | 1 | |
Modified residuei | 430 | Omega-N-methylarginineBy similarity | 1 | |
Modified residuei | 432 | Phosphoserine; alternateBy similarity | 1 | |
Glycosylationi | 432 | O-linked (GlcNAc) serine; alternateBy similarity | 1 | |
Modified residuei | 434 | PhosphoserineBy similarity | 1 | |
Modified residuei | 436 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 438 | PhosphoserineBy similarity | 1 | |
Modified residuei | 476 | Omega-N-methylarginineBy similarity | 1 | |
Glycosylationi | 526 | O-linked (GlcNAc) threonineBy similarity | 1 | |
Modified residuei | 534 | Omega-N-methylarginineBy similarity | 1 | |
Modified residuei | 547 | Omega-N-methylarginineBy similarity | 1 | |
Modified residuei | 551 | Phosphoserine; by PDPK11 Publication | 1 | |
Modified residuei | 553 | PhosphoserineBy similarity | 1 | |
Modified residuei | 556 | Omega-N-methylarginineBy similarity | 1 | |
Glycosylationi | 564 | O-linked (GlcNAc) threonineBy similarity | 1 | |
Modified residuei | 568 | Phosphoserine; by CaMK21 Publication | 1 | |
Glycosylationi | 578 | O-linked (GlcNAc) serineBy similarity | 1 | |
Modified residuei | 605 | Phosphoserine; by CaMK21 Publication | 1 | |
Modified residuei | 622 | Omega-N-methylarginineBy similarity | 1 | |
Modified residuei | 664 | PhosphoserineBy similarity | 1 | |
Modified residuei | 666 | PhosphoserineBy similarity | 1 | |
Modified residuei | 680 | Asymmetric dimethylarginineBy similarity | 1 | |
Modified residuei | 684 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Glycoprotein, Methylation, PhosphoproteinProteomic databases
PaxDbi | P17599 |
PRIDEi | P17599 |
PTM databases
GlyConnecti | 581, 1 O-Linked glycan |
iPTMneti | P17599 |
Interactioni
Subunit structurei
Homodimer.
Interacts with CAPON.
Forms a ternary complex with NOS1. Isoform Ib interacts with PRNP (By similarity).
By similarityGO - Molecular functioni
- actin binding Source: UniProtKB-KW
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000027503 |
Chemistry databases
BindingDBi | P17599 |
Structurei
Secondary structure
3D structure databases
SMRi | P17599 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P17599 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 72 | DisorderedSequence analysisAdd BLAST | 72 | |
Regioni | 1 – 28 | AAdd BLAST | 28 | |
Regioni | 29 – 112 | B; linkerAdd BLAST | 84 | |
Regioni | 113 – 420 | C; actin-binding and synaptic-vesicle bindingAdd BLAST | 308 | |
Regioni | 418 – 690 | DisorderedSequence analysisAdd BLAST | 273 | |
Regioni | 421 – 656 | D; Pro-rich linkerAdd BLAST | 236 | |
Regioni | 657 – 706 | EAdd BLAST | 50 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 23 | Polar residuesSequence analysisAdd BLAST | 23 | |
Compositional biasi | 25 – 41 | Pro residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 428 – 445 | Polar residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 455 – 481 | Pro residuesSequence analysisAdd BLAST | 27 | |
Compositional biasi | 513 – 533 | Polar residuesSequence analysisAdd BLAST | 21 | |
Compositional biasi | 541 – 556 | Pro residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 557 – 574 | Polar residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 614 – 630 | Pro residuesSequence analysisAdd BLAST | 17 |
Domaini
Sequence similaritiesi
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG3895, Eukaryota |
InParanoidi | P17599 |
OrthoDBi | 799740at2759 |
Family and domain databases
Gene3Di | 3.30.1490.20, 1 hit |
InterProi | View protein in InterPro IPR013815, ATP_grasp_subdomain_1 IPR016185, PreATP-grasp_dom_sf IPR028713, SYN1 IPR001359, Synapsin IPR020898, Synapsin_ATP-bd_dom IPR019735, Synapsin_CS IPR019736, Synapsin_P_site IPR020897, Synapsin_pre-ATP-grasp_dom |
PANTHERi | PTHR10841:SF24, PTHR10841:SF24, 1 hit |
Pfami | View protein in Pfam PF02078, Synapsin, 1 hit PF02750, Synapsin_C, 1 hit PF10581, Synapsin_N, 1 hit |
PRINTSi | PR01368, SYNAPSIN |
SUPFAMi | SSF52440, SSF52440, 1 hit |
PROSITEi | View protein in PROSITE PS00415, SYNAPSIN_1, 1 hit PS00416, SYNAPSIN_2, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MNYLRRRLSD SNFMANLPNG YMTDLQRPQP PPPPPAAPSP GATTGPATAT
60 70 80 90 100
AERASSAAPV ASPAAPSPGS SGGGGFFSSL SNAVKQTTAA AAATFSEQVG
110 120 130 140 150
GGSGGAGRGG AAARVLLVID EPHTDWAKYF KGKKIHGEID IKVEQAEFSD
160 170 180 190 200
LNLVAHANGG FSVDMEVLRN GVKVVRSLKP DFVLIRQHAF SMARNGDYRS
210 220 230 240 250
LVIGLQYAGI PSINSLHSVY NFCDKPWVFA QMVRLHKKLG TEEFPLINQT
260 270 280 290 300
FYPNHKEMLS STTYPVVVKM GHAHSGMGKV KVDNQHDFQD IASVVALTKT
310 320 330 340 350
YATTEPFIDA KYDVRIQKIG QNYKAYMRTS VSGNWKTNTG SAMLEQIAMS
360 370 380 390 400
DRYKLWVDTC SEIFGGLDIC AVEALHGKDG RDHIIQVVGS SMPLIGDHQD
410 420 430 440 450
EDKQLIVELV VNKMAQALPR QRQRDASPGR GSHSQTPSPG ALPLGRQISQ
460 470 480 490 500
QPAGPPAQQR PPPQGGPPQP GPGPQRQGPP LQQRPTPQGQ QHLSGLGPPA
510 520 530 540 550
GSPLPQRLPS PTSVPQQPAS QATPMTQGQG RQSRPVAGGP GAPPATRPPA
560 570 580 590 600
SPSPQRQAGP PQATRQTSVS GQAPPKASGV PPGGQQRQGP PQKPPGPAGP
610 620 630 640 650
TRQASQAGPM PRTGPPTTQQ PRPSGPGPAG RPTKPQLAQK PSQDVPPPAT
660 670 680 690 700
AAAGGPPHPQ LNKSQSLTNA FNLPEPAPPR PSLSQDEVKA ETIRSLRKSF
ASLFSD
The sequence of this isoform differs from the canonical sequence as follows:
662-670: NKSQSLTNA → KASPAQAQP
671-706: Missing.
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_006314 | 662 – 670 | NKSQSLTNA → KASPAQAQP in isoform IB. 1 Publication | 9 | |
Alternative sequenceiVSP_006315 | 671 – 706 | Missing in isoform IB. 1 PublicationAdd BLAST | 36 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M27810 mRNA Translation: AAA30761.1 M27811 mRNA Translation: AAA30762.1 |
PIRi | E30411 |
RefSeqi | NP_776616.1, NM_174191.2 [P17599-1] |
Genome annotation databases
GeneIDi | 281510 |
KEGGi | bta:281510 |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M27810 mRNA Translation: AAA30761.1 M27811 mRNA Translation: AAA30762.1 |
PIRi | E30411 |
RefSeqi | NP_776616.1, NM_174191.2 [P17599-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1AUV | X-ray | 2.15 | A/B | 110-420 | [»] | |
1AUX | X-ray | 2.30 | A/B | 110-420 | [»] | |
SMRi | P17599 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000027503 |
Chemistry databases
BindingDBi | P17599 |
ChEMBLi | CHEMBL3817719 |
PTM databases
GlyConnecti | 581, 1 O-Linked glycan |
iPTMneti | P17599 |
Proteomic databases
PaxDbi | P17599 |
PRIDEi | P17599 |
Genome annotation databases
GeneIDi | 281510 |
KEGGi | bta:281510 |
Organism-specific databases
CTDi | 6853 |
Phylogenomic databases
eggNOGi | KOG3895, Eukaryota |
InParanoidi | P17599 |
OrthoDBi | 799740at2759 |
Miscellaneous databases
EvolutionaryTracei | P17599 |
Family and domain databases
Gene3Di | 3.30.1490.20, 1 hit |
InterProi | View protein in InterPro IPR013815, ATP_grasp_subdomain_1 IPR016185, PreATP-grasp_dom_sf IPR028713, SYN1 IPR001359, Synapsin IPR020898, Synapsin_ATP-bd_dom IPR019735, Synapsin_CS IPR019736, Synapsin_P_site IPR020897, Synapsin_pre-ATP-grasp_dom |
PANTHERi | PTHR10841:SF24, PTHR10841:SF24, 1 hit |
Pfami | View protein in Pfam PF02078, Synapsin, 1 hit PF02750, Synapsin_C, 1 hit PF10581, Synapsin_N, 1 hit |
PRINTSi | PR01368, SYNAPSIN |
SUPFAMi | SSF52440, SSF52440, 1 hit |
PROSITEi | View protein in PROSITE PS00415, SYNAPSIN_1, 1 hit PS00416, SYNAPSIN_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SYN1_BOVIN | |
Accessioni | P17599Primary (citable) accession number: P17599 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1990 |
Last sequence update: | February 1, 1996 | |
Last modified: | September 29, 2021 | |
This is version 158 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families